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Your search keyword '"Shirai, Yasumasa"' showing total 1 results
Start Over Author "Shirai, Yasumasa" Topic immune response
1 results on '"Shirai, Yasumasa"'

1. Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the human nuclear factor kappa-beta subunit 1 (NFKB1) locus.

Author

Ota, Nobutaka, Nakajima, Toshiaki, Shirai, Yasumasa, and Emi, M.

Subjects
NF-kappa B, NUCLEOTIDES, IMMUNE response, CELL differentiation
Abstract

Abstract The transcriptional factor nuclear factor kappa-beta (NFKB) consists of a multicomponent protein complex that plays a major role in the regulation of many viral and cellular genes. The NFKB complex has two alternative DNA binding subunits. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the NFKB subunit 1 (NFKB1) gene located at 4q23-24. High heterozygosity (0.813) makes this polymorphism a useful marker in the genetic study of disorders affecting the immune response and cell differentiation. [ABSTRACT FROM AUTHOR]

Published
1999
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