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Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. It has been noticed that the occurrence of asthma has been increased dramatically. It affects both children and adults. Asthma is caused by multiple interacting genes, some having a protective effect and others contributing to the disease pathogenesis, Interleukin 1 beta which is an pro inflammatory cytokine has been seen associated with asthma by adhesion to vascular endothelium increase, growth factor for Th2 cells, B-cell growth factor, neutrophils chemo attractant, T cell and epithelial cell activation, eosinophil accumulation. On the basis of studies we can observe the association of interleukin 1 beta with asthma The patients and controls were from same age group with a male to female ratio 52:48. We have selected 160 asthmatic patients and 190 healthy population. As expected the asthmatic patients had differences in allelic variations of interleukin 1 beta gene as compared to healthy population. [ABSTRACT FROM AUTHOR]

Inflammation is a process in which the body's white blood cells and chemicals help protect us from infection and foreign substances such as bacteria and viruses. In some diseases, however, the body's defense system (immune system) triggers an inflammatory response when there are no foreign substances to fight off. Ethanolic extract of Clerodendrum serratum Linn., leaves were evaluated for anti-inflammatory activity. Extract did not show any signs of toxicity at the dose of 1000 mg/kg per organism (p.o.). From the acute toxicity test we selected two doses (50 and 100mg/kg) for subsequent pharmacological study. [ABSTRACT FROM AUTHOR]