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Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the human nuclear factor kappa-beta subunit 1 (NFKB1) locus.
- Source :
- Journal of Human Genetics; 1999, Vol. 44 Issue 2, p129, 2p
- Publication Year :
- 1999
-
Abstract
- Abstract The transcriptional factor nuclear factor kappa-beta (NFKB) consists of a multicomponent protein complex that plays a major role in the regulation of many viral and cellular genes. The NFKB complex has two alternative DNA binding subunits. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the NFKB subunit 1 (NFKB1) gene located at 4q23-24. High heterozygosity (0.813) makes this polymorphism a useful marker in the genetic study of disorders affecting the immune response and cell differentiation. [ABSTRACT FROM AUTHOR]
- Subjects :
- NF-kappa B
NUCLEOTIDES
IMMUNE response
CELL differentiation
Subjects
Details
- Language :
- English
- ISSN :
- 14345161
- Volume :
- 44
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Human Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 4688332
- Full Text :
- https://doi.org/10.1007/s100380050125