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Comparison study of in vivo dose response to laser-driven versus conventional electron beam.
- Source :
-
Radiation and environmental biophysics [Radiat Environ Biophys] 2015 May; Vol. 54 (2), pp. 155-66. Date of Electronic Publication: 2015 Jan 20. - Publication Year :
- 2015
-
Abstract
- The long-term goal to integrate laser-based particle accelerators into radiotherapy clinics not only requires technological development of high-intensity lasers and new techniques for beam detection and dose delivery, but also characterization of the biological consequences of this new particle beam quality, i.e. ultra-short, ultra-intense pulses. In the present work, we describe successful in vivo experiments with laser-driven electron pulses by utilization of a small tumour model on the mouse ear for the human squamous cell carcinoma model FaDu. The already established in vitro irradiation technology at the laser system JETI was further enhanced for 3D tumour irradiation in vivo in terms of beam transport, beam monitoring, dose delivery and dosimetry in order to precisely apply a prescribed dose to each tumour in full-scale radiobiological experiments. Tumour growth delay was determined after irradiation with doses of 3 and 6 Gy by laser-accelerated electrons. Reference irradiation was performed with continuous electron beams at a clinical linear accelerator in order to both validate the dedicated dosimetry employed for laser-accelerated JETI electrons and above all review the biological results. No significant difference in radiation-induced tumour growth delay was revealed for the two investigated electron beams. These data provide evidence that the ultra-high dose rate generated by laser acceleration does not impact the biological effectiveness of the particles.
- Subjects :
- Animals
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell radiotherapy
Cell Line, Tumor
Cell Proliferation radiation effects
Cell Transformation, Neoplastic
Dose-Response Relationship, Radiation
Female
Humans
Male
Mice
Radiometry
Electrons therapeutic use
Lasers
Particle Accelerators
Radiotherapy instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2099
- Volume :
- 54
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Radiation and environmental biophysics
- Publication Type :
- Academic Journal
- Accession number :
- 25600561
- Full Text :
- https://doi.org/10.1007/s00411-014-0582-1