5 results on '"Sabbatani, Sergio"'
Search Results
2. The rationale for a multi-step therapeutic approach based on antivirals, drugs and nutrients with immunomodulatory activity in patients with coronavirus-SARS2-induced disease of different severities.
- Author
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Fiorino, Sirio, Zippi, Maddalena, Gallo, Claudio, Sifo, Debora, Sabbatani, Sergio, Manfredi, Roberto, Rasciti, Edoardo, Rasciti, Leonardo, Giampieri, Enrico, Corazza, Ivan, Leandri, Paolo, and de Biase, Dario
- Subjects
ANTIVIRAL agents ,CELLS ,DRUGS ,GENOMES ,IMMUNE system ,IMMUNOLOGICAL adjuvants ,MOLECULAR structure ,NUTRITIONAL requirements ,VITAMINS ,SEVERITY of illness index ,COVID-19 ,CYTOKINE release syndrome ,SARS-CoV-2 - Abstract
In December 2019, a novel human-infecting coronavirus, named Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), was recognised to cause a pneumonia epidemic outbreak with different degrees of severity in Wuhan, Hubei Province in China. Since then, this epidemic has spread worldwide; in Europe, Italy has been involved. Effective preventive and therapeutic strategies are absolutely required to block this serious public health concern. Unfortunately, few studies about SARS-CoV-2 concerning its immunopathogenesis and treatment are available. On the basis of the assumption that the SARS-CoV-2 is genetically related to SARS-CoV (about 82 % of genome homology) and that its characteristics, like the modality of transmission or the type of the immune response it may stimulate, are still poorly known, a literature search was performed to identify the reports assessing these elements in patients with SARS-CoV-induced infection. Therefore, we have analysed: (1) the structure of SARS-CoV-2 and SARS-CoV; (2) the clinical signs and symptoms and pathogenic mechanisms observed during the development of acute respiratory syndrome and the cytokine release syndrome; (3) the modification of the cell microRNome and of the immune response in patients with SARS infection; and (4) the possible role of some fat-soluble compounds (such as vitamins A, D and E) in modulating directly or indirectly the replication ability of SARS-CoV-2 and host immune response. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
3. Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy.
- Author
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Fiorino, Sirio, Gallo, Claudio, Zippi, Maddalena, Sabbatani, Sergio, Manfredi, Roberto, Moretti, Renzo, Fogacci, Elisa, Maggioli, Caterina, Travasoni Loffredo, Francesca, Giampieri, Enrico, Corazza, Ivan, Dickmans, Christoph, Denitto, Claudio, Cammarosano, Michele, Battilana, Michele, Orlandi, Paolo Emilio, Del Forno, Francesco, Miceli, Francesco, Visani, Michela, and Acquaviva, Giorgia
- Subjects
VITAMIN therapy ,VITAMIN deficiency ,IMMUNE system ,MORTALITY ,PARADIGMS (Social sciences) ,PUBLIC health ,ADULT respiratory distress syndrome ,TREATMENT effectiveness ,SYSTEMIC inflammatory response syndrome ,COVID-19 ,OLD age - Abstract
Background: In December 2019, a novel human-infecting coronavirus, SARS-CoV-2, had emerged. The WHO has classified the epidemic as a "public health emergency of international concern". A dramatic situation has unfolded with thousands of deaths, occurring mainly in the aged and very ill people. Epidemiological studies suggest that immune system function is impaired in elderly individuals and these subjects often present a deficiency in fat-soluble and hydrosoluble vitamins. Methods: We searched for reviews describing the characteristics of autoimmune diseases and the available therapeutic protocols for their treatment. We set them as a paradigm with the purpose to uncover common pathogenetic mechanisms between these pathological conditions and SARS-CoV-2 infection. Furthermore, we searched for studies describing the possible efficacy of vitamins A, D, E, and C in improving the immune system function. Results: SARS-CoV-2 infection induces strong immune system dysfunction characterized by the development of an intense proinflammatory response in the host, and the development of a life-threatening condition defined as cytokine release syndrome (CRS). This leads to acute respiratory syndrome (ARDS), mainly in aged people. High mortality and lethality rates have been observed in elderly subjects with CoV-2-related infection. Conclusions: Vitamins may shift the proinflammatory Th17-mediated immune response arising in autoimmune diseases towards a T-cell regulatory phenotype. This review discusses the possible activity of vitamins A, D, E, and C in restoring normal antiviral immune system function and the potential therapeutic role of these micronutrients as part of a therapeutic strategy against SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
4. Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy
- Author
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Ivan Corazza, Roberto Manfredi, Christoph Dickmans, Claudio Denitto, Paolo Emilio Orlandi, Enrico Giampieri, Caterina Maggioli, Giovanni Tallini, Antonio De Leo, Sirio Fiorino, Elio Jovine, Michela Visani, Francesco Del Forno, Paolo Leandri, Claudio Gallo, Michele Cammarosano, Maddalena Zippi, Thomas Brand, Francesco Miceli, Giorgia Acquaviva, Elisa Fogacci, Roberto Jovine, Sergio Sabbatani, Michele Battilana, Dario de Biase, Francesca Travasoni Loffredo, Wandong Hong, Renzo Moretti, Fiorino, Sirio, Gallo, Claudio, Zippi, Maddalena, Sabbatani, Sergio, Manfredi, Roberto, Moretti, Renzo, Fogacci, Elisa, Maggioli, Caterina, Travasoni Loffredo, Francesca, Giampieri, Enrico, Corazza, Ivan, Dickmans, Christoph, Denitto, Claudio, Cammarosano, Michele, Battilana, Michele, Orlandi, Paolo Emilio, Del Forno, Francesco, Miceli, Francesco, Visani, Michela, Acquaviva, Giorgia, De Leo, Antonio, Leandri, Paolo, Hong, Wandong, Brand, Thoma, Tallini, Giovanni, Jovine, Elio, Jovine, Roberto, and de Biase, Dario
- Subjects
Aging ,ARDS ,medicine.medical_specialty ,Pneumonia, Viral ,Review ,Ascorbic Acid ,medicine.disease_cause ,Proinflammatory cytokine ,Betacoronavirus ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,CoV-2 ,Epidemiology ,Humans ,Vitamin E ,Medicine ,030212 general & internal medicine ,Vitamin D ,Vitamin A ,Pandemics ,Pathological ,Aged ,030304 developmental biology ,Coronavirus ,SARS ,0303 health sciences ,SARS-CoV-2 ,business.industry ,COVID-19 ,Vitamins ,medicine.disease ,Ageing ,Cytokine release syndrome ,Immunology ,Cytokines ,Th17 Cells ,Therapeutic strategy ,Geriatrics and Gerontology ,Coronavirus Infections ,business ,Cytokine storm - Abstract
Background In December 2019, a novel human-infecting coronavirus, SARS-CoV-2, had emerged. The WHO has classified the epidemic as a “public health emergency of international concern”. A dramatic situation has unfolded with thousands of deaths, occurring mainly in the aged and very ill people. Epidemiological studies suggest that immune system function is impaired in elderly individuals and these subjects often present a deficiency in fat-soluble and hydrosoluble vitamins. Methods We searched for reviews describing the characteristics of autoimmune diseases and the available therapeutic protocols for their treatment. We set them as a paradigm with the purpose to uncover common pathogenetic mechanisms between these pathological conditions and SARS-CoV-2 infection. Furthermore, we searched for studies describing the possible efficacy of vitamins A, D, E, and C in improving the immune system function. Results SARS-CoV-2 infection induces strong immune system dysfunction characterized by the development of an intense proinflammatory response in the host, and the development of a life-threatening condition defined as cytokine release syndrome (CRS). This leads to acute respiratory syndrome (ARDS), mainly in aged people. High mortality and lethality rates have been observed in elderly subjects with CoV-2-related infection. Conclusions Vitamins may shift the proinflammatory Th17-mediated immune response arising in autoimmune diseases towards a T-cell regulatory phenotype. This review discusses the possible activity of vitamins A, D, E, and C in restoring normal antiviral immune system function and the potential therapeutic role of these micronutrients as part of a therapeutic strategy against SARS-CoV-2 infection.
- Published
- 2020
5. The rationale for a multi-step therapeutic approach based on antivirals, drugs and nutrients with immunomodulatory activity in patients with coronavirus-SARS2-induced disease of different severities
- Author
-
Sergio Sabbatani, Debora Sifo, Sirio Fiorino, Maddalena Zippi, Claudio Gallo, Dario de Biase, Edoardo Rasciti, Leonardo Rasciti, Roberto Manfredi, Enrico Giampieri, Ivan Corazza, Paolo Leandri, Fiorino, Sirio, Zippi, Maddalena, Gallo, Claudio, Sifo, Debora, Sabbatani, Sergio, Manfredi, Roberto, Rasciti, Edoardo, Rasciti, Leonardo, Giampieri, Enrico, Corazza, Ivan, Leandri, Paolo, and de Biase, Dario
- Subjects
Gene Expression Regulation, Viral ,0301 basic medicine ,viruses ,Medicine (miscellaneous) ,Genome, Viral ,Disease ,medicine.disease_cause ,Antiviral Agents ,Severity of Illness Index ,Microbiology ,ORF, open reading frames ,Virus ,Viral Proteins ,03 medical and health sciences ,Therapeutic approach ,0302 clinical medicine ,Immune system ,medicine ,Humans ,Immunologic Factors ,skin and connective tissue diseases ,Coronavirus ,SARS ,VA, vitamin A ,Nutrition and Dietetics ,SARS-CoV-2 ,business.industry ,Transmission (medicine) ,Severe Acute Malnutrition ,RAR, nuclear RA receptors ,fungi ,COVID-19 ,Vitamins ,Full Papers ,biochemical phenomena, metabolism, and nutrition ,CRS, cytokine release syndrome ,medicine.disease ,body regions ,Pneumonia ,Cytokine release syndrome ,HBV, hepatitis B virus ,030104 developmental biology ,NPS, non-structural proteins ,030220 oncology & carcinogenesis ,Immunology ,Therapy ,business - Abstract
In December 2019, a novel human-infecting coronavirus, named Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), was recognised to cause a pneumonia epidemic outbreak with different degrees of severity in Wuhan, Hubei Province in China. Since then, this epidemic has spread worldwide; in Europe, Italy has been involved. Effective preventive and therapeutic strategies are absolutely required to block this serious public health concern. Unfortunately, few studies about SARS-CoV-2 concerning its immunopathogenesis and treatment are available. On the basis of the assumption that the SARS-CoV-2 is genetically related to SARS-CoV (about 82 % of genome homology) and that its characteristics, like the modality of transmission or the type of the immune response it may stimulate, are still poorly known, a literature search was performed to identify the reports assessing these elements in patients with SARS-CoV-induced infection. Therefore, we have analysed: (1) the structure of SARS-CoV-2 and SARS-CoV; (2) the clinical signs and symptoms and pathogenic mechanisms observed during the development of acute respiratory syndrome and the cytokine release syndrome; (3) the modification of the cell microRNome and of the immune response in patients with SARS infection; and (4) the possible role of some fat-soluble compounds (such as vitamins A, D and E) in modulating directly or indirectly the replication ability of SARS-CoV-2 and host immune response.
- Published
- 2020
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