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3 results on '"IFN beta"'

1. The Italian Multiple Sclerosis Database Network (MSDN): the risk of worsening according to IFNβ exposure in multiple sclerosis.

Author

Trojano, Maria, Russo, Pierluigi, Fuiani, Aurora, Paolicelli, Damiano, Di Monte, Elisabetta, Granieri, Enrico, Rosati, Giulio, Savettieri, Giovanni, Comi, Giancarlo, and Livrea, Paolo

Subjects
*INTERFERONS, *MULTIPLE sclerosis, *REGRESSION analysis, *CLINICAL trials, *PATIENTS
Abstract

We evaluated the risk of worsening according to the length of exposure to interferon beta (IFNβ) in a large cohort of 2090 multiple sclerosis patients collected by the Italian MS Database Network. Overall 44 140 patient-visits with a follow-up of 22 143 patient-years were evaluated. Forty-one per cent of patients were exposed to IFNβ for up to 2 years, 39% for 2–4 years and 20% for more than 4 years. A Cox regression model was used to analyse two clinical outcomes: disability progression and worsening of relapse rate. The technique of propensity score was applied to reduce bias in the comparison of non-randomized groups. The risks of disability progression (HR=0.23; 95% CI: 0.17–0.30) and worsening of relapse rate (HR=0.19; 95% CI: 0.14–0.27) were reduced by about 4–5-fold in patients exposed to IFNβ for more than four years, compared with patients exposed for up to two years. The propensity score technique confirmed the findings. The proportion of days covered by IFNβ treatment was lower (p<0.0001) in patients exposed to IFNβ for up to two years than in other groups. A clinical stabilization over two years of IFNβ exposure may predict a subsequent good clinical response to treatment. [ABSTRACT FROM AUTHOR]

Published
2006
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2. Tissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes

Author

Rinse K. Weersma, Bana Jabri, Raul Aguirre-Gamboa, Sebo Withoff, Toufic Mayassi, Shixian Hu, Cezary Ciszewski, Yang Li, Maria M. Zorro, Iris Jonkers, Donatella Barisani, Cisca Wijmenga, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Molecular Neuroscience and Ageing Research (MOLAR), Department of Health and Life Sciences, Zorro, M, Aguirre-Gamboa, R, Mayassi, T, Ciszewski, C, Barisani, D, Hu, S, Weersma, R, Withoff, S, Li, Y, Wijmenga, C, Jabri, B, Jonkers, I, and CiiM, Zentrum für individualisierte Infektionsmedizin, Feodor-Lynen-Str.7, 30625 Hannover.

Subjects
0301 basic medicine, medicine.medical_treatment, Autoimmunity, Intraepithelial lymphocytes, DISEASE, Transcriptome, Tissue-resident lymphocytes, 0302 clinical medicine, Autoimmune disease, IL-21, Immunology and Allergy, Cytotoxic T cell, Alarmins, Intestinal Mucosa, Promoter Regions, Genetic, Interleukin-15, ARCHITECTURE, Interleukin, ASSOCIATION, 3. Good health, Cell biology, Cytokine, IL-15, Interleukin 15, Cytokines, EXPRESSION, SUSCEPTIBILITY LOCI, Immunology, EFFECTOR CTL, GENETIC RISK, IMMUNITY, Biology, IFN beta, Article, Tissue-resident lymphocyte, 03 medical and health sciences, medicine, Humans, Epigenetics, 030203 arthritis & rheumatology, Cytotoxic T lymphocyte, Intraepithelial lymphocyte, IDENTIFICATION, Gene Expression Profiling, medicine.disease, Inflammatory Bowel Diseases, Cytotoxic T lymphocytes, Celiac Disease, 030104 developmental biology, Gene Expression Regulation, CELLS, IFNβ, T-Lymphocytes, Cytotoxic
Abstract

The respective effects of tissue alarmins interleukin (IL)-15 and interferon beta (IFNβ), and IL-21 produced by T cells on the reprogramming of cytotoxic T lymphocytes (CTLs) that cause tissue destruction in celiac disease is poorly understood. Transcriptomic and epigenetic profiling of primary intestinal CTLs showed massive and distinct temporal transcriptional changes in response to tissue alarmins, while the impact of IL-21 was limited. Only anti-viral pathways were induced in response to all the three stimuli, albeit with differences in dynamics and strength. Moreover, changes in gene expression were primarily independent of changes in H3K27ac, suggesting that other regulatory mechanisms drive the robust transcriptional response. Finally, we found that IL-15/IFNβ/IL-21 transcriptional signatures could be linked to transcriptional alterations in risk loci for complex immune diseases. Together these results provide new insights into molecular mechanisms that fuel the activation of CTLs under conditions that emulate the inflammatory environment in patients with autoimmune diseases., Highlights • We report the epigenetic and transcriptomic response of IE-CTLs to tissue-derived alarmins and adaptive cytokine. • IL-15 and IFNβ induce massive and distinct transcriptional changes in IE-CTLs, while the impact of IL-21 was limited. • Genes associated with immune-mediated intestinal diseases are enriched in genes responding to IL-15, IFNβ and IL-21 in IE-CTLs.

Published
2019

3. Guidelines on the clinical use for the detection of neutralizing antibodies (NAbs) to IFN beta in multiple sclerosis therapy: report from the Italian Multiple Sclerosis Study group

Author

Bertolotto A, Capobianco M, Amato MP, Capello E, Capra R, Centonze D, Di Ioia M, Grimaldi L, Imberti L, Lugaresi A, Mancinelli C, Marrosu MG, Moiola L, Montanari E, Romano S, Musu L, Paolicelli D, Patti F, Pozzilli C, Rossi S, Salvetti M, Tola MR, Troiano M, Zaffaroni M, Malucchi S, Italian Multiple Sclerosis Study group, GALLO, Antonio, TEDESCHI, Gioacchino, Bertolotto A, Capobianco M, Amato MP, Capello E, Capra R, Centonze D, Di Ioia M, Gallo A, Grimaldi L, Imberti L, Lugaresi A, Mancinelli C, Marrosu MG, Moiola L, Montanari E, Romano S, Musu L, Paolicelli D, Patti F, Pozzilli C, Rossi S, Salvetti M, Tedeschi G, Tola MR, Troiano M, Zaffaroni M, Malucchi S, Bertolotto, A, Capobianco, M, Amato, Mp, Capello, E, Capra, R, Centonze, D, Di Ioia, M, Gallo, Antonio, Grimaldi, L, Imberti, L, Lugaresi, A, Mancinelli, C, Marrosu, Mg, Moiola, L, Montanari, E, Romano, S, Musu, L, Paolicelli, D, Patti, F, Pozzilli, C, Rossi, S, Salvetti, M, Tedeschi, Gioacchino, Tola, Mr, Troiano, M, Zaffaroni, M, Malucchi, S, and Italian Multiple Sclerosis Study, Group

Subjects
Myxovirus Resistance Proteins, Oncology, medicine.medical_specialty, Multiple Sclerosis, Neurology, neutralizing antibodies, guidelines, immunogenicity, ifnβ, multiple sclerosis, ifn beta, interferon, antibodies, multiple sclerosis, Dermatology, Disease activity, Multiple Sclerosis, Relapsing-Remitting, Internal medicine, medicine, Humans, Immunologic Factors, Clinical significance, Beta (finance), Randomized Controlled Trials as Topic, medicine.diagnostic_test, biology, business.industry, Multiple sclerosis, Magnetic resonance imaging, Interferon-beta, General Medicine, medicine.disease, Antibodies, Neutralizing, Magnetic Resonance Imaging, Psychiatry and Mental health, Early Diagnosis, Italy, Immunology, biology.protein, Settore MED/26 - Neurologia, Neurology (clinical), Neurosurgery, Antibody, business
Abstract

Interferon beta (IFNβ) was the first specific disease-modifying treatment licensed for relapsing-remitting multiple sclerosis, and is still one of the most commonly prescribed treatments. A strong body of evidence supports the effectiveness of IFNβ preparations in reducing the annual relapse rate, magnetic resonance (MRI) disease activity and disease progression. However, the development of binding/neutralizing antibodies (BAbs/NAbs) during treatment negatively affects clinical and MRI outcomes. Therefore, guidelines for the clinical use for the detection of NAbs in MS may result in better treatment of these patients. In October 2012, a panel of Italian neurologists from 17 MS clinics convened in Milan to review and discuss data on NAbs and their clinical relevance in the treatment of MS. In this paper, we report the panel's recommendations for the use of IFNβ Nabs detection in the early identification of IFNβ non-responsiveness and the management of patients on IFNβ treatment in Italy, according to a model of therapeutically appropriate care.

Published
2014

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