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Your search keyword '"Romero-Vecchione, Eduardo"' showing total 5 results
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5 results on '"Romero-Vecchione, Eduardo"'

1. [Cardiovascular responses to hypertonic NaCI injection into the anteroventral third ventricle region in rats with fructose-induced hypertension and insulin resistance].

Author

Rosa FJ, Romero-Vecchione E, Vásquez J, Antequera R, and Strauss M

Subjects
Animals, Fructose administration & dosage, Heart Ventricles, Hypertension chemically induced, Hypertonic Solutions, Injections, Insulin Resistance, Male, Rats, Rats, Sprague-Dawley, Cardiovascular System drug effects, Cardiovascular System physiopathology, Hypertension physiopathology, Sodium Chloride administration & dosage
Abstract

Introduction and Objectives: To investigate the hemodynamic sympathetic response evoked by NaCI microinjection into the third ventricle anteroventral brain area (AV3V) in rats long-term fed with high fructose diet., Methods: Twelve male rats received 60% fructose enriched diet for 6 months. Control rats (n=12) received regular diet., Results: Fructose diet increased (P< .01) body weight; plasma glucose, triglycerides; cholesterol, insulin; systolic (SBP) and diastolic blood pressure (DBP). Basal heart rate (HR) did not change. AV3V microinjection of 2 microL of hypertonic 1.5 M NaCI in fructose fed rats increased SBP 44.64(3.6) mm Hg, DBP 19.9(2.4) mm Hg and HR 66.2(8.4) beats/min over basal values (P< .01). In control rats, smaller responses were observed, SBP increased 28.33(3.10) mm Hg, DBP 13.0(1.9) mm Hg and HR 23.0(5.0) beats/min over basal values (P< .01)., Conclusions: Long-term fructose diet in rats induces cardiovascular hyperactivity of AV3V neurons to sodium chloride, and is associated to hypertension and insulin-resistance.

Published
2007
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2. Testosterone and nandrolone sensitization of brain anteroventral area of third ventricle to hypertonic NaCl-induced sympathetic response.

Author

Rosa F, Antequera R, Vásquez J, Romero-Vecchione E, and Martínez A

Subjects
Androgens administration & dosage, Animals, Blood Pressure drug effects, Cholesterol, HDL blood, Cholesterol, LDL blood, Drug Synergism, Heart Rate drug effects, Hypertension blood, Hypertension chemically induced, Injections, Intraventricular, Male, Nandrolone administration & dosage, Rats, Rats, Sprague-Dawley, Saline Solution, Hypertonic, Testosterone administration & dosage, Third Ventricle drug effects, Time Factors, Triglycerides blood, Androgens pharmacology, Brain drug effects, Hypertension physiopathology, Nandrolone pharmacology, Sympathetic Nervous System drug effects, Testosterone pharmacology
Abstract

Androgenic steroids increase atherogenesis, thrombogenicity and endothelial dysfunction when administered in high doses, however their effects on NaCl sensitivity of the brain anteroventral area of the third ventricle (DeltaV3V) have not been explored. Sprague-Dawley male rats were anesthetized with sodium pentobarbital (40 mg/kg) and the femoral intra-arterial blood pressure and heart rate monitored through a strain-gauge blood pressure transducer and tachograph. DeltaV3V microinjections of (2 microl) 1.5 mol/l NaCl solution were done according to brain coordinates: AP = 7.0 mm, L = 1.0 mm, D = 7.5 mm through a 0.2-mm diameter stainless steel needle. The injection site was verified with 1.0 microl neutral red solution. Basal systolic blood pressure increased 37.6 and 39.6 mm Hg after testosterone (1 mg/kg/day for 20 days) and nandrolone (1 mg/kg/day for 20 days) treatment respectively; diastolic blood pressure also increased upon testosterone and nandrolone treatment in 36.4 and 53.1 mm Hg, respectively; basal heart rate did not change. Vasopressor response to 1.5 mol/l NaCl DeltaV3V microinjection was higher in testosterone-treated rats; systolic blood pressure increased 56.0 vs. 28.3 control mm Hg; diastolic blood pressure increased 54.0 vs. 25 control mm Hg. This hypertensive response was 29% longer lasting in testosterone compared to vehicle-treated rats. The same pattern of DeltaV3V sensitization to hypertonic NaCl was observed in nandrolone-treated rats. Blood lipid profile changed to a proatherogenic fashion upon testosterone and nandrolone long-term treatment; the plasma-free testosterone concentration increased from 4.9 +/- 0.9 to 36.0 +/-7.1 pg/ml with the same testosterone treatment schedule. In conclusion, long-term androgenic steroid treatment sensitizes the brain DeltaV3V region to hypertonic NaCl which in turn conducts into a sympathetic vasopressor and heart rate-stimulating action., (Copyright (c) 2005 S. Karger AG, Basel.)

Published
2005
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3. Adrenomedulina: ¿Más que una simple hormona?

Author

Lima, Marcos M, Torres, Christopher, Rosa, Francisco, Romero-Vecchione, Eduardo, Guerra, Ernesto, and Zerpa, José

Subjects
insuficiencia renal, Adrenomedullin, hypertension, insuficiencia cardiaca, Adrenomedulina, heart failure, hipertensión, síndrome metabólico, metabolic syndrome, kidney failure
Abstract

La adrenomedulina es un péptido vasodilatador, presente en el sistema cardiovascular, riñón, pulmón, glándula adrenal y en el adipocito. Este péptido ha venido adquiriendo una importancia creciente en los últimos años, ya que se han descrito niveles elevados del mismo en patologías como el síndrome metabólico, diabetes mellitus tipo 2, hipertensión arterial y en aterosclerosis, lo cual pone de manifiesto su relevancia en la fisiopatología de estos trastornos y su posible uso como marcador de riesgo cardiometabólico. A nivel cardíaco, el efecto inotrópico positivo de este péptido parece estar mediado por un aumento del calcio citosólico, independiente de AMP cíclico; reduce la hipertrofia de los miocardiocitos y en la insuficiencia cardíaca los niveles plasmáticos de adrenomedulina están incrementados. La adrenomedulina tiene efecto vasodilatador sistémico y pulmonar y se encuentra incrementada en el plasma de sujetos con hipertensión arterial esencial y en hipertensos con hiperaldosteronismo primario. En riñón, la adrenomedulina induce efecto diurético y natriurético, aumento de la filtración glomerular y disminución de la reabsorción tubular distal de sodio; sus niveles están elevados en la insuficiencia renal crónica. La adrenomedulina está elevada en pacientes diabéticos con mal control metabólico, pero su papel patogénico en la enfermedad no está claro. Adrenomedullin is a vasodilatory peptide found in the cardiovascular system, kidneys, lungs, adrenal glands and adipocytes. This peptide has been rising interest during the last years because increased plasma levels of it have been found in several pathological conditions such as the metabolic syndrome, type 2 diabetes mellitus, arterial hypertension and atherosclerosis, pointing to a possible physiopathologic role in these diseases and the potential use as a clinical cardiometabolic marker. In the heart, adrenomedullin has a positive inotropic action, probably mediated through cytosolic increase of calcium concentration, independent of cyclic AMP; it also can reduce cardiomyocites hypertrophy. In heart failure, adrenomedullin levels are increased and show systemic and pulmonar vasodilator effect; its plasma levels are increased in patients with essential arterial hypertension and hypertensives with primary hyperaldosteronism. In the kidneys, adrenomedullin is natriuretic and diuretic, it elevates glomerular filtration rate and reduce distal tubules sodium reabsorption; in patients with renal failure, adrenomedullin levels are increased. In diabetic patients, adrenomedullin plasma levels are increased; however, its pathogenic role in this disease is not yet clear.

Published
2011

4. Adrenomedulina: ¿más que una simple hormona?

Author

Lima, Marcos Miguel, Torres, Christopher, Rosa, Francisco Javier, Romero Vecchione, Eduardo, Guerra, Ernesto, and Zerpa, José

Subjects
Síndrome metabólico, Revistas, Adrenomedulina, Kidney failure, Metabolic syndrome, Adrenomedullin, Medicina y Salud, Revista Venezolana de Endocrinología y Metabolismo, Facultad de Medicina, Hipertensión, Hypertension, Sociedad Venezolana de Endocrinología y Metabolismo, Revisiones [Revista Venezolana de Endocrinología y Metabolismo], Insuficiencia cardiaca
Abstract

La adrenomedulina es un péptido vasodilatador, presente en el sistema cardiovascular, riñón, pulmón, glándula adrenal y en el adipocito. Este péptido ha venido adquiriendo una importancia creciente en los últimos años, ya que se han descrito niveles elevados del mismo en patologías como el síndrome metabólico, diabetes mellitus tipo 2, hipertensión arterial y en aterosclerosis, lo cual pone de manifiesto su relevancia en la fisiopatología de estos trastornos y su posible uso como marcador de riesgo cardiometabólico. A nivel cardíaco, el efecto inotrópico positivo de este péptido parece estar mediado por un aumento del calcio citosólico, independiente de AMP cíclico; reduce la hipertrofia de los miocardiocitos y en la insuficiencia cardíaca los niveles plasmáticos de adrenomedulina están incrementados. La adrenomedulina tiene efecto vasodilatador sistémico y pulmonar y se encuentra incrementada en el plasma de sujetos con hipertensión arterial esencial y en hipertensos con hiperaldosteronismo primario. En riñón, la adrenomedulina induce efecto diurético y natriurético, aumento de la filtración glomerular y disminución de la reabsorción tubular distal de sodio; sus niveles están elevados en la insuficiencia renal crónica. La adrenomedulina está elevada en pacientes diabéticos con mal control metabólico, pero su papel patogénico en la enfermedad no está claro. Adrenomedullin is a vasodilatory peptide found in the cardiovascular system, kidneys, lungs, adrenal glands and adipocytes. This peptide has been rising interest during the last years because increased plasma levels of it have been found in several pathological conditions such as the metabolic syndrome, type 2 diabetes mellitus, arterial hypertension and atherosclerosis, pointing to a possible physiopathologic role in these diseases and the potential use as a clinical cardiometabolic marker. In the heart, adrenomedullin has a positive inotropic action, probably mediated through cytosolic increase of calcium concentration, independent of cyclic AMP; it also can reduce cardiomyocites hypertrophy. In heart failure, adrenomedullin levels are increased and show systemic and pulmonar vasodilator effect; its plasma levels are increased in patients with essential arterial hypertension and hypertensives with primary hyperaldosteronism. In the kidneys, adrenomedullin is natriuretic and diuretic, it elevates glomerular filtration rate and reduce distal tubules sodium reabsorption; in patients with renal failure, adrenomedullin levels are increased. In diabetic patients, adrenomedullin plasma levels are increased; however, its pathogenic role in this disease is not yet clear. 4-11 marcoslimamedical@hotmail.com

Published
2011

5. Asociación entre los Cambios en Fondo de Ojo, Disfunción Diastólica Ventricular y Microalbuminuria en Pacientes Hipertensos.

Author

López, Gabriel, Rosa, Francisco, José Pérez, María, Rodney, Henry, Mendoza, Rafael Muci, and Romero-Vecchione, Eduardo

Subjects
*PATIENTS, *HYPERTENSION, *HYPERTROPHY, *CAROTID artery, *OPHTHALMOSCOPY, *PATHOLOGY
Abstract

Hypertensive retinopathy is related to the time of exposure of the arteries to increased blood pressure, and its pattern is useful to estimate hypertensive disease evolution. The retinal arterial changes start with an initial acute vasoconstrictor phase, followed by a chronic sclerotic stage. Clinical studies have demonstrated a relationship between hypertension and left ventricle diastolic dysfunction. On the other hand, urinary albumin excretion is linked to subclinical organs damage, such as left ventricle hypertrophy and thickening of carotid artery wall; microalbuminuria is considered as a marker of morbidity and mortality in hypertensive patients. This study included 45 male hypertensive patients (blood pressure > 140/90 mm Hg, systolic/diastolic), age range 18-65 years old. Eye funduscopy and retinography was found normal in 19 (42.2%) patients hypertensive retinopathy was found in 2 (57.8%) of patients. Stage I retinopathy was found in 1 (35.5%)patients; Stage II in 9 (20.0 %) patients and Stage III in 1 (2.2%) patient. No patients showed Stage IV retinopathy. Left ventricle (LV) mass was found normal in 25 (55.6%) patients and left ventricle hypertrophy in 20 (44.4 %) of them. LV diastolic dysfunction (DD) was found in 21 (46.6%) patients; Type I DD was observed in 20 (44.4%) patients and Type II DD in only one (2.2%) case. No patients showed Type III DD. Microalbuminuria was found in 12 (26.7%) patients. When hypertensive retinopathy was matched to microalbuminuria, 19 (73.07 %) of patients did not have microalbuminuria and only 7 (26.9%) patients presented this disorder (Cramer coefficient of association= 0.007, p= 0.96). In conclusion, our findings do not demonstrate association between hypertensive retinopathy and microalbuminuria, as it has been shown in other clinical studies. [ABSTRACT FROM AUTHOR]

Published
2008

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