47 results on '"Fatih Bayrak"'
Search Results
2. Co‐occurrence of late potential and discrete prepotential on ablation site in a case of cardiac crux located premature ventricular complexes successfully ablated within the middle cardiac vein
- Author
-
Veli Polat, Hasan Ali Barman, Ertugrul Okuyan, Kamil Gulsen, Fatih Bayrak, Baris Akdemir, Orhan Ince, and Acibadem University Dspace
- Subjects
medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_treatment ,Middle Cardiac Vein ,Case Report ,Case Reports ,030204 cardiovascular system & hematology ,Great cardiac vein ,middle cardiac vein ,03 medical and health sciences ,0302 clinical medicine ,Late potential ,Internal medicine ,medicine ,Anterior cardiac vein ,030212 general & internal medicine ,Cardiac crux ,late potential ,Premature ventricular complexes ,business.industry ,Ablation ,lcsh:RC666-701 ,cardiac crux ,Cardiology ,cardiovascular system ,premature ventricular complex ,Cardiology and Cardiovascular Medicine ,business ,discrete prepotential - Abstract
Some premature ventricular complexes (PVCs) originate from the coronary venous system. The great cardiac vein and the anterior cardiac vein are the most frequent localizations. The middle cardiac vein is an unusual anatomy for a point of origin for PVC. We present here a case of frequent PVCs with characteristic electrocardiographic features, which we successfully ablated inside the middle cardiac vein.
- Published
- 2019
3. Comparison of electrophysiological characteristics of right- and left-sided Mahaim-type accessory pathways
- Author
-
Cetin Alak, Ahmet Anil Baskurt, Resit Yigit Yilancioglu, Oguzhan Ekrem Turan, Emin Evren Özcan, Fatih Bayrak, Umut Dursun Inevi, and Baris Akdemir
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Catheter ablation ,Accessory pathway ,030204 cardiovascular system & hematology ,Left sided ,Pre-Excitation, Mahaim-Type ,03 medical and health sciences ,QRS complex ,Electrocardiography ,0302 clinical medicine ,Heart Conduction System ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Tachycardia, Atrioventricular Nodal Reentry ,030212 general & internal medicine ,business.industry ,Ablation ,Atrioventricular node ,Accessory Atrioventricular Bundle ,Electrophysiology ,medicine.anatomical_structure ,Cardiology ,Catheter Ablation ,Electrical conduction system of the heart ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aims Mahaim-type accessory pathways (MAPs) are generally right-sided due to the embryological differentiation, but left-sided localization is also possible. This study aims to compare the clinical and electrophysiological characteristics of right- and left-sided MAPs. Methods Of 251 patients diagnosed with AP by electrophysiological study between November 2015 and February 2020, 12 patients with MAP were included (right sided n = 8, left sided n = 4). MAP was diagnosed if; (1) no retrograde conduction; (2) anterograde decremental conduction; (3) adenosine sensitivity; and (4) Mahaim potential at successful ablation site were present. Results Ten of twelve MAPs were clustered on the lateral walls of the mitral (n = 3, 75%) and tricuspid annuli (n = 7, 87.5%). Right-sided MAPs were mostly long pathways extending toward the conduction system whereas left-sided MAPs were short extending toward the neighboring myocardium. For right- and left-sided APs, the median QRS times were 129 and 156 ms (p = .042), the median VAbl -RVApex intervals were -12 and 64 ms (p = .007), the median QRS-V(His) intervals were 16 and 86 ms (p = .120), and the median VAbl -QRS interval was -8 and 12 ms (p = .017), respectively. Coexistence of dual atrioventricular node physiology was observed only in right-sided APs (n = 3, 37.5%). Conclusion MAPs are more typically located on the right but may rarely be seen on the left. Catheter ablation was associated with high success without complications.
- Published
- 2020
4. CONTRIBUTION OF SARCOMERIC GENE VARIANTS TO THE PREDICTION OF SUDDEN CARDIAC DEATH RISK IN FAMILIAL HYPERTROPHIC CARDIOMYOPATHY
- Author
-
Filiz Geyik, Evrim Kömürcü Bayrak, Gökhan Kahveci, Fatih Bayrak, and Acibadem University Dspace
- Subjects
medicine.medical_specialty ,Familial Hypertrophic Cardiomyopathy ,business.industry ,familial hypertrophic cardiomyopathy ,medicine.disease ,sudden cardiac death ,Sarcomeric gene variant,familial hypertrophic cardiomyopathy,sudden cardiac death ,Sudden cardiac death ,Sarcomeric gene variant ,Health Care Sciences and Services ,Internal medicine ,medicine ,Cardiology ,cardiovascular system ,cardiovascular diseases ,Sarkomerik gen varyantı,ailesel hipertrofik kardiyomiyopati,ani kardiyak ölüm ,Sağlık Bilimleri ve Hizmetleri ,business ,Gene - Abstract
Amaç: Hipertrofik kardiyomiyopati (HKM), ani kardiyak ölümün (AKÖ) nedenlerinden biridir. Bu çalışmada, HKM’de en sık mutasyon bulunan üç sarkomerik gende, AKÖ için yüksek riskli patojenik varyantların belirlenmesi amaçlandı. Gereç ve Yöntem: Çalışmaya, AKÖ ve/veya HKM için aile öyküsü olan 12 yetişkin HKM’li indeks vaka ve 31 aile üyesi dahil edildi. Tüm katılımcılar, kardiyolojik olarak değerlendirildi. MYH7, MYBPC3 ve TNNT2 genlerinin ekzonik bölgeleri, CorTAG HCM1 dizileme sistemi kullanılarak analiz edildi. Bulgular: HKM’li indeks vakaların 8’inde, amino asit değişimine neden olan 6 farklı patojenik varyant bulundu. Bunlardan beşinin, MYH7 genindeki Val698Ala, Arg719Trp, Met822Leu ve Arg- 663Cys (üç vakada) ve TNNT2 genindeki Arg102Trp değişimlerinin daha önce tanımlanmış yanlış anlamlı patojenik varyantlar olduğu belirlendi. İleri yaşta AKÖ öyküsü olan bir HKM ailesinde, MYBPC3 geninde Tyr525Asn ve c.*27-21G>A varyantlar bileşik heterozigot olarak ilk defa tanımlandı. Bu varyantlar, Türk popülasyonu kontrol örneklerinde (n=777) saptanmadı. Sonuç: Bu çalışmada, AKÖ öyküsü olan bir HKM ailesinde yeni varyantlar tanımlandı. Ancak, HKM ailelerinde saptanan patojenik varyantlar ile AKÖ riski arasında net bir ilişki bulunamadı., Objective: Hypertrophic cardiomyopathy (HCM) is one of sudden cardiac death (SCD) causes. This study aimed to identify high-risk pathogenic variants for SCD in the three sarcomeric genes with the most frequent mutations in HCM. Material and Method: The study included 12 adult HCM index cases with a family history of SCD and/or HCM, and 31 of their family members. All the participants were evaluated with detailed cardiac examinations. The exonic regions of the MYH7, MYBPC3 and TNNT2 genes were analysed using CorTAG HCM1 resequencing arrays. Results: Six pathogenic variants causing amino acid substitutions were found in 8 of the index cases with HCM. Five of them were identified as previously defined missense variants of Val698Ala, Arg719Trp, Met822Leu and Arg663Cys (in three cases) in the MYH7 gene, and Arg102Trp in the TNNT2 gene. For the first time in an HCM family with a history of late-onset SCD, Tyr525Asn and c.*27-21G> A variants in the MYBPC3 gene were identified as compound heterozygous. These variants were not present in control subjects (n=777) from the Turkish population. Conclusion: In this study, novel variants in the MYBPC3 gene were identified in an HCM family with SCD history. However, there was no clear association between pathogenic variants and the risk of SCD.
- Published
- 2020
5. Value of latent outflow obstruction to predict clinical course of patients with hypertrophic cardiomyopathy
- Author
-
Fatih Bayrak, Bülent Mutlu, Ulaankhuu Batgerel, Tansu Karaahmet, Gökhan Kahveci, Ali Buturak, and Atilla Koyuncu
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Heart Ventricles ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,Ventricular Outflow Obstruction ,03 medical and health sciences ,0302 clinical medicine ,Cause of Death ,Internal medicine ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Survival rate ,Cause of death ,business.industry ,Hazard ratio ,Hypertrophic cardiomyopathy ,General Medicine ,Cardiomyopathy, Hypertrophic ,Middle Aged ,Prognosis ,medicine.disease ,Confidence interval ,Survival Rate ,Log-rank test ,Echocardiography ,Heart failure ,Disease Progression ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Objective The frequency, significance and prognostic value of left ventricle obstruction (LVO) induced with provocation (latent LVO) is controversial for hypertrophic cardiomyopathy (HC) patients. This study was designed to assess the value of latent LVO in predicting the clinical course in 101 patients with HC. Methods and results Patients were followed for a mean of 82 ± 48 months (range 2 to 148 months) for clinical end points defined as a composite of cardiovascular death resuscitated cardiac arrest, appropriate defibrillator shock or hospitalization due to worsening of heart failure symptoms. Presence of LVO (hazard ratio 3.63; 95% confidence interval, 1.85 to 7.12; P = 0.0001) and log NT-proBNP levels (hazard ratio, 1.40; 95% confidence interval, 1.14 to 1.72; P = 0.001) were the independent variables associated with an increased risk of experiencing clinical end points. HC patients with latent LVO have a trend toward decreased survival when compared with HC patients without LVO (log rank P = 0.027), but better survival than patients with resting LVO (log rank P = 0.007). HC patients with NT-proBNP levels
- Published
- 2017
6. The Back Side of The Medallion in Primary Tricuspid Valve Disease; Incremental Value Of the 3D Echocardiography
- Author
-
Selçuk Pala, Munevver Sari, Gökhan Kahveci, Duhan Fatih Bayrak, and Abdulkadir Uslu
- Subjects
medicine.medical_specialty ,Tricuspid valve ,business.industry ,Treatment options ,Regurgitation (circulation) ,Tricuspid valve disease ,medicine.anatomical_structure ,Posterior leaflet ,Internal medicine ,cardiovascular system ,medicine ,Cardiology ,cardiovascular diseases ,Permanent pacemaker ,Tricuspid Valve Regurgitation ,Cardiology and Cardiovascular Medicine ,business ,3d echocardiography - Abstract
Primary tricuspid valve regurgitation may be encountered in daily practice as a result of multiple etiologies. Described herein are the cases of 2 patients with severe primary tricuspid regurgitation. The underlying mechanism was posterior leaflet prolapse due to spontaneous chordae rupture in 1 case, and iatrogenic posterior leaflet tissue loss during removal of a permanent pacemaker in the other. Transthoracic and transesophageal echocardiography, which permit assessment of the tricuspid valve with multilevel imaging, are the techniques of choice for accurate detection and understanding of the etiology, the severity of valve regurgitation, and the determination of treatment options, in addition to providing assistance with timing and guidance during intervention. Three-dimensional echocardiography offers the ability to visualize the entire tricuspid valve and to identify which leaflets are affected by the pathology.
- Published
- 2018
7. Multiple left ventricle crypts in a patient with hypertrophic cardiomyopathy
- Author
-
Atilla Damlacık, Ali Buturak, Fatih Bayrak, and Sinan Dagdelen
- Subjects
lcsh:Internal medicine ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,business.industry ,lcsh:R ,congenital ,Hypertrophic cardiomyopathy ,lcsh:Medicine ,medicine.disease ,cardiac imaging ,lcsh:RC666-701 ,Internal medicine ,heart defects ,medicine ,Cardiology ,In patient ,lcsh:RC31-1245 ,Cardiology and Cardiovascular Medicine ,business ,Cardiac imaging - Published
- 2016
8. Elective percutaneous coronary intervention leads to significant changes in serum resistin, leptin, and adiponectin levels regardless of periprocedural myocardial injury: an observational study
- Author
-
Aleks Degirmencioglu, Fatih Bayrak, Ozgur Surgit, Ali Buturak, Ali Rıza Demir, Tuncay Kırış, Mehmet Erturk, Huseyin Karakurt, and Acibadem University Dspace
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Myocardial Infarction ,Adipokine ,030209 endocrinology & metabolism ,leptin ,03 medical and health sciences ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Myocardial infarction ,coronary ,Original Investigation ,Aged ,resistin ,Troponin T ,Adiponectin ,adiponectin ,business.industry ,Leptin ,Percutaneous coronary intervention ,Middle Aged ,medicine.disease ,Cross-Sectional Studies ,030220 oncology & carcinogenesis ,Conventional PCI ,Cardiology ,Female ,Resistin ,Cardiology and Cardiovascular Medicine ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Objective: Bioactive roles of adipokines in coronary atherosclerosis and acute coronary syndromes have been demonstrated previously. Ho-wever, there is a lack of data regarding the relationship between serum adipokines and periprocedural myocardial injury (PMI) following elective percutaneous coronary intervention (PCI). Therefore, we aimed to investigate the association between serum adipokines and PMI related to elective PCI. Methods: In total, 153 consecutive patients (aged 60.6 +/- 8.2 years, 98 men) with stable angina pectoris undergoing elective PCI were enrolled in this observational cross-sectional study. Serum resistin, leptin, adiponectin, and high-sensitive Troponin T (hscTnT) levels were measured immediately before PCI and after 12-h PCI. The no-injury, PMI, and type 4a myocardial infarction (type 4a MI) groups were defined as groups consisting patients with post-procedural hscTnT concentrations < 14 ng/L, between 14-70 ng/L, and > 70 ng/L, respectively. Results: Serum hscTnT, resistin, and leptin concentrations significantly (p
- Published
- 2016
9. Hipertrofik kardiyomiyopatide BOP geni varyasyonlari
- Author
-
Çağrı Güleç, Nihan Erginel Ünaltuna, Neslihan Abaci, Fatih Bayrak, Gökhan Kahveci, Evrim Kömürcü Bayrak, Abaci, N., Güleç, C., Bayrak, F., Kömürcü-Bayrak, E., Kahveci, G., Erginel-Ünaltuna, N., and Yeditepe Üniversitesi
- Subjects
Clinical heterogeneity ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,Chromosomes, Human, Pair 21 ,CD8 Antigens ,Muscle Proteins ,Single-nucleotide polymorphism ,Bioinformatics ,Mice ,Exon ,Modifying gene ,Reference Values ,Internal medicine ,Genetic variation ,Genotype ,medicine ,Animals ,Humans ,BOP ,Aged ,business.industry ,Haplotype ,Hypertrophic cardiomyopathy ,Genetic Variation ,Proteins ,RNA-Binding Proteins ,Electroencephalography ,Single-strand conformation polymorphism ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,Null allele ,Molecular biology ,DNA-Binding Proteins ,Cross-Sectional Studies ,QT dispersion ,Mutation ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Chickens ,Echocardiography, Transesophageal ,Transcription Factors - Abstract
Objective: The observation that Bop null allele mice show underdeveloped right ventricle and excessive development of left ventricle, suggests the possible relationship between human BOP gene and hypertrophic cardiomyopathy (HCMP). In our study, we investigated this possible relationship between BOP gene variations and QT dispersion, a noninvasive arrhythmic risk marker for HCMP. Methods: This cross-sectional study consisted of 50 patients clinically diagnosed with HCMP and 60 healthy subjects. Exonic regions of BOP gene were amplified by polymerase chain reaction and amplified exonic regions were analyzed by Single-Strand Conformation Polymorphisms (SSCP). The samples with different migration patterns were sequenced through an automated sequencing system. Continuous variables were compared by unpaired t-test for independent samples or Mann-Whitney U test. Genotype-disease relationship was tested by Chi-square test. Results: The nucleotide substitutions G275>A and C965>A in exon 2 and 7 were determined only in HCMP group. The G707>C, C710>T, T761>C, T1217>C SNPs in exon 6 and 9 are also found in the control group. Significant differences were found between two groups (p=0.002 and p
- Published
- 2010
10. Chronic Cigarette Smoking Affects Left and Right Ventricular Long-Axis Function in Healthy Young Subjects: A Doppler Myocardial Imaging Study
- Author
-
Muzaffer Degertekin, Sinan Aydın, Fatih Bayrak, Firat Yalniz, Ali Kemal Kalkan, Elif Eroglu, Eroglu, E., Aydin, S., Yalniz, F., Kalkan, A.K., Bayrak, F., Degertekin, M., and Yeditepe Üniversitesi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Heart Ventricles ,Ventricular Dysfunction, Right ,Diastole ,Coronary artery disease ,Ventricular Dysfunction, Left ,symbols.namesake ,Cigarette smoking ,Reference Values ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Ventricular function ,Coronary atherosclerosis ,Ultrasonography ,Doppler myocardial imaging ,Long axis ,business.industry ,Smoking ,medicine.disease ,Myocardial imaging ,Baseline characteristics ,symbols ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Doppler effect - Abstract
Objective: Cigarette smoking is one of the major risk factors for coronary artery disease. However, chronic smoking has additional cardiac adverse effects independent of coronary atherosclerosis. We assessed the possible effects of chronic smoking on left and right ventricular (LV, RV) long-axis function using Doppler myocardial imaging (DMI). Methods: Forty otherwise healthy smokers (mean age = 26 ± 3 years) and 40 age-matched nonsmoking controls enrolled. Standard echocardiography protocol was followed by DMI. Peak systolic (V S), early (VE) and late diastolic (VA) velocities, peak systolic strain (S), and strain rate (SR) were measured from septal, lateral, and RV free walls. Results: The baseline characteristics of two groups were similar. There were significant differences regarding Doppler myocardial velocity, S, and SR indices. Septal VE (P < 0.04), S (P < 0.0001) and SR (P < 0.02) were significantly reduced in smokers. For both lateral and RV free wall, VS (P < 0.003, P < 0.002, respectively), VE (P < 0.0001, P < 0.002, respectively), S (P < 0.0001 for both), and SR (P < 0.0001, P < 0.002, respectively) were significantly reduced in smokers. There were significant correlations between the amount of smoking and septal, lateral, and RV free wall S and SR. Conclusions: Chronic cigarette smoking causes alterations in long-axis systolic and diastolic functions of right and left ventricles in healthy young subjects. These changes can be accurately detected with Doppler myocardial velocity and SR imaging. (ECHOCARDIOGRAPHY, Volume 26, October 2009).
- Published
- 2009
11. Prevalence of left main coronary artery disease among patients referred to multislice computed tomography coronary examinations
- Author
-
Fatih Bayrak, Elif Eroglu, Tahsin Güneysu, Bülent Mutlu, Muzaffer Degertekin, Semih Aytaclar, Deniz Sevinc, Zafer Kaya, and Gökmen Gemici
- Subjects
Male ,medicine.medical_specialty ,Turkey ,medicine.medical_treatment ,Comorbidity ,Coronary Artery Disease ,Coronary Angiography ,Coronary artery disease ,Risk Factors ,Diabetes mellitus ,Internal medicine ,Prevalence ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Myocardial infarction ,Cardiac imaging ,Retrospective Studies ,Analysis of Variance ,Univariate analysis ,Chi-Square Distribution ,business.industry ,Percutaneous coronary intervention ,Multislice computed tomography ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Cardiology ,Radiographic Image Interpretation, Computer-Assisted ,Female ,Radiology ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
We have evaluated the prevalence of left main coronary artery disease (LMCAD) among patients referred to multislice computed tomography (MSCT) coronary angiography examinations. The study Group comprised of 1,000 consecutive patients (750 male and 250 female; mean age 53±12 years) who underwent successful 64-slice MSCT examinations. Left main coronary artery (LMCA) was classified into three Groups: normal LMCA; nonsignificant LMCAD with coronary plaques resulting in obstructions ≤50%; and significant LMCAD corresponding to obstructions >50%. We have found that 24 patients (2.4%) had significant LMCAD. Additional 200 patients (20%) had nonsignificant LMCAD. Univariate analysis revealed that LMCAD was associated with age, male gender, diabetes, hypertension, hyperlipidemia, typical symptoms, history of previous myocardial infarction and previous percutaneous coronary intervention. Only age and male gender were found as independent predictors for LMCAD in multivariate analysis (P < 0.001 and P = 0.001, respectively,). Angiographic follow-up was avaliable for the 24 patients with significant LMCAD, and conventional coronary angiography confirmed the presence of significant LMCAD in all of these patients. Significant LMCAD was found in 2.4% of the 1,000 patients referred to 64-slice MSCT examinations. Age and male gender were the independent predictors for LMCAD.
- Published
- 2008
12. Clinical Significance of High-Density Lipoprotein Cholesterol in Left-Sided Infective Endocarditis
- Author
-
Kursat Tigen, Yusuf Gurel, Yelda Basaran, Bülent Mutlu, Tansu Karaahmet, Fatih Bayrak, Gökhan Kahveci, Kahveci, G., Bayrak, F., Mutlu, B., Gurel, Y.E., Karaahmet, T., Tigen, K., Basaran, Y., and Yeditepe Üniversitesi
- Subjects
Male ,medicine.medical_specialty ,Sensitivity and Specificity ,Severity of Illness Index ,Gastroenterology ,chemistry.chemical_compound ,High-density lipoprotein ,Predictive Value of Tests ,Serum HDL cholesterol level ,Internal medicine ,medicine ,Left sided infective endocarditis ,Humans ,Clinical significance ,In patient ,Serum Albumin ,Triglycerides ,Retrospective Studies ,Endocarditis ,Cholesterol ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Hospitalization ,Lipoproteins, LDL ,Cross-Sectional Studies ,Endocrinology ,chemistry ,Case-Control Studies ,Creatinine ,Infective endocarditis ,Cardiology ,Female ,lipids (amino acids, peptides, and proteins) ,Lipoproteins, HDL ,Cardiology and Cardiovascular Medicine ,business ,Lipoprotein - Abstract
Decreased serum levels of high-density lipoprotein (HDL) cholesterol have been shown to be of prognostic significance in patients with severe infectious diseases. Serum HDL cholesterol levels were therefore investigated as a possible parameter for the prediction of clinical outcomes in patients with left-sided infective endocarditis (IE). Fifty-four patients with IE with available admission serum HDL cholesterol levels were included in the study. A clinical outcome was defined as a complicated course during hospitalization. Forty-two patients had complicated courses during their in-hospital stays. The median serum HDL cholesterol level was significantly lower in patients with IE (n = 54) than healthy controls (n = 26) (26 vs 47 mg/dl, p
- Published
- 2008
13. N-Terminal Pro Brain Natriuretic Peptide to Predict Prognosis in Dilated Cardiomyopathy with Sinus Rhythm
- Author
-
Kursat Tigen, Yelda Basaran, Ali Cevat Tanalp, Tansu Karaahmet, Hakan Fotbolcu, Fatih Bayrak, Atilla Bitigen, Bülent Mutlu, and Gökhan Kahveci
- Subjects
Adult ,Cardiomyopathy, Dilated ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Adolescent ,medicine.drug_class ,Cardiomyopathy ,Sensitivity and Specificity ,Ventricular Dysfunction, Left ,Heart Conduction System ,Internal medicine ,Natriuretic Peptide, Brain ,medicine ,Natriuretic peptide ,Humans ,Sinus rhythm ,Prospective Studies ,cardiovascular diseases ,Child ,Aged ,Proportional Hazards Models ,Heart Failure ,Analysis of Variance ,Ejection fraction ,Proportional hazards model ,business.industry ,Stroke Volume ,Dilated cardiomyopathy ,Stroke volume ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Peptide Fragments ,Death, Sudden, Cardiac ,Echocardiography ,Research Design ,Heart failure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Follow-Up Studies - Abstract
To assess the value of plasma NT proBNP levels for predicting adverse outcomes in patients with dilated cardiomyopathy (DCM).Seventy-eight patients with DCM (EF40%) with sinus rhythm were enrolled. All patients had undergone echocardiographic examination, coronary angiography, and cardiac catheterisation. Blood samples for plasma NT proBNP levels were taken at rest following echocardiographic examination. Patients were followed up for 660+/-270 days for clinical endpoints defined as; death from worsening heart failure, sudden cardiac death and heart transplantation (Tx).Clinical end points were observed in 19 patients (5 Tx, 4 sudden cardiac death, 10 death from worsening heart failure). Variables associated with an increased hazard of clinical endpoints in univariate analysis were log NT proBNP, age, NYHA functional class, left ventricle ejection fraction, mitral valve effective regurgitation orifice area, and E wave deceleration time. The plasma level of NT proBNP (Hazard ratio=2.5 [95% CI: 1.3-4.7], p=0.0024) and age (hazard ratio=0.94 [95% CI: 0.90-0.98], p=0.0005) were the independent variables associated with an increased risk of clinical endpoints. NT proBNP plasma level4500 pg/ml detected patients with clinical endpoints with a sensitivity, and specificity of 72%, 80%, respectively. The event free survival was found to be significantly lower in patients with NT proBNP levels4500 pg/ml.NT proBNP seems to be a strong predictor of adverse outcomes in patients with DCM with sinus rhythm and may be used as a reliable biological marker in risk stratification.
- Published
- 2007
14. Ventricular pre-excitation and cardiac hypertrophy mimicking hypertrophic cardiomyopathy in a Turkish family with a novel PRKAG2 mutation
- Author
-
Bülent Mutlu, Yelda Basaran, Evrim Komurcu-Bayrak, Nihan Erginel-Unaltuna, Fatih Bayrak, Gökhan Kahveci, Bayrak, F, Komurcu-Bayrak, E, Mutju, B, Kahveci, G, Basaran, Y, Erginel-Unaltuna, N, and Yeditepe Üniversitesi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pre-Excitation Syndromes ,Adolescent ,Turkey ,Cardiomyopathy ,Ventricular outflow tract obstruction ,Cardiomegaly ,AMP-Activated Protein Kinases ,Protein Serine-Threonine Kinases ,White People ,Diagnosis, Differential ,Multienzyme Complexes ,Ventricular hypertrophy ,Right ventricular hypertrophy ,Internal medicine ,Cardiomyopathy, Hypertrophic, Familial ,medicine ,Humans ,Missense mutation ,genetics ,Genetic Predisposition to Disease ,business.industry ,Hypertrophic cardiomyopathy ,ventricular pre-excitation ,Middle Aged ,medicine.disease ,Pedigree ,Case-Control Studies ,Heart failure ,Mutation ,Mutation (genetic algorithm) ,cardiovascular system ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,cardiomyopathy - Abstract
Background: Mutations in PRKAG2, the gene for the gamma 2 regulatory subunit of AMP-activated protein kinase, cause cardiac hypertrophy and electrophysiological abnormalities. We identified a novel mutation in PRKAG2 causing familial ventricular pre-excitation and severe cardiac hypertrophy. Methods and results: We studied 30 members of one family and 120 healthy controls. Molecular analysis of PRKAG2 gene revealed one missense mutation in exon 14 which was confirmed by restriction enzyme digestion. We identified a G to A transition, resulting in a Glu506Lys substitution in the PRKAG2 gene in 8 of the family members, who all had cardiac hypertrophy and ventricular pre-excitation. High incidence of right ventricular hypertrophy and left ventricular outflow tract obstruction are other prominent features of this novel PRKAG2 mutation. Family members without mutation had no cardiac disease. The 120 unrelated healthy individuals did not show this mutation. Conclusions: Coexistence of unexplained ventricular hypertrophy and pre-excitation should prompt the diagnosis of PRKAG2 mutations and these patients should be referred for genetic analysis. The possible alteration of AMP-activated protein kinase activity due to genetic defects in PRKAG2 may serve as a template for developing more specific therapies in the treatment of patients with this mutation. (c) 2006 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
- Published
- 2006
15. Fibrillatory wave amplitude as a marker of left atrial and left atrial appendage function, and a predictor of thromboembolic risk in patients with rheumatic mitral stenosis
- Author
-
Hakan Fotbolcu, Bülent Mutlu, Fatih Bayrak, Mustafa Karabulut, Kursat Tigen, Yelda Basaran, and Elif Eroglu
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Heart disease ,Statistics as Topic ,Severity of Illness Index ,Electrocardiography ,Predictive Value of Tests ,Risk Factors ,Thromboembolism ,Internal medicine ,Mitral valve ,Atrial Fibrillation ,Prevalence ,medicine ,Humans ,Mitral Valve Stenosis ,Atrial Appendage ,Heart Atria ,cardiovascular diseases ,Aged ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Vascular disease ,P wave ,Rheumatic Heart Disease ,Mitral Valve Insufficiency ,Stroke Volume ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Surgery ,Stenosis ,Logistic Models ,medicine.anatomical_structure ,Echocardiography ,cardiovascular system ,Cardiology ,Mitral Valve ,Rheumatic fever ,Atrial Function, Left ,Female ,Cardiology and Cardiovascular Medicine ,business ,Blood Flow Velocity ,Echocardiography, Transesophageal - Abstract
Patients with mitral stenosis, especially those with atrial fibrillation, are at increased risk for thromboembolic complications. Size of the left atrium, left atrial appendage dysfunction and severity of mitral stenosis are known risk factors for thromboembolism in patients with mitral stenosis. It has been postulated that F-wave amplitude on surface ECG is correlated with left atrial size, left atrial appendage function, and risk of thromboembolism in patients with nonrheumatic atrial fibrillation. The aims of this study were as follows: (1) to examine the relationship between surface ECG F-wave amplitude and left atrial appendage function, and (2) to assess the clinical significance of F-wave amplitude as it relates to risk of thromboembolism in a group of patients with rheumatic mitral stenosis.One hundred patients with rheumatic mitral stenosis and permanent atrial fibrillation but without moderate to severe mitral insufficiency were investigated by transthoracic and transesophageal echocardiography. Two groups were formed according to the presence of a coarse (Group 1; n=60; F-wave in lead V1or =1 mm) or fine (Group 2; n=40; F-wave in lead V11 mm) F-wave on surface ECG.Comparison showed that Group 1 had significantly smaller mitral valve area (1.44+/-0.6 versus 1.7+/-0.74 cm2, respectively; P0.05), lower peak left atrial appendage flow velocity (18.8+/-2.1 versus 25.6+/-1.9 cm/s, respectively; P0.005), higher-grade spontaneous echo contrast (2.05+/-1.44 versus 0.98+/-1.14, respectively; P0.0001), and higher prevalence of thromboembolism (35% versus 12.5%, respectively; P0.012). Multiple logistic regression analysis revealed that mitral valve area, left atrial appendage peak velocity, and coarse F-wave were independent clinical risk factors for thromboembolism in this patient group.The data suggest that presence of a coarse F-wave on surface ECG is associated with left atrial appendage dysfunction, and indicates higher thromboembolic risk in patients with predominant rheumatic mitral stenosis.
- Published
- 2003
16. Association between non-coding polymorphisms of HOPX gene and syncope in hypertrophic cardiomyopathy
- Author
-
Nihan Erginel Ünaltuna, Celal Güven, Neslihan Abaci, Fatih Bayrak, Çağrı Güleç, Gökhan Kahveci, Evrim Kömürcü Bayrak, and Acibadem University Dspace
- Subjects
Untranslated region ,Male ,medicine.medical_specialty ,Syncope ,polymorphism ,Internal medicine ,Genotype ,medicine ,Coding region ,Humans ,Gene ,Polymorphism, Single-Stranded Conformational ,Genetics ,Homeodomain Proteins ,modifier gene ,Polymorphism, Genetic ,business.industry ,Tumor Suppressor Proteins ,Haplotype ,Hypertrophic cardiomyopathy ,Single-strand conformation polymorphism ,HOPX ,Cardiomyopathy, Hypertrophic ,medicine.disease ,hypertrophic cardiomyopathy ,Case-Control Studies ,Cardiology ,Cancer research ,Female ,Restriction fragment length polymorphism ,Cardiology and Cardiovascular Medicine ,business ,Polymorphism, Restriction Fragment Length - Abstract
Objective Homeodomain Only Protein X (HOPX) is an unusual homeodomain protein which regulates Serum Response Factor (SRF) dependent gene expression. Due to the regulatory role of HOPX on SRF activity and the regulatory role of SRF on cardiac hypertrophy, we aimed to investigate the relationship between HOPX gene variations and hypertrophic cardiomyopathy (HCM). Methods In this study, designed as a case-control study, we analyzed coding and flanking non-coding regions of the HOPX gene through 67 patients with HCM and 31 healty subjects. Certain regions of the gene were investigated by Single Stranded Conformation Polymorphism (SSCP) and Restriction Fragment Length Polymorphism (RFLP). Statistical analyses of genotypes and their relationship with clinical parameters were performed by chi-square, Kruskal-Wallis and the Fisher's exact test. Results In 5' Untranslated Region (UTR) and intronic region of the HOPX gene, we found a C>T substitution and an 8-bp insertion/deletion (In/Del) polymorphism, respectively. These two polymorphisms seemed to constitute an haplotype. While the frequency of homozygous genotypes of In/Del and C/T polymorphisms were found significantly lower in the patients with syncope (p=0.014 and p=0.017, respectively), frequency of their heterozygous genotypes were found significantly higher in the patients with syncope (p=0.048 and p=0.030, respectively). CONCLUSION: Though there was not found any mutation in coding sequence of HOPX gene, two non-coding polymorphisms were found related to syncope in HCM patients. While homozygous status of these polymorphisms was found to be protective against the syncope, their heterozygous status seemed to be a risk factor for syncope in HCM patients. Our results suggest that HOPX may contribute to pathogenesis or manifestation of HCM as a modifier gene.
- Published
- 2014
17. PP-142 Radial Artery Dilatation with Impaired Vasodilatation as an Acute Response Occurs after Transradial Catheterization
- Author
-
Selçuk Yazıcı, Burak Murat Tekturk, Ali Buturak, Aleks Degirmencioglu, Tuncay Kırış, Ozden Sila Ulus, and Fatih Bayrak
- Subjects
Transradial catheterization ,medicine.medical_specialty ,business.industry ,medicine.artery ,Internal medicine ,Cardiology ,Medicine ,Vasodilation ,Radial artery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2015
18. The usefulness of the consensus clinical diagnostic criteria in Brugada syndrome
- Author
-
Yoshinao Yazaki, Andrea Sarkozy, Gian-Battista Chierchia, Josep Brugada, Mehdi Namdar, Sergio Richter, Pedro Brugada, Carlo de Asmundis, Ruben Casado-Arroyo, Fatih Bayrak, Gaetano Paparella, Tim Boussy, Cardio-vascular diseases, and Heartrhythmmanagement
- Subjects
Adult ,Male ,medicine.medical_specialty ,Consensus ,Adolescent ,Ventricular tachycardia ,Sudden cardiac death ,Electrocardiography ,Young Adult ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Registries ,cardiovascular diseases ,Family history ,Brugada syndrome ,Brugada Syndrome ,Univariate analysis ,Cardiovascular diseases [NCEBP 14] ,business.industry ,ECG ,Significant difference ,Atrial fibrillation ,Middle Aged ,medicine.disease ,ventricular fibrillation ,Ventricular fibrillation ,Cardiology ,cardiovascular system ,Female ,Human medicine ,ventricular tachycardia ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Background: Consensus statements were proposed for the diagnosis of Brugada syndrome (BS). The clinical diagnostic criteria were defined as documented ventricular fibrillation or ventricular tachycardia (VT), family history of sudden cardiac death at
- Published
- 2013
19. Prevalence, clinical characteristics and management of atrial fibrillation in patients with Brugada syndrome
- Author
-
Pedro Brugada, Carlo de Asmundis, Jayakeerthi Y. Rao, Andrea Sarkozy, Sophie Van Malderen, Kristel Wauters, Gian-Battista Chierchia, Mehdi Namdar, Ruben Casado-Arroyo, Danilo Ricciardi, Moisés Rodríguez-Mañero, Fatih Bayrak, Cardio-vascular diseases, and Heartrhythmmanagement
- Subjects
Adult ,Male ,medicine.medical_specialty ,Population ,Management of atrial fibrillation ,Sudden death ,Sudden cardiac death ,Electrocardiography ,Belgium ,Risk Factors ,Internal medicine ,Atrial Fibrillation ,medicine ,Prevalence ,Humans ,Brugada syndrome ,Family history ,education ,Retrospective Studies ,education.field_of_study ,Cardiovascular diseases [NCEBP 14] ,business.industry ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Prognosis ,Ajmaline ,Cardiology ,Female ,Human medicine ,Cardiology and Cardiovascular Medicine ,business ,Anti-Arrhythmia Agents ,medicine.drug - Abstract
Atrial fibrillation (AF) can be the first manifestation of latent Brugada syndrome (BS). The aim of our study was to assess the prevalence of AF as the first clinical diagnosis in patients with BS and their demographic and clinical characteristics and diagnosis management in a large cohort of patients. The patient group consisted of 611 patients with BS. The data from those with a diagnosis of AF previous to the identification of BS were analyzed (n = 35). Eleven cases were unmasked after the initiation of a class I antiarrhythmic drug and one during the establishment of general anesthesia. In the remaining population, BS was diagnosed using an ajmaline test performed mainly because of younger age in patients with lone AF (n = 13), previous syncope or sudden cardiac death (n = 3), or a clinical history of sudden cardiac death in the family (n = 5). The mean patient age was 49 +/- 15 years, 21 were male patients, 14 had a family history of sudden death, 15 had had previous syncope, and 4 had survived cardiac arrest. Concomitant electrical disorder was found in 13 patients. Remarkably, 21 patients had normal findings on the baseline electrocardiogram. In conclusion, AF could be one of the first clinical manifestations of latent BS in a considerable number of patients. This identification is crucial because the treatment of these patients is subject to relevant changes. The ajmaline test plays an essential role, mainly in young patients with a family history of sudden death, despite having normal findings on a baseline electrocardiogram. (C) 2013 Elsevier Inc. All rights reserved. (Am J Cardiol 2013;111:362-367)
- Published
- 2013
20. Simultaneous wide and narrow QRS complex tachycardia: what is the mechanism?
- Author
-
Andrea Sarkozy, Fatih Bayrak, Danilo Ricciardi, Ruben Casado-Arroyo, Gian-Battista Chierchia, Pedro Brugada, Moisés Rodríguez-Mañero, Mehdi Namdar, Carlo de Asmundis, Internal Medicine Specializations, and Cardio-vascular diseases
- Subjects
Male ,Tachycardia ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,Right Ventricular Outflow Tract Tachycardia ,Narrow QRS complex ,Syncope ,Electrocardiography ,QRS complex ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,General Environmental Science ,biology ,Cardiovascular diseases [NCEBP 14] ,Mechanism (biology) ,business.industry ,Syncope (genus) ,Middle Aged ,Sciences bio-médicales et agricoles ,biology.organism_classification ,lcsh:RC666-701 ,Anesthesia ,cardiovascular system ,Cardiology ,General Earth and Planetary Sciences ,Human medicine ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
We present the case of a 50-year-old patient with several episodes of syncope and documented simultaneous wide and narrow QRS complex tachycardia. We then review this tacharrhythmia, focusing on electrophysiological findings and pathophysiology, diagnosis and treatment., Journal Article, info:eu-repo/semantics/published
- Published
- 2013
21. The apple does not fall far from the tree: epicardial ventricular tachycardia due to blunt chest trauma
- Author
-
Andrea Sarkozy, Pedro Brugada, Mehdi Namdar, Mark La Meir, Fatih Bayrak, Ruben Casado-Arroyo, and Cardio-vascular diseases
- Subjects
Male ,medicine.medical_specialty ,Rib Fractures ,Thoracic Injuries ,Trees (plant) ,Wide QRS Tachycardia ,Ventricular tachycardia ,Wounds, Nonpenetrating ,Cryosurgery ,Blunt ,Internal medicine ,Palpitations ,Medicine ,Humans ,cardiovascular diseases ,business.industry ,Emergency department ,Middle Aged ,medicine.disease ,Sternotomy ,Wounds nonpenetrating ,Surgery ,Cardiology ,Tachycardia, Ventricular ,Accidental Falls ,Human medicine ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
A 62-year-old male was admitted to the emergency department of our centre because of recurrent episodes of palpitations and dizziness. The patient had a history of severe blunt chest trauma with multiple rib fractures (5–10th) due to a tractor fall 2 years before. The electrocardiographic tracing at admission showed ( Panel A ) a wide QRS tachycardia with the right …
- Published
- 2012
22. Verification of pulmonary vein isolation during single transseptal cryoballoon ablation : a comparison between the classical circular mapping catheter and the inner lumen mapping catheter
- Author
-
Ingrid Overeinder, Carlo de Asmundis, Andrea Sarkozy, Jayakeerthi Y. Rao, Danilo Ricciardi, Fatih Bayrak, Ruben Casado-Arroyo, Antonio Sorgente, Gaetano Paparella, Lucio Capulzini, Moisés Rodríguez-Mañero, Pedro Brugada, Mehdi Namdar, Gian-Battista Chierchia, Cardio-vascular diseases, and Heartrhythmmanagement
- Subjects
Male ,medicine.medical_specialty ,conduction ,cryoballoon ,medicine.medical_treatment ,Lumen (anatomy) ,Ablation ,Cryosurgery ,Sensitivity and Specificity ,Pulmonary vein isolation ,Cardiac Catheters ,Pulmonary vein ,classical circular mapping catheter ,inner lumen mapping catheter ,Heart Conduction System ,paroxysmal atrial-fibrillation ,Physiology (medical) ,Internal medicine ,Atrial Fibrillation ,Occlusion ,medicine ,Humans ,Fluoroscopy ,Cryoballoon ablation ,Cardiovascular diseases [NCEBP 14] ,medicine.diagnostic_test ,business.industry ,Body Surface Potential Mapping ,Reproducibility of Results ,Cryoablation ,Equipment Design ,Equipment Failure Analysis ,Catheter ,Treatment Outcome ,Pulmonary Veins ,cryoablation ,Cardiology ,Female ,Human medicine ,puncture ,Cardiology and Cardiovascular Medicine ,Nuclear medicine ,business ,Angioplasty, Balloon - Abstract
Item does not contain fulltext AIMS: Cryoballoon ablation has proven very effective in achieving pulmonary vein isolation (PVI). The novel Achieve inner lumen mapping catheter designed to be used in conjunction with the cryoballoon, serves as both a guidewire and a mapping catheter. To our knowledge, this is the first study comparing the latter to verification of electrical isolation with the 'traditional' circular mapping catheter. METHODS AND RESULTS: We assigned 40 consecutive patients matched for age and left atrial diameter suffering of paroxysmal atrial fibrillation to cryoballoon PVI using either the circular mapping catheter or the Achieve as a mapping catheter. Duration of procedure as well as fluoroscopy times were significantly lower in the Achieve group than in the circular mapping catheter group (111 +/- 14 min vs. 126 +/- 13 min, P < 0.005 and 22 +/- 5 min vs. 29 +/- 4 min, P < 0.0001, respectively). There were no significant differences between both groups in terms of mean degree of occlusion, mean minimal temperatures, and PVI. Pulmonary vein isolation could be documented by real-time recordings in 55% of veins in the Achieve group with mean time to isolation of 65 +/- 23 s. CONCLUSION: Cryoballoon ablation in conjunction with the novel Achieve is feasible, safe, and affords PVI in nearly all veins in similar proportions to the approach with the traditional guidewire. Furthermore, if compared to the procedure with the circular mapping catheter, cryoballoon ablation with the Achieve is significantly faster and associated to shorter fluoroscopy times.
- Published
- 2012
23. Value of electrocardiogram in the differentiation of hypertensive heart disease, hypertrophic cardiomyopathy, aortic stenosis, amyloidosis, and Fabry disease
- Author
-
Danilo Ricciardi, Mehdi Namdar, Giovanni G. Camici, Carlo de Asmundis, Andrea Sarkozy, Firat Duru, Christian Schmied, Jan Steffel, Gian-Battista Chierchia, David Hürlimann, Thomas F. Lüscher, Rolf Jenni, Jayakeerthi Y. Rao, Sandra Jetzer, Fatih Bayrak, Pedro Brugada, University of Zurich, and Namdar, M
- Subjects
Male ,medicine.medical_specialty ,Heart Diseases ,Heart Ventricles ,Cardiomyopathy ,610 Medicine & health ,030204 cardiovascular system & hematology ,Left ventricular hypertrophy ,Sensitivity and Specificity ,2705 Cardiology and Cardiovascular Medicine ,Diagnosis, Differential ,Electrocardiography ,03 medical and health sciences ,0302 clinical medicine ,Ventricular hypertrophy ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,PR interval ,Analysis of Variance ,medicine.diagnostic_test ,Cardiovascular diseases [NCEBP 14] ,business.industry ,Amyloidosis ,Hypertrophic cardiomyopathy ,Aortic Valve Stenosis ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,Hypertensive heart disease ,3. Good health ,ROC Curve ,Echocardiography ,Case-Control Studies ,Hypertension ,10209 Clinic for Cardiology ,Cardiology ,Fabry Disease ,Female ,Human medicine ,Cardiology and Cardiovascular Medicine ,business - Abstract
Left ventricular hypertrophy is 1 of the most frequent cardiac manifestations associated with an unfavorable prognosis. However, many different causes of left ventricular hypertrophy exist. The aim of the present study was to assess the diagnostic value of common electrocardiographic (ECG) parameters to differentiate Fabry disease (FD), amyloidosis, and nonobstructive hypertrophic cardiomyopathy (HC) from hypertensive heart disease (HHD) and aortic stenosis (AS). In 94 patients with newly diagnosed FD (n = 17), HHD (n = 20), amyloidosis (n = 17), AS (n = 20), and HC (n = 20), common ECG parameters were analyzed and tested for their diagnostic value. A stepwise approach including the Sokolow-Lyon index, corrected QT duration, and PQ interval minus P-wave duration in lead II to overcome P-wave abnormalities was applied. A corrected QT duration < 440 ms in combination with a PQ interval minus P-wave duration in lead II < 40 ms was 100% sensitive and 99% specific for the diagnosis of FD, whereas a corrected QT duration > 440 ms and a Sokolow-Lyon index
- Published
- 2012
24. Isolating the pulmonary veins as first-line therapy in patients with lone paroxysmal atrial fibrillation using the Cryoballoon
- Author
-
Fatih Bayrak, Carlo de Asmundis, Sjoerd W. Westra, Jayakeerthi Y. Rao, Mark La Meir, Gian-Battista Chierchia, Andrea Sarkozy, Danilo Ricciardi, Antonio Sorgente, Joep L.R.M. Smeets, Mehdi Namdar, Pedro Brugada, Internal Medicine Specializations, and Cardio-vascular diseases
- Subjects
Adult ,medicine.medical_specialty ,medicine.medical_treatment ,cryoballoon ,Cryosurgery ,Pulmonary vein ,Young Adult ,Heart Conduction System ,Physiology (medical) ,Angioplasty ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Young adult ,paroxysmal atrial fibrillation ,Aged ,Ejection fraction ,Cardiovascular diseases [NCEBP 14] ,business.industry ,AimsAtrial fibrillation ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Surgery ,Catheter ,Treatment Outcome ,Pulmonary Veins ,Cardiology ,Female ,Human medicine ,Electrical conduction system of the heart ,Cardiology and Cardiovascular Medicine ,business ,Angioplasty, Balloon ,Arrhythmia - Abstract
Item does not contain fulltext AIMS: Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice. Nowadays, catheter-based ablative approaches are mainly reserved for drug-refractory patients. However, the value of an ablative therapy as a first-line alternative remains elusive. The aim of our study was to analyse the acute procedural success and clinical outcome of patients with lone paroxysmal AF undergoing cryoballoon ablation (CBA) as first-line treatment. METHODS AND RESULTS: Eighteen individuals (mean age 44 +/- 9 years, range 23-61 years, 15 males) with lone paroxysmal AF preferring a catheter-based treatment to drug treatment as first-line therapy were consecutively enrolled in our study. Mean left atrial size was 39 +/- 4 mm and mean left ventricular ejection fraction 58 +/- 3%. After a mean of 2.4 CBA (range 2-4) applications pulmonary vein (PV) isolation could be demonstrated in 70 (97%) PVs. Additional lesions with a focal ablation catheter were needed to isolate one right inferior pulmonary vein and one left superior pulmonary vein in two different patients. At the end of the procedure, all (100%) PVs were isolated. After a 2-month blanking period, 16 patients (89%) were free of symptomatic AF recurrence at a mean follow-up of 14 +/- 9 months and without antiarrhythmic drugs (AADs). CONCLUSION: Cryoballoon ablation in patients with lone paroxysmal AF yields a high acute efficacy rate with a great chance of being free of symptomatic AF recurrence without antiarrhythmic drugs on a mid-term follow-up period, when offered as a first-line treatment. 01 februari 2012
- Published
- 2012
25. Acute myocardial infarction in a young woman with severe ulcerative colitis
- Author
-
Fatih Bayrak, Feruze Enc, Yelda Basaran, Onur Demirkol, Hakan Fotbolcu, Cem Ermeydan, and Bülent Mutlu
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Exacerbation ,business.industry ,Chest pain ,medicine.disease ,Ulcerative colitis ,Surgery ,Internal medicine ,Severity of illness ,medicine ,Myocardial infarction diagnosis ,Myocardial infarction ,medicine.symptom ,Colitis ,Cardiology and Cardiovascular Medicine ,business ,Electrocardiography - Abstract
In this report we present a case of a 28-year-old woman who was admitted to our emergency room complaining of chest pain. Her clinical ECG and biochemical evaluation was consistent with acute nonatherogenic myocardial infarction. Subsequent work is revealed that she was suffering from ulcerative colitis with acute exacerbation since last week. We discussed triggering factors for thrombogenic and inflammatory tendency of patient with comprehensive review of literature to clarify the causal relationship.
- Published
- 2002
26. Kalp pili her zaman doğru söylemeyebilir: Kalp pili telemetresindeki supraventriküler taşikardiye ventriküler taşikardi tanısı
- Author
-
Fatih Bayrak, Gian-Battista Chierchia, Carlo de Asmundis, Pedro Brugada, Bayrak, Fatih, Asmundıs, Carlo De, Chıerchıa, Gian-Battista, Brugada, Pedro, Yeditepe Üniversitesi, and Cardio-vascular diseases
- Subjects
Tachycardia ,Male ,medicine.medical_specialty ,Cardiac pacing ,Kalp ve Kalp Damar Sistemi ,Ventricular tachycardia ,Diagnosis, Differential ,Electrocardiography ,Internal medicine ,Telemetry ,Tachycardia, Supraventricular ,Medicine ,Humans ,cardiovascular diseases ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Cardiac Pacing, Artificial ,medicine.disease ,supraventricular tachycardia ,Holter recording ,Cardiology ,cardiovascular system ,Electrocardiography, Ambulatory ,Tachycardia, Ventricular ,Supraventricular tachycardia ,ventricular tachycardia ,medicine.symptom ,Pacemakers ,Cardiology and Cardiovascular Medicine ,business ,Algorithms - Abstract
Özet – Kalp pili telemetrisi kalp ritmi hakkında, cihazda kullanılan algoritmaya bağımlı yorumları yansıtır. Bu verilerin yararlı olabilmesi için, her bir algoritmaya ait kısıtlılıkların ve bu algoritmanın uyarma ve algılama parametreleriyle ilişkilerinin bilinmesi gerekir. Bu yazıda, kalp pili Holter kayıtlarının sürekli olmayan supraventriküler taşikardi epizotları göstermesine rağmen, kalp pili tarafından durumun yanlışlıkla ventrikül taşikardisi olarak tanımlandığı bir olgu sunuldu. Summary – Pacemaker telemetry reflects algorithmdependent interpretations about the cardiac rhythm. For these data to be useful, it is necessary to recognize the limitations of each algorithm and its interactions with pacing and sensing parameters. We report on a case in which pacemaker Holter recording showed several episodes of nonsustained supraventricular tachycardia which were erroneously classified as ventricular tachycardia.
- Published
- 2011
27. Ventricular repolarization changes for a single heart beat after short periods of ventricular pacing
- Author
-
Andrea Sarkozy, Pedro Brugada, Fatih Bayrak, Internal Medicine Specializations, and Cardio-vascular diseases
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pacemaker, Artificial ,Atrial action potential ,Heart Ventricles ,Beat (acoustics) ,apical hypertrophic cardiomyopathy ,Electrocardiography ,Heart Conduction System ,Heart Rate ,Internal medicine ,Medicine ,Repolarization ,Humans ,electrophysiological study ,Ventricular Remodeling ,business.industry ,Hypertrophic cardiomyopathy ,Cardiac Pacing, Artificial ,Stroke Volume ,General Medicine ,Ventricular pacing ,Cardiomyopathy, Hypertrophic ,medicine.disease ,Electrophysiology ,Bigeminy ,ventricular pacing ,Heart beat ,Cardiology ,cardiovascular system ,sense organs ,Human medicine ,Cardiology and Cardiovascular Medicine ,business - Abstract
We report two patients with apical hypertrophic cardiomyopathy who had repolarization changes for a single sinus beat after short periods of right ventricular apical pacing during invasive electrophysiological study.
- Published
- 2011
28. Evaluation of myocardial bridges with 64-slice computed tomography coronary angiography
- Author
-
Elif Eroglu, Muzaffer Degertekin, Tahsin Güneysu, Bülent Mutlu, Semih Aytaclar, Gökmen Gemici, Fatih Bayrak, and Deniz Sevinc
- Subjects
Myocardial bridge ,Coronary angiography ,Male ,medicine.medical_specialty ,Turkey ,Myocardial Bridging ,Computed tomography ,Coronary Artery Disease ,Coronary Angiography ,Coronary artery disease ,Sex Factors ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,medicine.diagnostic_test ,business.industry ,Age Factors ,General Medicine ,Middle Aged ,medicine.disease ,Coronary Vessels ,Coronary arteries ,medicine.anatomical_structure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Tomography, X-Ray Computed ,Artery - Abstract
Objective ― The aim of this study is to report the characteristics of myocardial bridging (MB) using 64-slice computed tomography and to demonstrate the association between atherosclerotic coronary artery disease (CAD) and MB. Methods and results― In 990 consecutive patients who underwent multi-slice computed tomography (MSCT) coronary angiography for suspected or known coronary artery disease, myocardial bridge evaluation was performed with axial, curved multiplanar reconstruction and three-dimensional volume-rendered images. 265 bridged segments were identified in 223 (22.5%) patients. Multiple MBs on left coronary arteries were found in 4I patients. Most of the MBs were in the LAD (62.6%), followed by the obtuse marginal artery (I4.7%) and diagonal artery (I4.3%). The average length of MBs was I4 ± 7 mm, and the average depth was I.6 ± I.I mm. No significant difference was observed between patients with and without MB on the middle LAD in respect of age, gender, prevalence of diabetes, hyperlipidaemia, hypertension, current smoking and prevalence of atherosclerotic plaques at the proximal LAD. On the other hand, prevalence of atherosclerotic plaques at the distal LAD were significantly lower in patients with MB on the middle LAD (3.5% vs. I9.7%, P: 0.0001). Conclusions - The presence and morphological characteristics of MB and its relation with atherosclerotic plaques in the involved coronary artery can be comprehensively analysed with 64-slice computed tomography coronary angiography. Atherosclerosis is a common finding in segments proximal to MB, but the prevalence of plaques in equivalent segments (proximal LAD in our study) is not higher than in patients under similar coronary artery disease risk and without MB. On the other hand, prevalence of atherosclerotic plaques at the distal LAD was significantly lower in our patients with MB on the middle LAD. Finally, we suggest that rather than causing proximal atherosclerosis, MB might have a more important role in the protection of distal segments of the bridged arteries from atherosclerosis.
- Published
- 2009
29. Acute myocardial infarction in a 24 year-old man possibly associated with sibutramine use
- Author
-
Gökmen Gemici, Muzaffer Degertekin, Fatih Bayrak, Elif Eroglu, Ali Kemal Kalkan, Eroglu, E., Gemici, G., Bayrak, F., Kalkan, A.K., Degertekin, M., and Yeditepe Üniversitesi
- Subjects
medicine.medical_specialty ,business.industry ,Acute myocardial infarction ,medicine.disease ,Risk profile ,Blood pressure ,Heart failure ,Internal medicine ,Anesthesia ,Cardiology ,Noradrenaline ,Medicine ,Sibutramine ,Myocardial infarction ,Myocardial infarction diagnosis ,Serotonin ,Obesity ,Young adult ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Sibutramine is an anti-obesity drug, which acts by inhibiting neuronal re-uptake of noradrenaline and serotonin. Although the most frequently seen effect of sibutramine on cardiovascular system is an increase in blood pressure and pulse rate, rare but severe side effects such as sibutramine-induced ventricular arrhythmias, heart failure and cardiovascular disease-related death are also reported. We describe a 24 year-old man with low atherosclerotic risk profile who had acute myocardial infarction possibly associated with sibutramine use. © 2008 Elsevier Ireland Ltd. All rights reserved.
- Published
- 2009
30. Determinants of Elevated NT-proBNP Levels in Patients With Hypertrophic Cardiomyopathy: An Echocardiographic Study
- Author
-
Fatih Bayrak, Yelda Basaran, Bülent Mutlu, Gökhan Kahveci, Kahveci, G., Bayrak, F., Mutlu, B., Basaran, Y., and Yeditepe Üniversitesi
- Subjects
Pulmonary and Respiratory Medicine ,Adult ,Male ,medicine.medical_specialty ,Diastole ,Cardiomyopathy ,Ventricular outflow tract obstruction ,Doppler echocardiography ,Cohort Studies ,Ventricular Dysfunction, Left ,Internal medicine ,Natriuretic Peptide, Brain ,medicine ,Humans ,cardiovascular diseases ,Mitral regurgitation ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Hypertrophic cardiomyopathy ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,Echocardiography, Doppler ,Peptide Fragments ,NT-proBNP ,Left atrium ,Cardiology ,cardiovascular system ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Isovolumic relaxation time ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Background: The purpose of this study was to explore the relationship between plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and extensive echocardiographic variables in patients with hypertrophic cardiomyopathy (HCM). Methods: We evaluated plasma NT-proBNP levels in 88 patients with HCM and examined the plasma NT-proBNP levels' relationships with echocardiographic indexes. Echocardiographic variables were analysed using univariate and multivariate logistic regression to identify predictors of NT-proBNP elevation. Results: Several echocardiographic variables predicted NT-proBNP elevation, including left atrial dimension index (LADI), left ventricular maximal wall thickness (MWT), left ventricular posterior wall thickness, severe mitral regurgitation, mitral septal and lateral tissue Doppler velocities, and mitral septal E/Ea ratio. Left ventricular ejection fraction, left ventricular dimensions, mitral early flow propagation velocity, isovolumic relaxation time, and left ventricular outflow tract obstruction were not significant predictors of NT-proBNP in this group of patients. With multivariate analysis LADI (HR 5.0; 95% CI 1.5-17.1, p = 0.01) and MWT (HR 4.0; 95% CI 1.2-13.2, p = 0.022) emerged as independent determinants of NT-proBNP elevation. Conclusions: In HCM plasma NT-proBNP is prominently increased. LADI and MWT are independent predictors of elevated levels. These data indicate that NT-proBNP elevations are mainly determined by diastolic load in HCM. © 2008 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand.
- Published
- 2009
31. Vanishing multiple thrombi in left ventricle of a patient with dilated cardiomyopathy
- Author
-
Bülent Mutlu, Muzaffer Degertekin, Gökhan Kahveci, Fatih Bayrak, Bayrak, F., Kahveci, G., Degertekin, M., Mutlu, B., and Yeditepe Üniversitesi
- Subjects
medicine.medical_specialty ,Cardiomyopathy ,Diastole ,Dilated cardiomyopathy ,Internal medicine ,medicine ,cardiovascular diseases ,Thrombus ,medicine.diagnostic_test ,Left bundle branch block ,business.industry ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Left ventricle ,medicine.disease ,ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,medicine.anatomical_structure ,ComputingMethodologies_PATTERNRECOGNITION ,Ventricle ,Heart failure ,Cardiology ,InformationSystems_MISCELLANEOUS ,Cardiology and Cardiovascular Medicine ,business ,Electrocardiography - Abstract
A 78 year old woman with history of uncontrolled hypertension was admitted complaining of severe dyspnea. Clinical evaluation revealed signs of biventricular heart failure. An ECG showed atrial fibrilation and left bundle branch block. Transthoracic echocardiography (TTE) of the patient revealed left ventricle (LV) enlargement (end systolic diameter 49 mm, end diastolic diameter 60 mm) with severely compromised systolic function, and multiple, mobile left ventricle masses located at apical (45×32 mm), basal inferior (25×22 mm) and mid-septal (11×9 mm) segments with the possible diagnosis of thrombus (Fig. 1. panels A, B, C). Moderate mitral and mild tricuspid regurgitation was noted. Protein S, protein C and antiphospholipid antibody levels of the patient were normal and Factor V Leiden mutation was not present. We elected to treat the patient conservatively, and she was fully anticoagulated with warfarin (target INR 3–4) and commenced on treatment for heart failure (ramipril, spironolactone, and furosemide). Further assessment was performed using cardiac MR imaging and confirmed the diagnosis of multiple thrombi in left ventricle (Fig. 1. panels D, E, F). After two weeks of warfarin treatment no thrombus could be detected in left ventricle with transthorasic echocardiography (Fig. 1. panels G, H, I). The patient was discharged
- Published
- 2009
32. Tissue Doppler imaging to predict clinical course of patients with hypertrophic cardiomyopathy
- Author
-
Kenan Sönmez, Gökhan Kahveci, Bülent Mutlu, Muzaffer Degertekin, Fatih Bayrak, Bayrak, F., Kahveci, G., Mutlu, B., Sonmez, K., Degertekin, M., and Yeditepe Üniversitesi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Diastole ,Ventricular tachycardia ,Sudden death ,Doppler imaging ,Sensitivity and Specificity ,Tissue Doppler imaging ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Systole ,Chi-Square Distribution ,business.industry ,Clinical outcome ,Hypertrophic cardiomyopathy ,Reproducibility of Results ,General Medicine ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,Prognosis ,Echocardiography, Doppler ,medicine.anatomical_structure ,Ventricle ,Heart failure ,Case-Control Studies ,Cardiology ,Disease Progression ,Regression Analysis ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Aims: Diastolic tissue Doppler (TD) parameters allow prediction of patients with hypertrophic cardiomyopathy (HC) at risk of sudden death, ventricular tachycardia, or cardiac arrest. The aim of this study was to assess the value of TD imaging in predicting the clinical course of patients with HC. Methods and results: Eighty-six HC patients were prospectively included in the study and followed-up for clinical endpoints (cardiovascular death or hospitalization due to worsening of heart failure symptoms). Patients with clinical endpoints (n = 25) had larger left atrium diameters, thicker left ventricle (LV) walls, more often LV outflow obstruction and lower TD velocities of LV. LV outflow tract obstruction (r=0.54, R2=0.29, P 4 cm/s were significantly free of clinical endpoints. Conclusion: In conclusion, LMSa seems to be a reliable parameter that can be used in predicting the HC patients at risk for clinical deterioration or death at long-term follow-up. © The Author 2008.
- Published
- 2008
33. Right ventricle-dependent coronary circulation demonstrated with 64-slice computed tomography
- Author
-
Deniz Sevinc, Levent Saltik, Funda Oztunc, Tahsin Güneysu, Fatih Bayrak, Muzaffer Degertekin, Saltik, L., Bayrak, F., Guneysu, T., Sevinc, D., Oztunc, F., Degertekin, M., and Yeditepe Üniversitesi
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Coronary Vessel Anomalies ,Heart Ventricles ,Collateral Circulation ,Computed tomography ,Right ventricle-dependent coronary circulation ,Shunt operation ,Arteriovenous Malformations ,Internal medicine ,Coronary Circulation ,Female patient ,medicine ,Humans ,Child ,Vascular Fistula ,medicine.diagnostic_test ,business.industry ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,medicine.disease ,ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,ComputingMethodologies_PATTERNRECOGNITION ,Pulmonary Atresia ,Cardiology ,Female ,Radiology ,InformationSystems_MISCELLANEOUS ,Cardiology and Cardiovascular Medicine ,Pulmonary atresia ,business ,Tomography, X-Ray Computed - Abstract
A 12-year-old female patient, who had emergency left modified Blalock–Taussig shunt operation during neonate and a total cavo-pulmonary shunt operation performed at the age of 5 years following a diagnosis of pulmonary atresia with intact ventricular septum (PAIVS), was under regular follow-up. At her last visit, she was admitted with exercised-induced anginal symptoms. …
- Published
- 2007
34. Usefulness of surface electrocardiogram in predicting the clinical course of patients with hypertrophic cardiomyopathy
- Author
-
Muzaffer Degertekin, Tansu Karaahmet, Gokhan Kahveci, Fatih Bayrak, B. Mutlu, Bayrak, F., Kahveci, G., Mutlu, B., Degertekin, M., Demirtaş, E., and Yeditepe Üniversitesi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Turkey ,Disease-Free Survival ,Electrocardiography ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Aged ,Ultrasonography ,business.industry ,Clinical course ,Hypertrophic cardiomyopathy ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,Prognosis ,Survival Analysis ,Surface electrocardiogram ,QT dispersion ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objective: Few data exist regarding the prognostic value of QT dispersion in hypertrophic cardiomyopathy (HCM). In this study, we prospectively investigated the association between baseline QT dispersion and clinical course of HCM. Methods: Overall, 101 patients with asymmetric septal hypertrophy (59 men, mean age 45±16 years, range 13-74 years) were included in the study and were followed up for 595±367 days for clinical endpoints defined as cardiac death and hospitalization due to worsening in heart failure symptoms. QRS duration, QT interval, and JT interval were manually measured on 12-lead electrocardiogram (ECG). QT dispersion and corrected QT dispersion were calculated accordingly. The ECG findings of the patients with and without clinical endpoints were compared. Results: Twenty-nine patients experienced clinical endpoints (3 sudden deaths, 26 hospitalizations due to worsening heart failure). The measurements of QT, JT and QRS intervals were all comparable between the two groups (p>0.05 for all). QT dispersion and corrected QT dispersion were significantly different between patients with and without clinical endpoints (64±30 ms vs. 83±18 ms and 71±33 ms vs. 90±18 ms, respectively, p=0.001 for both). Corrected QT dispersion >80 ms detected patients with clinical endpoints with sensitivity and specificity of 79% and 75%, respectively. Patients with corrected QT dispersion
- Published
- 2007
35. PP-079 Multiple Left Ventricular Crypts in a Patient with Obstructive Hypertrophic Cardiomyopathy
- Author
-
Duhan Fatih Bayrak and Ali Buturak
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Cardiology ,Obstructive hypertrophic cardiomyopathy ,Cardiology and Cardiovascular Medicine ,business - Published
- 2015
36. Large mural vegetation attached to the left ventricular outflow tract: a case report
- Author
-
Atila Bitigen, Bülent Mutlu, Fatih Bayrak, Kursat Tigen, Bitigen, A., Bayrak, F., Tigen, K., Mutlu, B., and Yeditepe Üniversitesi
- Subjects
Aortic valve ,Adult ,medicine.medical_specialty ,Aortic Valve Insufficiency ,Regurgitation (circulation) ,Internal medicine ,Medicine ,Ventricular outflow tract ,Humans ,cardiovascular diseases ,Cardiac Surgical Procedures ,Endocardium ,Staphylococcal endocarditis ,Unusual case ,business.industry ,Rheumatic Heart Disease ,Endocarditis, Bacterial ,Staphylococcal Infections ,medicine.anatomical_structure ,cardiovascular system ,Cardiology ,Surgery ,Female ,Radiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Vegetation (pathology) - Abstract
We describe an unusual case of staphylococcal endocarditis with vegetation attached to the left ventricular outflow endocardium in a patient with chronic severe aortic regurgitation that was diagnosed by transthoracic echocardiography. There was no involvement of aortic valve endocardium confirmed by transthoracic echocardiography, transesophageal echocardiography, and macroscopically in the operation. This report confirms that chronic endocardial trauma may provide a fertile nidus for the development of bacterial vegetation. © 2006 Forum Multimedia Publishing, LLC.
- Published
- 2006
37. Large renal artery aneurysm treated with stent Graft
- Author
-
Salih Güran, Fatih Bayrak, Bengi Gurses, Ertan Demirtas, Muzaffer Degertekin, Bülent Mutlu, Degertekin, M., Bayrak, F., Mutlu, B., Gürses, B., Güran, S., Demirtas, E., and Yeditepe Üniversitesi
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Resistant hypertension ,Stent ,Fibromuscular dysplasia ,medicine.disease ,Renal artery aneurysm ,Natural history ,ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,ComputingMethodologies_PATTERNRECOGNITION ,Physiology (medical) ,Internal medicine ,Cardiology ,medicine ,InformationSystems_MISCELLANEOUS ,Cardiology and Cardiovascular Medicine ,business ,Renal artery aneurysms - Abstract
Renal artery aneurysms are uncommon, and the underlying cause ranges from fibromuscular dysplasia to atherosclerosis. Hypertension is the most common presenting symptom. The natural history is unclear, but the likelihood of rupture appears to increase as the diameter of the renal artery aneurysm exceeds 15 mm. A 54-year-old woman with resistant hypertension despite a combination of 3 antihypertensive drugs who …
- Published
- 2006
38. Usefulness of N-Terminal Pro-B-Type Natriuretic Peptide to Predict Clinical Course in Patients With Hypertrophic Cardiomyopathy
- Author
-
Fatih Bayrak, Bülent Mutlu, Muzaffer Degertekin, Elif Eroglu, Gökhan Kahveci, Yelda Basaran, Mutlu, B., Bayrak, F., Kahveci, G., Degertekin, M., Eroglu, E., Basaran, Y., and Yeditepe Üniversitesi
- Subjects
Male ,medicine.medical_specialty ,Heart disease ,medicine.drug_class ,Population ,Sensitivity and Specificity ,Internal medicine ,Natriuretic Peptide, Brain ,Natriuretic peptide ,medicine ,Humans ,cardiovascular diseases ,education ,education.field_of_study ,business.industry ,Hazard ratio ,Hypertrophic cardiomyopathy ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,Brain natriuretic peptide ,Prognosis ,Confidence interval ,Peptide Fragments ,Heart failure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
This study was designed to assess the value of plasma N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) levels in predicting clinical courses in 80 patients with hypertrophic cardiomyopathy. Patients were followed for a mean of 571 ± 294 days for clinical end points, defined as a composite of cardiovascular death and hospitalization for worsening heart failure symptoms. NT-pro-BNP plasma level (hazard ratio 1.6, 95% confidence interval 1.10 to 2.55, p = 0.015) and New York Heart Association (NYHA) functional class (hazard ratio 3.7, 95% confidence interval 1.17 to 12.09, p = 0.025) were the independent variables associated with increased risk for experiencing clinical end points. NT-pro-BNP plasma level ?1,500 pg/ml detected patients with clinical end points with sensitivity, specificity, and accuracy of 83%, 81%, and 81%, respectively. The hypertrophic cardiomyopathy population was stratified into low-, medium-, and high-risk subgroups using 2 simple variables, NYHA functional class and NT-pro-BNP. Patients in lower NYHA classes and with NT-pro-BNP levels
- Published
- 2006
39. Pulmonary atresia and ventricular septal defect with MAPCAs associated with right sided endocarditis and paradoxical embolic event
- Author
-
Bülent Mutlu, Gökhan Kahveci, Salih Güran, Kıvılcım Özden, Yelda Basaran, Levent Saltik, and Fatih Bayrak
- Subjects
Adult ,Heart Septal Defects, Ventricular ,Male ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Coronary Vessel Anomalies ,Collateral Circulation ,Pulmonary Artery ,Internal medicine ,Ductus arteriosus ,medicine.artery ,medicine ,Endocarditis ,Humans ,Radiology, Nuclear Medicine and imaging ,Ultrasonography ,Heart septal defect ,Aorta ,Pulmonary Valve ,business.industry ,General Medicine ,Endocarditis, Bacterial ,medicine.disease ,medicine.anatomical_structure ,Embolism ,Pulmonary Atresia ,Heart failure ,Pulmonary artery ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Pulmonary atresia ,Embolism, Paradoxical - Abstract
Pulmonary atresia and ventricular septal defect (PA-VSD) with major aortopulmonary collaterals (MAPCAs) is a complex and extremely heterogeneous anomaly. PA-VSD with both pulmonary arteries originating from systemic arterial circulation without MAPCAs and patent ductus arteriosus (PDA) is a very rare disease and according to our knowledge a case without cyanosis and symptoms of congestive heart failure after the first decade of life has not been reported. The majority of untreated patients die in their first decade of life as a result of intractable congestive heart failure or respiratory distress. This report informs about a 21-year-old PA-VSD patient who presented without cyanosis with both pulmonary arteries arising from aorta associated with right sided endocarditis and a paradoxical embolic event.
- Published
- 2005
40. Isolated left ventricular diverticulum in an asymptomatic patient
- Author
-
Fatih, Bayrak, Bayrak, Fatih, Tahsin, Guneysu, Muzaffer, Degertekin, Gokmen, Gemici, Fatih, B., Guneysu, T., Degertekin, M., Gemici, G., and Yeditepe Üniversitesi
- Subjects
Male ,Coronary angiography ,medicine.medical_specialty ,Heart Diseases ,Heart Ventricles ,Asymptomatic ,Coronary artery disease ,Internal medicine ,medicine ,Humans ,Left ventricular diverticulum ,business.industry ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Atypical chest pain ,Multislice computed tomography ,Middle Aged ,medicine.disease ,ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,Diverticulum ,ComputingMethodologies_PATTERNRECOGNITION ,medicine.anatomical_structure ,Ventricle ,Cardiology ,Radiology ,InformationSystems_MISCELLANEOUS ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Cardiology and Cardiovascular Medicine - Abstract
A 47-year-old male with intermediate risk of coronary artery disease and atypical chest pain was referred to our hospital for multislice computed tomography (MSCT) coronary angiography. MSCT of the patient revealed apical interruption of myocardium and apical diverticulum (15 × 11 mm) of the left ventricle (Panels A–F). The ECG of …
- Published
- 2008
41. EVALUATION OF MYOCARDIAL BRIDGE WITH 64-SLICE COMPUTED TOMOGRAPHY CORONARY ANGIOGRAPHY
- Author
-
Fatih Bayrak, Elif Eroglu, Muzaffer Degertekin, Semih Aytaclar, Gökmen Gemici, B. Mutlu, Deniz Sevinc, and Tahsin Güneysu
- Subjects
Myocardial bridge ,Coronary angiography ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Internal Medicine ,Medicine ,Computed tomography ,General Medicine ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Published
- 2008
42. 136 Usefulness of Tissue Doppler Imaging in predicting the clinical course of patients with hypertrophic cardiomyopathy
- Author
-
M. Degertekin, E. Demirtas, Fatih Bayrak, G. Kahveci, and B. Mutlu
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,Hypertrophic cardiomyopathy ,Clinical course ,Cardiology ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease ,Doppler imaging - Published
- 2007
43. 703 Echocardiographic predictors of heart failure symptoms in hypertrophic cardiomyopathy
- Author
-
Yelda Basaran, Fatih Bayrak, Gökhan Kahveci, and Bülent Mutlu
- Subjects
medicine.medical_specialty ,biology ,business.industry ,Hypertrophic cardiomyopathy ,General Medicine ,medicine.disease ,Troponin ,Internal medicine ,Heart failure ,biology.protein ,Cardiology ,Medicine ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,business - Published
- 2005
44. 114 Validation of N Terminal pro brain natriuretic peptide levels for monitoring clinical course and assesing mortality in patients with idiopathic dilated cardiomyopathy
- Author
-
Fatih Bayrak, K. Tigen, B. Mutlu, H. Fotbolcu, Y. Baðaran, G. Kahveci, Tansu Karaahmet, and E. Türkyýlmaz
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,Idiopathic dilated cardiomyopathy ,medicine ,Cardiology ,Clinical course ,In patient ,Cardiology and Cardiovascular Medicine ,business ,N-terminal pro-Brain Natriuretic Peptide - Published
- 2004
45. The relationship between mitral annular calcification and red cell distribution width: a cross-sectional study
- Author
-
Çağrı Yayla, Mehmet Kadri Akboğa, Uğur Canpolat, Kadriye Gayretli Yayla, Fatih Bayraktar, Muhammed Süleymanoğlu, Serdar Kuyumcu, Azmi Eyiol, and Sinan Aydoğdu
- Subjects
inflammation ,red blood cell distribution width ,mitral annular calcification ,Medicine ,Internal medicine ,RC31-1245 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective: Mitral annular calcification (MAC) and atherosclerosis are similar in regard to risk factors and pathogenesis. Increased red blood cell distribution width (RDW) has been shown to be associated with atherosclerotic diseases. However, no data evaluating the association of MAC with RDW has been available. The aim of this cross-sectional study was to investigate the relationship between MAC and RDW among patients with various cardiovascular risk factors. Methods: A total of 623 patients (MAC-positive group: n=413; control group: n=210) admitted to our cardiology outpatient clinics were enrolled between March and November 2014. Demographic, clinical, and laboratory parameters of all participants were recorded. RDW was analyzed from complete blood samples of study participants. Results: Patients in MAC-positive group showed older age and higher rate of hypertension. Mean RDW value was significantly higher in MAC-positive group, compared to control group (15.3+-1.4% vs. 13.9+-1.4%, p
- Published
- 2015
- Full Text
- View/download PDF
46. Inefficacious ICD shocks treated with left cardiac sympathetic denervation in a patient with catecholaminergic polymorphic ventricular tachycardia
- Author
-
Pedro Brugada, Antonio Sorgente, Fatih Bayrak, Carlo de Asmundis, Andrea Sarkozy, Marc Noppen, Gian-Battista Chierchia, Internal Medicine Specializations, Cardio-vascular diseases, Heartrhythmmanagement, and UZB Other
- Subjects
medicine.medical_specialty ,business.industry ,ICD shocks ,Catecholaminergic polymorphic ventricular tachycardia ,medicine.disease ,Article ,Sympathetic Denervation ,Left cardiac sympathetic denervation ,Anesthesia ,Internal medicine ,Cardiology ,cardiovascular system ,Medicine ,Icd shocks ,business ,Cardiology and Cardiovascular Medicine - Abstract
▸ In this study we propose an innovative treatment strategy in patients with cathecolaminergic polymorphic ventricular tachycardia. ▸ These patients often suffer from inappropriate ICD shocks. ▸ Left cardiac symphatethic denervation could represent a solution in patients in whom arrhythmic episodes are refractory to betablockers or antiarrhythmic drugs.
- Full Text
- View/download PDF
47. The other side of the coin in primary tricuspid valve disease: The incremental value of 3D echocardiography
- Author
-
Münevver Sarı, Gökhan Kahveci, Duhan Fatih Bayrak, Abdulkadir Uslu, and Selçuk Pala
- Subjects
primary tricuspid valve regurgitation ,three-dimensional echocardiography. ,Medicine ,Internal medicine ,RC31-1245 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Primary tricuspid valve regurgitation may be encountered in daily practice as a result of multiple etiologies. Described herein are the cases of 2 patients with severe primary tricuspid regurgitation. The underlying mechanism was posterior leaflet prolapse due to spontaneous chordae rupture in 1 case, and iatrogenic posterior leaflet tissue loss during removal of a permanent pacemaker in the other. Transthoracic and transesophageal echocardiography, which permit assessment of the tricuspid valve with multilevel imaging, are the techniques of choice for accurate detection and understanding of the etiology, the severity of valve regurgitation, and the determination of treatment options, in addition to providing assistance with timing and guidance during intervention. Three-dimensional echocardiography offers the ability to visualize the entire tricuspid valve and to identify which leaflets are affected by the pathology.
- Published
- 2018
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.