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Prevalence, clinical characteristics and management of atrial fibrillation in patients with Brugada syndrome
- Source :
- The American journal of cardiology, American Journal of Cardiology, 111, 3, pp. 362-7, American Journal of Cardiology, 111, 362-7
- Publication Year :
- 2013
-
Abstract
- Atrial fibrillation (AF) can be the first manifestation of latent Brugada syndrome (BS). The aim of our study was to assess the prevalence of AF as the first clinical diagnosis in patients with BS and their demographic and clinical characteristics and diagnosis management in a large cohort of patients. The patient group consisted of 611 patients with BS. The data from those with a diagnosis of AF previous to the identification of BS were analyzed (n = 35). Eleven cases were unmasked after the initiation of a class I antiarrhythmic drug and one during the establishment of general anesthesia. In the remaining population, BS was diagnosed using an ajmaline test performed mainly because of younger age in patients with lone AF (n = 13), previous syncope or sudden cardiac death (n = 3), or a clinical history of sudden cardiac death in the family (n = 5). The mean patient age was 49 +/- 15 years, 21 were male patients, 14 had a family history of sudden death, 15 had had previous syncope, and 4 had survived cardiac arrest. Concomitant electrical disorder was found in 13 patients. Remarkably, 21 patients had normal findings on the baseline electrocardiogram. In conclusion, AF could be one of the first clinical manifestations of latent BS in a considerable number of patients. This identification is crucial because the treatment of these patients is subject to relevant changes. The ajmaline test plays an essential role, mainly in young patients with a family history of sudden death, despite having normal findings on a baseline electrocardiogram. (C) 2013 Elsevier Inc. All rights reserved. (Am J Cardiol 2013;111:362-367)
- Subjects :
- Adult
Male
medicine.medical_specialty
Population
Management of atrial fibrillation
Sudden death
Sudden cardiac death
Electrocardiography
Belgium
Risk Factors
Internal medicine
Atrial Fibrillation
medicine
Prevalence
Humans
Brugada syndrome
Family history
education
Retrospective Studies
education.field_of_study
Cardiovascular diseases [NCEBP 14]
business.industry
Atrial fibrillation
Middle Aged
medicine.disease
Prognosis
Ajmaline
Cardiology
Female
Human medicine
Cardiology and Cardiovascular Medicine
business
Anti-Arrhythmia Agents
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 00029149
- Database :
- OpenAIRE
- Journal :
- The American journal of cardiology
- Accession number :
- edsair.doi.dedup.....7bcebe5c2e27fdcf0c4b4f0e2461bd27