1. A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension.
- Author
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Ruilope L, Alcazar JM, Diaz VP, Jarillo MD, Millet VG, and Rodicio JL
- Subjects
- Adolescent, Adult, Aged, Amiloride adverse effects, Blood Chemical Analysis, Blood Pressure drug effects, Body Weight drug effects, Drug Therapy, Combination, Female, Gastrointestinal Diseases chemically induced, Humans, Hydrochlorothiazide adverse effects, Hyperglycemia chemically induced, Male, Middle Aged, Uric Acid blood, Amiloride administration & dosage, Hydrochlorothiazide administration & dosage, Hypertension drug therapy, Pyrazines administration & dosage
- Abstract
The combination of hydrochlorothiazide and amiloride has been used in a group of patients diagnosed as having essential hypertension. Sixty-five percent of the patients for whom dietary restrictions did not achieve a reduction in blood pressure were initially controlled with this combination; the addition of a second or third drug was required by the remaining patients. During the six-month follow-up, the control of blood pressure was satisfactory with increased drug requirements, but the diuretic had to be discontinued in 12 patients because of side effects.
- Published
- 1980