Back to Search
Start Over
[Cardiovascular responses to hypertonic NaCI injection into the anteroventral third ventricle region in rats with fructose-induced hypertension and insulin resistance].
- Source :
-
Revista espanola de cardiologia [Rev Esp Cardiol] 2007 Sep; Vol. 60 (9), pp. 952-8. - Publication Year :
- 2007
-
Abstract
- Introduction and Objectives: To investigate the hemodynamic sympathetic response evoked by NaCI microinjection into the third ventricle anteroventral brain area (AV3V) in rats long-term fed with high fructose diet.<br />Methods: Twelve male rats received 60% fructose enriched diet for 6 months. Control rats (n=12) received regular diet.<br />Results: Fructose diet increased (P< .01) body weight; plasma glucose, triglycerides; cholesterol, insulin; systolic (SBP) and diastolic blood pressure (DBP). Basal heart rate (HR) did not change. AV3V microinjection of 2 microL of hypertonic 1.5 M NaCI in fructose fed rats increased SBP 44.64(3.6) mm Hg, DBP 19.9(2.4) mm Hg and HR 66.2(8.4) beats/min over basal values (P< .01). In control rats, smaller responses were observed, SBP increased 28.33(3.10) mm Hg, DBP 13.0(1.9) mm Hg and HR 23.0(5.0) beats/min over basal values (P< .01).<br />Conclusions: Long-term fructose diet in rats induces cardiovascular hyperactivity of AV3V neurons to sodium chloride, and is associated to hypertension and insulin-resistance.
- Subjects :
- Animals
Fructose administration & dosage
Heart Ventricles
Hypertension chemically induced
Hypertonic Solutions
Injections
Insulin Resistance
Male
Rats
Rats, Sprague-Dawley
Cardiovascular System drug effects
Cardiovascular System physiopathology
Hypertension physiopathology
Sodium Chloride administration & dosage
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 1579-2242
- Volume :
- 60
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Revista espanola de cardiologia
- Publication Type :
- Academic Journal
- Accession number :
- 17915151
- Full Text :
- https://doi.org/10.1157/13109648