1. Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population
- Author
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Kazunari Yamaguchi, Rie Ibusuki, Shigeho Maenohara, Hideshi Niimura, Toshiro Takezaki, Yasuko Sagara, Tetsuhiro Owaki, Kazuyo Kuwabara, Noriko Tsumematsu-Nakahata, Shin Ogawa, Eva Mariane Mantjoro, Motahare Kheradmand, Yasuhito Nerome, Tara Sefanya Kairupan, Toshifumi Matsushita, and Yora Nindita
- Subjects
Adult ,Male ,0301 basic medicine ,Interaction ,Epidemiology ,Population ,HTLV-I ,Gene polymorphism ,Inflammation ,Disease ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Neoplasms ,Humans ,Medicine ,Risk factor ,education ,Aged ,lcsh:R5-920 ,education.field_of_study ,Polymorphism, Genetic ,Tumor Necrosis Factor-alpha ,business.industry ,Proportional hazards model ,Incidence ,Incidence (epidemiology) ,Hazard ratio ,NF-kappa B p50 Subunit ,General Medicine ,Middle Aged ,Atherosclerosis ,HTLV-I Infections ,Interleukin-10 ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cohort ,Immunology ,Original Article ,Female ,lcsh:Medicine (General) ,business - Abstract
Background An increased risk of total death owing to human T-lymphotropic virus type-I (HTLV-I) infection has been reported. However, its etiology and protective factors are unclear. Various studies reported fluctuations in immune-inflammatory status among HTLV-I carriers. We conducted a matched cohort study among the general population in an HTLV-I-endemic region of Japan to investigate the interaction between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases. Method We selected 2180 sub-cohort subjects aged 35–69 years from the cohort population, after matching for age, sex, and region with HTLV-I seropositives. They were followed up for a maximum of 10 years. Inflammatory gene polymorphisms were selected from TNF-α, IL-10, and NF-κB1. A Cox proportional hazard model was used to estimate the hazard ratio (HR) and the interaction between gene polymorphisms and HTLV-I for risk of total death and incidence of cancer and atherosclerosis-related diseases. Results HTLV-I seropositivity rate was 6.4% in the cohort population. The interaction between TNF-α 1031T/C and HTLV-I for atherosclerosis-related disease incidence was statistically significant (p = 0.020). No significant interaction was observed between IL-10 819T/C or NF-κB1 94ATTG ins/del and HTLV-I. An increased HR for total death was observed in the Amami island region, after adjustment of various factors with gene polymorphisms (HR 3.03; 95% confidence interval, 1.18–7.77). Conclusion The present study found the interaction between TNF-α 1031T/C and HTLV-I to be a risk factor for atherosclerosis-related disease. Further follow-up is warranted to investigate protective factors against developing diseases among susceptible HTLV-I carriers., Highlights • We observed death and incidence risk with HTLV-I and SNPs in a matched cohort study. • An increased risk for total death with HTLV-I was observed in the island region. • Inflammatory SNP interacted with HTLV-I for atherosclerosis-related disease risk.
- Published
- 2017