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The long-term goal to integrate laser-based particle accelerators into radiotherapy clinics not only requires technological development of high-intensity lasers and new techniques for beam detection and dose delivery, but also characterization of the biological consequences of this new particle beam quality, i.e. ultra-short, ultra-intense pulses. In the present work, we describe successful in vivo experiments with laser-driven electron pulses by utilization of a small tumour model on the mouse ear for the human squamous cell carcinoma model FaDu. The already established in vitro irradiation technology at the laser system JETI was further enhanced for 3D tumour irradiation in vivo in terms of beam transport, beam monitoring, dose delivery and dosimetry in order to precisely apply a prescribed dose to each tumour in full-scale radiobiological experiments. Tumour growth delay was determined after irradiation with doses of 3 and 6 Gy by laser-accelerated electrons. Reference irradiation was performed with continuous electron beams at a clinical linear accelerator in order to both validate the dedicated dosimetry employed for laser-accelerated JETI electrons and above all review the biological results. No significant difference in radiation-induced tumour growth delay was revealed for the two investigated electron beams. These data provide evidence that the ultra-high dose rate generated by laser acceleration does not impact the biological effectiveness of the particles.

the Institute of Optics and Quantum Electronics in Jena, Germany, the currently most powerful diode-pumped solid-state laser system with 25-TW peak power Polaris is in operation. In this paper we give an overview about the dispersion management of the chirped pulse amplification in order to minimize the pulse duration and thus to maximize the intensity available for experiments. A detailed description of the stretcher and compressor design with a novel alignment routine is given as well as measurements for the pulse duration and the temporal contrast. The far field measurement of the beam focussed by an off-axis parabola yields a nearly diffraction limited focal spot. [ABSTRACT FROM AUTHOR]

Purpose: In recent years, laser-based acceleration of charged particles has rapidly progressed and medical applications, e.g., in radiotherapy, might become feasible in the coming decade. Requirements are monoenergetic particle beams with long-term stable and reproducible properties as well as sufficient particle intensities and a controlled delivery of prescribed doses at the treatment site. Although conventional and laser-based particle accelerators will administer the same dose to the patient, their different time structures could result in different radiobiological properties. Therefore, the biological response to the ultrashort pulse durations and the resulting high peak dose rates of these particle beams have to be investigated. The technical prerequisites, i.e., a suitable cell irradiation setup and the precise dosimetric characterization of a laser-based particle accelerator, have to be realized in order to prepare systematic cell irradiation experiments. Methods: The Jena titanium:sapphire laser system (JETI) was customized in preparation for cell irradiation experiments with laser-accelerated electrons. The delivered electron beam was optimized with regard to its spectrum, diameter, dose rate, and dose homogeneity. A custom-designed beam and dose monitoring system, consisting of a Roos ionization chamber, a Faraday cup, and EBT-1 dosimetry films, enables real-time monitoring of irradiation experiments and precise determination of the dose delivered to the cells. Finally, as proof-of-principle experiment cell samples were irradiated using this setup. Results: Laser-accelerated electron beams, appropriate for in vitro radiobiological experiments, were generated with a laser shot frequency of 2.5 Hz and a pulse length of 80 fs. After laser acceleration in the helium gas jet, the electrons were filtered by a magnet, released from the vacuum target chamber, and propagated in air for a distance of 220 mm. Within this distance a lead collimator (aperture of 35 mm) was introduced, leading, along with the optimized setup, to a beam diameter of 35 mm, sufficient for the irradiation of common cell culture vessels. The corresponding maximum dose inhomogeneity over the beam spot was less than 10% for all irradiated samples. At cell position, the electrons posses a mean kinetic energy of 13.6 MeV, a bunch length of about 5 ps (FWHM), and a mean pulse dose of 1.6 mGy/bunch. Cross correlations show clear linear dependencies for the online recorded accumulated bunch charges, pulse doses, and pulse numbers on absolute doses determined with EBT-1 films. Hence, the established monitoring system is suitable for beam control and a dedicated dose delivery. Additionally, reasonable day-to-day stable and reproducible properties of the electron beam were achieved. Conclusions: Basic technical prerequisites for future cell irradiation experiments with ultrashort pulsed laser-accelerated electrons were established at the JETI laser system. The implemented online control system is suitable to compensate beam intensity fluctuations and the achieved accuracy of dose delivery to the cells is sufficient for radiobiological cell experiments. Hence, systematic in vitro cell irradiation experiments can be performed, being the first step toward clinical application of laser-accelerated particles. Further steps, including the transfer of the established methods to experiments on higher biological systems or to other laser-based particle accelerators, will be prepared. [ABSTRACT FROM AUTHOR]

We describe and demonstrate a novel experimental technique to record two picosecond-separated images of the evolution of a single-shot laser-produced plasma using a two-color probe beam. In this technique, the probe beam was first partially frequency doubled. The 1 ω and 2 ω components were then temporally separated in a dispersive medium. The pulses remained intrinsically synchronized, both having a duration of ∼150 fs, but they were separated by 4.1 ps. Using a Nomarskii-type interferometer, this novel technique was used to obtain two time-resolved snapshots of the evolution of the electron density at different time steps during the formation of a relativistic plasma channel. [ABSTRACT FROM AUTHOR]

Measurements of the bidirectional plasma jets that form at the surface of a solid target during a laser-generated driven magnetic reconnection are presented. Resistivity enhancement of at least 25× the classical Spitzer value is required when applying the Sweet–Parker model of reconnection to reconcile the experimentally observed reconnection time scale. Analytic calculations show that a fast reconnection model, which includes a priori the effects of microturbulent resistivity enhancement, better reproduces the experimental observations. [ABSTRACT FROM AUTHOR]

Laser-driven relativistic electron transport through aluminum foils preheated and expanded by amplified spontaneous emission (ASE) prepulses has been studied by means of two- and three-dimensional hybrid particle-in-cell simulations. This study is motivated by recent proton acceleration experiments [M. Kaluza, J. Schreiber, M. I. K. Santala, G. D. Tsakiris, K. Eidmann, J. Meyer-ter-Vehn, and K. J. Witte, Phys. Rev. Lett. 93, 045003 (2004)] showing a significant effect of the ASE prepulse on the proton spectra. Here, it is found that electron-beam collimation due to magnetic fields is reduced and resistive heating by return currents is significantly enhanced, when considering ASE-expanded rather than unperturbed solid target foils. It is shown that this allows for a consistent picture of the new proton spectra and the parameters of the driving electron pulse (angular spread at injection, laser-to-electron conversion, and energy spectrum). [ABSTRACT FROM AUTHOR]

Experiments in the context of fast ignition were carried out by focusing a 6-TW laser beam into a preformed plasma. An electron population with a quasi-temperature of 2 MeV was generated. The 2ω self-emission image reveals a self-focused plasma channel formation, whereas X-ray pinhole photography shows a postheating of the preformed plasma. [ABSTRACT FROM AUTHOR]