Study on Association of Genetic Polymorphism of inflammatory gene IL-1βin susceptibility to Asthma: A Case Control study on population of Central Indian Region.

Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. It has been noticed that the occurrence of asthma has been increased dramatically. It affects both children and adults. Asthma is caused by multiple interacting genes, some having a protective effect and others contributing to the disease pathogenesis, Interleukin 1 beta which is an pro inflammatory cytokine has been seen associated with asthma by adhesion to vascular endothelium increase, growth factor for Th2 cells, B-cell growth factor, neutrophils chemo attractant, T cell and epithelial cell activation, eosinophil accumulation. On the basis of studies we can observe the association of interleukin 1 beta with asthma The patients and controls were from same age group with a male to female ratio 52:48. We have selected 160 asthmatic patients and 190 healthy population. As expected the asthmatic patients had differences in allelic variations of interleukin 1 beta gene as compared to healthy population. [ABSTRACT FROM AUTHOR]