Topic: instrumentation - Searchworks@Jio Institute Digital Library Search Results

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1. Experimental investigation and process optimization of the ultrasonic welding applied to papers.

Author: Charlier, Q., Viguié, J., Harthong, B., Toni, J.‐B., Terrien, M., Imbault, D., and Peyroux, R.
Subjects: *PROCESS optimization, *WELDED joints, *ULTRASONIC welding, *MANUFACTURING processes, *SUPPLY & demand, *WELDABILITY
Abstract: Ultrasonic welding is a serious candidate in the development of methods to assemble papers and paperboards without using additional substances. However, the ultrasonic welding of papers remains a technological challenge considering the low weldability of lignocellulosic materials. This study aims to investigate on the ultrasonic welding process applied to papers in order to identify the processing conditions which favor the formation of strong welded joints. To reach such purpose, an experimental strategy was developed by combining the characterization of welded materials and the monitoring of process parameters. Experimentations were performed using a reference paper displaying a good weldability to specifically highlight the contribution of process parameters. Results indicate that the process is highly sensitive to vibration amplitude, power supplied by the high frequency generator, and sample thickness. Power seems to be a reliable indicator of the severity of the process. A strong decrease in the strength of the welded joints is observed when working with low thicknesses. It seems that the layers coated on top of papers are the main part of the material contributing in the development of adhesion at the welding joint. Overall, instrumenting the device has led to a better understanding of the ultrasonic welding of papers. [ABSTRACT FROM AUTHOR]
Published: 2021
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2. Distance-Based All-In-One Immunodevice for Point-of-Care Monitoring of Cytokine Interleukin-6

Author: Kawin Khachornsakkul, Wijitar Dungchai, and Nicole Pamme
Subjects: Immunoassay, Paper, Fluid Flow and Transfer Processes, Interleukin-6, Point-of-Care Systems, Process Chemistry and Technology, Cytokines, Humans, Bioengineering, Instrumentation
Abstract: We report the development of a distance-based paper analytical device combined with a hydrophilic bridge valve (B-dPAD) as a quantitative immunoassay method to monitor human interleukin-6 (IL-6) in human samples. Our device design features (i) a circular sample inlet zone, (ii) a circular capture zone with immobilized anti-IL-6 (anti-Ab
Published: 2022

3. Digital Quantification Method for Sensitive Point-of-Care Detection of Salivary Uric Acid Using Smartphone-Assisted μPADs

Author: Kexin Fan, Jiayang Zeng, Chenyu Yang, Gonglei Wang, Kai Lian, Xiuhong Zhou, Yaping Deng, and Guozhen Liu
Subjects: Paper, Fluid Flow and Transfer Processes, Point-of-Care Systems, Process Chemistry and Technology, Colorimetry, Bioengineering, Smartphone, Instrumentation, Uric Acid
Abstract: Uric acid (UA) is an important biomarker for many diseases. A sensitive point-of-care (POC) testing platform is designed for the digital quantification of salivary UA based on a colorimetric reaction on an easy-to-build smartphone-assisted microfluidic paper-based analytical device (SμPAD). UA levels are quantified according to the color intensity of Prussian blue on the SμPAD with the aid of a MATLAB code or a smartphone APP. A color correction method is specifically applied to exclude the light effect. Together with the engineering design of SμPADs, the background calibration function with the APP increases the UA sensitivity by 100-fold to reach 0.1 ppm with a linear range of 0.1-200 ppm. The assay time is less than 10 min. SμPADs demonstrate a correlation of 0.97 with a commercial UA kit for the detection of salivary UA in clinical samples. SμPADs provide a sensitive, fast, affordable, and reliable tool for the noninvasive POC quantification of salivary UA for early diagnosis of abnormal UA level-associated health conditions.
Published: 2022

4. Trends in Paper-Based Sensing Devices for Clinical and Environmental Monitoring

Author: Shekher Kummari, Lakshmi R. Panicker, Jagadeeswara Rao Bommi, Sampath Karingula, Venisheety Sunil Kumar, Kuldeep Mahato, and Kotagiri Yugender Goud
Subjects: Paper, screening and diagnosis, optical sensors, Clinical Biochemistry, Biomedical Engineering, electrochemical sensors, Bioengineering, General Medicine, Biosensing Techniques, Electrochemical Techniques, biosensors, 4.1 Discovery and preclinical testing of markers and technologies, Analytical Chemistry, Detection, paper-based sensing devices, Environmental Pollutants, Biochemistry and Cell Biology, Instrumentation, Engineering (miscellaneous), Ecosystem, Biotechnology, clinical diagnostics, environmental monitoring
Abstract: Environmental toxic pollutants and pathogens that enter the ecosystem are major global issues. Detection of these toxic chemicals/pollutants and the diagnosis of a disease is a first step in efficiently controlling their contamination and spread, respectively. Various analytical techniques are available to detect and determine toxic chemicals/pathogens, including liquid chromatography, HPLC, mass spectroscopy, and enzyme-linked immunosorbent assays. However, these sensing strategies have some drawbacks such as tedious sample pretreatment and preparation, the requirement for skilled technicians, and dependence on large laboratory-based instruments. Alternatively, biosensors, especially paper-based sensors, could be used extensively and are a cost-effective alternative to conventional laboratory testing. They can improve accessibility to testing to identify chemicals and pollutants, especially in developing countries. Due to its low cost, abundance, easy disposal (by incineration, for example) and biocompatible nature, paper is considered a versatile material for the development of environmentally friendly electrochemical/optical (bio) sensor devices. This review presents an overview of sensing platforms constructed from paper, pointing out the main merits and demerits of paper-based sensing systems, their fabrication techniques, and the different optical/electrochemical detection techniques that they exploit.
Published: 2023

5. Multilayer Sheets Based on Double Coatings of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) on Paper Substrate for Sustainable Food Packaging Applications

Author: Eva Hernández-García, Pedro A. V. Freitas, Pedro Zomeño, Chelo González-Martínez, and Sergio Torres-Giner
Subjects: Fluid Flow and Transfer Processes, Process Chemistry and Technology, paper, PHBV, multilayers, food packaging, Circular Economy, General Engineering, General Materials Science, Instrumentation, Computer Science Applications
Abstract: This work reports on the development and performance evaluation of newly developed paper sheets coated, on both sides, with thin films of biodegradable poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) for applications of food packaging. For this, PHBV/paper/PHBV multilayers were first prepared by the thermo-sealing technique, optimizing the process variables of temperature and time. Thereafter, the multilayer sheets were characterized in terms of their morphological, optical, thermal, mechanical, and barrier properties and compared with equivalent paper structures double coated with high-barrier multilayer films of petrochemical polymers. The results indicated that the double coatings of PHBV successfully improved the mechanical resistance and ductility, protected from moisture, and also reduced the aroma and oxygen permeances of paper, having a minimal effect on its optical and thermal properties. Finally, the compostability of the resultant multilayer sheets was analyzed, confirming that the presence of the PHBV coatings slightly delayed the aerobic biodegradation and disintegration of paper.
Published: 2022
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6. A Chemometric-Assisted Colorimetric-Based Inexpensive Paper Biosensor for Glucose Detection

Author: Vinay Kishnani, Shrishti Kumari, and Ankur Gupta
Subjects: chemometric detection, glucose, smartphone-based sensors, machine learning, Paper, Clinical Biochemistry, Biomedical Engineering, General Medicine, Biosensing Techniques, Analytical Chemistry, Glucose, Humans, Colorimetry, Chemometrics, Instrumentation, Engineering (miscellaneous), Biotechnology
Abstract: This article reports a simple and inexpensive leak-proof paper pad with an initial selection of a paper substrate on the grounds of surface morphology and fluid absorption time. Herein, a drying method is used for glucose detection on a paper pad through colorimetric analysis, and the spot detection of glucose is analyzed by optimizing the HRP concentration and volume to obtain accurate results. The rapid colorimetric method for the detection of glucose on the paper pad was developed with a limit of detection (LOD) of 2.92 mmol L−1. Furthermore, the effects of the detection conditions were investigated and discussed comprehensively with the help of chemometric methods. Paper pads were developed for glucose detection with a range of 0.5–20 mM (apropos to the normal glucose level in the human body) and 0.1–0.5 M (to test the excessive intake of glucose). The developed concept has huge potential in the healthcare sector, and its extension could be envisioned to develop the reported paper pad as a point-of-care testing device for the initial screening of a variety of diseases.
Published: 2022

7. Simple and Sensitive Detection of Bacterial Hydrogen Sulfide Production Using a Paper-Based Colorimetric Assay

Author: Byung-Ki Ahn, Yong-Jin Ahn, Young-Ju Lee, Yeon-Hee Lee, and Gi-Ja Lee
Subjects: Bacteria, hydrogen sulfide, bacteria, paper, colorimetric assay, Colorimetry, Hydrogen Sulfide, Electrical and Electronic Engineering, Sulfides, Biochemistry, Instrumentation, Atomic and Molecular Physics, and Optics, Analytical Chemistry, Hydrogen
Abstract: Hydrogen sulfide (H2S) is known to participate in bacteria-induced inflammatory response in periodontal diseases. Therefore, it is necessary to quantify H2S produced by oral bacteria for diagnosis and treatment of oral diseases including halitosis and periodontal disease. In this study, we introduce a paper-based colorimetric assay for detecting bacterial H2S utilizing silver/Nafion/polyvinylpyrrolidone membrane and a 96-well microplate. This H2S-sensing paper showed a good sensitivity (8.27 blue channel intensity/μM H2S, R2 = 0.9996), which was higher than that of lead acetate paper (6.05 blue channel intensity/μM H2S, R2 = 0.9959). We analyzed the difference in H2S concentration released from four kinds of oral bacteria (Eikenella corrodens, Streptococcus sobrinus, Streptococcus mutans, and Lactobacillus casei). Finally, the H2S level in Eikenella corrodens while varying the concentration of cysteine and treatment time was quantified. This paper-based colorimetric assay can be utilized as a simple and effective tool for in vitro screening of H2S-producing ability of many bacteria as well as salivary H2S analysis.
Published: 2022

8. A paper-based point-of-care testing device for the colourimetric estimation of bilirubin in blood sample

Author: A. Lakshmi Devi, PE. Resmi, Aarathi Pradeep, P.V. Suneesh, Bipin G. Nair, and T.G. Satheesh Babu
Subjects: Paper, Point-of-Care Testing, Sulfates, Colorimetry, Bilirubin, Instrumentation, Spectroscopy, Atomic and Molecular Physics, and Optics, Analytical Chemistry
Abstract: A paper-based colourimetric assay for the Point-of-Care Testing (PoCT) of bilirubin has been developed based on the formation of a green-coloured copper-bilirubin complex from a blue-coloured tetraamminecopper(II) sulphate complex. The reaction was studied and optimized by UV-Visible absorption spectroscopy and translated onto a paper strip. Hydrophobic circular well patterns on Whatman chromatography paper were created by wax printing. The tetraamminecopper(II) sulphate complex was drop cast and dried on the reagent zones in the wax-patterned paper. The images of reagent zones captured using a scanner were analyzed using ImageJ software. Bilirubin spiked blood serum was tested in the concentration range of 1.2 to 950 µM. The PAD exhibited sensitivities of 0.4197 a.u/μM and 0.1040 a.u/μM for concentration ranges of bilirubin 1.2 to 96 μM and 105 to 950 μM respectively and a low detection limit of 0.799 µM. The method is highly selective to bilirubin, even in the presence of other biomarkers in serum. A plasma separation membrane incorporated PAD was fabricated for the final testing and quantification of bilirubin from whole blood.
Published: 2022

9. A Simple Counting-Based Measurement for Paper Analytical Devices and Their Application

Author: Kawin Khachornsakkul, Danai Phuengkasem, Kitiya Palkuntod, Wuttichai Sangkharoek, Opor Jamjumrus, and Wijitar Dungchai
Subjects: Fluid Flow and Transfer Processes, Ions, Paper, Process Chemistry and Technology, Humans, Bioengineering, Microfluidic Analytical Techniques, Instrumentation
Abstract: This work introduces the concept of a counting-based measurement on paper analytical devices (cPADs) to improve the utilization of numerous reactions. The design of cPADs consists of two layers of paper substrates; the first layer contains a central sample zone combined with a radial surrounded by 12 detection zones that are predeposited with the various reagents, and the second layer acts as a connection channel between the sample zone and each detection zone. The solution can vertically flow from the first to the second layer and then move through the area to each subsequent detection zone. The analyte level can be evaluated by counting the number of detection zones that change color from a blank signal. Furthermore, our cPADs exhibit a capability of implementation for a broad series of reactions. Compared to the dPAD technique, some reactions that are possibly difficult to apply in such devices can be wholly enabled in our devices. The final color reaction on cPADs can apparently occur due to its identity. We applied this technique to the monitoring of carbaryl (CBR) and copper ions (Cu
Published: 2022

10. Paper-Based Fluidic Sensing Platforms for β-Adrenergic Agonist Residue Point-of-Care Testing

Author: Hongzhi Luo, Shan Liu, Lina Shi, Zhu Li, Qianwen Bai, Xiaoxin Du, Lijun Wang, He Zha, and Chenzhong Li
Subjects: Immunoassay, Paper, Point-of-Care Systems, Clinical Biochemistry, Biomedical Engineering, General Medicine, Adrenergic beta-Agonists, Microfluidic Analytical Techniques, Analytical Chemistry, Point-of-Care Testing, Lab-On-A-Chip Devices, Instrumentation, Engineering (miscellaneous), Biotechnology
Abstract: The illegal use of β-adrenergic agonists during livestock growth poses a threat to public health; the long-term intake of this medication can cause serious physiological side effects and even death. Therefore, rapid detection methods for β-adrenergic agonist residues on-site are required. Traditional detection methods such as liquid chromatography have limitations in terms of expensive instruments and complex operations. In contrast, paper methods are low cost, ubiquitous, and portable, which has led to them becoming the preferred detection method in recent years. Various paper-based fluidic devices have been developed to detect β-adrenergic agonist residues, including lateral flow immunoassays (LFAs) and microfluidic paper-based analytical devices (μPADs). In this review, the application of LFAs for the detection of β-agonists is summarized comprehensively, focusing on the latest advances in novel labeling and detection strategies. The use of μPADs as an analytical platform has attracted interest over the past decade due to their unique advantages and application for detecting β-adrenergic agonists, which are introduced here. Vertical flow immunoassays are also discussed for their shorter assay time and stronger multiplexing capabilities compared with LFAs. Furthermore, the development direction and prospects for the commercialization of paper-based devices are considered, shedding light on the development of point-of-care testing devices for β-adrenergic agonist residue detection.
Published: 2022

11. Modeling-Guided Design of Paper Microfluidic Networks: A Case Study of Sequential Fluid Delivery

Author: Dharitri Rath and Bhushan J. Toley
Subjects: Paper, Optimal design, Reverse engineering, Computer science, Microfluidics, Bioengineering, 02 engineering and technology, computer.software_genre, 01 natural sciences, Lab-On-A-Chip Devices, Instrumentation, Immunoassay, Fluid Flow and Transfer Processes, Mathematical model, Process Chemistry and Technology, 010401 analytical chemistry, Control engineering, Microfluidic Analytical Techniques, 021001 nanoscience & nanotechnology, Trial and error, 0104 chemical sciences, Flow (mathematics), Richards equation, 0210 nano-technology, Convection–diffusion equation, computer
Abstract: Paper-based microfluidic devices are popular for their ability to automate multistep assays for chemical or biological sensing at a low cost, but the design of paper microfluidic networks has largely relied on experimental trial and error. A few mathematical models of flow through paper microfluidic devices have been developed and have succeeded in explaining experimental flow behavior. However, the reverse engineering problem of designing complex paper networks guided by appropriate mathematical models is largely unsolved. In this article, we demonstrate that a two-dimensional paper network (2DPN) designed to sequentially deliver three fluids to a test zone on the device can be computationally designed and experimentally implemented without experimental trial and error. This was accomplished by three new developments in modeling flow through paper networks: (i) coupling of the Richards equation of flow through porous media to the species transport equation, (ii) modeling flow through assemblies of multiple paper materials (test membrane and wicking pad), and (iii) incorporating limited-volume fluid sources. We demonstrate the application of this model in the optimal design of a paper-based signal-enhanced immunoassay for a malaria protein, PfHRP2. This work lays the foundation for the development of a computational design toolbox to aid in the design of paper microfluidic networks. Â©
Published: 2020

12. Research Progress and Future Trends of Microfluidic Paper-Based Analytical Devices in In-Vitro Diagnosis

Author: Taiyi Zhang, Feng Ding, Yujing Yang, Gaozhen Zhao, Chuanhao Zhang, Ruiming Wang, and Xiaowen Huang
Subjects: Paper, Point-of-Care Testing, Lab-On-A-Chip Devices, Clinical Biochemistry, Microfluidics, Biomedical Engineering, General Medicine, Microfluidic Analytical Techniques, Instrumentation, Engineering (miscellaneous), Analytical Chemistry, Biotechnology
Abstract: In vitro diagnosis (IVD) has become a hot topic in laboratory research and achievement transformation. However, due to the high cost, and time-consuming and complex operation of traditional technologies, some new technologies are being introduced into IVD, to solve the existing problems. As a result, IVD has begun to develop toward point-of-care testing (POCT), a subdivision field of IVD. The pandemic has made governments and health institutions realize the urgency of accelerating the development of POCT. Microfluidic paper-based analytical devices (μPADs), a low-cost, high-efficiency, and easy-to-operate detection platform, have played a significant role in advancing the development of IVD. μPADs are composed of paper as the core material, certain unique substances as reagents for processing the paper, and sensing devices, as auxiliary equipment. The published reviews on the same topic lack a comprehensive and systematic introduction to μPAD classification and research progress in IVD segmentation. In this paper, we first briefly introduce the origin of μPADs and their role in promoting IVD, in the introduction section. Then, processing and detection methods for μPADs are summarized, and the innovative achievements of μPADs in IVD are reviewed. Finally, we discuss and prospect the upgrade and improvement directions of μPADs, in terms of portability, sensitivity, and automation, to help researchers clarify the progress and overcome the difficulties in subsequent μPAD research.
Published: 2022

13. Colorimetric Paper-Based Sensors against Cancer Biomarkers

Author: Mariana Carneiro, Maria Goreti Ferreira Sales, Ligia Rodrigues, Felismina Moreira, and Repositório Científico do Instituto Politécnico do Porto
Subjects: Paper, Point-of-Care Systems, Cancer diagnosis, Microfluidic Analytical Techniques, Biochemistry, Atomic and Molecular Physics, and Optics, Analytical Chemistry, Lab-On-A-Chip Devices, Neoplasms, Biomarkers, Tumor, Colorimetry, Paper-based devices, Electrical and Electronic Engineering, Instrumentation, Colorimetric detection, Biomarkers
Abstract: Cancer is a major cause of mortality and morbidity worldwide. Detection and quantification of cancer biomarkers plays a critical role in cancer early diagnosis, screening, and treatment. Clinicians, particularly in developing countries, deal with high costs and limited resources for diagnostic systems. Using low-cost substrates to develop sensor devices could be very helpful. The interest in paper-based sensors with colorimetric detection increased exponentially in the last decade as they meet the criteria for point-of-care (PoC) devices. Cellulose and different nanomaterials have been used as substrate and colorimetric probes, respectively, for these types of devices in their different designs as spot tests, lateral-flow assays, dipsticks, and microfluidic paper-based devices (μPADs), offering low-cost and disposable devices. However, the main challenge with these devices is their low sensitivity and lack of efficiency in performing quantitative measurements. This review includes an overview of the use of paper for the development of sensing devices focusing on colorimetric detection and their application to cancer biomarkers. We highlight recent works reporting the use of paper in the development of colorimetric sensors for cancer biomarkers, such as proteins, nucleic acids, and others. Finally, we discuss the main advantages of these types of devices and highlight their major pitfalls., This research was funded by Portuguese Foundation for Science and Technology (FCT), under the scope of the strategic funding of UIDB/04469/2020 unit and through Mariana Carneiro PhD grant reference SFRH/BD/131959/2017.
Published: 2022

14. Influence of Air Cold Plasma Modification on the Surface Properties of Paper Used for Packaging Production

Author: Konrad Terpiłowski, Michał Chodkowski, Salvador Peréz-Huertas, and Łukasz Wiechetek
Subjects: Paper, Composite material, Fluid Flow and Transfer Processes, cold plasma, low-pressure plasma, air plasma, plasma modification, paper, printing, composite material, adhesion, contact angle, surface free energy, Plasma modification, Surface free energy, Process Chemistry and Technology, General Engineering, Low-pressure plasma, Computer Science Applications, Cold plasma, Adhesion, Printing, General Materials Science, Contact angle, Instrumentation, Air plasma
Abstract: In this study, the effect of air plasma on the surface properties of printed and coated cardboard was investigated. The material was activated by low-pressure cold plasma for 1, 10, 20, and 30 s. Wettability changes on the surface were examined by contact angle measurements using the sessile droplet technique. The differences in the surface free energy were calculated using the Lifshitz–van derWaals/acid–base and Contact Angle Hysteresis approaches. Optical profilometry was used for the surface roughness evaluation and an X-ray photoelectron spectroscopy analysis was performed to find changes in surface chemistry. Adhesive strength tests were carried out to estimate the adhesion changes after the material’s modification. It was found that the water and formamide contact angles increased after the plasma treatment while the diiodomethane contact angle did not change. As a result of the modification, the surface free energy also increased significantly and the surface roughness increased. The pull-off tests confirmed the improvement in the material’s surface properties. Moreover, it was demonstrated that the optimal effect can be obtained after just 10 s of the plasma process.
Published: 2022
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15. Paper-Based Device for the Facile Colorimetric Determination of Lithium Ions in Human Whole Blood

Author: Takeshi Komatsu, Akihiko Ishida, Hirofumi Tani, Manabu Tokeshi, and Masatoshi Maeki
Subjects: Paper, Materials science, Coefficient of variation, chemistry.chemical_element, Bioengineering, 02 engineering and technology, Lithium, 01 natural sciences, Ion, chemistry.chemical_compound, Humans, Colorimetry, Instrumentation, Whole blood, Ions, Fluid Flow and Transfer Processes, Detection limit, Reproducibility, Chromatography, Process Chemistry and Technology, 010401 analytical chemistry, Lithium carbonate, Reproducibility of Results, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, 0210 nano-technology
Abstract: Lithium carbonate is an effective medicine for the treatment of the bipolar disorder, but the concentration of lithium in the patient's blood must be frequently monitored because of its toxicity. To date, no colorimetric methods of lithium ion detection in whole blood without pretreatment have been reported. Here, we report a colorimetric paper-based device that allows point-of-care testing in one step. This device is composed of two paper-based elements linked to each other: a blood cell separation unit and a colorimetric detection unit. After a portion of whole blood has been placed on the end of the separation unit, plasma in the sample is automatically transported to the detection unit, which displays a diagnostic color. The key feature of this device is its simple, user-friendly operation. The limit of detection is 0.054 mM and the coefficient of variance is below 6.1%, which are comparable to those of conventional instruments using the same colorimetric reaction. Furthermore, we achieved high recovery (>90%) and reproducibility (
Published: 2020

16. The development of the NNBAR experiment

Author: Backman, F., Barrow, J., Beßler, Y., Bianchi, A., Bohm, C., Brooijmans, G., Broussard, L. J., Calen, H., Cederkäll, J., Damian, J. I. M., Dian, E., Di Julio, D. D., Dunne, K., Eklund, L., Ferreira, M. J., Fierlinger, P., Friman-Gayer, U., Happe, C., Holl, M., Johansson, T., Kamyshkov, Y., Klinkby, E., Kolevatov, R., Kupsc, A., Meirose, B., Milstead, D., Nepomuceno, A., Nilsson, T., Oskarsson, A., Perrey, H., Ramic, K., Rataj, B., Rizzi, N., Santoro, V., Silverstein, S., Snow, W. M., Takibayev, A., Wagner, R., Wolke, M., Yiu, S. C., Young, A. R., Zanini, L., and Zimmer, O.
Subjects: Physics - Instrumentation and Detectors, Instrumentation for neutron sources, Large detector systems for particle and astroparticle physics, Detector modelling and simulations I (interaction of radiation with matter, FOS: Physical sciences, interaction of photons with matter, Acceleratorfysik och instrumentering, Instrumentation and Detectors (physics.ins-det), Accelerator Physics and Instrumentation, Detector modelling and simulations I (interactin of radiation with matter, interaction of photons with matter, interactions of hadrons with matter, etc), High Energy Physics - Experiment, ddc, High Energy Physics - Experiment (hep-ex), interaction of hadrons with matter&nbsp, paper, Detector modelling and simulations I (interaction of radiation with matter, interaction of photons with matter, interaction of hadrons with matter, etc), Simulation methods and programs, ddc:610, Nuclear Experiment (nucl-ex), Nuclear Experiment, Instrumentation, Mathematical Physics, etc)
Abstract: Journal of Instrumentation 17(10), P10046 - (2022). doi:10.1088/1748-0221/17/10/P10046, The NNBAR experiment for the European Spallation Source will search for freeneutrons converting to antineutrons with a sensitivity improvement of three orders of magnitudecompared to the last such search. This paper describes progress towards a conceptual design reportfor NNBAR. The design of a moderator, neutron reflector, beamline, shielding and annihilationdetector is reported. The simulations used form part of a model which will be used for optimisationof the experiment design and quantification of its sensitivity., Published by Inst. of Physics, London
Published: 2022

17. Modeling the effect of creep in paper fibres under the influence of external loading and changes in moisture

Author: P. Samantray, Marc G.D. Geers, Ron H. J. Peerlings, Thierry Massart, Mechanics of Materials, Group Peerlings, and EAISI Foundational
Subjects: Paper, Work (thermodynamics), Résistance et comportement des matériaux, Materials science, Moisture, Scale (ratio), Hygro-mechanics, Mechanics, Creep, Microstructure, Sciences de l'ingénieur, Power law, Technologie matières ligneuses, Mechanics of Materials, Fibrous network, Stress relaxation, Connaissance des matériaux, Relaxation (physics), Déformation, rupture matériaux, General Materials Science, Instrumentation
Abstract: Paper is a material exhibiting a complex microstructure that is composed of a network of fibres at the micro-level. When subjected to external loading or variations in moisture conditions over different time scales, changes in strain that are non-linear with respect to time are observed at the sheet level (macro-scale). In order to investigate this time-dependent behavior of paper, a creep power law model is implemented within a finite element approach at the level of single fibres. This rate-dependent model is found to capture experimental results available in literature for single fibres with a good agreement (both quantitatively and qualitatively). Based on the identified model at the level of single fibres, the time-dependent hygro-mechanical response is upscaled towards the network scale. To this end, random model networks of ribbon shaped fibres are generated and their response is simulated. The network-scale response, emerging from the rate-dependent fibre model, demonstrates the ability to predict the response of networks subjected to relaxation at a constant moisture level. The developed numerical model predicts lower values of overall stress response in single fibres as compared to networks. Also, stress relaxation predicted by the rate-dependent model in the cross-direction of the networks is in agreement with the experimental observations. Therefore, one of the remarkable findings of the present work is that the developed rate-dependent model is robust enough to capture the sheet scale response also qualitatively. Based on the study of these computational results, a better understanding is achieved regarding the influence of mechanical and rate-dependent properties of single fibres on the hygro-expansion of complete fibre networks, and in particular of paper sheets., info:eu-repo/semantics/published
Published: 2021

18. Characterization measurements of the TRISTAN multi-pixel silicon drift detector

Author: Urban, K., Carminati, M., Descher, M., Edzards, F., Fink, D., Fiorini, C., Gugiatti, M., Hinz, D., Houdy, T., King, P., Lechner, P., Mertens, S., Siegmann, D., Steidl, M., and Wolf, J.
Subjects: Physics - Instrumentation and Detectors, Spectrometers, Physics::Instrumentation and Detectors, Physics, High Energy Physics::Phenomenology, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Very low-energy charged particle detectors, Paper, Solid state detectors, ddc, ddc:530, High Energy Physics::Experiment, Instrumentation, Mathematical Physics
Abstract: Sterile neutrinos are a minimal extension of the standard model of particle physics. A laboratory-based approach to search for this particle is via tritium β-decay, where a sterile neutrino would cause a kink-like spectral distortion. The Karlsruhe Tritium Neutrino (KATRIN) experiment extended by a multi-pixel Silicon Drift Detector system has the potential to reach an unprecedented sensitivity to the keV-scale sterile neutrino in a lab-based experiment. The new detector system combines good spectroscopic performance with a high rate capability. In this work, we report about the characterization of charge-sharing between pixels and the commissioning of a 47-pixel prototype detector in a MAC-E filter.
Published: 2021

19. A Customized Microfluidic Paper-Based Platform for Colorimetric Immunosensing: Demonstrated via hCG Assay for Pregnancy Test

Author: Mahroo Baharfar, Guozhen Liu, Siyi Zou, and Mohammad Rahbar
Subjects: Pregnancy test, Paper, Analyte, Chorionic gonadotrophin, Pregnancy Tests, Clinical Biochemistry, Microfluidics, Biomedical Engineering, Early pregnancy factor, 02 engineering and technology, microfluidic paper-based analytical devices, point-of-care testing, human chorionic gonadotrophin, colorimetric detection, immunosensing, pregnancy test, 01 natural sciences, Article, Analytical Chemistry, Home pregnancy tests, Pregnancy, Humans, Instrumentation, Engineering (miscellaneous), Immunoassay, Chromatography, biology, Filter paper, Chemistry, 010401 analytical chemistry, General Medicine, Paper based, Microfluidic Analytical Techniques, 021001 nanoscience & nanotechnology, 0104 chemical sciences, biology.protein, Colorimetry, Female, 0210 nano-technology, TP248.13-248.65, Biotechnology
Abstract: Over the past decades, paper-based lateral flow immunoassays (LFIAs) have been extensively developed for rapid, facile, and low-cost detection of a wide array of target analytes in a point-of-care manner. Conventional home pregnancy tests are the most significant example of LFAs, which detect elevated concentrations of human chorionic gonadotrophin (hCG) in body fluids to identify early pregnancy. In this work, we have upgraded these platforms to a higher version by developing a customized microfluidic paper-based analytical device (μPAD), as the new generation of paper-based point-of-care platforms, for colorimetric immunosensing. This will offer a cost-efficient and environmentally friendly alternative platform for paper-based immunosensing, eliminating the need for nitrocellulose (NC) membrane as the substrate material. The performance of the developed platform is demonstrated by detection of hCG (as a model case) in urine samples and subsequently indicating positive or negative pregnancy. A dual-functional silane-based composite was used to treat filter paper in order to enhance the colorimetric signal intensity in the detection zones of μPADs. In addition, microfluidic pathways were designed in a manner to provide the desired regulated fluid flow, generating sufficient incubation time (delays) at the designated detection zones, and consequently enhancing the obtained signal intensity. The presented approaches allow to overcome the existing limitations of μPADs in immunosensing and will broaden their applicability to a wider range of assays. Although, the application of the developed hCG μPAD assay is mainly in qualitative (i.e., positive or negative) detection of pregnancy, the semi-quantitative measurement of hCG was also investigated, indicating the viability of this assay for sensitive detection of the target hCG analyte within the related physiological range (i.e., 10–500 ng/mL) with a LOD value down to 10 ng/mL.
Published: 2021

20. Experimental investigation and process optimization of the ultrasonic welding applied to papers

Author: Barthélémy Harthong, J. Viguié, M. Terrien, Robert Peyroux, Didier Imbault, Quentin Charlier, J.‐B. Toni, Laboratoire sols, solides, structures - risques [Grenoble] (3SR), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Mécanique et Couplages Multiphysiques des Milieux Hétérogènes (CoMHet), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Centre Technique du Papier (CTP), Laboratoire Génie des procédés papetiers (LGP2), Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), and Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)
Subjects: 010302 applied physics, instrumentation, Ultrasonic welding, Materials science, Mechanical Engineering, paper, paperboard, Mechanical engineering, 02 engineering and technology, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, [SPI.MAT]Engineering Sciences [physics]/Materials, experimentation, Mechanics of Materials, process optimization, 0103 physical sciences, [SPI.MECA.MEMA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph], General Materials Science, Process optimization, 0210 nano-technology
Abstract: International audience; Ultrasonic welding is a serious candidate in the development of methods to assemble papers and paperboards without using additional substances. However, the ultrasonic welding of papers remains a technological challenge considering the low weldability of lignocellulosic materials. This study aims to investigate on the ultrasonic welding process applied to papers in order to identify the processing conditions which favor the formation of strong welded joints. To reach such purpose, an experimental strategy was developed by combining the characterization of welded materials and the monitoring of process parameters. Experimentations were performed using a reference paper displaying a good weldability to specifically highlight the contribution of process parameters. Results indicate that the process is highly sensitive to vibration amplitude, power supplied by the high frequency generator, and sample thickness. Power seems to be a reliable indicator of the severity of the process. A strong decrease in the strength of the welded joints is observed when working with low thicknesses. It seems that the layers coated on top of papers are the main part of the material contributing in the development of adhesion at the welding joint. Overall, instrumenting the device has led to a better understanding of the ultrasonic welding of papers.
Published: 2021

21. Folding Paper-Based Aptasensor Platform Coated with Novel Nanoassemblies for Instant and Highly Sensitive Detection of 17β-Estradiol

Author: Jinping Luo, Yang Wang, Yu Xing, Tao Ming, Hongyan Jin, Xinxia Cai, Shuai Sun, Juntao Liu, and Guihua Xiao
Subjects: Paper, Working electrode, Materials science, Aptamer, Metal Nanoparticles, Bioengineering, Nanotechnology, Biosensing Techniques, 02 engineering and technology, 01 natural sciences, chemistry.chemical_compound, Limit of Detection, Lab-On-A-Chip Devices, Humans, Electrodes, Instrumentation, Fluid Flow and Transfer Processes, Detection limit, Base Sequence, Estradiol, Nanotubes, Carbon, Process Chemistry and Technology, 010401 analytical chemistry, New methylene blue, Electrochemical Techniques, Folding (DSP implementation), Aptamers, Nucleotide, Microfluidic Analytical Techniques, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Methylene Blue, Linear range, chemistry, Point-of-Care Testing, Colloidal gold, Gold, 0210 nano-technology, Luminescence
Abstract: Owing to its critical role in the development of female reproductive tissues and as a clinical biomarker, there is an urgent need to develop a rapid and cost-effective method to sensitively detect 17β-estradiol (E2). In this work, a folding aptasensor platform with microfluidic channels for the label-free electrochemical detection of E2 is described. The platform, designed with a delicate folding structure, integrating filter holes, microfluidic channels, reaction chambers, and a three-electrode system, is extremely easy to use. To increase the detection sensitivity and immobilize the aptamer, we synthesized a novel nanoassembly consisting of amine-functionalized single-walled carbon nanotube/new methylene blue/gold nanoparticles (AuNPs) and modified the working electrode with this nanoassembly. The calibration curve obtained from the experimental results exhibited a linear range between 10 pg mL-1 and 500 ng mL-1 (R2 = 0.993), and a detection limit of 5 pg mL-1 was achieved (S/N = 3). Furthermore, experiments to detect E2 in clinical serum were conducted, and the results were highly similar to those obtained using a large electrochemical luminescence apparatus. By integrating multiple functional components, adopting novel nanoassemblies, and using a folding structure, this paper-based platform not only has great potential as a simple and convenient integrated device for point-of-care testing of E2, but also as a portable, low-cost, and highly sensitive aptasensor platform capable of detecting many diagnostic biomarkers with the appropriate aptamers.
Published: 2019

22. Intelligent Platform for Simultaneous Detection of Multiple Aminoglycosides Based on a Ratiometric Paper-Based Device with Digital Fluorescence Detector Readout

Author: Hua Yang, Fawei Zhu, Lumin Wang, Xiaoqing Chen, Miao Chen, Yu Xiong, Yuqiu Zhu, Qi Liu, and Siqi Xie
Subjects: Paper, Materials science, Aptamer, Food Contamination, Bioengineering, 02 engineering and technology, Phenylenediamines, 01 natural sciences, Signal, Fluorescence, Fluorescence spectroscopy, chemistry.chemical_compound, Rivers, Kanamycin, Limit of Detection, Animals, Fluidics, Nitrogen Compounds, Instrumentation, Fluorescent Dyes, Fluid Flow and Transfer Processes, Signal processing, business.industry, Process Chemistry and Technology, 010401 analytical chemistry, Graphitic carbon nitride, Reproducibility of Results, Hydrogen Peroxide, Aptamers, Nucleotide, 021001 nanoscience & nanotechnology, Anti-Bacterial Agents, Nanostructures, 0104 chemical sciences, Milk, Spectrometry, Fluorescence, chemistry, Reagent, Streptomycin, Tobramycin, Phenazines, Optoelectronics, Graphite, 0210 nano-technology, business, Water Pollutants, Chemical
Abstract: A digital fluorescence detector (DFD), a handheld fluorescence detection device, can convert the fluorescence signal of samples into the corresponding fluorescer concentration. Herein, by adopting a DFD as the readout, a novel intelligent platform was developed based on a ratiometric paper-based device (RPD) for multiple aminoglycoside detection. There are five layers and four parallel channels contained in the designed RPD, functioning as reagent storage, fluidic path control and signal processing, respectively. The rationale of this design lies in the fact that aptamer/graphitic carbon nitride nanosheet (Apt/g-C3N4 NS) modified layers can catalyze o-phenylenediamine to fluorescent 2,3-diaminophenazine (DAP) in the presence of H2O2. When Apt was removed from nanosheets via the Apt-target reaction, the peroxidase-like activity would be decreased, thus decreasing the production of DAP. All the changes of the fluorescence DAP signal can be read out using a portable DFD. Based on the DFD signal change related to the concentration of the target, a quantitative reaction platform was established. Furthermore, the sample flow and Apt-target reaction time can be reasonably regulated using the H2O2-cleavable hydrophobic compound modified layer placed between the target recognition region and detection region. Then, the practicality of this platform was verified through realizing sensitive analysis of streptomycin, tobramycin, and kanamycin simultaneously. Overall, with merits including portability and ease of operation, the platform shows great potential in on-site simultaneous detection of multiple targets, especially in resource-limited settings.
Published: 2019

23. Surface Engineering of Carbon Fiber Paper toward Exceptionally High-Performance and Stable Electrochemical Nitrite Sensing

Author: Jianlong Wang, Jiandong Gong, Wenxin Zhu, Yi Zhang, Yiyue Ma, Jing Sun, and Tao Li
Subjects: Paper, Work (thermodynamics), Materials science, Surface Properties, Bioengineering, 02 engineering and technology, Surface engineering, Electrochemistry, 01 natural sciences, chemistry.chemical_compound, Carbon Fiber, Air annealing, Particle Size, Nitrite, Instrumentation, Nitrites, Fluid Flow and Transfer Processes, Process Chemistry and Technology, 010401 analytical chemistry, Food sample, Electrochemical Techniques, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Electrochemical gas sensor, chemistry, Chemical engineering, 0210 nano-technology
Abstract: In this work, we introduce our recent finding that the carbon fiber paper (CFP) treated by simple air annealing (OCFP) could be used for exceptionally high-performance electrochemical nitrite sensing. The air-annealing process endows the pristine CFP with higher defective edge/plane sites, more oxygen-containing functional groups, higher roughness, and improved wettability. The electrochemical studies show that the OCFP exhibits excellent sensing performance for nitrite, with an ultralow determination limit of 0.1 μM and a detection limit of 0.07 μM, an ultrawide linear determination range of 0.1-3838.5 μM, a fast current response of 1 s, and a high sensitivity of 930.4 μA mM
Published: 2019

24. Enhanced Detection of Infectious Pancreatic Necrosis Virus via Lateral Flow Chip and Fluorometric Biosensors Based on Self-Assembled Protein Nanoprobes

Author: Mintai P. Hwang, Min-Ho Lee, Jeongho Kim, Sachin Chavan, Jonghoon Choi, Yonghyun Choi, Jangsun Hwang, Dasom Kim, and Jong Wook Hong
Subjects: Paper, medicine.drug_class, Nanoprobe, Bioengineering, Biosensing Techniques, 02 engineering and technology, Monoclonal antibody, 01 natural sciences, Virus, law.invention, GTP-Binding Proteins, Limit of Detection, law, Escherichia coli, medicine, Humans, Fluorometry, Instrumentation, Infectious pancreatic necrosis virus, Fluorescent Dyes, Immunoassay, Fluid Flow and Transfer Processes, Detection limit, Chemistry, Magnetic Phenomena, Process Chemistry and Technology, 010401 analytical chemistry, Antibodies, Monoclonal, 021001 nanoscience & nanotechnology, Fragment crystallizable region, Molecular biology, Recombinant Proteins, 0104 chemical sciences, Apoferritins, Recombinant DNA, Nanoparticles, 0210 nano-technology, Antibodies, Immobilized, Biosensor
Abstract: Salmon fish farmers face remarkable problems in fish rearing and handling due to the spread of disease by infectious pancreatic necrosis virus (IPNV). Therefore, we developed a straightforward and sensitive technique to detect IPNV-based on recombinant human apoferritin heavy chain (hAFN-H) protein nanoparticles. In this study, the 24 subunits of the hAFN-H were genetically modified to express 6×His-tag and protein-G at their C-terminal site using Escherichia coli. We thus achieved a two-step signal amplifying strategy that utilizes a recombinant hAFN-H nanoprobe having a protein-G-binding site that targets the Fc region of monoclonal antibodies and a 6×His-tag that actively interacts with the functionalized Ni-NTA derivatives. In this study, we report a considerable advancement in magnetic bead-based detection systems that use Ni-NTA-Atto 550, reliably exhibiting detection limits of 1.02 TCID50/mL (50% tissue culture infective dose). Additionally, we propose a lateral flow chip-based detection method that uses the hAFN-H surface functionalized with 5 nm of the Ni-NTA-nanogold complex as a nanoprobe; the limit of detection towards IPNV was 0.88 TCID50/mL. The detection of IPNV by this recombinant hAFN-H nanoprobe was linear to virus titers in the range of 101-103 TCID50/mL.
Published: 2019

25. Plasmonic Paper Microneedle Patch for On-Patch Detection of Molecules in Dermal Interstitial Fluid

Author: Sisi Cao, Chandana Kolluru, Rohit Gupta, Hamed Gholami Derami, Mikayla Williams, Mark R. Prausnitz, Richard K. Noel, Qisheng Jiang, and Srikanth Singamaneni
Subjects: Paper, Materials science, Injections, Intradermal, Bioengineering, Nanotechnology, 02 engineering and technology, Spectrum Analysis, Raman, Proof of Concept Study, 01 natural sciences, Article, Rhodamine 6G, chemistry.chemical_compound, symbols.namesake, Interstitial fluid, Animals, Molecule, Instrumentation, Plasmon, Fluid Flow and Transfer Processes, Nanotubes, Filter paper, Rhodamines, Process Chemistry and Technology, 010401 analytical chemistry, Extracellular Fluid, Dermis, Surface-enhanced Raman spectroscopy, 021001 nanoscience & nanotechnology, Rats, 0104 chemical sciences, chemistry, Needles, Point-of-Care Testing, symbols, Polystyrenes, Female, Nanorod, Gold, 0210 nano-technology, Raman scattering
Abstract: Minimally invasive devices to detect molecules in dermal interstitial fluid (ISF) are desirable for point-of-care diagnostic and monitoring applications. In this study, we developed a microneedle (MN) patch that collects ISF for on-patch biomarker analysis by surface-enhanced Raman scattering (SERS). The micrometer-scale MNs create micropores in the skin surface, through which microliter quantities of ISF are collected onto plasmonic paper on the patch backing. The plasmonic paper was prepared by immobilizing poly(styrenesulfonate) (PSS) coated gold nanorods (AuNRs) on a thin strip of filter paper using plasmonic calligraphy. Negatively charged PSS was used to bind positively charged rhodamine 6G (R6G), which served as a model compound, and thereby localize R6G on AuNR surface. R6G bound on the AuNR surface was detected and quantified by acquiring SERS spectra from the plasmonic paper MN patch. This approach was used to measure pharmacokinetic profiles of R6G in ISF and serum from rats in vivo. This proof-of-concept study indicates that a plasmonic paper MN patch has the potential to enable on-patch measurement of molecules in ISF for research and future medical applications.
Published: 2019

26. Structural Elucidation and Ultrasensitive Analyses of Volatile Organic Compounds by Paper-Based Nano-Optoelectronic Noses

Author: Javad Tashkhourian, Mohammad Mahdi Bordbar, and Bahram Hemmateenejad
Subjects: Paper, Materials science, Bioengineering, 02 engineering and technology, 01 natural sciences, Silver nanoparticle, Pattern Recognition, Automated, Limit of Detection, Nano, Nanotechnology, Electronic Nose, Instrumentation, Fluid Flow and Transfer Processes, Volatile Organic Compounds, business.industry, Process Chemistry and Technology, fungi, 010401 analytical chemistry, Optical Devices, food and beverages, Paper based, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Odor, Colloidal gold, Optoelectronics, Colorimetry, 0210 nano-technology, business
Abstract: Paper-based optoelectronic noses (OENs) are being developed based on printing of organic and organometallic reagents on hydrophilic substrates that can visualize the odor of volatiles. In this work, we report for the first time the use of nanoparticles for fabrication of novel paper-based OENs, which represent much higher sensitivity and produce simple but discriminant colorimetric signature of volatile metabolomes. This nano-optoelectronic nose (NOEN) system, which is fabricated by dropping of gold and silver nanoparticles (each synthesized by 8 chemical species) on the paper, gives obvious colorimetric signatures for chemicals having individual or combined functional groups. Owning to their ultrasensitivity, these simple devices need very small amounts of analytes. These devices could detect and discriminate 45 volatile organic compounds in 9 chemical families including phenols, alchohols, ketones, aldehydes, amines, acids, esters, arenes, and hydrocarbons. In addition to excellent discrimination ability, this NOEN sensor shows ultrahigh sensitivity such that could determine volatile compounds with detection limits around or lower than 10 ppb. Moreover, it can be combined with multivariate calibration methods for quantitative analysis of a metabolite in a complex mixture.
Published: 2019

27. Colorimetric Detection of Salivary α-Amylase Using Maltose as a Noncompetitive Inhibitor for Polysaccharide Cleavage

Author: Iuna Tsyrulneva, Bo Liedberg, Palaniappan Alagappan, School of Materials Science and Engineering, School of Mechanical and Aerospace Engineering, Institute for Sports Research, and Center for Biomimetic Sensor Science
Subjects: Adult, Male, Paper, Saliva, Bioengineering, 02 engineering and technology, Polysaccharide, 01 natural sciences, chemistry.chemical_compound, Non-competitive inhibition, Limit of Detection, Humans, α-Amylase, Enzyme Inhibitors, Maltose, Instrumentation, Fluid Flow and Transfer Processes, Detection limit, chemistry.chemical_classification, Aqueous solution, Chromatography, Paper-based Strip, Chemistry, Process Chemistry and Technology, 010401 analytical chemistry, Substrate (chemistry), 021001 nanoscience & nanotechnology, 0104 chemical sciences, Kinetics, Salivary alpha-Amylases, Mechanical engineering [Engineering], Colorimetry, Female, Phadebas, 0210 nano-technology, Trisaccharides
Abstract: This paper describes an approach for colorimetric detection of salivary α-amylase, one of the potential biomarkers of autonomic nervous system (ANS) activity, for enabling assessment of fatigue. The ability of α-amylase to cleave α-bonds of polysaccharides is utilized for developing a colorimetric assay. In the proposed approach, 2-chloro-4-nitrophenyl-α-d-maltotrioside as substrate releases a colored byproduct upon cleavage by salivary α-amylase. Introduction of maltose as a noncompetitive inhibitor yields desirable linear responses in the physiologically relevant concentration range (20–500 μg/mL) with a limit of detection (LOD) of 8 μg/mL (in aqueous solution). The concentrations of substrate and noncompetitive inhibitor are subsequently optimized for colorimetric detection of salivary α-amylase. A facile paper-based “strip” assay is proposed for analysis of human saliva samples with marginal interference from saliva components. The proposed assay is rapid, specific, and easy-to-implement for colorimetric detection of salivary α-amylase between 20 and 500 μg/mL. Complementary RGB (red, green, blue components) analysis offers quantitative detection with a LOD of 11 μg/mL. The two assay formats are benchmarked against the Phadebas test, a state of the art method for spectrophotometric detection of α-amylase. The reported paper-based methodology possesses a high potential for estimation of altered ANS responses toward stressors that possibly could find applications in assessment of fatigue and for monitoring onset of fatigue. Nanyang Technological University Accepted version This work is supported by Provost’s office and Institute for Sports Research (ISR), School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore.
Published: 2019

28. Easy Diagnosis of Jaundice: A Smartphone-Based Nanosensor Bioplatform Using Photoluminescent Bacterial Nanopaper for Point-of-Care Diagnosis of Hyperbilirubinemia

Author: Seyyed Hamid Ahmadi, Raziyeh Sadat Tabatabaee, and Hamed Golmohammadi
Subjects: Paper, medicine.medical_specialty, Light, Bioengineering, 02 engineering and technology, 01 natural sciences, Gastroenterology, Polymerization, Nanosensor, Internal medicine, Quantum Dots, medicine, Humans, Cellulose, Instrumentation, Point of care, Fluid Flow and Transfer Processes, Carbon dot, Luminescent Agents, business.industry, Process Chemistry and Technology, 010401 analytical chemistry, Infant, Newborn, Bilirubin, Jaundice, 021001 nanoscience & nanotechnology, Carbon, Jaundice, Neonatal, 0104 chemical sciences, Point-of-Care Testing, Luminescent Measurements, Smartphone, medicine.symptom, 0210 nano-technology, business
Abstract: One of the concerns of parents in the first days of their baby's birth is the baby's risk of jaundice/hyperbilirubinemia. This is because more than 60% of babies are born with jaundice that, if not timely diagnosed and subsequently treated, can lead to serious damage to their health. On the other hand, despite recent progress in sensor technology for clinical applications, the development of easy-to-use, cost-effective, sensitive, specific, and portable diagnostic devices, which use nontoxic and biodegradable materials in their design and fabrication, is still in high demand. Herein we present an easy-to-use, cost-effective, selective, nontoxic, and disposable photoluminescent nanopaper-based assay kit with a smartphone readout for easy diagnosis of neonatal jaundice through visual determination of Bilirubin (BR) in infants' blood samples. The developed BR assay kit comprises highly photoluminescent carbon dot (CD) sensing probes embedded in a bacterial cellulose (BC) nanopaper substrate (CDBN). The photoluminescence (PL) of the developed BR sensor is quenched in the presence of BR as a PL quencher and then selectively recovered upon blue light (λ = 470 nm) exposure, due to conversion of the unconjugated BR to the colorless oxidation products (non-PL quencher) through BR photoisomerization and photooxidation, that subsequently leads to selective PL enhancement of CDBN. The recovered PL intensity of the developed BR assay kit, which was monitored by integrated smartphone camera, was linearly proportional to the concentration of BR in the range of 2-20 mg dL
Published: 2019

29. Paper Based Photoluminescent Sensing Platform with Recognition Sites for Tributyltin

Author: Esma Sari, Arben Merkoçi, Recep Üzek, Agencia Estatal de Investigación (España), The Scientific and Technological Research Council of Turkey, European Commission, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Generalitat de Catalunya, Merkoçi, Arben [0000-0003-2486-8085], and Merkoçi, Arben
Subjects: Paper, Molecular imprinting, Materials science, Polymers, Nanoparticle, Bioengineering, Nanotechnology, 02 engineering and technology, 01 natural sciences, law.invention, chemistry.chemical_compound, Limit of Detection, Nanosensor, law, Instrumentation, Fluorescent Dyes, Fluid Flow and Transfer Processes, Detection limit, Nanocomposite, Graphene quantum dots, Graphene, Process Chemistry and Technology, 010401 analytical chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Polymerization, chemistry, Luminescent Measurements, Optical sensor, Tributyltin, Nanoparticles, Trialkyltin Compounds, 0210 nano-technology
Abstract: In this study, a novel photoluminescence material for the detection of tributyltin (TBT) was developed by using a paper-based nanocomposite system. For this purpose, molecularly imprinted polymeric nanoparticles (MIN) were synthesized with mini-emulsion polymerization technique. Graphene quantum dots obtained by the hydrothermal pyrolysis were immobilized to the nanoparticle surface via EDC-NHS coupling. The fabrication of sensing platform for TBT can be divided into two steps that are the preparation of nanocomposite and the applying the nanocomposite onto nitrocellulose membrane. The selectivity constant and association kinetics were calculated to analyze the interaction of TBT with immobilized MINs. The results proved that the developed nanosensor is promising for the determination of TBT with high selectivity and sensitivity reaching a detection limit of 0.23 ppt in seawater. This novel photoluminescent nanosensor has the potential to pave the way for further studies and applications., Recep Üzek thanks to TUBITAK for the given scholarship. We acknowledge the support from European Commission through the Graphene Flagship Core 2 project and from Ministerio de Economıa, Industria y Competitividad (MINECO), Agencia Estatal de Investigacion (AEI) for the project MAT2017-87202-P. The ICN2 is funded by the CERCA Programme/Generalitat de Catalunya. ICN2 is supported by the Severo Ochoa program from Spanish MINECO (Grant No. SEV2017-0706).
Published: 2019

30. Silver nanoparticles inkjet-printed flexible biosensor for rapid label-free antibiotic detection in milk

Author: Alessandro De Toni, A. Paccagnella, Giulio Rosati, Marco Ravarotto, and M. Scaramuzza
Subjects: Paper, Materials science, Aptamer, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Silver nanoparticle, Microsystem, Materials Chemistry, Electrical and Electronic Engineering, Flexible biosensor, Instrumentation, Label free, chemistry.chemical_classification, EIS, Inkwell, Antibiotic, Metals and Alloys, Polymer, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Inkjet, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry, Surface modification, 0210 nano-technology, Biosensor
Abstract: Inkjet printing is an established technology that has been revisited in recent years for the low-cost and easy production of electrical sensing and biosensing systems. With this technique, it is possible to produce flexible microsystems on eco-compatible substrates such as polymers and paper. In this sense, we investigated the printing performances of a common office inkjet printer and of a commercial conducting ink, to produce aptamer-based electrochemical biosensors for antibiotics detection. During our analysis we characterized both the morphological and electrical properties of the printed electrodes, considering also their stability over time and tuning all the parameters to obtain reproducible micrometric systems. The produced devices proved to be able to undergo aptamer functionalization and to detect Ampicillin, a common used antibiotic, in few minutes with a LOD of 10 μg/ml in milk. Therefore, in this preliminary work we demonstrated the feasibility of low-cost customized inkjet-printed biosensors, and their possible use to prevent both antibiotic contaminations and antibiotic resistance development.
Published: 2019

31. A laser-induced breakdown spectroscopy method to assess the stochasticity of plasma-flame transition in sprays

Author: De Oliveira, PM, Sitte, MP, Kotzagianni, M, M Allison, P, Mastorakos, E, de Oliveira, PM [0000-0002-5527-8128], Sitte, MP [0000-0002-7502-9858], M Allison, P [0000-0001-7819-2303], Mastorakos, E [0000-0001-8245-5188], Apollo - University of Cambridge Repository, and Mastorakos, Epaminondas [0000-0001-8245-5188]
Subjects: Paper, plasma-flame transition, polydisperse sprays, Fluids, laser-induced breakdown spectroscopy, LIBS, Applied Mathematics, spray combustion, ignition, Physics::Chemical Physics, Instrumentation, Engineering (miscellaneous)
Abstract: An experimental approach is presented to evaluate the impact of plasma composition arising from pulse-to-pulse energy and mixture fluctuations on the non-resonant laser-induced ignition of sprays. This allows for spark events to be conditioned on the successful or failed establishment of a flame kernel, a phase dominated by plasma decomposition and recombination reactions and the on-set of combustion reactions, that is, independent of the subsequent flame growth phase controlled by propagation phenomena only, such as fuel availability and turbulent strain. For that, laser-induced breakdown spectroscopy of the spark-generated plasma is carried out, followed by OH ∗ high-speed imaging of the kernel. Exploratory experiments in spatially uniform and polydisperse kerosene droplet distributions in a jet suggest that the hydrogen concentration in the plasma deriving from the fuel dissociated by the spark is closely related to the generated OH ∗ radicals levels and, in turn, with the success of establishing a flame kernel. This suggests that the ignition process is heavily controlled by mixture fluctuations at the spark, inherent of spray flows. The instantaneous mixture at the spark is estimated with a stochastic model, with the probability density function of the equivalence ratio exhibiting values higher than twice the mean value, while the highest probability occurs at lean conditions between the gaseous equivalence ratio and the overall equivalence ratio. The findings corroborate insights on the early-phase ignition obtained from direct numerical simulations, and the framework paves the way for the development of smart online engine-health tools to assess relight capability in future aeroengines.
Published: 2022

32. The ATLAS fast TracKer system

Author: Aad, Georges, Abbott, Braden Keim, Abreu, Henso, Arcangeletti, Chiara, Gutierrez Zagazeta, Luis Felipe, Gutschow, Christian, Guyot, Claude, Gwenlan, Claire, Gwilliam, Carl, Haaland, Even Simonsen, Haas, Andy, Haas, Andrew, Haber, Carl, Hadavand, Haleh, Arce, Ayana Tamu, Hadef, Asma, Haleem, Mahsana, Haley, Joseph, Hall, Jack Joseph, Halladjian, Garabed, Hallewell, Gregory, Hamano, Kenji, Hamdaoui, Hassane, Hamer, Matthias, Hamity, Guillermo Nicolas, Arguin, Jean-francois, Han, Kunlin, Han, Liangliang, Han, Liang, Han, Shuo, Han, Yi Fei, Hanagaki, Kazunori, Hance, Mike, Hank, Michael Donald, Hankache, Robert, Hansen, Eva Brottmann, Argyropoulos, Spyros, Hansen, Jorgen Beck, Hansen, Dines, Hansen, Maike Christina, Hansen, Peter, Hanson, Emily Claire, Hara, Kazuhiko, Harenberg, Torsten, Harkusha, Siarhei, Harrison, Paul Fraser, Hartman, Nicole Michelle, Arling, Jan-hendrik, Hartmann, Nikolai, Hasegawa, Yoji, Hasib, Ahmed, Hasley, Lloyd Alan, Hassani, Samira, Haug, Sigve, Hauser, Reiner, Havranek, Miroslav, Hawkes, Chris, Hawkings, Richard, Armbruster, Aaron James, Hayashida, Shota, Hayden, Daniel, Hayes, Christopher Robyn, Hayes, Robin, Hays, Chris, Hays, Jonathan, Hayward, Helen, Haywood, Stephen, He, Fudong, He, Yunjian, Armstrong, Alexander, Heath, Matthew Peter, Hedberg, Vincent, Heggelund, Andreas Lokken, Hehir, Natasha, Heidegger, Constantin, Heidegger, Kim Katrin, Heidorn, William Dale, Heilman, Jesse Alan, Heim, Sarah, Heim, Timon, Arnaez, Olivier, Heinemann, Beate, Heinlein, James Geddy, Heinrich, Jochen Jens, Heinrich, Lukas Alexander, Hejbal, Jiri, Helary, Louis, Held, Alexander, Hellesund, Simen, Helling, Cole Michael, Hellman, Sten, Arnold, Hannah, Helsens, Clement, Henderson, Robert, Henkelmann, Lars, Henriques Correia, Ana Maria, Herde, Hannah Elizabeth, Hernandez Jimenez, Yesenia, Herr, Holger Arnold, Herrmann, Maximilian Georg, Herrmann, Tim, Herten, Gregor, Arrubarrena Tame, Zulit Paola, Hertenberger, Ralf, Hervas, Luis, Hessey, Nigel, Hibi, Hiroaki, Higashino, Satoshi, Higon-rodriguez, Emilio, Hildebrand, Kevin, Hill, John, Hill, Kurt Keys, Hiller, Karl Heinz, Abulaiti, Yiming, Artoni, Giacomo, Hu, Yi Fan, Hiller, Karlheinz, Hillier, Stephen, Hils, Maximilian, Hinchliffe, Ian, Hinterkeuser, Florian, Hirose, Minoru, Hirose, Shigeki, Hirschbuehl, Dominic, Hiti, Bojan, Asada, Haruka, Hladik, Ondrej, Hobbs, John David, Hobincu, Radu, Tal Hod, Noam, Hodgkinson, Mark, Hoecker, Andreas, Hohn, David, Hohov, Dmytro, Holm, Tanja, Holmes, Tova, Asai, Kanae, Holzbock, Michael, Hommels, Bart, Hong, Tae Min, Honig, Jan Cedric, Honle, Andreas, Hooberman, Benjamin Henry, Hopkins, Walter, Horii, Yasuyuki, Horn, Philipp, Horyn, Lesya Anna, Asai, Shoji, Hou, Suen, Howarth, James William, Hoya, Joaquin, Hrabovsky, Miroslav, Hrynevich, Aliaksei, Hrynova, Tetiana, Hsu, Pai-hsien, Hsu, Shih-chieh, Hu, Qipeng, Hu, Shuyang, Asawatavonvanich, Thanawat, Iakovidis, Georgios, Hu, Yifan, Huang, Danping, Huang, Xiaozhong, Huang, Yicong, Huang, Yanping, Hubacek, Zdenek, Hubaut, Fabrice, Hubner, Michael, Huegging, Fabian, Asbah, Nedaa Alexandra, Huffman, Todd Brian, Huhtinen, Mika, Hulsken, Raphael, Hunter, Robert Francis, Husejko, Michal, Huseynov, Nazim, Huston, Joey, Huth, John, Hyneman, Rachel Jordan, Hyrych, Sofiia, Asimakopoulou, Eleni Myrto, Iacobucci, Giuseppe, Iakovidis, George, Ibragimov, Iskander, Iconomidou-fayard, Lydia, Iengo, Paolo, Ignazzi, Rosanna, Iguchi, Ryunosuke, Iizawa, Tomoya, Ikegami, Yoichi, Ilic, Nikolina, Asquith, Lily, Imam, Hajar, Introzzi, Gianluca, Iodice, Mauro, Iordanidou, Kalliopi, Ippolito, Valerio, Isacson, Max Fredrik, Ishino, Masaya, Islam, Wasikul, Issever, Cigdem, Istin, Serhat, Assahsah, Jihad, Ito, Hiroki, Iturbe, Julia, Iuppa, Roberto, Ivina, Anna, Izen, Joseph Michael, Izzo, Vincenzo, Jacka, Petr, Jackson, Paul, Jacobs, Ruth Magdalena, Jaeger, Benjamin Paul, Assamagan, Ketevi Adikle, Jakel, Gunnar, Jakobi, Katharina Bianca, Jakobs, Karl, Jakoubek, Tomas, Jamieson, Jonathan, Janas, Krzysztof, 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Serbanp, Proudfoot, James, Przybycien, Mariusz, Pudzha, Dennis, Puri, Akshat, Puzo, Patrick Michel, Behr, Janna Katharina, Pyatiizbyantseva, Diana, Qian, Jianming, Qin, Quake, Quadt, Arnulf, Queitsch-maitland, Michaela, Rabanal Bolanos, Gabriel, Racko, Michal, Ragusa, Francesco, Rahal, Ghita, Raine, Johnny, Beisiegel, Florian, Rajagopalan, Srini, Ramirez Morales, Andres, Ran, Kunlin, Rassloff, Damir Fabrice, Rauch, Daniel, Rauscher, Felix, Rave, Stefan, Ravina, Baptiste, Ravinovich, Ilia, Raymond, Michel, Belfkir, Mohamed, Read, Alexander Lincoln, Readioff, Nathan Peter, Reale, Marilea, Rebuzzi, Daniela, Redlinger, George, Reeves, Kendall, Reikher, David, Reiss, Andreas Dominik, Rej, Amartya, Rembser, Christoph, Bella, Gideon, Renardi, Alessia, Renda, Michele, Rendel, Marian Benedikt, Rennie, Adam, Resconi, Silvia, Resseguie, Elodie Deborah, Rettie, Sebastien, Reynolds, Bryan, Reynolds, Elliot, Rezanova, Olga, Bellagamba, Lorenzo, Reznicek, Pavel, Ricci, Ester, Richter, Robert, 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R. D., Schaile, Dorothee, Schamberger Jr, Robert Dean, Schanet, Eric, Scharf, Christian, Scharmberg, Nicolas, Berge, David, Chtcheguelski, Valery, Scheirich, Daniel, Schenck, Ferdinand, Schernau, Michael, Schiavi, Carlo, Schildgen, Lara Katharina, Schillaci, Zachary Michael, Schioppa, Enrico Junior, Schioppa, Marco, Schleicher, Katharina, Bergeaas Kuutmann, Elin, Schlenker, Stefan, Schmidt-sommerfeld, Korbinian Ralf, Schmieden, Kristof, Schmitt, Christian, Schmitt, Stefan, Schoeffel, Laurent Olivier, Schoening, Andre, Scholer, Patrick, Schopf, Elisabeth, Schott, Matthias, Berger, Nicolas, Schouwenberg, Jeroen, Schovancova, Jaroslava, Schramm, Steven, Schroeder, Frederic, Schulte, Alexandra, Schultz-coulon, Hans-christian, Schumacher, Markus, Schumm, Bruce Andrew, Schune, Philippe, Schwartzman, Ariel Gustavo, Bergmann, Benedikt Ludwig, Schwarz, Thomas Andrew, Schwemling, Philippe, Schwienhorst, Reinhard, Sciandra, Andrea, Sciolla, Gabriella, Scuri, Fabrizio, Scutti, Federico, Scyboz, Ludovic Michel, Sebastiani, Cristiano, Sedlaczek, Kevin, Bergsten, Laura Jean, Seema, Pienpen, Seidel, Sally, Seiden, Abraham, Seidlitz, Blair Daniel, Seiss, Todd Michael, Seitz, Claudia, Seixas, Jose, Sekhniaidze, Givi, Sekula, Stephen Jacob, Semprini Cesari, Nicola, Beringer, Juerg, Sen, Sourav, Serfon, Cedric, Serin, Laurent, Serkin, Leonid, Sessa, Marco, Severini, Horst, Sevova, Stanislava, Sforza, Federico, Sfyrla, Anna, Shabalina, Elizaveta, Berlendis, Simon, Shahinian, Jeffrey David, Shaikh, Nabila Wahab, Shatalov, Pavel, Shojaii, Jafar, Sijacki, Djordje, Soukharev, Andrey, Shahinian, Jeff, Ahlgren, Nabila Wahab, Shaked Renous, Dan, Shan, Lianyou, Bernardi, Gregorio, Shang, Ruo-yu, Shapiro, Marjorie, Sharma, Abhishek, Shatalov, Sppavel, Shaw, Kate, Shaw, Savanna, Shehade, Mahran, Shen, Yu-ting, Sherwood, Peter, Bernius, Catrin, Shi, Liaoshan, Shimmin, Chase Owen, Shimogama, Yoshihiro, Shimojima, Makoto, Shinner, James David, Shipsey, Ian, Shirabe, Shohei, Shiyakova, Mariya, Shlomi, Jonathan, Shmeleva, Alevtina, Agapopoulou, Christina, Bernlochner, Florian Urs, Shochet, Mel, Shojaii, Seyed Ruhollah, Shope, David Richard, Shrestha, Suyog, Shrif, Esra Mohammed, Shroff, Maheyer Jamshed, Shulga, Evgeny, Sicho, Petr, Sickles, Anne Marie, Sideras Haddad, Elias, Berry, Tracey, Sidiropoulou, Ourania, Sidoti, Antonio, Siegert, Frank, Solodkov, Alexander, Sijacki, Dorde, Silva Oliveira, Marcos Vinicius, Silverstein, Samuel, Simion, Stefan, Simoniello, Rosa, Simpson-allsop, Cameron James, Berta, Peter, Simsek, Sinem, Sinervo, Pekka, Sinetckii, Viktor, Singh, Sundeep, Sinha, Sukanya, Sioli, Maximiliano, Siral, Ismet, Sivoklokov, Serguei, Sjoelin, Joergen, Skaf, Ali, Berthold, Anne-sophie, Skorda, Eleni, Skubic, Patrick, Slawinska, Magdalena, Sliwa, Krzysztof Jan, Smakhtin, Vladimir, Smart, Ben Harry, Smiesko, Juraj, Smirnov, Nikita, Smirnov, Serge, Smirnov, Yury, Bertram, Iain, Smirnova, Lidia, Smirnova, Oxana, Smith, Emily Ann, Smith, Hayden Alexander, Smizanska, Maria, Smolek, Karel, Smykiewicz, Andrzej, Snesarev, Andrei, Snoek, Hella, Snyder, Ian Michael, Bessidskaia Bylund, Olga, Snyder, Scott, Sobie, Randall, Soffer, Abner, Soloshenko, Alexei, Sopio, Alexander Linus, Sobie, Randy, Soffer, Abi, Sogaard, Andreas, Sohns, Fabian, Solans Sanchez, Carlos, Bethke, Siegfried, Soldatov, Evgeny, Soldevila Serrano, Urmila, Solodkov, Sanya, Soloshenko, Aleksey, Solovyanov, Oleg, Solovyev, Victor, Sommer, Philip, Son, Hyungsuk, Sonay, Anil, Song, Wen Yi, Betti, Alessandra, Sopczak, Andre, Sopio, Alex, Sopkova, Filomena, Sotiropoulou, Calliope-louisa, Sottocornola, Simone, Soualah, Rachik, Sukharev, Andrei, South, David, Stavropoulos, Georgios, Spagnolo, Stefania, Bevan, Adrian, Spalla, Margherita, Spangenberg, Martin, Spano, Francesco, Sperlich, Dennis, Spieker, Thomas Malte, Spigo, Giancarlo, Spina, Mario, Spiteri, Dwayne Patrick, Spousta, Martin, Strauss, Michael, Bhatta, Somadutta, Stabile, Alberto, Stamas, Brianna, Stamen, Rainer, Stamenkovic, Marko, Stampekis, Alexios, Stanecka, Ewa, Stanislaus, Beojan, Stanitzki, Marcel, Stankaityte, Migle, Stapf, Birgit Sylvia, Agaras, Merve Nazlim, Bhattacharya, Deb Sankar, Starchenko, Jenya, Stark, Giordon Holtsberg, Stark, Jan, Staroba, Pavel, Starovoitov, Pavel, Staerz, Steffen, Staszewski, Rafal, Stavropoulos, George, Steinberg, Peter Alan, Steinhebel, Amanda, Bhattarai, Prajita, Stelzer, Bernd, Stelzer, Joerg, Stelzer-chilton, Oliver, Stenzel, Hasko, Stevenson, Thomas James, Stewart, Graeme A, Stockton, Mark, Stoicea, Gabriel, Stolarski, Marcin, Stonjek, Stefan, Bhopatkar, Vallary Shashikant, Straessner, Arno, Strandberg, Jonas, Strandberg, Sara, Strauss, Mike, Strebler, Thomas, Strizenec, Pavol, Strohmer, Raimund, Strom, David, Stroynowski, Ryszard, Strubig, Antonia, Bi, Runyu, Stucci, Stefania Antonia, Stugu, Bjarne, Stupak, John, Styles, Nicholas, Su, Dong, Su, Wanyun, Su, Xiaowen, Suarez, Nicholas Bruno, Sulin, Vladimir, Sullivan, Matthew James, Bianchi, Riccardo Maria, Sultan, D. 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S., Sultanov, Salekh, Sumida, Toshi, Sun, Siyuan, Sun, Xiaohu, Suster, Carl Joseph Edmund, Sutton, Mark, Svatos, Michal, Swiatlowski, Maximilian J, Swift, Stewart Patrick, Biebel, Otmar, Swirski, Thorben, Sydorenko, Alexander, Sykora, Ivan, Sykora, Martin, Sykora, Tomas, Ta, Duc Bao, Tackmann, Kerstin, Kinghorn-taenzer, Joseph Peter, Taffard, Anyes, Tafirout, Reda, Biedermann, Dustin, Tagiev, Emin, Taibah, Reem Hani M, Takashima, Ryuichi, Takeda, Kosuke, Takeshita, Toru, Takeva, Emily Petrova, Takubo, Yosuke, Talby, Mossadek, Talyshev, Alexei, Tam, Kai Chung, Bielski, Rafal, Tamir, Nadav Michael, Tanaka, Junichi, Tanaka, Reisaburo, Tokar, Stanislav, Tsukerman, Ilya, Tsybychev, Dmitri, Tuts, Michael, Vacek, Vaclav, Tanaka, Rei, Tang, Fukun, Bierwagen, Katharina, Tapia Araya, Sebastian, Tapprogge, Stefan, Tarek, Ahmed, Tarem, Shlomit, Tariq, Khuram, Tarna, Grigore, Vandewall, Evan Richard, Vermeulen, Jos, Tartarelli, Francesco, Tas, Petr, Biesuz, Nicolo Vladi, Tasevsky, Marek, Tassi, 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Zorbas, Theodore, Zou, Rui, Zwalinski, Lukasz, ATLAS Collaboration, Abed Abud, Adam, Ahmadov, Faig, Bortoletto, Daniela, Boscherini, Davide, Fernandez-bosman, Martine, Bossio, Jonathan, Bouaouda, Khalil, Boudreau, Joseph, Bouhova-thacker, Eva, Boumediene, Djamel Eddine, Bouquet, Romain, Bourlis, Georgios, Ahmed, Waleed Syed, Boveia, Antonio, Boyd, Jamie, Boye, Diallo, Boyko, Igor, Bozson, Adam, Bracinik, Juraj, Brahimi, Nihal, Brandt, Gerhard Immanuel, Brandt, Oleg, Braren, Frued Erik, Ai, Xiaocong, Brau, Benjamin Paul, Brau, Jim, Breaden Madden, Will, Brendlinger, Kurt, Schimmel Brener, Roy, Brenner, Lydia, Brenner, Richard, Bressler, Shikma, Brickwedde, Bernard, Briglin, Daniel Lawrence, Aielli, Giulio, Britton, David, Britzger, Daniel Andreas, Brock, Ian, Brock, Raymond, Brooijmans, Gustaaf, Brooks, William King, Brost, Elizabeth, Bruckman De Renstrom, Pawel, Bruers, Ben, Bruncko, Dusan, Akatsuka, Shunichi, Bruni, Alessia, Bruni, Graziano, Bruschi, Marco, Bruscino, Nello, Bryant, Patrick Eugene, Bryngemark, Lene Kristian, Buanes, Trygve, Buat, Quentin, Buchholz, Peter, Buckley, Andy, Akbiyik, Melike, Budagov, Ioulian, Bugge, Magnar Kopangen, Bulekov, Oleg, Bullard, Brendon, Burch, Tyler James, Burdin, Sergey, Burgard, Carsten Daniel, Burger, Angela Maria, Burghgrave, Blake Oliver, Burr, Jon, Akesson, Torsten, Burton, Charles, Burzynski, Jackson Carl, Buescher, Volker, Buschmann, Eric, Bussey, Peter John, Butler, John Mark, Buttar, Craig, Butterworth, Jonathan, Buzykaev, Aleksey, Buttinger, Will, Akilli, Ece, Buxo Vazquez, Carlos Josue, Buzykaev, Alexey, Cabras, Grazia, Cabrera Urban, Susana, Caforio, Davide, Cai, Huacheng, Cairo, Valentina, Cakir, Orhan, Calace, Noemi, Calafiura, Paolo, Akimov, Andrei, Calderini, Giovanni, Calfayan, Philippe, Callea, Giuseppe, Caloba, Luiz, Caltabiano, Alessandro, Calvente Lopez, Sergio, Calvet, David, Calvet, Samuel, Calvet, Thomas Philippe, Calvetti, Milene, Al Khoury, Konie, Camacho Toro, Reina Coromoto, Camarda, Stefano, Camarero Munoz, Daniel, Camarri, Paolo, Camerlingo, Maria Teresa, Cameron, David, Camincher, Clement, Campana, Simone, Campanelli, Mario, Camplani, Alessandra, Abeling, Kira, Alberghi, Gian Luigi, Canale, Vincenzo, Canesse, Auriane, Bret Cano, Marc, Cantero Garcia, Josu, Cao, Yumeng, Capua, Marcella, Cardarelli, Roberto, Cardillo, Fabio, Carducci, Giovandomenico, Carli, Tancredi, Albert, Justin, Carlino, Giampaolo, Carlson, Ben, Carlson, Evan Michael, Carminati, Leonardo, Carney, Rebecca, Caron, Sascha, Carquin Lopez, Edson, Carra, Sonia, Carratta, Giuseppe, Carter, Joseph, Albicocco, Pietro, Carter, Thomas Michael, Casado Lechuga, Pilar, Casha, Albert Francis, Castiglia, Emma Grace, Castillo, Florencia Luciana, Castillo Garcia, Lucia, Castillo Gimenez, Victoria, Castro, Nuno, Catinaccio, Andrea, Catmore, James, Alconada, Josefina, Cattai, Ariella, Cavaliere, Viviana, Cavasinni, Vincenzo, Celebi, Emre, Celli, Federico, Cerny, Karel, Santiago Cerqueira, Augusto, Cerri, Alex, Cerrito, Lucio, Cerutti, Fabio, Alderweireldt, Sara, Cervelli, Alberto, Cetin, Serkant, Chadi, Zakaria, Chakraborty, Dhiman, Chan, Jay, Chan, Terry Ws, Chan, Wai Yuen, Chapman, John Derek, Chargeishvili, Bakar, Charlton, Dave, Aleksa, Martin, Charman, Thomas Paul, Chatterjee, Meghranjana, Chau, Chav Chhiv, Chekanov, Sergei, Chekulaev, Sergey, Shelkov, G., Chen, Boping, Chen, Cheng, Chen, Chunhui, Chen, Huirun, Alexandrov, Igor, Chen, Hucheng, Chen, Jing, Chen, Jue, Chen, Jiayi, Chen, Shion, Chen, Shenjian, Chen, Xin, Chen, Ye, Chen, Yu-heng, Cheng, Hok Chuen, Alexa, Calin, Cheng, Huajie, Cheplakov, Alexander, Cheremushkina, Evgeniya, Cherkaoui El Moursli, Rajaa, Cheu, Elliott, Cheung, Kingman, Chevalerias, Thibault, Chevalier, Laurent, Chiarella, Vitaliano, Chiarelli, Giorgio, Alexopoulos, Theodoros, Chiodini, Gabriele, Chisholm, Andrew Stephen, Chitan, Adrian, Chiu, I-huan, Chiu, Justin, Chizhov, Mihail, Choi, Kyungeon, Chomont, Arthur, Chou, Yuan-tang, Chow, Edwin, Alfonsi, Alice, Christopher, Lawrence Davou, Chu, Ming Chung, Chu, Xiaotong, Chudoba, Jiri, Chwastowski, Janusz, Cieri, Davide, Ciesla, Krzysztof, Cindro, Vladimir, Cioara, Irina Antonela, Ciocio, Alessandra, Abhayasinghe, Deshan Kavishka, Alfonsi, Fabrizio, Cirotto, Francesco, Citraro, Saverio, Citron, Zvi, Citterio, Mauro, Ciubotaru, Dan Andrei, Ciungu, Bianca Monica, Clark, Allan, Clark, Philip, Clawson, Savannah, Clement, Christophe, Alhroob, Muhammad, Clissa, Luca, Coadou, Yann, Cobal, Marina, Coccaro, Andrea, Cochran Jr, James Herbert, Coelho Lopes De Sa, Rafael, Cohen, Hadar, Coimbra, Artur, Cole, Brian, Colijn, Auke-pieter, Ali, Babar, Collot, Johann, Conde Muino, Patricia, Connell, Simon, Connelly, Ian Allan, Conventi, Francesco, Sarkar, Amanda, Cormier, Felix, Corpe, Louie Dartmoor, Corradi, Massimo, Corrigan, Eric Edward, Ali, Shahzad, Corriveau, Francois, Costa Mezquita, Maria Jose, Costanza, Francesco, Costanzo, Davide, Cowan, Glen, Cowley, James William, Crane, Jonathan, Cranmer, Kyle Stuart, Creager, Rachael Ann, Crepe-renaudin, Sabine, Aliev, Malik, Crescioli, Francesco, Cristinziani, Markus, Cristoforetti, Marco, Croft, Vincent Alexander, Crone, Gordon, Crosetti, Giovanni, Cunningham, William Reilly, Crosetti, Nanni, Cueto Gomez, Ana Rosario, Cuhadar Donszelmann, Tulay, Alimonti, Gianluca, Cui, Han, Cukierman, Aviv Ruben, Dandoy, Jeffrey Rogers, Darbo, Giovanni, Cunningham, Liam, Czekierda, Sabina Anna, Czodrowski, Patrick Karl, Czurylo, Marta, Sousa, Mario Jose, Da Fonseca Pinto, Joao Victor, Alison, John, Da Via, Cinzia, Dabrowski, Wladyslaw, Dachs, Florian, Dado, Tomas, Dahbi, Salah-eddine, Dai, Tiesheng, Dallapiccola, Carlo, Dam, Mogens, D'amen, Gabriele, D'amico, Valerio, Allaire, Corentin, Damp, Johannes Frederic, Dandoy, Jeff, Daneri, Maria Florencia, Danninger, Matthias, Dao, Valerio, Darbo, Nanni, Dartsi, Olympia, Dattagupta, Aparajita, D'auria, Saverio, David, Claire, Allbrooke, Benedict, Davidek, Tomas, Davis, Douglas Raymond, Dawson, Ian, De, Kaushik, De Asmundis, Riccardo, De Beurs, Marcus, De Castro, Stefano, De Groot, Nicolo, Vicente, Marcelo, De Jong, Paul, Allport, Philip Patrick, De La Torre Perez, Hector, De Maria, Antonio, De Pedis, Daniele, De Salvo, Alessandro, De Sanctis, Umberto, De Santis, Maurizio, De Santo, Antonella, De Vivie De Regie, Jean-baptiste, Dedovich, Dmitri, Deiana, Allison Mccarn, Abidi, Haider, Aloisio, Alberto, Del Peso, Jose, Delabat Diaz, Yasiel, Delgove, David, Deliot, Frederic, Delitzsch, Chris Malena, Della Pietra, Massimo, Della Volpe, Domenico, Dell'acqua, Andrea, Dell'asta, Lidia, Delmastro, Marco, Alonso, Francisco, Delporte, Charles Eliaz, Delsart, Pierre Antoine, Demers Konezny, Sarah Marie, Demichev, Mikhail, Demontigny, Gabriel, Denisov, Sergey, Denisov, Serguei, D'eramo, Louis, Derendarz, Dominik Karol, Derkaoui, Jamal, Alpigiani, Cristiano, Derue, Frederic, Dervan, Paul, Desch, Klaus, Dette, Karola, Deutsch, Christopher, Deviveiros, Pier-olivier, Di Bello, Francesco Armando, Di Ciaccio, Anna, Di Ciaccio, Lucia, Di Donato, Camilla, Alunno Camelia, Elio, Di Girolamo, Alessandro, Di Gregorio, Giulia, Di Luca, Andrea, Di Micco, Biagio, Di Nardo, Roberto, Di Sipio, Riccardo, Diaconu, Cristinel, De Almeida Dias, Flavia, Vale, Tiago, Diaz Gutierrez, Marco Aurelio, Alvarez Estevez, Manuel, Diaz Capriles, Federico Guillermo, Dickinson, Jennet Elizabeth, Didenko, Mariia, Diehl, Edward, Dietrich, Janet, Diez Cornell, Sergio, Diez Pardos, Carmen, Dimitrievska, Aleksandra, Ding, Wei, Dingfelder, Jochen Christian, Alviggi, Mariagrazia, Dittmeier, Sebastian, Dittus, Fido, Djama, Fares, Djobava, Tamar, Djuvsland, Julia Isabell, Barros do Vale, Maria Aline, Dobre, Monica, Dodsworth, David Michael, Doglioni, Caterina, Dolejsi, Jiri, Do Amaral Coutinho, Yara, Dolezal, Zdenek, Donadelli, Marisilvia, Dong, Binbin, Donini, Julien Noce, D'onofrio, Adelina, D'onofrio, Monica, Dopke, Jens, Doria, Alessandra, Dova, Maria Teresa, Doyle, Tony, Ambler, Alessandro, Drake, Gary, Drechsler, Eric, Dreyer, Etienne, Dreyer, Timo, Drobac, Alec Swenson, Du, Dongshuo, Du Pree, Tristan Arnoldus, Duan, Yanyun, Dubinin, Filipp, Dubovsky, Michal, Ambroz, Luca, Dubreuil, Arnaud, Duchovni, Ehud, Duckeck, Guenter, Ducu, Otilia Anamaria, Duda, Dominik, Dudarev, Alexey, Dudder, Andreas Christian, D'uffizi, Matteo, Duflot, Laurent, Duehrssen-debling, Michael, Amelung, Christoph, Dulsen, Carsten, Dumancic, Mirta, Dumitriu, Ana Elena, Dunford, Monica, Dungs, Sascha, Duperrin, Arnaud, Yildiz, Duran, Dueren, Michael Johannes, Durglishvili, Archil, Dutta, Baishali, Abouzeid, Hass, Amidei, Dante, Duvnjak, Damir, Dyckes, George, Ellis, Nicolas, Dyckes, Ian, Dyndal, Mateusz, Dysch, Samuel Dezso, Dziedzic, Bartosz Sebastian, Eggleston, Michael Glenn, Eifert, Till, Eigen, Gerald, Amor Dos Santos, Susana Patricia, Einsweiler, Kevin Frank, Ekelof, Tord Johan Carl, El Jarrari, Hassnae, Ellajosyula, Venugopal, Ellert, Mattias, Ellinghaus, Frank, Elliot, Alison, Ellis, Nick, Emerman, Alexander, Elmsheuser, Johannes, Amoroso, Simone, Elsing, Markus, Emeliyanov, Dmitry, Ezhilov, Alexey, Emerman, Alex, Enari, Yuji, Erdmann, Johannes, Ereditato, Antonio, Erland, Paula Agnieszka, Errenst, Martin, Escalier, Marc, Amrouche, Cherifa Sabrina, Escobar Ibanez, Carlos, Estrada Pastor, Oscar, Etzion, Erez, Gaspar De Andrade Evans, Guiomar, Evans, Hal, Evans, Meirin Oan, Ezhilov, Aleksei, Fabbri, Federica, Fabbri, Laura, Fabiani, Veronica, Anastopoulos, Christos, Facini, Gabriel, Fakhrutdinov, Rinat, Falciano, Speranza, Falke, Peter Johannes, Falke, Saskia, Faltova, Jana, Fang, Yi, Fang, Yaquan, Fanourakis, Georgios, Fanti, Marcello, Andari, Nansi, Faraj, Mohammed, Farbin, Amir, Farilla, Addolorata, Farilla, Ada, Farina, Edoardo Maria, Farooque, Trisha, Farrington, Sinead, Farthouat, Philippe, Fassi, Farida, Fassnacht, Patrick, Andeen, Timothy Robert, Fassouliotis, Dimitris, Faucci Giannelli, Michele, Fawcett, William James, Fayard, Louis, Fedin, Oleg, Fehr, Armin, Feickert, Matthew Carl, Feligioni, Lorenzo, Fell, Alix, Fell, Alexandra, Anders, John Kenneth, Feng, Cunfeng, Feng, Minyu, Fenton, Michael James, Fenyuk, Alexandre, Ferguson, Sarah Whitney, Ferrando, James Edward, Ferrari, Arnaud, Ferrari, Pamela, Ferrari, Roberto, Ferrer Soria, Antonio, Anderson, John Thomas, Ferrere, Didier, Ferretti, Claudio, Fiedler, Frank, Filipcic, Andrej, Filthaut, Frank, Finelli, Kevin Daniel, Castro Nunes Fiolhais, Miguel, Fiorini, Luca, Fischer, Florian, Fischer, Julian, Andrean, Stefio Yosse, Fisher, Wade Cameron, Fitschen, Tobias, Fleck, Ivor, Fleischmann, Philipp, Flick, Tobias, Flierl, Bernhard Matthias, Flores, Lucas Macrorie, Flores Castillo, Luis Roberto, Follega, Francesco Maria, Fomin, Nikolai, Abraham, Nicola Louise, Andreazza, Attilio, Foo, Joel Hengwei, Forcolin, Giulio Tiziano, Forland, Blake Christopher, Formica, Andrea, Forster, Fabian Alexander, Forti, Alessandra, Fortin, Etienne Marie, Foti, Maria Giovanna, Fournier, Daniel, Fox, Harald, Andrei, Victor, Francavilla, Paolo, Francescato, Simone, Franchini, Matteo, Franchino, Silvia, Francis, David, Franco, Luca, Franconi, Laura, Franklin, Melissa, Frattari, Guglielmo, Freeman, Patrick Moriishi, Anelli, Christopher Ryan, Freund, Benjamin, Spolidoro Freund, Werner, Freundlich, Elena Murielle, Frizzell, Dylan Cooper, Froidevaux, Daniel, Frost, James, Fujimoto, Minori, Fullana Torregrosa, Esteban, Fusayasu, Takahiro, Fuster Verdu, Juan, Angelidakis, Stylianos, Gabrielli, Alessandro, Gabrielli, Andrea, Gadow, Paul Philipp, Gagliardi, Guido, Gagnon, Louis-guillaume, Gallardo, Gabriel, Gallas, Elizabeth, Gallop, Bruce Joseph, Gamboa Goni, Rodrigo, Gan, KK, Angerami, Aaron, Garcia Pascual, Juan Antonio, Gan, Kock Kiam, Ganguly, Sanmay, Gao, Jun, Gao, Yanyan, Gao, Yongsheng, Garay Walls, Francisca, Garcia, Carmen, Garcia Navarro, Jose Enrique, Garcia, Juanan, Anisenkov, Alexey, Garcia-sciveres, Maurice, Gardner Jr, Robert William, Garelli, Nicoletta, Gargiulo, Simona, Garner, Christopher Andrew, Garonne, Vincent, Gasiorowski, Sean Joseph, Do Nascimento Gaspar, Philipp, Gatta, Maurizio, Gaudio, Gabriella, Annovi, Alberto, Gauzzi, Paolo, Gavrilenko, Igor, Gavrilyuk, Alexander, Gavriliuk, Aleksandr, Gay, Colin Warren, Gaycken, Goetz, Gazis, Evangelos, Geanta, Andrei Alexandru, Gee, Carolyn, Gee, Norman, Antel, Claire, Geisen, Jannik, Geisen, Marc, Gemme, Claudia, Genest, Marie-helene, Geng, Cong, Gentile, Simonetta, Gentsos, Christos, George, Simon, Geralis, Theodoros, Gerlach, Lino Oscar, Anthony, Matthew Thomas, Gessinger-befurt, Paul, Gessner, Gregor, Ghasemi Bostanabad, Meisam, Ghneimat, Mazuza, Ghosh, Aishik, Ghosh, Anindya, Giacobbe, Benedetto, Giagu, Stefano, Giangiacomi, Nico, Giannetti, Paola, Antipov, Egor, Giannini, Antonio, Giannini, Giulia, Gibson, Stephen, Gignac, Matthew, Gil, Damian Tomasz, Gilbert, Benjamin Jacob, Gillberg, Dag, Gilles, Geoffrey, Gillwald, Nils, Gingrich, Douglas, Abramowicz, Halina, Antonelli, Mario, Giordani, MarioPaolo, Gingrich, Doug, Giordani, Mapo, Giraud, Pierre-francois, Giugliarelli, Gilberto, Giugni, Danilo, Giuli, Francesco, Gkaitatzis, Stamatios, Gkialas, Ioannis, Gkougkousis, Evangelos, Antrim, Daniel Joseph, Gkougkousis, Vagelis, Gkountoumis, Panagiotis, Gladilin, Leonid, Glasman, Claudia, Glaysher, Paul, Gledhill, Galen Rhodes, Gnesi, Ivan, Goblirsch-kolb, Maximilian Emanuel, Godin, Dominique, Goldfarb, Steven, Anulli, Fabio, Golling, Tobias, Golubkov, Dmitry, Da Silva Gomes, Agostinho, Goncalves Gama, Rafael, Morais Silva Goncalo, Ricardo Jose, Gonella, Giulia, Gonella, Laura, Gongadze, Alexi, Gonnella, Francesco, Gonski, Julia Lynne, Aoki, Masato, Gonzalez De La Hoz, Santiago, Gonzalez Fernandez, Sergio, Gonzalez Lopez, Ricardo, Gonzalez Renteria, Cesar, Gonzalez Suarez, Rebeca, Gonzalez Sevilla, Sergio, Gonzalvo Rodriguez, Galo Rafael, Goossens, Luc, Gorasia, Nandish Arjan, Gorbounov, Petr, Aparisi Pozo, Javier Alberto, Gordon, Howard, Gorini, Benedetto, Gorini, Edoardo, Gorisek, Andrej, Goshaw, Alfred, Grillo, Alexander, Goshaw, Al, Gostkin, Mikhail, Gottardo, Carlo Alberto, Gouighri, Mohamed, Aparo, Marco, Goussiou, Anna, Govender, Nicolin, Goy, Corinne, Grabowska-bold, Iwona, Gramstad, Eirik, Grancagnolo, Sergio, Grandi, Mario, Grachev, Vadim, Gravila, Paul, Gravili, Francesco Giuseppe, Aperio Bella, Ludovica, Gray, Chloe, Gray, Heather, Green, Barry, Grefe, Christian, Gregor, Ingrid, Grenier, Philippe, Grevtsov, Kirill, Grieco, Chiara, Grieser, Nathan Allen, Grillo, Alex, Aranzabal Barrio, Nordin, Grimm, Kathryn, Grinstein, Sebastian, Grivaz, Jean-francois, Groh, Sabrina, Gross, Eilam, Grosse-knetter, Joern, Grout, Zara Jane, Grud, Christopher Ryan, Grummer, Aidan, Grundy, James Cameron, Araujo Ferraz, Victor, Guan, Liang, Guan, Wen, Gubbels, Chris, Guenther, Jaroslav, Gubbels, Christopher, Guerrero Rojas, Jesus, Guescini, Francesco, Guest, Dan, Guest, Daniel, Gugel, Ralf, Pereira, Rodrigo, Guida, Alessandro, Guillemin, Thibault, Guindon, Stefan, Guo, Jun, Guo, Ziyu, Gupta, Ruchi, Gurbuz, Saime, Gustavino, Giuliano, Guth, Manuel, Gutierrez, Phillip, Aad, G, Bachas, K, Chiodini, G, Gorini, E, Gravili, F, Longo, L, Primavera, M, Reale, M, Schioppa, E, Spagnolo, S, Ventura, A, ATLAS Collaboration, And, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), De Castro , S., Fabbri , L., Gabrielli , A., Rinaldi , L., Semprini Cesari , N., Sioli , M., Villa , M., Zoccoli , A., Bellagamba , L., Boscherini , D., Bruni , A., Bruni , G., Giacobbe , B., Polini , A., Sbarra , C., Sidoti , A., Franchini , M., Romano , M., Valentinetti , S., Alberghi , G. L., Lasagni Manghi , F, Massa , L., Vittori , C., Alfonsi , F, Cabras , G., Cervelli , A., Negrini , M., Todome , K., Carratta , G., Cavalli , N., Clissa , L., ATLAS collaboration, Aad, G., Abbott, B., Abbott, D. C., Abud, A. A., Abeling, K., Abhayasinghe, D. K., Abidi, S. H., Abouzeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B. S., Achkar, B., Adam, L., Bourdarios, C. A., Adamczyk, L., Adamek, L., Adelman, J., Adiguzel, A., Adorni, S., Adye, T., Affolder, A. A., Afik, Y., Agapopoulou, C., Agaras, M. N., Aggarwal, A., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmad, A., Ahmadov, F., Ahmed, W. S., Ai, X., Aielli, G., Akatsuka, S., Akbiyik, M., Akesson, T. P. A., Akilli, E., Akimov, A. V., Al Khoury, K., Alberghi, G. L., Albert, J., Albicocco, P., Verzini, M. J. A., Alderweireldt, S., Aleksa, M., Aleksandrov, I. 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[0000-0003-1988-8401], Yoshihara, K. [0000-0002-3656-2326], Young, C.J.S. [0000-0001-5858-6639], Young, C. [0000-0003-3268-3486], Yuan, R. [0000-0002-8452-0315], Yue, X. [0000-0001-6956-3205], Zaazoua, M. [0000-0002-4105-2988], Zabinski, B. [0000-0001-5626-0993], Zacharis, G. [0000-0002-3156-4453], Zaffaroni, E. [0000-0003-1714-9218], Zahreddine, J. [0000-0002-6932-2804], Zaitsev, A.M. [0000-0002-4961-8368], Zakareishvili, T. [0000-0001-7909-4772], Zakharchuk, N. [0000-0002-4963-8836], Zambito, S. [0000-0002-4499-2545], Zanzi, D. [0000-0002-1222-7937], Zeißner, S.V. [0000-0002-9037-2152], Zeitnitz, C. [0000-0003-2280-8636], Zemaityte, G. [0000-0001-6331-3272], Zeng, J.C. [0000-0002-2029-2659], Zenin, O. [0000-0002-5447-1989], Ženiš, T. [0000-0001-8265-6916], Zenz, S. [0000-0002-9720-1794], Zerradi, S. [0000-0001-9101-3226], Zerwas, D. [0000-0002-4198-3029], Zgubič, M. [0000-0002-5110-5959], Zhang, B. [0000-0002-9726-6707], Zhang, D.F. [0000-0001-7335-4983], Zhang, G. [0000-0002-5706-7180], Zhang, J. [0000-0002-9907-838X], Zhang, K. [0000-0002-9778-9209], Zhang, L. [0000-0002-9336-9338], Zhang, L. [0000-0001-5241-6559], Zhang, M. [0000-0001-8659-5727], Zhang, R. [0000-0002-8265-474X], Zhang, X. [0000-0003-4731-0754], Zhang, X. [0000-0003-4341-1603], Zhang, Y. [0000-0002-4554-2554], Zhang, Z. [0000-0002-7853-9079], Zhao, P. [0000-0003-0054-8749], Zhao, Y. [0000-0003-0494-6728], Zhao, Z. [0000-0001-6758-3974], Zhemchugov, A. [0000-0002-3360-4965], Zheng, Z. [0000-0002-8323-7753], Zhong, D. [0000-0001-9377-650X], Zhou, C. [0000-0001-5904-7258], Zhou, H. [0000-0002-7986-9045], Zhou, M. [0000-0001-7223-8403], Zhou, N. [0000-0002-1775-2511], Zhu, C.G. [0000-0001-8015-3901], Zhu, C. [0000-0002-5918-9050], Zhu, H.L. [0000-0001-8479-1345], Zhu, H. [0000-0001-8066-7048], Zhu, J. [0000-0002-5278-2855], Zhu, Y. [0000-0002-7306-1053], Zhuang, X. [0000-0003-0996-3279], Zhukov, K. [0000-0003-2468-9634], Zhulanov, V. [0000-0002-0306-9199], Zieminska, D. [0000-0002-6311-7420], Zimine, N.I. [0000-0003-0277-4870], Zimmermann, S. [0000-0002-1529-8925], Živković, L. [0000-0003-4236-8930], Zoccoli, A. [0000-0002-0993-6185], Zoch, K. [0000-0003-2138-6187], Zorbas, T.G. [0000-0003-2073-4901], Zou, R. [0000-0002-0542-1264], Zwalinski, L. [0000-0002-9397-2313], Apollo - University of Cambridge Repository, Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2890, Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Massarotti, Paolo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, and Atlas, Collaboration
Subjects: Kjerne- og elementærpartikkelfysikk: 431 [VDP], Physics - Instrumentation and Detectors, Computer science, data acquisition, Tracking (particle physics), 01 natural sciences, Online farms and online filtering, High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), Data acquisition, Software, cluster finding, Subatomic Physics, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], hardware, Calibration and fitting methods, Cluster finding, Modular electronics, Pattern recognition, Trigger concepts and systems (hardware and software), Detectors and Experimental Techniques, Instrumentation, Mathematical Physics, FPGA, Settore FIS/01, Large Hadron Collider, Pattern recognition, cluster finding, calibration and fitting methods, track data analysis, Detector, integrated circuit, microstrip [semiconductor detector], Modular electronic, Instrumentation and Detectors (physics.ins-det), calibration and fitting methods, ATLAS, medicine.anatomical_structure, Nuclear and elementary particle physics: 431 [VDP], Pattern recognition (psychology), design [electronics], semiconductor detector: microstrip, LHC, Computer hardware, performance, Particle Physics - Experiment, 530 Physics, FOS: Physical sciences, LHC, ATLAS, High Energy Physics, Accelerator Physics and Instrumentation, programming, Calibration and fitting method, semiconductor detector: pixel, Atlas (anatomy), 0103 physical sciences, medicine, High Energy Physics, ddc:610, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Field-programmable gate array, numerical calculations, pixel [semiconductor detector], 010308 nuclear & particles physics, business.industry, paper, bibliography, Acceleratorfysik och instrumentering, trigger, LHC, Particle Tracking, High-level Trigger, Particle Tracking, efficiency, High-level Trigger, data management, business, Hadron-hadron collisions, electronics: design
Abstract: We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerba¼an; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRT, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; JINR; MES of Russia and NRC KI, Russian Federation; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZŠ, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada, CRC and IVADO, Canada; Be¼ing Municipal Science & Technology Commission, China; COST, ERC, ERDF, Horizon 2020 and Marie Skłodowska-Curie Actions, European Union; Investissements d’Avenir Labex, Investissements d’Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO TEO and GenT Programmes Generalitat Valenciana, Spain; Göran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF(Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (U.K.) and BNL (U.S.A.), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of computing resources are listed in ref. [52]., The ATLAS Fast TracKer (FTK) was designed to provide full tracking for the ATLAS high-level trigger by using pattern recognition based on Associative Memory (AM) chips and fitting in high-speed field programmable gate arrays. The tracks found by the FTK are based on inputs from all modules of the pixel and silicon microstrip trackers. The as-built FTK system and components are described, as is the online software used to control them while running in the ATLAS data acquisition system. Also described is the simulation of the FTK hardware and the optimization of the AM pattern banks. An optimization for long-lived particles with large impact parameter values is included. A test of the FTK system with the data playback facility that allowed the FTK to be commissioned during the shutdown between Run 2 and Run 3 of the LHC is reported. The resulting tracks from part of the FTK system covering a limited η-ϕ region of the detector are compared with the output from the FTK simulation. It is shown that FTK performance is in good agreement with the simulation., ANPCyT, Argentina, YerPhI, Armenia, ARC, Australia, BMWFW and FWF, Austria, ANAS, Azerbaijan, SSTC, Belarus, CNPq and FAPESP, Brazil, NSERC, NRC and CFI, Canada, CERN, ANID, Chile, CAS, MOST and NSFC, China, COLCIENCIAS, Colombia, MSMT CR, MPO CR and VSC CR, Czech Republic, DNRF and DNSRC, Denmark, IN2P3-CNRS and CEA-DRF/IRFU, France, SRNSFG, Georgia, BMBF, HGF and MPG, Germany, GSRT, Greece, RGC and Hong Kong SAR, China, ISF and Benoziyo Center, Israel, INFN, Italy, MEXT and JSPS, Japan, CNRST, Morocco, NWO, Netherlands, RCN, Norway, MNiSW and NCN, Poland, FCT, Portugal, MNE/IFA, Romania, JINR, MES of Russia and NRC KI, Russian Federation, MESTD, Serbia, MSSR, Slovakia, ARRS and MIZŠ, Slovenia, DST/NRF, South Africa, MICINN, Spain, SRC and Wallenberg Foundation, Sweden, SERI, SNSF and Cantons of Bern and Geneva, Switzerland, MOST, Taiwan, TAEK, Turkey, STFC, United Kingdom, DOE and NSF, United States of America, BCKDF, CANARIE, Compute Canada, CRC and IVADO, Canada, Bejiing Municipal Science & Technology Commission, China, COST, ERC, ERDF, Horizon 2020 and Marie Skłodowska-Curie Actions, European Union, Investissements d’Avenir Labex, Investissements d’Avenir Idex and ANR, France, DFG and AvH Foundation, Germany, Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece, BSF-NSF and GIF, Israel, La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain, Göran Gustafssons Stiftelse, Sweden, The Royal Society and Leverhulme Trust, United Kingdom
Published: 2021

33. Performance of the ATLAS RPC detector and Level-1 muon barrel trigger at √s = 13 TeV

Author: Aad, Georges, Abbott, Braden Keim, Abbott, Brad, Abbott, Dale, Abed Abud, Adam, Abeling, Kira, Abhayasinghe, Deshan Kavishka, Abidi, Haider, Abouzeid, Hass, Abouzeid, Ossama, Abraham, Nicola Louise, Abramowicz, Halina, Abreu, Henso, Abulaiti, Yiming, Acharya, Bobby Samir, Achkar, Baida, Adam, Lennart, Adam Bourdarios, Claire, Adamczyk, Leszek, Adamek, Lukas, Adelman, Jahred, Adiguzel, Aytul, Adorni Braccesi Chiassi, Sofia, Adye, Tim, Affolder, A.A., Affolder, Tony, Afik, Yoav, Agapopoulou, Christina, Agaras, Merve Nazlim, Aggarwal, Anamika, Agheorghiesei, Catalin, Aguilar Saavedra, Juan Antonio, Ahmad, Ammara, Ahmadov, Faig, Ahmed, Waleed Syed, Ai, Xiaocong, Aielli, Giulio, Akatsuka, Shunichi, Akbiyik, Melike, Akesson, Torsten, Akilli, Ece, Akimov, Andrei, Al Khoury, Konie, Alberghi, Gian Luigi, Albert, Justin, Alconada, Josefina, Alderweireldt, Sara, Aleksa, Martin, Alexandrov, Igor, Alexa, Calin, Alexopoulos, Theodoros, Alfonsi, Alice, Alfonsi, Fabrizio, Alhroob, Muhammad, Ali, Babar, Ali, Shahzad, Aliev, Malik, Alimonti, Gianluca, Allaire, Corentin, Allbrooke, Benedict, Allport, Philip Patrick, Aloisio, Alberto, Alonso, Francisco, Alpigiani, Cristiano, Alunno Camelia, Elio, Alvarez Estevez, Manuel, Alviggi, Mariagrazia, Do Amaral Coutinho, Yara, Ambler, Alessandro, Ambroz, Luca, Amelung, Christoph, Amidei, Dante, Amor dos Santos, Susana Patricia, Amoroso, Simone, Amrouche, Cherifa Sabrina, Anastopoulos, Christos, Andari, Nansi, Andeen, Timothy Robert, Anders, John Kenneth, Andrean, Stefio Yosse, Andreazza, Attilio, Andrei, Victor, Anelli, Christopher Ryan, Angelidakis, Stylianos, Angerami, Aaron, Anisenkov, Alexey, Annovi, Alberto, Antel, Claire, Anthony, Matthew Thomas, Antipov, Egor, Antonelli, Mario, Antrim, Daniel Joseph, Anulli, Fabio, Aoki, Masato, Aparisi Pozo, Javier Alberto, Aparo, Marco, Aperio Bella, Ludovica, Aranzabal Barrio, Nordin, Araujo Ferraz, Victor, Pereira, Rodrigo, Arcangeletti, Chiara, Arce, Ayana Tamu, Arguin, Jean-Francois, Argyropoulos, Spyros, Argyropoulos, Spyridon, Arling, Jan-Hendrik, Armbruster, Aaron James, Armstrong, Alexander, Arnaez, Olivier, Arnold, Hannah, Arrubarrena Tame, Zulit Paola, Artoni, Giacomo, Asada, Haruka, Asai, Kanae, Asai, Shoji, Asawatavonvanich, Thanawat, Asbah, Nedaa Alexandra, Asimakopoulou, Eleni Myrto, Asquith, Lily, Assahsah, Jihad, Assamagan, Ketevi Adikle, Astalos, Robert, Atkin, Ryan Justin, Atkinson, Markus Julian, Atlay, Naim Bora, Atmani, Hicham, Atmasiddha, Prachi, Augsten, Kamil, Austrup, Volker Andreas, Avolio, Giuseppe, Ayoub, Mohamad Kassem, Azuelos, Georges, Babal, Dominik, Bachacou, Henri, Bachas, Dinos, Bachas, Konstantinos, Backman, Karl Filip, Bagnaia, Paolo, Bahmani, Marzieh, Bahrasemani, Sina, Bahrasemani, H., Bailey, Adam, Bailey, Virginia, Baines, John, Bakalis, Christos, Baker, Keith, Bakker, Pepijn Johannes, Bakos, Evelin, Bakshi Gupta, Debottam, Balaji, Shyam, Balasubramanian, Rahul, Baldin, Evgenii, Balek, Petr, Balli, Fabrice, Balunas, William Keaton, Balz, Johannes, Banas, Elzbieta, Bandieramonte, Marilena, Bandyopadhyay, Anjishnu, Barak, Liron, Barbe, William Mickael, Barberio, Elisabetta, Barberis, Dario, Barbero, Marlon Benoit, Barbour, Gregory, Barillari, Teresa, Barisits, Martin, Barkeloo, Jason Tyler Colt, Barklow, Tim, Barklow, Timothy, Barnett, Bruce M, Barnett, Michael, Barnovska-Blenessy, Z., Baroncelli, Toni, Baroncelli, Antonio, Barone, Gaetano, Barr, Alan, Barranco Navarro, Laura, Barreiro Alonso, Fernando, Barreiro Guimaraes da Costa, Joao, Barron, Uriel, Barsov, Sergey, Bartels, Falk, Bartoldus, Rainer, Bartolini, Giovanni, Barton, Adam Edward, Bartos, Pavol, Basalaev, Artem, Basan, Alexander, Bassalat, Ahmed, Basso, Matthew Joseph, Basson, Candice Ruth, Bates, Richard, Batlamous, Souad, Batley, Richard, Batool, Binish, Battaglia, Marco, Bauce, Matteo, Bauer, Florian, Bauer, Patrick, Bawa, Harinder Singh, Bayirli, Arif, Beacham, James, Beau, Tristan, Beauchemin, Pierre-Hugues, Becherer, Fabian, Bechtle, Philip, Beck, Hans Peter, Becker, Kathrin, Becot, Cyril Pascal, Beddall, Andrew, Bednyakov, Vadim, Bee, Chris, Bee, Christopher, Beermann, Thomas, Begalli, Marcia, Begel, Michael, Behera, Arabinda, Behr, Janna Katharina, Beisiegel, Florian, Belfkir, Mohamed, Bella, Gideon, Bellagamba, Lorenzo, Bellerive, Alain, Bellos, Panagiotis, Beloborodov, Konstantin, Belotskiy, Konstantin, Belyaev, Nikita, Benchekroun, Driss, Benekos, Nectarios, Benhammou, Yan, Benjamin, Doug, Benjamin, Douglas, Benoit, Mathieu, Bensinger, Jim, Bensinger, James, Bentvelsen, Stan, Beresford, Lydia Audrey, Beretta, Matteo Mario, Berge, David, Bergeaas Kuutmann, Elin, Berger, Nicolas, Bergmann, Benedikt Ludwig, Bergsten, Laura Jean, Beringer, Juerg, Berlendis, Simon, Bernardi, Gregorio, Bernius, Catrin, Bernlochner, Florian Urs, Berry, Tracey, Berta, Peter, Berthold, Anne-Sophie, Bertram, Iain, Bessidskaia Bylund, Olga, Bethke, Siegfried, Betti, Alessandra, Bevan, Adrian, Bhatta, Somadutta, Bhattacharya, Deb Sankar, Bhattarai, Prajita, Bhopatkar, Vallary Shashikant, Bi, Runyu, Bianchi, Riccardo Maria, Biebel, Otmar, Biedermann, Dustin, Bielski, Rafal, Bierwagen, Katharina, Biesuz, Nicolo Vladi, Biglietti, Michela, Billoud, Thomas, Bindi, Marcello, Bingul, Ahmet, Bini, Cesare, Biondi, Silvia, Birch-Sykes, Callum Jacob, Birman, Mattias, Bisanz, Tobias, Biswal, Jyoti Prakash, Biswas, Diptaparna, Bitadze, Alexander, Bittrich, Carsten, Bjoerke, Kristian, Blazek, Tomas, Bloch, Ingo, Blocker, Craig, Blue, Andrew James, Blumenschein, Ulla, Blumenschein, Ulrike, Bobbink, Gerjan, Bobrovnikov, Viktor, Bogavac, Danijela, Bogdanchikov, Alexander, Bohm, Christian, Boisvert, Veronique, Bokan, Petar, Bold, Tomasz, Bomben, Marco, Bona, Marcella, Bonilla, Johan Sebastian, Boonekamp, Maarten, Booth, Callum Dale, Borbely, Albert Gyorgy, Borecka-Bielska, Hanna Maria, Borgna, Lucas Santiago, Borisov, Anatoli, Borissov, Guennadi, Bortoletto, Daniela, Boscherini, Davide, Fernandez-Bosman, Martine, Bossio, Jonathan, Bouaouda, Khalil, Boudreau, Joseph, Bouhova-Thacker, Eva, Bouhova-Thacker, Evelina Vassileva, Boumediene, Djamel Eddine, Bouquet, Romain, Boveia, Antonio, Boyd, Jamie, Boyd, James, Boye, Diallo, Boyko, Igor, Bozson, Adam, Bracinik, Juraj, Brahimi, Nihal, Brandt, Gerhard Immanuel, Brandt, Oleg, Braren, Frued Erik, Brau, Benjamin Paul, Brau, Jim, Breaden Madden, Will, Brau, James, Breaden Madden, William Dmitri, Brendlinger, Kurt, Schimmel Brener, Roy, Brenner, Lydia, Brenner, Richard, Bressler, Shikma, Brickwedde, Bernard, Briglin, Daniel Lawrence, Britton, David, Britton, Dave, Britzger, Daniel Andreas, Brock, Ian, Brock, Raymond, Brooijmans, Gustaaf, Brooks, William King, Brost, Elizabeth, Bruckman de Renstrom, Pawel, Bruers, Ben, Bruncko, Dusan, Bruni, Alessia, Bruni, Graziano, Bruschi, Marco, Bruscino, Nello, Bryngemark, Lene Kristian, Buanes, Trygve, Buat, Quentin, Buchholz, Peter, Buckley, Andy, Buckley, Andrew, Budagov, Ioulian, Bugge, Magnar Kopangen, Bulekov, Oleg, Bullard, Brendon, Burch, Tyler James, Burdin, Sergey, Burgard, Carsten Daniel, Burger, Angela Maria, Burghgrave, Blake Oliver, Burr, Jon, Burr, Jonathan Thomas, Burton, Charles, Burzynski, Jackson Carl, Buescher, Volker, Buschmann, Eric, Bussey, Peter John, Butler, John Mark, Buttar, Craig, Butterworth, Jonathan, Buzykaev, Aleksey, Buttinger, Will, Buttinger, William, Buxo Vazquez, Carlos Josue, Buzykaev, Alexey, Cabras, Grazia, Cabrera Urban, Susana, Caforio, Davide, Cai, Huacheng, Cairo, Valentina, Cakir, Orhan, Calace, Noemi, Calafiura, Paolo, Calderini, Giovanni, Calfayan, Philippe, Callea, Giuseppe, Caloba, Luiz, Caltabiano, Alessandro, Calvente Lopez, Sergio, Calvet, David, Calvet, Samuel, Calvet, Thomas Philippe, Calvetti, Milene, Camacho Toro, Reina Coromoto, Camarda, Stefano, Camarero Munoz, Daniel, Camarri, Paolo, Camerlingo, Maria Teresa, Cameron, David, Camincher, Clement, Campanelli, Mario, Camplani, Alessandra, Canale, Vincenzo, Canesse, Auriane, Bret Cano, Marc, Cantero Garcia, Josu, Cao, Yumeng, Capua, Marcella, Cardarelli, Roberto, Cardillo, Fabio, Carducci, Giovandomenico, Carli, Tancredi, Carlino, Giampaolo, Carlson, Ben, Carlson, Benjamin Taylor, Carlson, Evan Michael, Carminati, Leonardo, Carney, Rebecca, Caron, Sascha, Carquin Lopez, Edson, Carra, Sonia, Carratta, Giuseppe, Carter, Joseph, Carter, Thomas Michael, Casado Lechuga, Pilar, Casado, Maria Pilar, Casha, Albert Francis, Castiglia, Emma Grace, Castillo, Florencia Luciana, Castillo Garcia, Lucia, Castillo Gimenez, Victoria, Castro, Nuno, Catinaccio, Andrea, Catmore, James, Cattai, Ariella, Cavaliere, Viviana, Cavasinni, Vincenzo, Celebi, Emre, Celli, Federico, Cerny, Karel, Santiago Cerqueira, Augusto, Cerri, Alex, Cerri, Alessandro, Cerrito, Lucio, Cerutti, Fabio, Cervelli, Alberto, Cetin, Serkant, Chadi, Zakaria, Chakraborty, Dhiman, Chan, Jay, Chan, Terry Ws, Chan, Wing Sheung, Chan, Wai Yuen, Chapman, John Derek, Chargeishvili, Bakar, Charlton, Dave, Charman, Thomas Paul, Chatterjee, Meghranjana, Chau, Chav Chhiv, Chekanov, Sergei, Chekulaev, Sergey, Shelkov, G, Chen, Boping, Chen, Cheng, Chen, Chunhui, Chen, Huirun, Chen, Hucheng, Chen, Jing, Chen, Jue, Chen, Jiayi, Chen, Shion, Chen, Shenjian, Chen, Xin, Chen, Ye, Chen, Yu-Heng, Cheng, Hok Chuen, Cheng, Huajie, Cheplakov, Alexander, Cheremushkina, Evgeniya, Cherkaoui El Moursli, Rajaa, Cheu, Elliott, Cheung, Kingman, Chevalerias, Thibault, Chevalier, Laurent, Chiarella, Vitaliano, Chiarelli, Giorgio, Chiodini, Gabriele, Chisholm, Andrew Stephen, Chitan, Adrian, Chiu, I-Huan, Chiu, Justin, Chizhov, Mihail, Choi, Kyungeon, Chomont, Arthur, Chou, Yuan-Tang, Chow, Edwin, Chow, Yun Sang, Christopher, Lawrence Davou, Chu, Ming Chung, Chu, Xiaotong, Chudoba, Jiri, Chwastowski, Janusz, Cieri, Davide, Ciesla, Krzysztof, Cindro, Vladimir, Cioara, Irina Antonela, Ciocio, Alessandra, Cirotto, Francesco, Citron, Zvi, Citterio, Mauro, Ciubotaru, Dan Andrei, Ciungu, Bianca Monica, Clark, Allan, Clark, Philip, Clawson, Savannah, Clement, Christophe, Clissa, Luca, Coadou, Yann, Cobal, Marina, Coccaro, Andrea, Cochran, James Herbert, Coelho Lopes de Sa, Rafael, Cohen, Hadar, Coimbra, Artur, Cole, Brian, Collot, Johann, Conde Muino, Patricia, Connell, Simon, Connelly, Ian Allan, Conventi, Francesco, Sarkar, Amanda, Cormier, Felix, Corpe, Louie Dartmoor, Corradi, Massimo, Corrigan, Eric Edward, Corriveau, Francois, Costa Mezquita, Maria Jose, Costanza, Francesco, Costanzo, Davide, Cowan, Glen, Cowley, James William, Crane, Jonathan, Cranmer, Kyle Stuart, Creager, Rachael Ann, Crepe-Renaudin, Sabine, Crescioli, Francesco, Cristinziani, Markus, Cristoforetti, Marco, Croft, Vincent Alexander, Crosetti, Giovanni, Cunningham, William Reilly, Crosetti, Nanni, Cueto Gomez, Ana Rosario, Cuhadar Donszelmann, Tulay, Cui, Han, Cukierman, Aviv Ruben, Dandoy, Jeffrey Rogers, Darbo, Giovanni, Cunningham, Liam, Czekierda, Sabina Anna, Czodrowski, Patrick Karl, Czurylo, Marta, Sousa, Mario Jose, da Fonseca Pinto, Joao Victor, da Via, Cinzia, Dabrowski, Wladyslaw, Dachs, Florian, Dado, Tomas, Dahbi, Salah-Eddine, Dai, Tiesheng, Dallapiccola, Carlo, Dam, Mogens, d'Amen, Gabriele, d'Amico, Valerio, Damp, Johannes Frederic, Dandoy, Jeff, Daneri, Maria Florencia, Danninger, Matthias, Dao, Valerio, Darbo, Nanni, Dartsi, Olympia, Dattagupta, Aparajita, d'Auria, Saverio, David, Claire, Davidek, Tomas, Davis, Douglas Raymond, Dawson, Ian, De, Kaushik, de Asmundis, Riccardo, de Beurs, Marcus, de Castro, Stefano, de Groot, Nicolo, de Jong, Paul, de la Torre Perez, Hector, de Maria, Antonio, de Pedis, Daniele, de Salvo, Alessandro, de Sanctis, Umberto, de Santis, Maurizio, de Santo, Antonella, de Vivie de Regie, Jean-Baptiste, Dedovich, Dmitri, Deiana, Allison Mccarn, del Peso, Jose, Delabat Diaz, Yasiel, Delgove, David, Deliot, Frederic, Delitzsch, Chris Malena, Della Pietra, Massimo, Della Volpe, Domenico, Dell'Acqua, Andrea, Dell'Asta, Lidia, Delmastro, Marco, Delporte, Charles Eliaz, Delsart, Pierre Antoine, Demers Konezny, Sarah Marie, Demichev, Mikhail, Demontigny, Gabriel, Denisov, Sergey, Denisov, Serguei, d'Eramo, Louis, Derendarz, Dominik Karol, Derkaoui, Jamal, Derue, Frederic, Dervan, Paul, Desch, Klaus, Dette, Karola, Deutsch, Christopher, Deviveiros, Pier-Olivier, Di Bello, Francesco Armando, Di Ciaccio, Anna, Di Ciaccio, Lucia, Di Donato, Camilla, Di Girolamo, Alessandro, Di Gregorio, Giulia, Di Luca, Andrea, Di Micco, Biagio, Di Nardo, Roberto, Di Sipio, Riccardo, Diaconu, Cristinel, de Almeida Dias, Flavia, Vale, Tiago, Diaz Gutierrez, Marco Aurelio, Diaz Capriles, Federico Guillermo, Dickinson, Jennet Elizabeth, Didenko, Mariia, Diehl, Edward, Dietrich, Janet, Diez Cornell, Sergio, Diez Pardos, Carmen, Dimitrievska, Aleksandra, Ding, Wei, Dingfelder, Jochen Christian, Dittmeier, Sebastian, Dittus, Fido, Djama, Fares, Djobava, Tamar, Djuvsland, Julia Isabell, Barros Do Vale, Maria Aline, Dobre, Monica, Dodsworth, David Michael, Doglioni, Caterina, Dolejsi, Jiri, Dolezal, Zdenek, 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Caterina, Marjanovic, Marija, Marshall, Zach, Martensson, Mikael, Marti I Garcia, Salvador, Martin, T.A., Martin, Victoria, Martin Dit Latour, Bertrand, Martinelli, Luca, Martinez-Perez, Mario, Martinez Agullo, Pablo, Martinez Outschoorn, Verena Ingrid, Martin-Haugh, Stewart, Martoiu, Sorin, Martyniuk, Alex Christopher, Marzin, Antoine, Maschek, Stefan Raimund, Masetti, Lucia, Mashimo, Tetsuro, Mashinistov, Ruslan, Masik, Jiri, Maslennikov, Alexei, Massa, Lorenzo, Massarotti, Paolo, Mastrandrea, Paolo, Mastroberardino, Anna, Masubuchi, Tatsuya, Matakias, Dimitrios, Mathisen, Thomas, Matic, Andrea, Matsuzawa, Nobuo, Maurer, Julien, Macek, Bostjan, Maximov, Dmitriy, Mazini, Rachid, Maznas, Ioannis, Mazza, Simone Michele, Mc Ginn, Christopher, Mc Gowan, John Patrick, Mc Kee, Shawn, Mccarthy, Thomas, Mccormack, William Patrick, Mckay, Madalyn Ann, Mcmahon, Steve, Mcpherson, Robert, Mikenberg, Giora, Mcdonald, Millie, Mcdougall, Ashley Ellen, Mcfayden, Josh, Mchedlidze, Gvantsa, Mc Kay, 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Varnes, Erich Ward, Varni, Carlo, Mete, Tulin, Varouchas, Dimitris, Varvell, Kevin, Vasile, Matei, Vasquez, Gerardo, Vazeille, Francois, Vazquez Furelos, David, Vazquez Schroeder, Tamara, Veatch, Jason Robert, Vecchio, Valentina, Veen, Michiel Jan, Veloce, Laurelle Maria, Veloso, Filipe, Veneziano, Stefano, Ventura, Andrea, Verbytskyi, Andrii, Verducci, Monica, Vergis, Christos, Verkerke, Wouter, Vermeulen, Ambrosius Thomas, Vermeulen, Joseph, Vernieri, Caterina, Verschuuren, Pim Jordi, Vetterli, Michel Joseph, Viaux Maira, Nicolas, Vickey, Trevor, Vickey Boeriu, Oana, Viehhauser, G.H.A., Vigani, Luigi, Villa, Mauro, Villaplana, Miguel, Villhauer, Elena Michelle, Vilucchi, Elisabetta, Vincter, Manuella, Virdee, Govindraj Singh, Vishwakarma, Akanksha, Vittori, Camilla, Vivarelli, Iacopo, Vogel, Marcelo, Vokac, Petr, von Ahnen, Janik, von Buddenbrock, Stefan, von Torne, Eckhard, Vorobel, Vit, Vorobev, Konstantin, Vos, Marcel, Vossebeld, Joost, Vozak, Matous, Vranjes, Nenad, Vranjes Milosavljevic, Marija, Vrba, Vaclav, Vreeswijk, Marcel, Vu, Ngoc Khanh, Vuillermet, Raphael, Vukotic, Ilija, Wada, Sayaka, Wagner, Cooper, Wagner, Peter, Wagner, Wolfgang, Wahdan, Shayma, Wahlberg, Hernan Pablo, Wakasa, Rena, Walbrecht, Verena Maria, Walder, James William, Walker, Rodney, Walker, Stuart Derek, Walkowiak, Wolfgang, Wallangen, Veronica, Wang, Ann Miao, Wang, Alex Zeng, Wang, Chen, Wang, Chenliang, Wang, Haichen, Wang, Jiawei, Wang, Peilong, Wang, Renjie, Wang, Rongkun, Wang, Rui, Wang, Song-Ming, Wang, Shuanggeng, Wang, Tao, Wang, Weitao, Wang, Wenxiao, Wang, Yufeng, Wang, Zirui, Wanotayaroj, Chaowaroj, Warburton, Andreas, Ward, Patricia, Ward, Robert James, Warrack, Neil, Watson, Alan, Watson, Miriam, Watts, Gordon, Waugh, Benedict Martin, Webb, Aaron, Weber, Christian, Weber, Michele, Weber, Stephen, Weber, Sebastian Mario, Wei, Yingjie, Weidberg, Anthony, Weingarten, Jens, Weirich, Marcel, Weiser, Christian, Wells, Pippa, Wenaus, Torre, Wendland, Bjoern, Wengler, Thorsten, Wenig, Siegfried, Wermes, Norbert, Wessels, Martin, Weston, Thomas, Whalen, Kathleen, Wiik, Liv Antje Mari, Whalen, Kate, Wharton, Andrew Mark, White, Aaron Stephen, White, Andrew, White, Martin John, Whiteson, Daniel, Whitmore, Ben, Wiedenmann, Werner, Wiel, Christian, Wielers, Monika, Wieseotte, Natalie, Wiglesworth, Craig, Wiik-Fuchs, Liv, Wilkens, Henric, Wilkins, Lewis, Williams, Daniel, Williams, Hugh, Williams, Sarah Louise, Willocq, Stephane, Windischhofer, Philipp, Wingerter, Isabelle, Winkels, Emma, Winklmeier, Frank, Winter, Benedict Tobias, Wittgen, Matthias, Wobisch, Markus, Wolf, Anton, Woelker, Ricardo, Wollrath, Julian, Wolter, Marcin, Wolters, Helmut, Wong, Vincent Wai Sum, Wongel, Alicia, Woods, Natasha Lee, Worm, Steven, Wosiek, Barbara Krystyna, Wozniak, Krzysztof Wieslaw, Wraight, Kenneth Gibb, Wu, Sau Lan, Wu, Xin, Wu, Yusheng, Wurzinger, Jonas, Wyatt, Terry, Wynne, Benjamin Michael, Xella, Stefania, Xiang, Jianhuan, Xiao, Xiong, Xie, Xiangyu, Xiotidis, Ioannis, Xu, Da, Xu, Hanlin, Xu, Hao, Xu, Lailin, Xu, Riley, Xu, Tairan, Xu, Wenhao, Xu, Yue, Xu, Zhongyukun, Xu, Zijun, Yabsley, Bruce Donald, Yacoob, Sahal, Yallup, David, Yamaguchi, Naoki, Yamaguchi, Yohei, Yamatani, Masahiro, Yamauchi, Hiroki, Yamazaki, Tomohiro, Yamazaki, Yuji, Yan, Jun, Yan, Zhen, Yang, Haijun, Yang, Hongtao, Yang, Siqi, Yang, Tianyi, Yang, Xiao, Yang, Xuan, Yang, Yi-Lin, Yang, Zhe, Yao, Weiming, Young, Charles, Zaitsev, Alexander, Zeng, Jian Cong, Zhu, Cheng Guang, Yao, Wei-Ming, Yap, Yee Chinn, Ye, Hanfei, Ye, Jingbo, Ye, Shuwei, Yeletskikh, Ivan, Yexley, Melissa, Yin, Pengqi, Yorita, Kohei, Yoshihara, Keisuke, Young, Christopher, Young, Charlie, Yuan, Rui, Yue, Xiaoguang, Zaazoua, Mohamed, Zabinski, Bartlomiej Henryk, Zacharis, Georgios, Zacharis, George, Zaffaroni, Ettore, Zahreddine, Jad, Zaytsev, Alexandre, Zakareishvili, Tamar, Zakharchuk, Nataliia, Zambito, Stefano, Zanzi, Daniele, Zeissner, Sonja Verena, Zeitnitz, Christian, Zemaityte, Gabija, Zeng, Jiancong, Zenin, Oleg, Zenis, Tibor, Zenz, Seth, Zerradi, Soufiane, Zerwas, Dirk, Zgubic, Miha, Zhang, Bowen, Zhang, Dengfeng, Zhang, Gang, Zhang, Jinlong, Zhang, Kaili, Zhang, Lei, Zhang, Liqing, Zhang, Matt, Zhang, Rui, Zhang, Shuzhou, Zhang, Xiangke, Zhang, Xueyao, Zhang, Yu, Zhang, Zhiqing Philippe, Zhao, Pingchuan, Zhao, Yuzhan, Zhao, Zhengguo, Zhemchugov, Alexey, Zheng, Zhi, Zhong, Dewen, Zhou, Bing, Zhou, Chen, Zhou, Hao, Zhou, Mingliang, Zhou, Ning, Zhou, You, Zhu, Chengguang, Zhu, Chenzheng, Zhu, Heling, Zhu, Hongbo, Zhu, Junjie, Zhu, Yingchun, Zhuang, Xuai, Zhukov, Konstantin, Zhulanov, Vladimir, Zieminska, Daria, Zimine, Nikolai, Zimmermann, Stephanie Ulrike, Zinonos, Zinonas, Ziolkowski, Michal, Zivkovic, Lidija, Zoccoli, Antonio, Zoch, Knut, Zorbas, Theodore, Zou, Rui, Zwalinski, Lukasz, Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Massarotti, Paolo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, Atlas, Collaboration, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2842, Aad, G. [0000-0002-6665-4934], Abbott, B. [0000-0002-5888-2734], Abbott, D.C. [0000-0002-7248-3203], Abed Abud, A. [0000-0002-2788-3822], Abeling, K. [0000-0002-1002-1652], Abhayasinghe, D.K. [0000-0002-2987-4006], Abidi, S.H. [0000-0002-8496-9294], AbouZeid, O.S. [0000-0002-8279-9324], Abramowicz, H. [0000-0001-5329-6640], Abreu, H. [0000-0002-1599-2896], Abulaiti, Y. [0000-0003-0403-3697], Acharya, B.S. [0000-0002-8588-9157], Achkar, B. [0000-0002-0288-2567], Adam, L. [0000-0001-6005-2812], Adam Bourdarios, C. [0000-0002-2634-4958], Adamczyk, L. [0000-0002-5859-2075], Adamek, L. [0000-0003-1562-3502], Adelman, J. [0000-0002-1041-3496], Adiguzel, A. [0000-0001-6644-0517], Adorni, S. [0000-0003-3620-1149], Adye, T. [0000-0003-0627-5059], Affolder, A.A. [0000-0002-9058-7217], Afik, Y. [0000-0001-8102-356X], Agapopoulou, C. [0000-0002-2368-0147], Agaras, M.N. [0000-0002-4355-5589], Aggarwal, A. [0000-0002-1922-2039], Agheorghiesei, C. [0000-0003-3695-1847], Aguilar-Saavedra, J.A. 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Subjects: LHC, Particle Physics, muon detectors, Physics - Instrumentation and Detectors, Kjerne- og elementærpartikkelfysikk: 431 [VDP], Physics::Instrumentation and Detectors, trigger [muon], 01 natural sciences, Particle identification, High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), Gaseous detectors, Subatomic Physics, scattering [p p], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Detectors and Experimental Techniques, time resolution, Instrumentation, Mathematical Physics, decay [Z0], Physics, Settore FIS/01, Luminosity (scattering theory), Large Hadron Collider, Resistive-plate chambers, Z0: decay, Muon spectrometers, ATLAS experiment, Detector, resistive plate chamber, High voltage, Instrumentation and Detectors (physics.ins-det), ATLAS, Trigger detectors, muon: pair production, Nuclear and elementary particle physics: 431 [VDP], medicine.anatomical_structure, Particle Physics - Experiment, performance, p p: scattering, 530 Physics, FOS: Physical sciences, LHC, ATLAS, High Energy Physics, Accelerator Physics and Instrumentation, Resistive-plate chamber, Nuclear physics, Atlas (anatomy), Muon spectrometer, 0103 physical sciences, medicine, High Energy Physics, ddc:610, pair production [muon], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Gaseous detector, 010306 general physics, activity report, Muon, 010308 nuclear & particles physics, paper, Acceleratorfysik och instrumentering, muon: trigger, current, efficiency [trigger], trigger: efficiency, High Energy Physics::Experiment
Abstract: We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRT, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; JINR; MES of Russia and NRC KI, Russian Federation; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada, CRC and IVADO, Canada; Be 1/4 ing Municipal Science & Technology Commission, China; COST, ERC, ERDF, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF(Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (U.K.) and BNL (U.S.A.), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of computing resources are listed in ref. [48]., The ATLAS experiment at the Large Hadron Collider (LHC) employs a trigger system consisting of a first-level hardware trigger (L1) and a software-based high-level trigger. The L1 muon trigger system selects muon candidates, assigns them to the correct LHC bunch crossing and classifies them into one of six transverse-momentum threshold classes. The L1 muon trigger system uses resistive-plate chambers (RPCs) to generate the muon-induced trigger signals in the central (barrel) region of the ATLAS detector. The ATLAS RPCs are arranged in six concentric layers and operate in a toroidal magnetic field with a bending power of 1.5 to 5.5 Tm. The RPC detector consists of about 3700 gas volumes with a total surface area of more than 4000 m(2). This paper reports on the performance of the RPC detector and L1 muon barrel trigger using 60.8 fb(-1) of proton-proton collision data recorded by the ATLAS experiment in 2018 at a centre-of-mass energy of 13 TeV. Detector and trigger performance are studied using Z boson decays into a muon pair. Measurements of the RPC detector response, efficiency, and time resolution are reported. Measurements of the L1 muon barrel trigger efficiencies and rates are presented, along with measurements of the properties of the selected sample of muon candidates. Measurements of the RPC currents, counting rates and mean avalanche charge are performed using zero-bias collisions. Finally, RPC detector response and efficiency are studied at different high voltage and front-end discriminator threshold settings in order to extrapolate detector response to the higher luminosity expected for the High Luminosity LHC., ANPCyT, YerPhI, Armenia, Australian Research Council, BMWFW, Austrian Science Fund (FWF), Azerbaijan National Academy of Sciences (ANAS), SSTC, Belarus, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Natural Sciences and Engineering Research Council of Canada (NSERC) NRC, Canada Canada Foundation for Innovation, CERN, ANID, Chile, Chinese Academy of Sciences Ministry of Science and Technology, China National Natural Science Foundation of China (NSFC), Departamento Administrativo de Ciencia, Tecnologia e Innovacion Colciencias, MSMT CR, Czech Republi Czech Republic Government, DNRF, Denmark Danish Natural Science Research Council, Centre National de la Recherche Scientifique (CNRS) CEA-DRF/IRFU, France, SRNSFG, Georgia, Federal Ministry of Education & Research (BMBF), HGF, Germany, Max Planck Society, Greek Ministry of Development-GSRT, RGC, China Hong Kong SAR, China, Israel Science Foundation Benoziyo Center, Israel, Istituto Nazionale di Fisica Nucleare (INFN), Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science, CNRST, Morocco, Netherlands Organization for Scientific Research (NWO) Netherlands Government, RCN, Norway, Ministry of Science and Higher Education, Poland NCN, Poland, Portuguese Foundation for Science and Technology European Commission, MNE/IFA, Romania, JINR, MES of Russia NRC KI, Russian Federation, Ministry of Education, Science & Technological Development, Serbia, MSSR, Slovakia, Slovenian Research Agency - Slovenia MIZS, Slovenia, DST/NRF, South Africa, Spanish Government, SRC, Sweden Wallenberg Foundation, Sweden, SERI, Switzerland Swiss National Science Foundation (SNSF) Cantons of Bern and Geneva, Switzerland, Ministry of Science and Technology, Taiwan, Ministry of Energy & Natural Resources - Turkey, UK Research & Innovation (UKRI), Science & Technology Facilities Council (STFC), United States Department of Energy (DOE), National Science Foundation (NSF), United States of America, European Commission, Greek NSRF, Greece, BSF-NSF, German-Israeli Foundation for Scientific Research and Development, La Caixa Foundation CERCA Programme Generalitat de Catalunya PROMETEO and GenT Programmes Generalitat Valenciana, Spain, Goran Gustafssons Stiftelse, Sweden, Royal Society of London, Leverhulme Trust
Published: 2021
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34. Measurements of sensor radiation damage in the ATLAS inner detector using leakage currents

Author: Aad, G., Abbott, B., Abbott, D. C., Abed Abud, A., Abeling, K., Abhayasinghe, D. K., Abidi, S. H., Abouzeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B. S., Achkar, B., Adam, L., Adam Bourdarios, C., Adamczyk, L., Adamek, L., Adelman, J., Adersberger, M., Adiguzel, A., Adorni, S., Adye, T., Affolder, A. A., Afik, Y., Agapopoulou, C., Agaras, M. N., Aggarwal, A., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmad, A., Ahmadov, F., Ahmed, W. S., Ai, X., Aielli, G., Akatsuka, S., Akbiyik, M., Åkesson, T. P. A., Akilli, E., Akimov, A. V., Al Khoury, K., Alberghi, G. L., Albert, J., Alconada Verzini, M. J., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexopoulos, T., Alfonsi, A., Alfonsi, F., Alhroob, M., Ali, B., Ali, S., Aliev, M., Alimonti, G., Allaire, C., Allbrooke, B. M. M., Allen, B. W., Allport, P. P., Aloisio, A., Alonso, F., Alpigiani, C., Alunno Camelia, E., Alvarez Estevez, M., Alviggi, M. G., Amaral Coutinho, Y., Ambler, A., Ambroz, L., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amoroso, S., Amrouche, C. S., An, F., Anastopoulos, C., Andari, N., Andeen, T., Anders, J. K., Andrean, S. Y., Andreazza, A., Andrei, V., Anelli, C. R., Angelidakis, S., Angerami, A., Anisenkov, A. V., Annovi, A., Antel, C., Anthony, M. T., Antipov, E., Antonelli, M., Antrim, D. J. A., Anulli, F., Aoki, M., Aparisi Pozo, J. A., Aparo, M. A., Aperio Bella, L., Aranzabal, N., Araujo Ferraz, V., Pereira, R. A., Arcangeletti, C., Arce, A. T. H., Arduh, F. A., Arguin, J. -F., Argyropoulos, S., Arling, J. -H., Armbruster, A. J., Armstrong, A., Arnaez, O., Arnold, H., Arrubarrena Tame, Z. P., Artoni, G., Asada, H., Asai, K., Asai, S., Asawatavonvanich, T., Asbah, N. A., Asimakopoulou, E. M., Asquith, L., Assahsah, J., Assamagan, K., Astalos, R., Atkin, R. J., Atkinson, M., Atlay, N. B., Atmani, H., Augsten, K., Austrup, V. A., Avolio, G., Ayoub, M. 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G., Zou, R., Zou, W., Zwalinski, L., Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Massarotti, Paolo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, Atlas, Collaboration, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2842, Aad, G, Bachas, K, Chiodini, G, Gorini, E, Gravili, F, Longo, L, Primavera, M, Reale, M, Schioppa, E, Spagnolo, S, Ventura, A, ATLAS Collaboration, And, Aad, G. [0000-0002-6665-4934], Abbott, B. [0000-0002-5888-2734], Abbott, D.C. [0000-0002-7248-3203], Abed Abud, A. [0000-0002-2788-3822], Abeling, K. [0000-0002-1002-1652], Abhayasinghe, D.K. [0000-0002-2987-4006], Abidi, S.H. [0000-0002-8496-9294], AbouZeid, O.S. [0000-0002-8279-9324], Abramowicz, H. [0000-0001-5329-6640], Abreu, H. [0000-0002-1599-2896], Abulaiti, Y. [0000-0003-0403-3697], Abusleme Hoffman, A.C. [0000-0003-0762-7204], Acharya, B.S. [0000-0002-8588-9157], Achkar, B. [0000-0002-0288-2567], Adam, L. [0000-0001-6005-2812], Adam Bourdarios, C. [0000-0002-2634-4958], Adamczyk, L. [0000-0002-5859-2075], Adamek, L. [0000-0003-1562-3502], Adelman, J. [0000-0002-1041-3496], Adiguzel, A. [0000-0001-6644-0517], Adorni, S. [0000-0003-3620-1149], Adye, T. [0000-0003-0627-5059], Affolder, A.A. [0000-0002-9058-7217], Afik, Y. [0000-0001-8102-356X], Agapopoulou, C. [0000-0002-2368-0147], Agaras, M.N. [0000-0002-4355-5589], Aggarwal, A. [0000-0002-1922-2039], Agheorghiesei, C. 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[0000-0003-3453-6156], Vannicola, D. [0000-0001-6814-4674], Vari, R. [0000-0002-2814-1337], Varnes, E.W. [0000-0001-7820-9144], Varni, C. [0000-0001-6733-4310], Varol, T. [0000-0002-0697-5808], Varouchas, D. [0000-0002-0734-4442], Varvell, K.E. [0000-0003-1017-1295], Vasile, M.E. [0000-0001-8415-0759], Vasquez, G.A. [0000-0002-3285-7004], Vazeille, F. [0000-0003-1631-2714], Vazquez Furelos, D. [0000-0002-5551-3546], Vazquez Schroeder, T. [0000-0002-9780-099X], Veatch, J. [0000-0003-0855-0958], Vecchio, V. [0000-0002-1351-6757], Veen, M.J. [0000-0001-5284-2451], Veloce, L.M. [0000-0003-1827-2955], Veloso, F. [0000-0002-5956-4244], Veneziano, S. [0000-0002-2598-2659], Ventura, A. [0000-0002-3368-3413], Verbytskyi, A. [0000-0002-3713-8033], Verducci, M. [0000-0001-8209-4757], Vergis, C. [0000-0002-3228-6715], Verissimo De Araujo, M. [0000-0001-8060-2228], Verkerke, W. [0000-0001-5468-2025], Vermeulen, A.T. [0000-0002-8884-7112], Vermeulen, J.C. [0000-0003-4378-5736], Vernieri, C. [0000-0002-0235-1053], Verschuuren, P.J. [0000-0002-4233-7563], Vesterbacka, M.L. [0000-0002-6966-5081], Vetterli, M.C. [0000-0002-7223-2965], Viaux Maira, N. [0000-0002-5102-9140], Vickey, T. [0000-0002-1596-2611], Vickey Boeriu, O.E. [0000-0002-6497-6809], Viehhauser, G.H.A. [0000-0002-0237-292X], Vigani, L. [0000-0002-6270-9176], Villa, M. [0000-0002-9181-8048], Villaplana Perez, M. [0000-0002-0048-4602], Vilucchi, E. [0000-0002-4839-6281], Vincter, M.G. [0000-0002-5338-8972], Virdee, G.S. [0000-0002-6779-5595], Vishwakarma, A. [0000-0001-8832-0313], Vittori, C. [0000-0001-9156-970X], Vivarelli, I. [0000-0003-0097-123X], Vogel, M. [0000-0003-0672-6868], Vokac, P. [0000-0002-3429-4778], Von Ahnen, J. [0000-0003-4032-0079], von Buddenbrock, S.E. [0000-0002-8399-9993], Von Toerne, E. [0000-0001-8899-4027], Vorobel, V. [0000-0001-8757-2180], Vorobev, K. [0000-0002-7110-8516], Vos, M. [0000-0001-8474-5357], Vossebeld, J.H. [0000-0001-8178-8503], Vozak, M. [0000-0002-7561-204X], Vranjes, N. [0000-0001-5415-5225], Vranjes Milosavljevic, M. [0000-0003-4477-9733], Vreeswijk, M. [0000-0001-8083-0001], Vu, N.K. [0000-0002-6251-1178], Vuillermet, R. [0000-0003-3208-9209], Vukotic, I. [0000-0003-0472-3516], Wada, S. [0000-0002-8600-9799], Wagner, P. [0000-0001-7481-2480], Wagner, W. [0000-0002-9198-5911], Wahdan, S. [0000-0002-6324-8551], Wahlberg, H. [0000-0003-0616-7330], Wakasa, R. [0000-0002-8438-7753], Walbrecht, V.M. [0000-0002-7385-6139], Walder, J. [0000-0002-9039-8758], Walker, R. [0000-0001-8535-4809], Walkowiak, W. [0000-0002-0385-3784], Wang, A.M. [0000-0001-8972-3026], Wang, A.Z. [0000-0003-2482-711X], Wang, C. [0000-0001-9116-055X], Wang, C. [0000-0002-8487-8480], Wang, H. [0000-0003-3952-8139], Wang, J. [0000-0002-5246-5497], Wang, P. [0000-0002-6730-1524], Wang, R. [0000-0001-9839-608X], Wang, R. [0000-0001-8530-6487], Wang, S.M. [0000-0002-5821-4875], Wang, T. [0000-0002-1152-2221], Wang, W.T. [0000-0002-7184-9891], Wang, W.X. [0000-0002-1444-6260], Wang, X. [0000-0002-2411-7399], Wang, Y. [0000-0003-2693-3442], Wang, Z. [0000-0002-0928-2070], Wanotayaroj, C. [0000-0002-8178-5705], Warburton, A. [0000-0002-2298-7315], Ward, C.P. [0000-0002-5162-533X], Ward, R.J. [0000-0001-5530-9919], Warrack, N. [0000-0002-8268-8325], Watson, A.T. [0000-0001-7052-7973], Watson, M.F. [0000-0002-9724-2684], Watts, G. [0000-0002-0753-7308], Waugh, B.M. [0000-0003-0872-8920], Webb, A.F. [0000-0002-6700-7608], Weber, C. [0000-0002-8659-5767], Weber, M.S. [0000-0002-2770-9031], Weber, S.A. [0000-0003-1710-4298], Weber, S.M. [0000-0002-2841-1616], Wei, Y. [0000-0001-9725-2316], Weidberg, A.R. [0000-0002-5158-307X], Weingarten, J. [0000-0003-2165-871X], Weirich, M. [0000-0002-5129-872X], Weiser, C. [0000-0002-6456-6834], Wells, P.S. [0000-0003-4999-896X], Wenaus, T. [0000-0002-8678-893X], Wendland, B. [0000-0003-1623-3899], Wengler, T. [0000-0002-4375-5265], Wenig, S. [0000-0002-4770-377X], Wermes, N. [0000-0001-9971-0077], Wessels, M. [0000-0002-8192-8999], Whalen, K. [0000-0002-9383-8763], Wharton, A.M. [0000-0002-9507-1869], White, A.S. [0000-0003-0714-1466], White, A. [0000-0001-8315-9778], White, M.J. [0000-0001-5474-4580], Whiteson, D. [0000-0002-2005-3113], Wiedenmann, W. [0000-0003-3605-3633], Wiel, C. [0000-0003-1995-9185], Wielers, M. [0000-0001-9232-4827], Wiglesworth, C. [0000-0001-6219-8946], Wiik-Fuchs, L.A.M. [0000-0002-5035-8102], Wilkens, H.G. [0000-0002-8483-9502], Wilkins, L.J. [0000-0002-7092-3500], Williams, D.M. [0000-0002-5646-1856], Williams, S. [0000-0001-6174-401X], Willocq, S. [0000-0002-4120-1453], Windischhofer, P.J. [0000-0001-5038-1399], Wingerter-Seez, I. [0000-0001-9473-7836], Winklmeier, F. [0000-0001-8290-3200], Winter, B.T. [0000-0001-9606-7688], Wobisch, M. [0000-0002-0688-3380], Wolf, A. [0000-0002-4368-9202], Wölker, R. [0000-0002-7402-369X], Wolter, M.W. [0000-0001-9184-2921], Wolters, H. [0000-0002-9588-1773], Wong, V.W.S. [0000-0001-5975-8164], Wongel, A.F. [0000-0002-6620-6277], Woods, N.L. [0000-0002-8993-3063], Worm, S.D. [0000-0002-3865-4996], Wosiek, B.K. [0000-0003-4273-6334], Woźniak, K.W. [0000-0003-1171-0887], Wraight, K. [0000-0002-3298-4900], Wu, J. [0000-0002-3173-0802], Wu, S.L. [0000-0001-5866-1504], Wu, X. [0000-0001-7655-389X], Wu, Y. [0000-0002-1528-4865], Wu, Z. [0000-0002-5392-902X], Wuerzinger, J. [0000-0002-4055-218X], Wyatt, T.R. [0000-0001-9690-2997], Wynne, B.M. [0000-0001-9895-4475], Xella, S. [0000-0002-0988-1655], Xiao, X. [0000-0002-1344-8723], Xie, X. [0000-0001-6473-7886], Xu, D. [0000-0001-6355-2767], Xu, H. [0000-0001-6110-2172], Xu, L. [0000-0001-8997-3199], Xu, R. [0000-0002-1928-1717], Xu, T. [0000-0002-0215-6151], Xu, W. [0000-0001-5661-1917], Xu, Y. [0000-0001-9563-4804], Xu, Z. [0000-0001-9571-3131], Xu, Z. [0000-0001-9602-4901], Yabsley, B. [0000-0002-2680-0474], Yacoob, S. [0000-0001-6977-3456], Yallup, D.P. [0000-0003-4716-5817], Yamaguchi, N. [0000-0002-6885-282X], Yamaguchi, Y. [0000-0002-3725-4800], Yamauchi, H. [0000-0003-2123-5311], Yamazaki, T. [0000-0003-0411-3590], Yamazaki, Y. [0000-0003-3710-6995], Yan, Z. [0000-0002-2483-4937], Yang, H.J. [0000-0001-7367-1380], Yang, H.T. [0000-0003-3554-7113], Yang, S. [0000-0002-0204-984X], Yang, T. [0000-0002-4996-1924], Yang, X. [0000-0002-1452-9824], Yang, X. [0000-0002-9201-0972], Yang, Y. [0000-0001-8524-1855], Yang, Z. [0000-0002-7374-2334], Yap, Y.C. [0000-0001-8939-666X], Ye, H. [0000-0002-4886-9851], Ye, J. [0000-0001-9274-707X], Ye, S. [0000-0002-7864-4282], Yeletskikh, I. [0000-0003-0586-7052], Yexley, M.R. [0000-0002-1827-9201], Yin, P. [0000-0003-2174-807X], Yorita, K. [0000-0003-1988-8401], Yoshihara, K. [0000-0002-3656-2326], Young, C.J.S. [0000-0001-5858-6639], Young, C. [0000-0003-3268-3486], Yuan, R. [0000-0002-8452-0315], Yue, X. [0000-0001-6956-3205], Zaazoua, M. [0000-0002-4105-2988], Zabinski, B. [0000-0001-5626-0993], Zacharis, G. [0000-0002-3156-4453], Zaffaroni, E. [0000-0003-1714-9218], Zahreddine, J. [0000-0002-6932-2804], Zaitsev, A.M. [0000-0002-4961-8368], Zakareishvili, T. [0000-0001-7909-4772], Zakharchuk, N. [0000-0002-4963-8836], Zambito, S. [0000-0002-4499-2545], Zanzi, D. [0000-0002-1222-7937], Zeißner, S.V. [0000-0002-9037-2152], Zeitnitz, C. [0000-0003-2280-8636], Zemaityte, G. [0000-0001-6331-3272], Zeng, J.C. [0000-0002-2029-2659], Zenin, O. [0000-0002-5447-1989], ženiš, T. [0000-0001-8265-6916], Zenz, S. [0000-0002-9720-1794], Zerradi, S. [0000-0001-9101-3226], Zerwas, D. [0000-0002-4198-3029], Zgubič, M. [0000-0002-5110-5959], Zhang, B. [0000-0002-9726-6707], Zhang, D.F. [0000-0001-7335-4983], Zhang, G. [0000-0002-5706-7180], Zhang, J. [0000-0002-9907-838X], Zhang, K. [0000-0002-9778-9209], Zhang, L. [0000-0002-9336-9338], Zhang, L. [0000-0001-5241-6559], Zhang, M. [0000-0001-8659-5727], Zhang, R. [0000-0002-8265-474X], Zhang, X. [0000-0003-4731-0754], Zhang, X. [0000-0003-4341-1603], Zhang, Z. [0000-0002-7853-9079], Zhao, P. [0000-0003-0054-8749], Zhao, Y. [0000-0003-0494-6728], Zhao, Z. [0000-0001-6758-3974], Zhemchugov, A. [0000-0002-3360-4965], Zheng, Z. [0000-0002-8323-7753], Zhong, D. [0000-0001-9377-650X], Zhou, C. [0000-0001-5904-7258], Zhou, H. [0000-0002-7986-9045], Zhou, M. [0000-0001-7223-8403], Zhou, N. [0000-0002-1775-2511], Zhu, C.G. [0000-0001-8015-3901], Zhu, C. [0000-0002-5918-9050], Zhu, H.L. [0000-0001-8479-1345], Zhu, H. [0000-0001-8066-7048], Zhu, J. [0000-0002-5278-2855], Zhu, Y. [0000-0002-7306-1053], Zhuang, X. [0000-0003-0996-3279], Zhukov, K. [0000-0003-2468-9634], Zhulanov, V. [0000-0002-0306-9199], Zieminska, D. [0000-0002-6311-7420], Zimine, N.I. [0000-0003-0277-4870], Zimmermann, S. [0000-0002-1529-8925], živković, L. [0000-0003-4236-8930], Zoccoli, A. [0000-0002-0993-6185], Zoch, K. [0000-0003-2138-6187], Zorbas, T.G. [0000-0003-2073-4901], Zou, R. [0000-0002-0542-1264], Zou, W. [0000-0002-0779-8815], Zwalinski, L. [0000-0002-9397-2313], and Apollo - University of Cambridge Repository
Subjects: Physics::Instrumentation and Detectors, design, 01 natural sciences, damage [radiation], High Energy Physics - Experiment, design [detector], High Energy Physics - Experiment (hep-ex), NIEL damage, pixel, scattering [p p], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Detector modelling and simulations I (interaction of radiation with matter, interaction of photons with matter, interaction of hadrons with matter, etc), Radiation damage to detector materials (solid state), tracking detector, Instrumentation, Mathematical Physics, Leakage (electronics), radiation: damage, Physics, Settore FIS/01, Large Hadron Collider, track data analysis, 4. Education, pixel [detector], Detector, microstrip [semiconductor detector], interaction of photons with matter, Monte Carlo [numerical calculations], ATLAS, semiconductor, charged particle, Semiconductor detector, interaction of hadrons with matter, medicine.anatomical_structure, CERN LHC Coll, semiconductor detector: microstrip, LHC, colliding beams [p p], numerical calculations: Monte Carlo, LHC, NIEL damage, silicon sensor, damage, Particle Physics - Experiment, safety, p p: scattering, 530 Physics, energy loss, Detector modelling and simulations I (interaction of radiation with matter, FOS: Physical sciences, LHC, ATLAS, High Energy Physics, Radiation, Optics, Atlas (anatomy), 0103 physical sciences, medicine, detector: pixel, High Energy Physics, ddc:610, 010306 general physics, detector: design, etc), Pixel, detector, 010308 nuclear & particles physics, business.industry, paper, radiation, Semiconductor, 13. Climate action, silicon sensor, semiconductor detector, High Energy Physics::Experiment, business, microstrip, p p: colliding beams, experimental results
Abstract: We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerba 1/4 an; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRT, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; JINR; MES of Russia and NRC KI, Russian Federation; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada, CRC and IVADO, Canada; Be 1/4 ing Municipal Science & Technology Commission, China; COST, ERC, ERDF, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom., Non-ionizing energy loss causes bulk damage to the silicon sensors of the ATLAS pixel and strip detectors. This damage has important implications for data-taking operations, charged-particle track reconstruction, detector simulations, and physics analysis. This paper presents simulations and measurements of the leakage current in the ATLAS pixel detector and semiconductor tracker as a function of location in the detector and time, using data collected in Run 1 (2010-2012) and Run 2 (2015-2018) of the Large Hadron Collider. The extracted fluence shows a much stronger vertical bar z vertical bar-dependence in the innermost layers than is seen in simulation. Furthermore, the overall fluence on the second innermost layer is significantly higher than in simulation, with better agreement in layers at higher radii. These measurements are important for validating the simulation models and can be used in part to justify safety factors for future detector designs and interventions., ANPCyT, YerPhI, Armenia, Australian Research Council, Austrian Science Fund (FWF), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Natural Sciences and Engineering Research Council of Canada (NSERC), NRC, Canada, Canada Foundation for Innovation, ANID, Chile, Chinese Academy of Sciences, Ministry of Science and Technology, China, National Natural Science Foundation of China (NSFC), Departamento Administrativo de Ciencia, Tecnologia e Innovacion Colciencias, Ministry of Education, Youth & Sports - Czech Republic, Czech Republic Government, DNRF, Denmark, Federal Ministry of Education & Research (BMBF), HGF, Germany, Max Planck Society, Greek Ministry of Development-GSRT, Israel Science Foundation, Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT), Japan Society for the Promotion of Science, Netherlands Organization for Scientific Research (NWO), Netherlands Government, RCN, Norway, Ministry of Science and Higher Education, Poland, NCN, Poland, Portuguese Foundation for Science and Technology, European Commission, JINR, Russian Federation, NRC KI, Russian Federation, MSSR, Slovakia, Slovenian Research Agency - Slovenia, DST/NRF, South Africa, Spanish Government, SRC, Sweden, Wallenberg Foundation, Sweden, Ministry of Science and Technology, Taiwan, Ministry of Energy & Natural Resources - Turkey, UK Research & Innovation (UKRI), Science & Technology Facilities Council (STFC), United States Department of Energy (DOE), National Science Foundation (NSF), BCKDF, Canada, CRC, Canada, COST, European Union, European Research Council (ERC), ERDF, European Union, Horizon 2020, European Union, Marie Sklodowska-Curie Actions, European Union, French National Research Agency (ANR), German Research Foundation (DFG), Alexander von Humboldt Foundation, EU-ESF, Greece, Greek NSRF, Greece, BSF-NSF, Israel, German-Israeli Foundation for Scientific Research and Development, La Caixa Banking Foundation, Spain, BMWFW, Austria, CERN, Danish Natural Science Research Council, Centre National de la Recherche Scientifique (CNRS), CEA-DRF/IRFU, France, RGC, China, Hong Kong SAR, China, Benoziyo Center, Israel, Istituto Nazionale di Fisica Nucleare (INFN), CNRST, Morocco, MNE/IFA, Romania, Ministry of Education, Science & Technological Development, Serbia, MIZS, Slovenia, SERI, Switzerland, Swiss National Science Foundation (SNSF), Canton of Bern, Switzerland, Canton of Geneva, Switzerland, CANARIE, Canada, Compute Canada, Canada, IVADO, Canada, Be 1/4 ing Municipal Science & Technology Commission, China, Herakleitos programme, Thales Group, Aristeia programme, CERCA Programme Generalitat de Catalunya, Spain PROMETEO Programme Generalitat Valenciana, Spain, GenT Programme Generalitat Valenciana, Spain, Goran Gustafssons Stiftelse, Sweden, Royal Society of London, Leverhulme Trust
Published: 2021

35. Paper-based netlike rolling circle amplification (NRCA) for ultrasensitive and visual detection of SARS-CoV-2

Author: Song, Yuchen, Chao, Yuqing, Guo, Yi, Zhang, Fan, Mao, Changqing, Guan, Chaoyang, Chen, Guifang, and Feng, Chang
Subjects: Paper, Point-of-care testing, SARS-CoV-2, Netlike rolling circle amplification, Materials Chemistry, Metals and Alloys, Electrical and Electronic Engineering, Condensed Matter Physics, Instrumentation, Article, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials
Abstract: COVID-19 is a highly diffuse respiratory infection caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Currently, quantitative real-time polymerase chain reaction (qRT-PCR) technology is commonly used in clinical diagnosis of COVID-19. However, this method is time-consuming and labor-intensive, which is limited in clinical application. Here, we propose a new method for the ultrasensitive and visual detection of SARS-CoV-2 viral nucleic acid. The assay integrates with a paper device and highly efficient isothermal amplification technology - Netlike rolling circle amplification (NRCA), which can reach a limit of detection of 4.12 aM. The paper-based NRCA owns advantages of specificity, portability, visualization and low-cost. Therefore, this method can effectively meet the requirements of point-of-care testing, providing a novel molecular detection technology for clinical diagnosis of COVID-19 and promoting the development of NRCA devices., Graphical Abstract ga1
Published: 2022

36. A Three-Reagent 'Green' Paper-Based Analytical Device for Solid-Phase Spectrometric and Colorimetric Determination of Dihydroquercetin

Author: Vladimir V. Apyari, Aleksei A. Furletov, Vyacheslav I. Kalinin, Stanislava G. Dmitrienko, and Yury A. Zolotov
Subjects: Paper, Colorimetry, Indicators and Reagents, Quercetin, Microfluidic Analytical Techniques, Electrical and Electronic Engineering, Ferric Compounds, Biochemistry, Instrumentation, Atomic and Molecular Physics, and Optics, Analytical Chemistry
Abstract: Microfluidic paper-based analytical devices (µPADs) represent one of the promising green analytical strategies for low-cost and simple determination of various analytes. The actual task is the development of such devices for quantitation of antioxidants, e.g., flavonoids. In this paper, possibilities of a novel three-reagent µPAD including silver nitrate, 4-nitrophenyldiazonium tetrafluoroborate, and iron(III) chloride as reagents are assessed with respect to the determination of dihydroquercetin. It is shown that all the three reagents produce different colorimetric responses that can be detected by a mini-spectrophotometer–monitor calibrator or by a smartphone. The method is applicable to direct measuring high contents of dihydroquercetin (the linearity range is 0.026–1 mg mL−1, and the limit of detection is 7.7 µg mL−1), which is favorable for many dietary supplements. The analysis of a food supplement was possible with the relative standard deviations of 9–26%, which is satisfactory for quantitative and semiquantitative determinations. It was found that plotting a calibration graph in 3D space of the three reagents’ responses allows us to distinguish dihydroquercetin from its close structural analogue, quercetin.
Published: 2022

37. Graphitic Carbon Nitride as an Amplification Platform on an Electrochemical Paper-Based Device for the Detection of Norovirus-Specific DNA

Author: Manika Khanuja, Ashish Mathur, Annu Mishra, Arun Kumar, Aditya Rana, Roberto Pilloton, Jagriti Narang, Manjari Killa, and Neelam Yadav
Subjects: Paper, Materials science, Immobilized Nucleic Acids, norovirus, Amplification Platform, Nanotechnology, 02 engineering and technology, Biosensing Techniques, lcsh:Chemical technology, 01 natural sciences, Biochemistry, Article, Analytical Chemistry, chemistry.chemical_compound, Limit of Detection, lcsh:TP1-1185, Electrical and Electronic Engineering, Nitrogen Compounds, Instrumentation, Electrodes, Detection limit, Horizontal scan rate, 010401 analytical chemistry, Graphitic carbon nitride, technology, industry, and agriculture, Nucleic Acid Hybridization, Electrochemical Paper-Based Biosensor, DNA, Electrochemical Techniques, 021001 nanoscience & nanotechnology, paper-based analytical device, oxidized graphitic carbon nitride, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, Electrochemical gas sensor, Nanostructures, Graphitic Carbon Nitride, chemistry, Electrode, RNA, Viral, methylene blue, Graphite, Differential pulse voltammetry, Cyclic voltammetry, 0210 nano-technology, DNA Probes, Biosensor, genosensor
Abstract: Norovirus is one of the leading causes of gastroenteritis, acute vomiting, intense diarrhoea, acute pain in the stomach, high fever, headaches, and body pain. Conventional methods of detection gave us very promising results but had disadvantages such as low sensitivity, cost ineffectiveness, reduced specificity and selectivity, etc. Therefore, biosensors can be a viable alternative device which can overcome all setbacks associated with the conventional method. An electrochemical sensor based on oxidized graphitic carbon nitride (Ox-g-C3N4) modified electrochemical paper-based analytical device (ePAD) was fabricated for the detection of norovirus DNA. The synthesized Ox-g-C3N4 nanosheets were characterized by field emission scanning electron microscopy (FESEM), X-ray Diffraction (XRD), UV-Vis spectroscopy and X-Ray Photoelectron Spectroscopy. The capture probe DNA (PDNA) modified electrodes were characterized by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). These two characterization techniques were also employed to find the optimal scan rate, response time and temperature of the fabricated sensor. The fabricated biosensor showed a limit of detection (LOD) of 100 fM. Furthermore, the specificity of the reported biosensor was affirmed by testing the response of capture probe DNA with oxidized graphitic carbon nitride (PDNA/Ox-g-C3N4) modified ePAD on the introduction of a non-complimentary DNA. The fabricated ePAD sensor is easy to fabricate, cost effective and specific, and requires a minimum analysis time of 5 s.
Published: 2020

38. Cytokine and Cancer Biomarkers Detection: The Dawn of Electrochemical Paper-Based Biosensor

Author: Tze Sian Pui, Song Wei Loo, and School of Chemical and Biomedical Engineering
Subjects: Bioengineering [Engineering], Paper, Computer science, cancer biomarkers, 02 engineering and technology, Electrochemical detection, Review, Biosensing Techniques, Electrochemistry, biosensor, lcsh:Chemical technology, 01 natural sciences, Biochemistry, Electrochemical Detection, Analytical Chemistry, Paper based biosensor, Neoplasms, Biomarkers, Tumor, cytokine, Humans, lcsh:TP1-1185, Electrical and Electronic Engineering, Paper-based Device, Instrumentation, point-of-care device, 010401 analytical chemistry, technology, industry, and agriculture, Electrochemical Techniques, paper-based device, 021001 nanoscience & nanotechnology, Point of care device, Atomic and Molecular Physics, and Optics, Quantitative determination, 0104 chemical sciences, Point-of-Care Testing, electrochemical detection, Cytokines, Cancer biomarkers, Biochemical engineering, 0210 nano-technology, Biosensor
Abstract: Although the established ELISA-based sensing platforms have many benefits, the importance of cytokine and cancer biomarkers detection for point-of-care diagnostics has propelled the search for more specific, sensitive, simple, accessible, yet economical sensor. Paper-based biosensor holds promise for future in-situ applications and can provide rapid analysis and data without the need to conduct in a laboratory. Electrochemical detection plays a vital role in interpreting results obtained from qualitative assessment to quantitative determination. In this review, various factors affecting the design of an electrochemical paper-based biosensor are highlighted and discussed in depth. Different detection methods, along with the latest development in utilizing them in cytokine and cancer biomarkers detection, are reviewed. Lastly, the fabrication of portable electrochemical paper-based biosensor is ideal in deliberating positive societal implications in developing countries with limited resources and accessibility to healthcare services. Ministry of Education (MOE) Published version The authors would like to acknowledge the financial support for this work funded by Singapore Ministry of Education Academic Research Fund Tier 1 (MOE-2018-T1-001-004).
Published: 2020

39. High-throughput, multi-parametric, and correlative fluorescence lifetime imaging

Author: Chetan Poudel, Clemens F. Kaminski, Ioanna Mela, Poudel, Chetan [0000-0002-8512-9238], Mela, Ioanna [0000-0002-2914-9971], Kaminski, Clemens [0000-0002-5194-0962], Apollo - University of Cambridge Repository, and Kaminski, Clemens F [0000-0002-5194-0962]
Subjects: Correlative, Paper, Fluorescence-lifetime imaging microscopy, FLIM, Computer science, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Single sample, 02 engineering and technology, high throughput, 010402 general chemistry, 01 natural sciences, Imaging modalities, Electronic engineering, fluorescence lifetime, Humans, General Materials Science, acquisition time, Instrumentation, Throughput (business), Spectroscopy, High content imaging, correlative FLIM, Multi parametric, Special Issue on Fluorescence Lifetime Imaging (FLIM): from Fundamentals to Applications, Optical Imaging, SPAD array, 021001 nanoscience & nanotechnology, Atomic and Molecular Physics, and Optics, 3. Good health, 0104 chemical sciences, Acquisition time, 0210 nano-technology, multi-parametric imaging
Abstract: In this review, we discuss methods and advancements in fluorescence lifetime imaging microscopy that permit measurements to be performed at faster speed and higher resolution than previously possible. We review fast single-photon timing technologies and the use of parallelized detection schemes to enable high-throughput and high content imaging applications. We appraise different technological implementations of fluorescence lifetime imaging, primarily in the time-domain. We also review combinations of fluorescence lifetime with other imaging modalities to capture multi-dimensional and correlative information from a single sample. Throughout the review, we focus on applications in biomedical research. We conclude with a critical outlook on current challenges and future opportunities in this rapidly developing field.
Published: 2020
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40. Triple-Indicator-Based Multidimensional Colorimetric Sensing Platform for Heavy Metal Ion Detections

Author: Daping Chu and Noorhayati Idros
Subjects: Paper, Materials science, Metal ions in aqueous solution, Microfluidics, Color, chemistry.chemical_element, Bioengineering, Nanotechnology, 02 engineering and technology, Wastewater, 010402 general chemistry, Proof of Concept Study, 01 natural sciences, Metal, Lab-On-A-Chip Devices, Metals, Heavy, Ponds, Instrumentation, Fluid Flow and Transfer Processes, Color calibration, Drinking Water, Process Chemistry and Technology, Digital imaging, Heavy metals, Microfluidic Analytical Techniques, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Mercury (element), chemistry, Color changes, visual_art, Calibration, visual_art.visual_art_medium, Colorimetry, Indicators and Reagents, 0210 nano-technology, Water Pollutants, Chemical
Abstract: Heavy metals are highly toxic at trace levels and their pollution has shown great threat to the environment and public health worldwide where current detection methods require expensive instrumentation and laborious operation, which can only be accomplished in centralized laboratories. Herein, we report a low-cost, paper-based microfluidic analytical device (μPAD) for facile, portable, and disposable monitoring of mercury, lead, chromium, nickel, copper, and iron ions. Triple indicators or ligands that contain ions or molecules are preloaded on the μPADs and upon addition of a metal ion, the colorimetric indicators will elicit color changes observed by the naked eyes. The color features were quantitatively analyzed in a three-dimensional space of red, green, and blue or the RGB-space using digital imaging and color calibration techniques. The sensing platform offers higher accuracy for cross references, and is capable of simultaneous detection and discrimination of different metal ions in even real water samples. It demonstrates great potential for semiquantitative and even qualitative analysis with a sensitivity below the safe limit concentrations, and a controlled error range.
Published: 2018

41. Simple Way To Fabricate Novel Paper-Based Valves Using Plastic Comb Binding Spines

Author: Lingxin Chen, Junrui Zhou, Bowei Li, Anjin Qi, Guan Wang, and Jinglong Han
Subjects: Paper, Computer science, Iron, Microfluidics, Bioengineering, 02 engineering and technology, 01 natural sciences, GeneralLiterature_MISCELLANEOUS, Simple (abstract algebra), Lab-On-A-Chip Devices, Layer (object-oriented design), Instrumentation, Throughput (business), Nitrites, Desk, Fluid Flow and Transfer Processes, business.industry, Process Chemistry and Technology, 010401 analytical chemistry, Process (computing), Equipment Design, Paper based, Microfluidic Analytical Techniques, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Lakes, Calibration, Colorimetry, 0210 nano-technology, business, Water Pollutants, Chemical, Computer hardware, Communication channel
Abstract: A novel strategy for fabricating the paper-based valves on microfluidic paper-based analytical devices (μPADs) was described to control fluid in a user-friendly way. Initial prototypes of 3D μPADs manipulate the spatial distribution of fluid within the device. The movable paper channel in a different layer could be achieved using the channel's connection or disconnection to realize the valve function using plastic comb binding spines (PCBS). The entire valve manipulation process was similar to a desk calendar that can be flipped over and turned back. It is notable that this kind of PCBS valve can control a fluid in a simple and easy way without the timing setting or any trigger, and this advantage makes it user-friendly for untrained users to carry out the complex and high throughput operations. The reusable plastic comb binding spines greatly reduce the cost of fabricating paper-based valves. To evaluate the performance, the actual samples of Fe (II) and nitrite were successfully analyzed. We hope this method will introduce a new approach to fabrication of paper-based valves on μPADs in the future.
Published: 2018

42. Functional paper-based SERS substrate for rapid and sensitive detection of Sudan dyes in herbal medicine

Author: Qingxia Zhu, Wu Mianmian, Li Hao, Wu Meiran, Pan Li, and Feng Lu
Subjects: Paper, Sudan IV, Nanotechnology, 02 engineering and technology, Spectrum Analysis, Raman, 010402 general chemistry, 01 natural sciences, Analytical Chemistry, Inclusion compound, Sudan III, Nanomaterials, chemistry.chemical_compound, Limit of Detection, Coloring Agents, Instrumentation, Spectroscopy, Cyclodextrins, Nanotubes, Filter paper, Reproducibility of Results, Substrate (chemistry), Surface-enhanced Raman spectroscopy, 021001 nanoscience & nanotechnology, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, chemistry, Nanorod, Gold, 0210 nano-technology, Azo Compounds
Abstract: There has been an increasing demand for rapid and sensitive techniques for the identification of Sudan compounds that emerged as the most often illegally added fat-soluble dyes in herbal medicine. In this report, we have designed and fabricated a functionalized filter paper consisting of gold nanorods (GNRs) and mono-6-thio-cyclodextrin (HS-β-CD) as a surface-enhanced Raman spectroscopy (SERS) substrate, in which the GNR provides sufficient SERS enhancement, and the HS-β-CD with strong chemical affinity toward GNR provides the inclusion compound to capture hydrophobic molecules. Moreover, the CD-GNR were uniformly assembled on filter paper cellulose through the electrostatic adsorption and hydrogen bond, so that the CD-GNR paper-based SERS substrate (CD-GNR-paper) demonstrated higher sensitivity for the determination of Sudan III (0.1μM) and Sudan IV (0.5μM) than GNRs paper-based SERS substrate (GNR-paper), with high stability after the storage in the open air for 90days. Importantly, CD-GNR-paper can effectively collect the Sudan dyes from illegally adulterated onto samples of Resina Draconis with a simple operation, further open up new exciting opportunity for SERS detection of more compounds illegally added with high sensitivity and fast signal responses.
Published: 2018

43. Determination of Gold Ions in Human Urine Using Genetically Engineered Microorganisms on a Paper Device

Author: Kai-Hong Guo, I-Ren Lee, Yi Chun Yeh, Pei-Hsuan Chen, Chien-Fu Chen, and Chieh Lin
Subjects: Paper, 0301 basic medicine, Microorganism, 030106 microbiology, Bioengineering, Nanotechnology, Biosensing Techniques, Personal health monitoring, Urine, 03 medical and health sciences, Humans, Instrumentation, Ions, Fluid Flow and Transfer Processes, Detection limit, Luminescent Agents, biology, Genetically engineered, Cupriavidus metallidurans, Chemistry, Process Chemistry and Technology, Cupriavidus, biology.organism_classification, Highly sensitive, Luminescent Proteins, 030104 developmental biology, Gold, Genetic Engineering, Biosensor
Abstract: This paper presents a whole-cell biosensor that operates in conjunction with a smartphone-based fluorescence diagnostic system on a paper device to monitor the concentration of gold ions in human urine. The heavy metal-tolerant bacteria Cupriavidus metallidurans was genetically engineered for use as a chassis in a red fluorescent protein (RFP)-based microbial sensor. The biosensor is highly sensitive to gold ions, with a detection limit of 110 nM. The proposed smartphone-based analysis system provides a user-friendly approach to design tools of personal health monitoring for reporting the presence of gold ions in human urine.
Published: 2018

44. Rapid Veterinary Diagnosis of Bovine Reproductive Infectious Diseases from Semen Using Paper-Origami DNA Microfluidics

Author: Jonathan M. Cooper, Syed Atif Ali, Zhugen Yang, Gaolian Xu, John McGiven, Praveen K. Gupta, Gurpreet Kaur, Julien Reboud, Pallab Chaudhuri, and Nongthombam Boby
Subjects: DNA, Bacterial, Paper, Veterinary medicine, Microfluidics, Loop-mediated isothermal amplification, Brucella abortus, Cattle Diseases, Bioengineering, Semen, 02 engineering and technology, Brucella, 01 natural sciences, Brucellosis, Bovine, Limit of Detection, Leptospira, Animals, Leptospirosis, Instrumentation, Pathogen, Herpesvirus 1, Bovine, Fluid Flow and Transfer Processes, biology, Process Chemistry and Technology, 010401 analytical chemistry, Herpesviridae Infections, 021001 nanoscience & nanotechnology, biology.organism_classification, 0104 chemical sciences, 3. Good health, genomic DNA, Molecular Diagnostic Techniques, Infectious disease (medical specialty), DNA, Viral, Cattle, 0210 nano-technology, Bacteria
Abstract: The health and well-being of cattle is a significant concern for global agricultural output. In dairy production within low and middle income countries (LMICs), there is a significant biosensing challenge in detecting sexually transmitted infection (STI) pathogens during animal husbandry, due in part to difficulties associated with the limited infrastructure for veterinary medicine. Here we demonstrate low-cost, multiplexed and sample-to-answer paper-origami tests for the detection of three bovine infectious reproductive diseases in semen samples, collected at a test site in rural India. Pathogen DNA from one viral pathogen, Bovine Herpes virus-1 (BoHV-1) and two bacteria (Brucella and Leptospira) was extracted, amplified (using loop-mediated isothermal amplification, LAMP) and detected fluorescently, enabling
Published: 2018

45. Subnanomolar Sensitivity of Filter Paper-Based SERS Sensor for Pesticide Detection by Hydrophobicity Change of Paper Surface

Author: Hye-Jung Youn, Dae Hong Jeong, Han Kyu Choi, Kyudeok Oh, Hak Lae Lee, Sung Gun Lee, and Minwoo Lee
Subjects: Paper, Analyte, Silver, Materials science, Metal Nanoparticles, Nanoparticle, Bioengineering, 02 engineering and technology, Spectrum Analysis, Raman, 010402 general chemistry, 01 natural sciences, Silver nanoparticle, Contact angle, Limit of Detection, Pesticides, Absorption (electromagnetic radiation), Instrumentation, Alkyl, Fluid Flow and Transfer Processes, chemistry.chemical_classification, Filter paper, Process Chemistry and Technology, Reproducibility of Results, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Cellulose fiber, chemistry, Chemical engineering, 0210 nano-technology, Hydrophobic and Hydrophilic Interactions
Abstract: As a cost-effective approach for detecting trace amounts of pesticides, filter paper-based SERS sensors have been the subject of intensive research. One of the hurdles to overcome is the difficulty of retaining nanoparticles on the surface of the paper because of the hydrophilic nature of the cellulose fibers in paper. This reduces the sensitivity and reproducibility of paper-based SERS sensors due to the low density of nanoparticles and short retention time of analytes on the paper surface. In this study, filter paper was treated with alkyl ketene dimer (AKD) to modify its property from hydrophilic to hydrophobic. AKD treatment increased the contact angle of the aqueous silver nanoparticle (AgNP) dispersion, which consequently increased the density of AgNPs. The retention time of the analyte was also increased by preventing its rapid absorption into the filter paper. The SERS signal was strongly enhanced by the increased number of SERS hot spots owing to the increased density of AgNPs on a small contact area of the filter surface. The reproducibility and sensitivity of the SERS signal were optimized by controlling the distribution of AgNPs on the surface of the filter paper by adjusting the concentration of the AgNP solution. Using this SERS sensor with a hydrophobicity-modified filter paper, the spot-to-spot variation of the SERS intensity of 25 spots of 4-aminothiophenol was 6.19%, and the limits of detection of thiram and ferbam as test pesticides were measured to be 0.46 nM and 0.49 nM, respectively. These proof-of-concept results indicate that this paper-based SERS sensor can serve for highly sensitive pesticide detection with low cost and easy fabrication.
Published: 2018

46. Determination of the Conservation State of Some Documents Written on Cellulosic Support in the Poni-Cernătescu Museum, Iași City in Romania

Author: Maria Haulică, Ioana Stănculescu, Robert Hrițac, Viorica Vasilache, Ion Sandu, and Oana Florescu
Subjects: Technology, QH301-705.5, QC1-999, cultural artefacts, Civil engineering, Ft raman, SEM-EDX, ink, General Materials Science, Biology (General), micro-FTIR, QD1-999, Instrumentation, Cellulose crystallinity, Fluid Flow and Transfer Processes, PCA, OM, Physics, paper, Process Chemistry and Technology, conservation, General Engineering, Engineering (General). Civil engineering (General), Computer Science Applications, Chemistry, Environmental science, TA1-2040, FT-Raman
Abstract: An important step in the conservation of old paper documents is the analysis of both the medium and the ink, in an attempt first to determine the extent of deterioration and degradation and then to choose the best preservation and restoration solutions. Our paper focuses on the analysis of three old documents displayed at the ‘Poni-Cernătescu’ Museum in Iaşi City, Romania by optical microscopy (OM), scanning electron microscopy and energy dispersive X-ray spectroscopy (SEM-EDX), micro-FTIR spectroscopy and FT-Raman. Thus, the morphology and chemical composition of the paper media and the type of ink, as well as the cellulose crystallinity index were determined. PCA (Principal Component Analysis) was also used while relying on spectra collected by FTIR spectroscopy. We were able to determine the extent of degradation of the documents by corroborating all these findings.
Published: 2021

47. Estimation of the shielding ability of a tungsten functional paper for diagnostic x‐rays and gamma rays

Author: Masahiro Hiraoka, Hajime Monzen, Takahiro Fujimoto, and Ikuo Kanno
Subjects: Paper, Radiation Protection & Regulations, Materials science, Analytical chemistry, chemistry.chemical_element, Dose profile, x‐rays, Tungsten, Radiation Dosage, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Radiation Protection, 0302 clinical medicine, Diagnostic x-rays, Humans, tungsten functional paper (TFP), Radiology, Nuclear Medicine and imaging, Computed radiography, Cellulose, Instrumentation, Radiation, business.industry, X-Rays, Gamma ray, gamma rays, Radiation shielding, chemistry, Cesium Radioisotopes, 030220 oncology & carcinogenesis, Electromagnetic shielding, diagnostic imaging field, 87.61.Tg, Radiation protection, business, Nuclear medicine, radiation shielding
Abstract: Tungsten functional paper (TFP) is a novel paper‐based radiation‐shielding material. We measured the shielding ability of TFP against x‐rays and gamma rays. The TFP was supplied in 0.3‐mm‐thick sheets that contained 80% tungsten powder and 20% cellulose (C6H10O5) by mass. In dose measurements for x‐rays (60, 80, 100, and 120 kVp), we measured doses after through 1, 2, 3, 5, 10, and 12 TFP sheets, as well as 0.3 and 0.5 mm of lead. In lead equivalence measurements, we measured doses after through 2 and 10 TFP sheets for x‐rays (100 and 150 kVp), and 0, 7, 10, 20, and 30 TFP sheets for gamma rays from cesium‐137 source (662 keV). And then, the lead equivalent thicknesses of TFP were determined by comparison with doses after through standard lead plates (purity >99.9%). Additionally, we evaluated uniformity of the transmitted dose by TFP with a computed radiography image plate for 50 kVp x‐rays. A single TFP sheet was found to have a shielding ability of 65%, 53%, 48%, and 46% for x‐rays (60, 80, 100, and 120 kVp), respectively. The lead equivalent thicknesses of two TFP sheets were 0.10 ± 0.02, 0.09 ± 0.02 mmPb, and of ten TFP sheets were 0.48 ± 0.02 and 0.51 ± 0.02 mmPb for 100 and 150 kVp x‐rays, respectively. The lead equivalent thicknesses of 7, 10, 20, and 30 sheets of TFP for gamma rays from cesium‐137 source were estimated as 0.28, 0.43, 0.91, and 1.50 mmPb with an error of ± 0.01 mm. One TFP sheet had nonuniformity, however, seven TFP sheets provided complete shielding for 50 kVp x‐rays. TFP has adequate radiation shielding ability for x‐rays and gamma rays within the energy range used in diagnostic imaging field.
Published: 2017

48. Paper-Based Microfluidic Device (DON-Chip) for Rapid and Low-Cost Deoxynivalenol Quantification in Food, Feed, and Feed Ingredients

Author: Kang Yao, Qian Jiang, Max M. Gong, Francis Lin, Yulong Yin, Jiandong Wu, and Chengbo Yang
Subjects: Paper, Mycotoxin contamination, Microfluidics, Bioengineering, Food Contamination, 02 engineering and technology, 01 natural sciences, chemistry.chemical_compound, Lab-On-A-Chip Devices, Food Industry, Mycotoxin, Instrumentation, Analysis method, Fluid Flow and Transfer Processes, Process Chemistry and Technology, 010401 analytical chemistry, food and beverages, Paper based, 021001 nanoscience & nanotechnology, Chip, Pulp and paper industry, 0104 chemical sciences, Microfluidic chip, chemistry, Environmental science, Competitive immunoassay, 0210 nano-technology, Trichothecenes, Food Analysis, Water Pollutants, Chemical
Abstract: Mycotoxin contamination causes over $5 billion of economic loss per year in the North American food and feed industry. A rapid, low-cost, portable, and reliable method for on-site detection of deoxynivalenol (DON), a representative mycotoxin predominantly occurring in grains, would be helpful to control mycotoxin contamination. In this study, a paper-based microfluidic chip capable of measuring DON (DON-Chip) in food, feed, and feed ingredients was developed. The DON-Chip incorporated a colorimetric competitive immunoassay into a paper microfluidic device and used gold nanoparticles as a signal indicator. Furthermore, a novel ratiometric analysis method was proposed to improve detection resolvability. Detection of DON in the aqueous extracts from solid food, feed, or feed ingredients was successfully validated with a detection range of 0.01-20 ppm (using dilution factors from 10 to 104). Compared with conventional methods, the DON-Chip method could greatly reduce the cost and time of mycotoxin detection in the food and feed industry.
Published: 2019

49. Flexible paper-based SERS substrate strategy for rapid detection of methyl parathion on the surface of fruit

Author: Zhouping Wang, Jie Xie, Li Liangyu, Imran Mahmood Khan, and Xiaoyuan Ma
Subjects: Paper, Surface Properties, Analytical chemistry, Metal Nanoparticles, Food Contamination, 02 engineering and technology, Methyl Parathion, 010402 general chemistry, Spectrum Analysis, Raman, 01 natural sciences, Analytical Chemistry, symbols.namesake, chemistry.chemical_compound, Limit of Detection, Parathion methyl, Pesticides, Instrumentation, Spectroscopy, Detection limit, Filter paper, Substrate (chemistry), 021001 nanoscience & nanotechnology, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, chemistry, Linear range, Colloidal gold, Fruit, Malus, symbols, Gold, 0210 nano-technology, Raman spectroscopy, Raman scattering
Abstract: Herein, we reported a simple, flexible and sensitive surface-enhanced Raman scattering (SERS) substrate to detect methyl parathion residues in real life. The substrate was fabricated by filter paper and gold nanoparticles (Au NPs) with excellent reproducibility and stability. First, Au NPs were synthesized by the seed mediated growth method and assembled to the filter paper through immersion. The Raman probe molecule 4-MBA was used to evaluate performance of the substrate for an optimized signal using a portable Raman spectrometer coupled with 785 nm laser. Then, the paper-based substrate was applied to detect methyl parathion standard solution whose detection limit was down to 0.011 μg/cm2, and the linear range was between 0.018 μg/cm2 and 0.354 μg/cm2. Afterwards, actual sample (apple) spiked with methyl parathion was taken to verify the practicality of the substrate by a simple way of “press–peel off”. The recovery rate was ranged from 94.09% to 98.72%, indicating that this method is reliable in actual sample detection without complicated pretreatment steps. This work demonstrates that the flexible paper-based substrate combined with portable Raman instruments can be potentially applied to on-site detection of hazardous substances in the field of food safety.
Published: 2019

50. Preserve Your Books through the Smell

Author: Marta I.S. Veríssimo, João Pedro Oliveira, Dmitry V. Evtuguin, and M. Teresa S.R. Gomes
Subjects: Paper, Early signs, Bioengineering, 02 engineering and technology, 01 natural sciences, Gas Chromatography-Mass Spectrometry, Electronic Nose, Instrumentation, Fluid Flow and Transfer Processes, Volatile Organic Compounds, Electronic nose, Molecular Structure, Process Chemistry and Technology, Books, 010401 analytical chemistry, Electrochemical Techniques, Quartz, Hydrogen-Ion Concentration, 021001 nanoscience & nanotechnology, Pulp and paper industry, 0104 chemical sciences, Cultural heritage, Smell, Environmental science, Identification (biology), 0210 nano-technology
Abstract: The identification of paper composition, pH, early signs of paper degradation, and emitting volatile organic compounds (VOCs) are mandatory for effective preventive conservation of paper/books. Sampling restrictions in the analysis of cultural heritage materials limit the choice of appropriate analytical methods. Solvent-free analytical techniques with nondestructive sampling are needed. Addressing this challenge, an electronic nose based on six-coated piezoelectric quartz crystals was assembled and used to analyze VOCs emitted from books. Careful selection of sensor coatings and cluster analysis allowed us to achieve a clear distinction between cotton/linen rag and wood pulp paper, and among the letter group, the discrimination between papers manufactured from alkaline and acidic stocks. This six-element sensor array was therefore able to replace destructive tests as the ones ordinarily used for paper pH measurements. The same electronic nose was able to separate aged pale-yellow paper, a visible initial sign of paper degradation, from well-preserved still white papers, even when made from the same raw material. One of the used sensors detected furfural, often seen as a marker of cellulose degradation, at lower levels than the detection limit found in the literature with gas chromatography-mass spectrometry, a much more complex bulky and expensive instrument.
Published: 2019

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