104 results on '"Xiao-ting Wu"'
Search Results
2. Inflammatory bowel diseases and the risk of adverse health outcomes: Umbrella review of meta-analyses of observational studies
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Yaping Cui, Xiaoding Shen, Xiangnan Su, Qianyi Wan, Rui Zhao, Xiao-Ting Wu, Yutao Wu, and Yong Wang
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Male ,medicine.medical_specialty ,Long Term Adverse Effects ,Disease ,Health outcomes ,Inflammatory bowel disease ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Risk Factors ,Internal medicine ,Outcome Assessment, Health Care ,medicine ,Humans ,Adverse effect ,Crohn's disease ,Hepatology ,business.industry ,Gastroenterology ,Inflammatory Bowel Diseases ,medicine.disease ,Ulcerative colitis ,Observational Studies as Topic ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Observational study ,business - Abstract
Background and Aim Accumulating evidence indicates a plausible association between inflammatory bowel diseases and the risk of adverse health outcomes. However, the conclusions are inconsistent. We aimed to perform an umbrella review of meta-analyses to appraise and grade the evidence of the association between inflammatory bowel diseases and the risk of adverse health outcomes. Methods Meta-analyses of observational studies that examined the associations between inflammatory bowel disease and the risk of adverse health outcomes in PubMed, EMBASE, and Web of Science were screened. Results This umbrella review identified 25 meta-analyses, which yielded 123 effect estimates for 60 unique putative health outcomes. Patients with inflammatory bowel diseases had a higher risk of adverse health outcomes, including multiple cancers, cardiovascular disease, adverse pregnancy outcomes, adverse oral outcomes, and other adverse events. Moreover, inflammatory bowel diseases caused greater harm to health based on the presented evidence. However, none of the evidence was classified as “high” quality, only 15% was classified as “moderate,” and 65% of outcomes were rated as “very low.” Conclusion Patients with inflammatory bowel diseases had a higher risk of adverse health outcomes and further studies should be conducted to draw firmer conclusions.
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- 2021
3. Role of Removed Lymph Nodes on the Prognosis of M0 Small-Bowel Neuroendocrine Tumors: a Propensity Score Matching Analysis from SEER Database
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Jie-Bin Xie, Yueshan Pang, Xiao-Ting Wu, and Xun Li
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Oncology ,medicine.medical_specialty ,Optimal cutoff ,Seer database ,Neuroendocrine tumors ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Propensity score matching ,medicine ,Overall survival ,Cutoff ,Humans ,Propensity Score ,Neoplasm Staging ,Retrospective Studies ,business.industry ,Gastroenterology ,Distant metastasis ,medicine.disease ,Prognosis ,SEER ,Neuroendocrine Tumors ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Surgery ,Original Article ,Lymph ,Lymph Nodes ,business ,SEER Program - Abstract
Background Current studies on the number of removed lymph nodes (LNs) and their prognostic value in small-bowel neuroendocrine tumors (SBNETs) are limited. This study aimed to clarify the prognostic value of removed LNs for SBNETs. Methods SBNET patients without distant metastasis from 2004 to 2017 in the SEER database were included. The optimal cutoff values of examined LNs (ELNs) and negative LNs (NLNs) were calculated by the X-tile software. Propensity score matching (PSM) was done to match patients 1:1 on clinicopathological characteristics between the two groups. The Kaplan-Meier method with log-rank test and multivariable Cox proportional-hazards regression model were used to evaluate the prognostic effect of removed LNs. Results The cutoff values of 14 for ELNs and 9 for NLNs could well distinguish patients with different prognoses. After 1:1 PSM, the differences in clinicopathological characteristics between the two groups were significantly reduced (all P > 0.05). Removal of more than one LN significantly improved the prognosis of the patients (P < 0.001). The number of lymphatic metastasis in the sufficiently radical resection group (SRR, 3.74 ± 3.278, ELN > 14 and NLN > 9) was significantly more than that in the insufficiently radical resection group (ISRR, 2.72 ± 3.19, ELN < 14 or NLN < 9). The 10-year overall survival (OS) of the SRR was significantly better than that of the ISRR (HR = 1.65, P = 0.001, 95% CI: 1.24–2.19). Conclusion Both ELNs and NLNs can well predict the OS of patients. Systematic removal of more than 14 LNs and more than 9 NLNs can increase the OS of SBNET patients.
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- 2021
4. Inflammatory bowel disease and risk of gastric, small bowel and colorectal cancer: a meta-analysis of 26 observational studies
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Yaping Cui, Xiaoding Shen, Yong Zhou, Qianyi Wan, Yutao Wu, Yong Wang, Xiao-Ting Wu, Lin Xia, and Rui Zhao
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0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Colorectal cancer ,Subgroup analysis ,Disease ,Gastroenterology ,Inflammatory bowel disease ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,Intestinal Neoplasms ,Intestine, Small ,medicine ,Humans ,Intestinal Cancer ,business.industry ,digestive, oral, and skin physiology ,Cancer ,General Medicine ,Inflammatory Bowel Diseases ,Prognosis ,medicine.disease ,Ulcerative colitis ,digestive system diseases ,Observational Studies as Topic ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Meta-analysis ,Colorectal Neoplasms ,business - Abstract
The purpose of this meta-analysis was to assess the associations between inflammatory bowel disease (IBD) and risk of the gastric, small bowel and colorectal cancer. We searched the PubMed and Web of Science for observational studies published before June 2020, and the quality of each included study was evaluated according to the Newcastle–Ottawa–Scale. Twenty-six studies comprising 531 449 IBD patients and more than 65 million reference individuals were included. Although IBD was significantly associated with 67% increased risk of the total gastric, small bowel and colorectal cancer. After stratifying by cancer location, IBD mainly increased the risk of intestinal cancer instead of gastric cancer. Furthermore, Crohn’s disease (CD) significantly increased the risk of both small bowel cancer and colorectal cancer, while ulcerative colitis (UC) only increased the risk of colorectal cancer. In subgroup analysis, associations between IBD and risk of total gastric, small bowel and colorectal cancer were similar between male and female, except for that male IBD patients but not female had a significantly higher risk of small bowel cancer. Additionally, IBD patients in different geographical areas had different associations with risk of various gastrointestinal tract cancers. IBD is mainly associated with increased risk of cancers in the lower gastrointestinal tract, including small bowel cancer and colorectal cancer. Because studies about the association between IBD and risk of gastric cancer and the populations in Asia are limited, more observational studies are required in the future.
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- 2021
5. Effect of laparoscopic surgery for colorectal cancer with N. O. S. E. on recovery and prognosis of patients
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Shan He, Heng-Yi Deng, Man Hu, Nian Li, Chuan-Ming Zhang, Hong-Jun Yuan, Jing Wen, Xiao-Ting Wu, and Jun Bu
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Natural Orifice Endoscopic Surgery ,Laparoscopic surgery ,medicine.medical_specialty ,Colorectal cancer ,business.industry ,medicine.medical_treatment ,Length of Stay ,Prognosis ,medicine.disease ,Natural orifice ,Surgery ,Postoperative Complications ,Treatment Outcome ,medicine.anatomical_structure ,Quality of life ,Quality of Life ,medicine ,Humans ,Laparoscopy ,Colorectal Neoplasms ,business ,Nose - Abstract
To investigate the effect of laparoscopic surgery in colorectal cancer (CRC) patients with natural orifice specimen extraction (NOSE) on the recovery and quality of life (QOL) of patients.Ninety-two eligible patients were randomly assigned into two groups: the traditional laparoscopy group (L group,A total of 46 patients in each group were enrolled in this study. The general data and surgery-related indicators were comparable between the two groups (all
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- 2020
6. Elevated matrix metalloproteinase 7 expression promotes the proliferation, motility and metastasis of tongue squamous cell carcinoma
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Bo-Hua Su, Dali Zheng, Yong Zhao, Shuo Yuan, Rui-Huan Gan, Xiao-ting Wu, Li Huang, Lisong Lin, and You-Guang Lu
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Male ,0301 basic medicine ,Cancer Research ,Proliferation ,Apoptosis ,Matrix metalloproteinase ,medicine.disease_cause ,MMP7 ,Metastasis ,Mice ,0302 clinical medicine ,Nude mouse ,Cell Movement ,Tongue cancer ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Immunohistochemistry ,Tongue Neoplasms ,Gene Expression Regulation, Neoplastic ,medicine.anatomical_structure ,Oncology ,Matrix Metalloproteinase 7 ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Female ,Research Article ,Adult ,Cell Survival ,Biology ,lcsh:RC254-282 ,03 medical and health sciences ,Tongue ,Cell Line, Tumor ,Genetics ,medicine ,Animals ,Humans ,Aged ,Cell Proliferation ,Cancer ,biology.organism_classification ,medicine.disease ,Xenograft Model Antitumor Assays ,Disease Models, Animal ,030104 developmental biology ,Cancer cell ,Cancer research ,Carcinogenesis - Abstract
BackgroundMatrix metalloproteinase 7 (MMP7), as the smallest member of the matrix metalloproteinase family, has been verified to be implicated in cancer progression, especially metastasis. However, its expression pattern and function in tongue cancer is not clear.MethodsThe expression of MMP7 in human tongue squamous cell carcinoma (TSCC) specimens compared with their respective paired nontumour tissues by real-time PCR and immunohistochemical staining. The effect of MMP7 on the proliferation, apoptosis, migration, invasion of tongue cancer cells was tested in appropriate ways after MMP7 siRNA knockdown or overexpression. The effect of MMP7 on lymph node metastasis in vivo was analyzed using a high-metastasis orthotopic nude mouse tongue transplanted tumour model.ResultsWe found markedly elevated expression of MMP7 in human TSCC specimens compared with their respective paired nontumour tissues, and this high expression was correlated with the patients’ lymph node metastasis. Furthermore, the results of molecular functional assays confirmed that MMP7 promotes cell proliferation, migration and invasion of TSCC cells. Knockdown of MMP7 inhibited lymph nodes metastasis in vivo.ConclusionsMMP7 plays an oncogenic role in carcinogenesis and metastasis of tongue cancer, and may serve as a potential therapeutic target for tongue cancer.
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- 2020
7. No Effect on Change in Fasting Ghrelin at ≤ 12 Months and Increased at ≥ 24 Months After Roux-en-Y Gastric Bypass
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Yong Wang, Xiao-Ting Wu, and Jing Chen
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Blood Glucose ,medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Endocrinology, Diabetes and Metabolism ,Gastric bypass ,Gastric Bypass ,Fasting ,medicine.disease ,Roux-en-Y anastomosis ,Gastroenterology ,Obesity ,Ghrelin ,Obesity, Morbid ,Internal medicine ,Humans ,Medicine ,Surgery ,business - Published
- 2019
8. Taxifolin suppresses the malignant progression of gastric cancer by regulating the AhR/CYP1A1 signaling pathway
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Jie-Bin Xie, Yueshan Pang, and Xiao-Ting Wu
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Male ,Cell Survival ,Pyridines ,Cell ,Mice, Nude ,taxifolin ,Cell Movement ,Stomach Neoplasms ,Cell Line, Tumor ,Cytochrome P-450 CYP1A1 ,Genetics ,medicine ,Animals ,Humans ,Neoplasm Invasiveness ,Viability assay ,Cell Proliferation ,Mice, Inbred BALB C ,Oncogene ,biology ,aryl hydrocarbon receptor ,gastric cancer ,Imidazoles ,Cancer ,Articles ,General Medicine ,Cell cycle ,invasion ,Aryl hydrocarbon receptor ,medicine.disease ,medicine.anatomical_structure ,Receptors, Aryl Hydrocarbon ,Apoptosis ,Cancer cell ,Disease Progression ,Cancer research ,biology.protein ,Quercetin ,cytochrome P450 1A1 ,Signal Transduction - Abstract
The development of novel approaches for the treatment of gastric cancer is of utmost importance. Taxifolin (Tax) has been reported to possess biological activities against a number of types of cancer. The objective of the present study was to examine the effects of Tax on gastric cancer and to explore its potential mechanisms of action. For this purpose, AGS and NCI-N87 cells, as well as BALB/c mice with gastric cancer cell-derived tumors were treated with Tax. Cell Counting Kit-8 and colony formation assays were performed to detect cell viability and proliferation, respectively. Wound-healing and Transwell assays were also conducted to determine the cell migratory and invasive abilities, respectively. Western blot analysis was performed to determine protein expression in vitro and in vivo. The results revealed that Tax significantly inhibited the viability, proliferation, migration and invasion of gastric cancer cells through the aryl hydrocarbon receptor (AhR)/cytochrome P450 1A1 (CYP1A1) signaling pathway. SB203580, an AhR agonist, partly abolished the inhibitory effects of Tax on gastric cancer cell viability, proliferation, migration and invasion. In addition, Tax also suppressed tumor growth in vivo. Collectively, the present study demonstrated that Tax significantly suppressed the tumor characteristics of gastric cancer. Tax may thus prove to be a potential therapeutic strategy for gastric cancer.
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- 2021
9. Sedatives during circulatory arrest are not necessary for aortic arch repair in acute type A aortic dissection
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Alexander O. Makkinejad, Jeffrey Clemence Jr, Elizabeth L. Norton, Linda Farhat, Xiao-Ting Wu, Daniel H. Ferman, Bo Yang, and Pei-Fang Wei
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Aortic arch ,Clinical Observations ,medicine.medical_specialty ,lcsh:Medicine ,Aorta, Thoracic ,Aortic aneurysm ,Blood Vessel Prosthesis Implantation ,Aneurysm ,medicine.artery ,medicine ,Humans ,Hypnotics and Sedatives ,Aortic dissection ,Aorta ,Aortic Aneurysm, Thoracic ,business.industry ,lcsh:R ,General Medicine ,medicine.disease ,Surgery ,Aortic Dissection ,Treatment Outcome ,Acute type ,Cardiothoracic surgery ,Circulatory system ,business - Published
- 2020
10. Zhengyuan capsule for the treatment of cancer-related fatigue in lung cancer patients undergoing operation: a study protocol for a randomized controlled trial
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Zhou-Ji, Zhang, Ming, Zhang, Xiao-Ting, Wu, Qing, Cui, and Yi-Jun, Guo
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China ,Lung Neoplasms ,Treatment Outcome ,Humans ,Prospective Studies ,Fatigue ,Randomized Controlled Trials as Topic - Abstract
To evaluate the efficacy and safety of Zhengyuan capsule () when treating Cancer-related fatigue (CRF) in lung cancer patients undergoing surgical operation.This is a single-center, double-blinded, prospective, and randomized controlled trial in the Department of Integrated Chinese and Western Medicine, Shanghai Chest Hospital Shanghai JiaoTong University, Shanghai. Eligible participants will be randomly allocated into two groups: a treatment group receiving an 8-week Zhengyuan capsule regimen therapy and a control group receiving an 8-week placebo capsule regimen therapy. Evaluation will be carried out at four timelines: the participants' screening period, baseline period, the middle of the intervention period, and the end of the intervention period. The primary outcome assessment is fatigue scoring using the Cancer Fatigue Scale (CFS) measurement system. Secondary measurements include fatigue severity assessment using the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF) measurement system, Traditional Chinese Medicine syndrome pattern differentiation, levels of immunologic indicators (TNF-α, IL-6, IL-1, T lymphocytes subsets and B lymphocyte subsets), patient's pulmonary function, performance status scale (PS), self-rating scale of sleep (SRSS), and adverse events (AEs).The trial results can provide efficacy and safety data of Zhengyuan capsule when treating CRF in clinic. The data can also be imported into the management and treatment guidelines for CRF in lung cancer patients undergoing operation throughout China.
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- 2021
11. Metabolic syndrome and the risk of colorectal cancer: a systematic review and meta-analysis
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Lihao Zhao, Xiao-Ting Wu, Rui Zhao, Xiaoding Shen, Yutao Wu, Yong Wang, and Qianyi Wan
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Oncology ,Male ,Metabolic Syndrome ,medicine.medical_specialty ,Waist ,Colorectal cancer ,business.industry ,Gastroenterology ,Hepatology ,medicine.disease ,Confidence interval ,Body Mass Index ,Risk Factors ,Internal medicine ,Meta-analysis ,Relative risk ,medicine ,Humans ,Observational study ,Female ,Metabolic syndrome ,Waist Circumference ,business ,Colorectal Neoplasms - Abstract
Observational studies have reported an association between metabolic syndrome (MetS) and colorectal cancer risk with inconsistent risk estimates. We conducted this meta-analysis to evaluate the risk of colorectal cancer in individuals with MetS. PubMed, Embase, and Web of Science were searched for related studies from database inception to 21 January 2021. Risk estimates for colorectal cancer were extracted from individual articles and pooled using a fixed-effect or random-effect model according to the heterogeneity. MetS was significantly associated with a higher risk of colorectal cancer in both sexes (relative risk [RR] 1.36, 95% confidence interval [CI] 1.26–1.47, P
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- 2021
12. Roux-en-Y Gastric Bypass Versus Sleeve Gastrectomy for Super Super Obese and Super Obese: Systematic Review and Meta-analysis of Weight Results, Comorbidity Resolution
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Yinghan Song, Yaping Cui, Xiao-Ting Wu, Rui Zhao, Jing Chen, Lin Xia, Yong Zhou, Zhiyong Rao, and Yong Wang
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medicine.medical_specialty ,Sleeve gastrectomy ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Gastric Bypass ,030209 endocrinology & metabolism ,Comorbidity ,Gastroenterology ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,Gastrectomy ,Internal medicine ,Diabetes mellitus ,Statistical significance ,Weight Loss ,Diabetes Mellitus ,medicine ,Humans ,Dyslipidemias ,Nutrition and Dietetics ,business.industry ,nutritional and metabolic diseases ,medicine.disease ,Roux-en-Y anastomosis ,Obesity, Morbid ,Treatment Outcome ,Meta-analysis ,Hypertension ,030211 gastroenterology & hepatology ,Surgery ,Complication ,business ,Dyslipidemia - Abstract
Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) used for super obesity (SO) and super super obesity (SSO) remain controversial. The meta-analysis was to summarize the evidence. We searched in MEDLINE and PubMed for studies concerning RYGB and SG for SO or SSO and pooled complication, percentage excess weight loss (%EWL), and resolution of comorbidities. Twelve studies were identified. RYGB achieved higher %EWL at 12 months, but no significant difference at 24 months. Resolution of diabetes mellitus and dyslipidemia reached a statistical significance; however, there was no significant difference in hypertension. RYGB was superior in %EWL for SSO and SO at 12 months. However, regarding at 24 months, RYGB was equal to SG, which is from a meta-analysis and cannot be seen as a definitive conclusion.
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- 2019
13. Green leafy vegetable and lutein intake and multiple health outcomes
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Chuncheng Wu, Rui Zhao, Yi Chen, Xiao-Ting Wu, Lin Xia, Mengshi Yi, Wen Zhuang, Yong Zhou, Liang Du, Yong Wang, Ni Li, Qianyi Wan, and Zhiyong Rao
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Lutein ,Physiology ,Disease ,01 natural sciences ,Analytical Chemistry ,chemistry.chemical_compound ,0404 agricultural biotechnology ,Cataracts ,Neoplasms ,Outcome Assessment, Health Care ,Vegetables ,Medicine ,Humans ,Stroke ,business.industry ,010401 analytical chemistry ,Cancer ,04 agricultural and veterinary sciences ,General Medicine ,Macular degeneration ,medicine.disease ,040401 food science ,eye diseases ,0104 chemical sciences ,Diet ,chemistry ,Cardiovascular Diseases ,Meta-analysis ,Metabolic syndrome ,business ,Food Science - Abstract
Green leafy vegetables (GLVs) are a key element of healthy eating patterns and are an important source of lutein. To clarify the evidence for associations between GLVs and lutein intake and multiple health outcomes, we performed a review. A total of 24 meta-analyses with 29 health outcomes were identified by eligibility criteria. Dose-response analyses revealed that, per 100 g/d GLV intake was associated with a decreased risk (ca. 25%) of all-cause mortality, coronary heart disease and stroke. Beneficial effects of GLV intake were found for cardiovascular disease and bladder and oral cancer. Dietary lutein intake was inversely associated with age-related macular degeneration, age-related cataracts, coronary heart disease, stroke, oesophageal cancer, non-Hodgkin lymphoma, metabolic syndrome, and amyotrophic lateral sclerosis. Caution was warranted for contamination with potentially pathogenic organisms, specifically Escherichia coli. GLV consumption and lutein intake therein are generally safe and beneficial for multiple health outcomes in humans.
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- 2021
14. Laparoscopic proximal gastrectomy with double-tract reconstruction for upper third gastric cancer
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Zhi Ding, Ping Zhao, Shuo-meng Xiao, Rui Xu, Yang Chao, and Xiao-ting Wu
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Male ,medicine.medical_specialty ,Proximal gastrectomy ,lcsh:Surgery ,Double-tract reconstruction ,Gastrectomy ,Stomach Neoplasms ,medicine ,Humans ,Operation time ,Laparoscopic proximal gastrectomy ,Aged ,Retrospective Studies ,business.industry ,Significant difference ,Cancer ,Feasibility ,lcsh:RD1-811 ,General Medicine ,Middle Aged ,Plastic Surgery Procedures ,medicine.disease ,Surgery ,Laparoscopy proximal gastrectomy ,Treatment Outcome ,Reflux oesophagitis ,Case-Control Studies ,Female ,Laparoscopy ,Open proximal gastrectomy ,Upper third ,Safety ,Gastric cancer ,business ,Hospital stay ,Research Article - Abstract
Background Proximal gastrectomy with double-tract reconstruction (DTR) has been used for upper third gastric cancer as a function-preserving procedure. However, the safety and feasibility of laparoscopic proximal gastrectomy (LPG) with DTR remain uncertain. This study compared open proximal gastrectomy (OPG) with DTR and LPG with DTR for proximal gastric cancer. Methods Sixty-four patients who had undergone OPG with DTR and forty-six patients who had undergone LPG with DTR were enrolled in this case–control study. The clinical characteristics, surgical outcomes and postoperative nutrition index were analysed retrospectively. Results The operation time was significantly longer in the LGP group than in the OPG group (258.3 min vs 205.8 min; p = 0.00). However, the time to first flatus and postoperative hospital stay were shorter in the LPG group [4.0 days vs 3.5 days (p = 0.00) and 10.6 days vs 9.2 days (p = 0.001), respectively]. No significant difference was found between the two groups in the number of retrieved lymph nodes, complications or reflux oesophagitis. The nutrition status was assessed using the haemoglobin, albumin, prealbumin and weight levels from pre-operation to six months after surgery. No significant difference was found between the groups. Conclusion LPG with DTR can be safely performed for proximal gastric cancer patients by experienced surgeons.
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- 2021
15. Effects of omega-3 polyunsaturated fatty acid supplementation in patients with obesity awaiting bariatric surgery
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Qianyi Wan, Yong Wang, Xiaoding Shen, Xiao-Ting Wu, Jing Chen, and Rui Zhao
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medicine.medical_specialty ,business.industry ,MEDLINE ,Bariatric Surgery ,medicine.disease ,Obesity ,Surgery ,Polyunsaturated fatty acid supplementation ,Dietary Supplements ,Fatty Acids, Omega-3 ,medicine ,Humans ,In patient ,business - Published
- 2021
16. Immediate vs. gradual advancement to goal of enteral nutrition after elective abdominal surgery : A multicenter non-inferiority randomized trial
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Zhida Chen, Feng Tian, Huanlong Qin, Junde Zhou, Xinying Wang, Arthur R. H. van Zanten, Yong Wang, Guoli Li, Yingchao Gu, Dong Guo, Hua Yang, Gang Jin, Fangyou Gong, Zhigang Xue, Bo Lian, Yun Tang, Jieshou Li, Yanbing Zhou, Zhenyi Jia, Yupeng Zhang, Hao Hu, Kunhua Wang, Xuejin Gao, Qiang Chi, Ning Li, Da Zhou, Tingting Gao, Mengbin Li, Yuxiu Liu, Li Zhang, Jian-Chun Yu, and Xiao-Ting Wu
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Male ,medicine.medical_specialty ,Population ,Nutritional risk ,Nutritional Status ,Critical Care and Intensive Care Medicine ,Infections ,Enteral administration ,law.invention ,Postoperative Complications ,Randomized controlled trial ,law ,Internal medicine ,Abdomen ,medicine ,Clinical endpoint ,Humans ,Dosing ,education ,Aged ,Elective abdominal surgery ,Postoperative Care ,education.field_of_study ,Cross Infection ,Nutrition and Dietetics ,business.industry ,Middle Aged ,Confidence interval ,Nutritional Biology ,Parenteral nutrition ,Elective Surgical Procedures ,Female ,business ,Energy Intake ,Enteral nutrition ,Abdominal surgery - Abstract
Background & aims: The strategy of increasing the postoperative enteral nutrition dose to the target goal has not yet been clarified. This study aimed to determine whether an immediate goal-dose enteral nutrition (IGEN) strategy is non-inferior to a gradual goal-dose enteral nutrition (GGEN) strategy in reducing infections in patients undergoing abdominal surgery involving the organs of the digestive system. Methods: This randomized controlled trial enrolled postoperative patients with nutritional risk screening 2002 scores ≥3 from 11 Chinese hospitals. Energy targets were calculated as 25 kcal/kg and 30 kcal/kg of ideal body weight for women and men, respectively. Patients were randomly assigned 1:1 to IGEN or GGEN group after enteral tolerance was confirmed (30% of the target on day 2). The IGEN group immediately started receiving 100% of the caloric requirements on day 3, while the GGEN group received 40% progressing to 80% of target on day 7. The primary endpoint was the infection rate until discharge, based on the intention-to-treat population. Results: A total of 411 patients were enrolled and randomized to the IGEN and GGEN groups, and five patients did not receive the allocated intervention. A total of 406 patients were included in the primary analysis, with 199 and 207 in the IGEN and GGEN groups, respectively. Infection was observed in 17/199 (8.5%) in the IGEN group and 19/207 (9.2%) in the GGEN group, respectively (difference, −0.6%; [95% confidence interval (CI), −6.2%–4.9%]; P = 0.009 for non-inferiority test). There were significantly more gastrointestinal intolerance events with IGEN than with GGEN (58/199 [29.1%] vs. 32/207 [15.5%], P < 0.001). All other secondary endpoints were non-significant. Conclusions: Among postoperative patients at nutritional risk, IGEN was non-inferior to GGEN in regards to infectious complications. IGEN was associated with more gastrointestinal intolerance events. It showed that IGEN cannot be considered to be clinically directive. ClinicalTrials.gov (#NCT03117348).
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- 2021
17. M1-like TAMs are required for the efficacy of PD-L1/PD-1 blockades in gastric cancer
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Yinghan Song, Yi Chen, Xiaoding Shen, Qiqi Li, Shuomeng Xiao, Rui Zhao, Lin Xia, Yutao Wu, Yong Wang, Wen Zhuang, Hanshuo Yang, Yong Zhou, Qianyi Wan, and Xiao-Ting Wu
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0301 basic medicine ,Programmed Cell Death 1 Receptor ,Immunology ,CXCR3 ,B7-H1 Antigen ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Stomach Neoplasms ,PD-L1 ,medicine ,Humans ,Immunology and Allergy ,RC254-282 ,Original Research ,biology ,CD68 ,business.industry ,Tumor-associated macrophages ,gastric cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Cancer ,RC581-607 ,Gene signature ,Prognosis ,medicine.disease ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,biology.protein ,Cancer research ,CXCL9 ,Microsatellite Instability ,PD-L1/PD-1 blockades ,Immunologic diseases. Allergy ,business ,CD163 ,Research Article - Abstract
The efficacy of PD-1/PD-L1 blockades is heterogeneous in different molecular subtypes of gastric cancer (GC). In this study, we analyzed relevant clinical trials to identify the molecular subtypes associated with the efficacy of PD-1/PD-L1 blockades, and public datasets, patient samples, and GC cell lines were used for investigating potential mechanisms. We found that GC with EBV-positive, MSI-H/dMMR, TMB-H or PIK3CA mutant subtype had enhanced efficacy of PD-L1/PD-1 blockades. Also, differentially expressed genes of these molecular subtypes shared the same gene signature and functional annotations related to immunity. Meanwhile, CIBERSORT identified that the overlapping landscapes of tumor-infiltrating immune cells in the four molecular subtypes were mainly M1-like macrophages (M1). The relationships between M1 and clinical characteristics, M1, and gene signatures associated with PD-1/PD-L1 blockades also revealed that M1 was associated with improved prognosis and required for the efficacy of PD-L1/PD-1 blockades in GC. We identified that tumor-infiltrating CD68+CD163− macrophages could represent M1 calculated by CIBERSORT in clinical application, and CXCL9, 10, 11/CXCR3 axis was involved in the mechanism of CD68+CD163− macrophages in the enhanced efficacy of PD-L1/PD-1 blockades. In conclusion, CD68+CD163− macrophages are required for the efficacy of PD-L1/PD-1 blockades and expand the applicable candidates in GC patients without the molecular subtypes.
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- 2020
18. Comparison of the incidence of cholelithiasis after sleeve gastrectomy and Roux-en-Y gastric bypass: a meta-analysis
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Xiao-Ting Wu, Yi Chen, Rui Zhao, Qianyi Wan, Yutao Wu, and Yong Wang
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medicine.medical_specialty ,Sleeve gastrectomy ,medicine.medical_treatment ,Gastric Bypass ,030209 endocrinology & metabolism ,Subgroup analysis ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Cholelithiasis ,Gastrectomy ,Internal medicine ,medicine ,Humans ,Retrospective Studies ,business.industry ,Incidence (epidemiology) ,Incidence ,nutritional and metabolic diseases ,Odds ratio ,Roux-en-Y anastomosis ,Confidence interval ,Surgery ,Obesity, Morbid ,030211 gastroenterology & hepatology ,Cholecystectomy ,business ,Cohort study - Abstract
Background Bariatric surgery could increase the risk of cholelithiasis, although it is unclear whether the incidence rates of cholelithiasis are similar after different bariatric procedures. Objectives To compare the incidence rates of cholelithiasis after sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) in people with obesity. Setting Meta-analysis of cohort studies. Methods We searched the PubMed and Web of Science databases for relevant studies before December 2020, and estimated the summary odds ratios (OR) and 95% confidence intervals (CI) using a random-effects model or fixed-effects model, according to the heterogeneity. Results In total, 8 cohort studies were included in this meta-analysis, and 94,855 and 106,844 participants received SG and RYGB, respectively. Compared with those receiving RYGB, the summary results showed that participants receiving SG had a 35% lower rate of cholelithiasis (OR, .65; 95% CI, .49–.86). Also, the participants receiving SG had a significantly lower incidence of cholecystectomy than those receiving RYGB (OR, .54; 95% CI, .30–.99). In a subgroup analysis, SG was associated with a significantly lower incidence of subsequent cholelithiasis than RYGB in both Western and non-Western countries. SG led to a significantly lower incidence of cholelithiasis than RYGB only when the follow-up was Conclusion Participants receiving SG had a significantly lower incidence of cholelithiasis than those receiving RYGB, particularly within the first 2 years after the bariatric surgery.
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- 2020
19. Comprehensive analysis of plasmid-mediated tet(X4)-positive Escherichia coli isolates from clinical settings revealed a high correlation with animals and environments-derived strains
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Qiu-Lin Jia, Jian Sun, Liang-Xing Fang, Cang Li, Chong Chen, Xiao-Ting Wu, Chao-Yue Cui, Ya-Hong Liu, Zhuo-Yu Lin, Xiao-Ping Liao, Qian He, Bo Hu, Xiao-Jie Li, and Xiao-Jing Zhang
- Subjects
Environmental Engineering ,Microbial Sensitivity Tests ,Tigecycline ,medicine.disease_cause ,Microbiology ,Plasmid ,Drug Resistance, Bacterial ,Escherichia coli ,medicine ,Animals ,Humans ,Environmental Chemistry ,Vector (molecular biology) ,Waste Management and Disposal ,Gene ,Phylogeny ,Feces ,biology ,Phylogenetic tree ,biochemical phenomena, metabolism, and nutrition ,biology.organism_classification ,Pollution ,Enterobacteriaceae ,Anti-Bacterial Agents ,Plasmids ,medicine.drug - Abstract
The emergence of novel plasmid-mediated high-level tigecycline resistance genes tet(X) in the Enterobacteriaceae has increased public health risk for treating severe bacterial infections. Despite growing reports of tet(X)-positive isolates detected in animal sources, the epidemiological association of animal- and environment-derived isolates with human-derived isolates remains unclear. Here, we performed a comprehensive analysis of tet(X4)-positive Escherichia coli isolates collected in a hospital in Guangdong province, China. A total of 48 tet(X4)-positive E. coli isolates were obtained from 1001 fecal samples. The tet(X4)-positive E. coli isolates were genetically diverse but certain strains that belonged to ST48, ST10, and ST877 etc. also have clonally transmitted. Most of the tet(X4) genes from these patient isolates were located on conjugative plasmids that were successfully transferred (64.6%) and generally coexisted with other antibiotic resistance genes including aadA, floR, blaTEM and qnrS. More importantly, we found the IncX1 type plasmid was a common vector for tet(X4) and was prevalent in these patient-derived strains (31.3%). This plasmid type has been detected in animal-derived strains from different species in different regions demonstrating its strong transmission ability and wide host range. Furthermore, phylogenetic analysis revealed that certain strains of patient and animal origin were closely related indicating that the tet(X4)-positive E. coli isolates were likely to have cross-sectorial clonal transmission between humans, animals, and farm environments. Our research greatly expands the limited epidemiological knowledge of tet(X4)-positive strains in clinical settings and provides definitive evidence for the epidemiological link between human-derived tet(X4)-positive isolates and animal-derived isolates.
- Published
- 2022
20. Application of Thromboelastography to Predict Lung Cancer Stage
- Author
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Zhouji Zhang, Xiao-Ting Wu, Ya-Ning Zhou, Kaiyan Yi, Yun Dong, Qing Cui, Ming Zhang, Yijun Guo, and Xiaoyue Cai
- Subjects
Oncology ,Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,030204 cardiovascular system & hematology ,lcsh:RC254-282 ,03 medical and health sciences ,0302 clinical medicine ,cancer stage ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Stage (cooking) ,Neoplasm Metastasis ,Lung cancer ,Whole blood ,Aged ,Neoplasm Staging ,Retrospective Studies ,Coagulation ,medicine.diagnostic_test ,business.industry ,Cancer stage ,Disease Management ,thromboelastography ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Clot formation ,lung adenocarcinoma ,Thromboelastography ,Original Article (Technical Edit) ,Thrombelastography ,lung cancer ,ROC Curve ,030220 oncology & carcinogenesis ,Female ,business - Abstract
Objective: Lung cancer is often associated with hypercoagulability. Thromboelastography provides integrated information on clot formation in whole blood. This study explored the possible relationship between thromboelastography and lung cancer. Methods: Lung cancer was staged according to the Tumor, Node, and Metastasis (TNM) classification system. Thromboelastography parameters in different stages of disease were compared. The value of thromboelastography for stage prediction was determined by area under the receiver operating characteristic curve analysis. Results: A total of 182 patients diagnosed with lung cancer were included. Thromboelastography parameters, including kinetics time, α-angle, and maximum amplitude, differed significantly between patients with metastatic and limited lung cancers ( P < 0.05). Kinetics time was significantly reduced and maximum amplitude was significantly increased in patients with stage I and II compared with stage III and IV tumors ( P < 0.05). TNM stage was significantly negatively correlated with kinetics time ( r = −0.186), and significantly positively correlated with α-angle ( r = 0.151) and maximum amplitude ( r = 0.251) (both P < 0.05). The area under the curve for kinetics time in patients with stage I cancer was 0.637 ( P < 0.05) and that for α-angle in stage ≥ II was 0.623 ( P < 0.05). The areas under the curves for maximum amplitude in stage ≥ III and stage IV cancer were 0.650 and 0.605, respectively (both P < 0.05). Thromboelastography parameters were more closely associated with TNM stage in patients with lung adenocarcinoma than in the whole lung cancer population. Conclusion: This study identified the diagnostic value of thromboelastography parameters for determining tumor stage in patients with lung cancer. Thromboelastography can be used as an independent predictive parameter for lung cancer severity.
- Published
- 2020
21. Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species
- Author
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Liang Chen, Qiu Lin Jia, Ya Hong Liu, Xi Ran Wang, Chong Chen, Xiao-Ping Liao, Yan Zhang, Min Ge Wang, Jun Jun Yu, Tang Tian, Bin Huang, Ze Hua Cui, Shi Dan Zhou, Ruan Yang Sun, Cang Li, Jian Sun, Chao Yue Cui, Yu Zhang He, Qian He, Hong Du, Xiang Guang Shen, Xiao Ting Wu, and Barry N. Kreiswirth
- Subjects
0301 basic medicine ,lcsh:Medicine ,ISCR2 ,Tigecycline ,Genetic analysis ,Flavobacteriaceae bacteria ,Acinetobacter species ,polycyclic compounds ,Genetics (clinical) ,Genetics ,biology ,Acinetobacter ,bla NDM-1 ,Anti-Bacterial Agents ,tet(X) ,Tetracyclines ,Horizontal gene transfer ,Molecular Medicine ,Flavobacteriaceae ,medicine.drug ,Ecological niches ,China ,lcsh:QH426-470 ,Tetracycline ,030106 microbiology ,Microbial Sensitivity Tests ,Evolution, Molecular ,03 medical and health sciences ,stomatognathic system ,Molecular evolution ,Tigecycline resistance ,medicine ,Animals ,Humans ,Molecular Biology ,Gene ,Genetic diversity ,Whole Genome Sequencing ,Research ,lcsh:R ,Genetic Variation ,Bayes Theorem ,biochemical phenomena, metabolism, and nutrition ,biology.organism_classification ,lcsh:Genetics ,030104 developmental biology ,Genes, Bacterial - Abstract
Background The recent emergence and dissemination of high-level mobile tigecycline resistance Tet(X) challenge the clinical effectiveness of tigecycline, one of the last-resort therapeutic options for complicated infections caused by multidrug-resistant Gram-negative and Gram-positive pathogens. Although tet(X) has been found in various bacterial species, less is known about phylogeographic distribution and phenotypic variance of different genetic variants. Methods Herein, we conducted a multiregional whole-genome sequencing study of tet(X)-positive Acinetobacter isolates from human, animal, and their surrounding environmental sources in China. The molecular and enzymatic features of tet(X) variants were characterized by clonal expression, microbial degradation, reverse transcription, and gene transfer experiments, while the tet(X) genetic diversity and molecular evolution were explored by comparative genomic and Bayesian evolutionary analyses. Results We identified 193 tet(X)-positive isolates from 3846 samples, with the prevalence ranging from 2.3 to 25.3% in nine provinces in China. The tet(X) was broadly distributed in 12 Acinetobacter species, including six novel species firstly described here. Besides tet(X3) (n = 188) and tet(X4) (n = 5), two tet(X5) variants, tet(X5.2) (n = 36) and tet(X5.3) (n = 4), were also found together with tet(X3) or tet(X4) but without additive effects on tetracyclines. These tet(X)-positive Acinetobacter spp. isolates exhibited 100% resistance rates to tigecycline and tetracycline, as well as high minimum inhibitory concentrations to eravacycline (2–8 μg/mL) and omadacycline (8–16 μg/mL). Genetic analysis revealed that different tet(X) variants shared an analogous ISCR2-mediated transposon structure. The molecular evolutionary analysis indicated that Tet(X) variants likely shared the same common ancestor with the chromosomal monooxygenases that are found in environmental Flavobacteriaceae bacteria, but sequence divergence suggested separation ~ 9900 years ago (7887 BC), presumably associated with the mobilization of tet(X)-like genes through horizontal transfer. Conclusions Four tet(X) variants were identified in this study, and they were widely distributed in multiple Acinetobacter spp. strains from various ecological niches across China. Our research also highlighted the crucial role of ISCR2 in mobilizing tet(X)-like genes between different Acinetobacter species and explored the evolutionary history of Tet(X)-like monooxygenases. Further studies are needed to evaluate the clinical impact of these mobile tigecycline resistance genes.
- Published
- 2020
22. [Microanalysis of Acetaldehyde Dehydrogenase 2 Genotype Based on SNaPShot-FCA]
- Author
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Shu-Shu, Zeng, Xiu-Feng, Gao, You, Zhang, Chuan-Rui, Feng, Ya-Xiong, Luo, Xiao-Ting, Wu, and Yong-Sheng, Li
- Subjects
Genotype ,Aldehyde Dehydrogenase, Mitochondrial ,Humans ,Sequence Analysis, DNA ,Fluorescence - Abstract
To establish SNaPShot-fluorescence capillary analysis (SNaPShot-FCA) assay for rapid detection of the genotype of aldehyde dehydrogenase 2 gene (The genomic DNA was extracted from peripheral blood cells. Using R6G-ddATP and cy5-ddGTP as fluorescent substrates, theThe optimal concentrations of R6G-ddATP and cy5-ddGTP were 1.4This study successfully established the SNaPShot-FCA for the micro-detection of
- Published
- 2019
23. Effect of Gastrointestinal Bleeding on Gastrointestinal Stromal Tumor Patients: A Retrospective Cohort Study
- Author
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Yi Chen, Yuqian Huang, Yong Zhou, Xiao-Ting Wu, Yaping Cui, Lin Xia, Rui Zhao, and Yong Wang
- Subjects
Adult ,Male ,China ,medicine.medical_specialty ,Gastrointestinal bleeding ,Adolescent ,Gastrointestinal Stromal Tumors ,Hemorrhage ,Gastroenterology ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Clinical Research ,Internal medicine ,parasitic diseases ,Biomarkers, Tumor ,Humans ,Medicine ,Stromal tumor ,Child ,Survival rate ,Aged ,Retrospective Studies ,Aged, 80 and over ,Univariate analysis ,GiST ,business.industry ,Proportional hazards model ,Retrospective cohort study ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,digestive system diseases ,Survival Rate ,Child, Preschool ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Neoplasm Recurrence, Local ,Gastrointestinal Hemorrhage ,business ,Cohort study - Abstract
BACKGROUND The contemporary risk classification criteria of gastrointestinal stromal tumors (GISTs) may still have room to improve. The aim of our research was to analyze the impact factors for GIST patients' relapse-free survival (RFS). Furthermore, we explore whether gastrointestinal (1) bleeding will be a valuable indicator to predict GIST patients' prognosis. MATERIAL AND METHODS R0 resection GISTs patients were retrospectively enrolled during an 8-year period at West China Hospital of Sichuan University, and all patients' data were from the WCHSU-GIST database. Of a total of 333 GIST patients, 164 patients had GI bleeding. Univariate analysis and Cox regression analysis were used to calculate the survival and recurrence rates. RESULTS Compared with non-GI-bleeding patients, GI-bleeding patients had a shorter relapse-free survival (RFS, P=0.003), but among the different risk groups, GI bleeding only affected the RFS rate of the high-risk group. A Cox regression analysis illustrated that tumor site (P
- Published
- 2018
24. Adjuvant imatinib for patients with high-risk gastrointestinal stromal tumors: a retrospective cohort study
- Author
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Yong Wang, Yuqian Huang, Yaping Cui, Yi Chen, Yong Zhou, Wen Zhuang, Lin Xia, Rui Zhao, and Xiao-Ting Wu
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Stromal cell ,Gastrointestinal Stromal Tumors ,medicine.medical_treatment ,lcsh:Medicine ,Kaplan-Meier Estimate ,Gastroenterology ,Article ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,lcsh:Science ,Protein Kinase Inhibitors ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Chemotherapy ,Multidisciplinary ,Tumor size ,business.industry ,Proportional hazards model ,lcsh:R ,Mitotic rate ,Retrospective cohort study ,Imatinib ,Middle Aged ,Prognosis ,030104 developmental biology ,Chemotherapy, Adjuvant ,030220 oncology & carcinogenesis ,Imatinib Mesylate ,Female ,lcsh:Q ,business ,Adjuvant ,medicine.drug - Abstract
The duration of adjuvant imatinib for high-risk patients with gastrointestinal stromal tumors (GISTs) is still controversial. Therefore, we retrospectively analyzed the data of high-risk patients with GISTs to investigate the appropriate duration. All 185 patients were divided into 4 groups: 3 years (Group D). The mean recurrence-free survival (RFS) in Groups A, B, and C were 44.3, 62.1, and 86.8 months, respectively (P P = 0.009). The 5-year RFS in Groups A, B, C, and D was 15%, 26%, 83%, and 100%, respectively (P P P P
- Published
- 2017
25. Crohn’s disease instead of UC might increase the risk of small bowel cancer
- Author
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Yutao Wu, Yong Wang, Xiaoding Shen, Rui Zhao, Yaping Cui, Xiao Ting Wu, and Qianyi Wan
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Colorectal cancer ,Disease ,Inflammatory bowel disease ,03 medical and health sciences ,0302 clinical medicine ,Crohn Disease ,Internal medicine ,Intestine, Small ,Epidemiology ,medicine ,Humans ,Crohn's disease ,business.industry ,Gastroenterology ,medicine.disease ,Ulcerative colitis ,030104 developmental biology ,Adenocarcinoma ,Colitis, Ulcerative ,030211 gastroenterology & hepatology ,Colorectal Neoplasms ,business ,Small intestine cancer - Abstract
We read with interest the study by Axelrad et al 1 which reported that Crohn’s disease (CD) and UC were associated with nearly ninefold and twofold increased risk of small bowel cancer (SBC), respectively. However, there were also two observational studies2 3 suggesting that UC was not associated with risk of SBC. Because epidemiological studies about IBD and risk of SBC were controversial, to better understand this issue, we conducted this meta-analysis. We searched the PubMed and Web of Science for relevant studies published before 1 June 2020. We included observational studies investigating the associations between IBD and risk of SBC (including adenocarcinoma, neuroendocrine tumour and sarcoma) and reporting the HR, OR or other measures of association. The pooled OR and 95% CIs were estimated with random-effect model when the significant …
- Published
- 2020
26. Different effect on improvement of renal injury in urinary albumin-creatinine ratio at different follow-up time and metabolic surgery
- Author
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Yong Wang, Xiao-Ting Wu, and Jing Chen
- Subjects
medicine.medical_specialty ,Urinary albumin ,Urology ,Bariatric Surgery ,Kidney ,chemistry.chemical_compound ,Insulin resistance ,Renal injury ,Albumins ,Diabetes mellitus ,medicine ,Albuminuria ,Humans ,Creatinine ,Adiponectin ,business.industry ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Diabetes Mellitus, Type 2 ,chemistry ,Insulin Resistance ,medicine.symptom ,business ,Follow-Up Studies - Published
- 2020
27. Tea Consumption and Health Outcomes: Umbrella Review of Meta-Analyses of Observational Studies in Humans
- Author
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Yi Chen, Lin Xia, Mengshi Yi, Liang Du, Xiao-Ting Wu, Rui Zhao, Qianyi Wan, Wen Zhuang, and Yong Zhou
- Subjects
0301 basic medicine ,Health outcomes ,law.invention ,Coronary artery disease ,03 medical and health sciences ,Cognition ,Randomized controlled trial ,Meta-Analysis as Topic ,law ,Environmental health ,Neoplasms ,medicine ,Humans ,Tea consumption ,Stroke ,030109 nutrition & dietetics ,Tea ,business.industry ,Type 2 Diabetes Mellitus ,medicine.disease ,Observational Studies as Topic ,030104 developmental biology ,Cardiovascular Diseases ,Meta-analysis ,Observational study ,business ,Publication Bias ,Food Science ,Biotechnology - Abstract
Scope The aim of this article is to conduct an umbrella review to study the strength and validity of associations between tea consumption and diverse health outcomes. Methods and results Meta-analyses of observational studies examining associations between tea consumption and health outcomes in all human populations and settings are screened. The umbrella review identifies 96 meta-analyses with 40 unique health outcomes. Tea consumption shows greater benefits than harm to health in this review. Dose-response analyses of tea consumption indicates reduced risks of total mortality, cardiac death, coronary artery disease, stroke, and type 2 diabetes mellitus with increment of two to three cups per day. Beneficial associations are also found for several cancers, skeletal, cognitive, and maternal outcomes. Harmful associations are found for esophageal and gastric cancer when the temperature of intake is more than 55-60 °C. Conclusion Tea consumption, except for very hot tea, seems generally safe at usual levels of intake, with summary estimates indicating the largest reduction for diverse health outcomes at two to three cups per day. Generally, tea consumption seems more beneficial than harmful in this umbrella review. Randomized controlled trials are further needed to understand whether the observed associations are causal.
- Published
- 2019
28. PD‐1/PD‐L1 blockade rescue exhausted CD8+ T cells in gastrointestinal stromal tumours via the PI3K/Akt/mTOR signalling pathway
- Author
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Yaping Cui, Yong Zhou, Rui Zhao, Yong Wang, Xiao-Ting Wu, Mengshi Yi, Zhigui Li, Lin Xia, Yuqian Huang, Yinghan Song, and Wen Zhuang
- Subjects
0301 basic medicine ,Gastrointestinal Stromal Tumors ,medicine.medical_treatment ,Programmed Cell Death 1 Receptor ,Apoptosis ,CD8-Positive T-Lymphocytes ,gastrointestinal stromal tumour ,B7-H1 Antigen ,03 medical and health sciences ,Interferon-gamma ,Phosphatidylinositol 3-Kinases ,0302 clinical medicine ,Lymphocytes, Tumor-Infiltrating ,PD-L1 ,Cell Line, Tumor ,medicine ,Cytotoxic T cell ,Humans ,RNA, Messenger ,RNA, Neoplasm ,Protein kinase B ,neoplasms ,PI3K/AKT/mTOR pathway ,PD‐1/PD‐L1 ,Gastrointestinal Neoplasms ,GiST ,biology ,business.industry ,TOR Serine-Threonine Kinases ,Cell Biology ,General Medicine ,Immunotherapy ,Original Articles ,Prognosis ,digestive system diseases ,Blockade ,exhausted CD8+ T cell ,030104 developmental biology ,030220 oncology & carcinogenesis ,biology.protein ,Cancer research ,Imatinib Mesylate ,Original Article ,PI3K/Akt/mTOR ,business ,Proto-Oncogene Proteins c-akt ,CD8 ,Signal Transduction - Abstract
Objectives Although targeted therapy has revolutionized the treatment of gastrointestinal stromal tumours (GIST), it is almost never curative in GIST, and resistance commonly develops. One potential strategy is to combine targeted therapy with immunotherapy. Materials and methods We first studied Programmed cell death 1 ligand 1 (PD‐L1) expression and tumour‐infiltrating T cells (TILs) in GIST. IFN‐γ was used to induce the upregulation of PD‐L1 expression in GIST‐882 cells, a well‐known GIST cell line. CD8+ T‐cell apoptosis was determined by flow cytometry. The PI3K/Akt/mTOR levels in CD8+ T cells were examined by Western blotting. Results PD‐L1 expression was an independent factor of poor prognosis in GIST and resulted in exhausted T cells in the TILs population or the blood. Then, we found that PD‐L1 blockade alone could not increase tumour cell apoptosis in GIST. The apoptosis rate of CD8+ T cells was higher when T cells were cultured with PD‐L1+ GIST‐882 cells (GIST‐882 cells with high PD‐L1 expression) than when T cells were cultured with control GIST‐882 cells. However, when the PD‐L1 blockade was used, the apoptosis rates of the CD8+ T cells in the two groups became similar. Then, Western blotting showed the PI3K/Akt/mTOR levels of the CD8+ T cells rescued by the PD‐1/PD‐L1 blockade were higher than those of the CD8+ T cells not treated with the PD‐1/PD‐L1 blockade. Conclusions PD‐L1 expression was an independent poor prognosis factor in GIST. PD‐1/PD‐L1 blockade rescued exhausted CD8+ T cells in GIST via the PI3K/Akt/mTOR signalling pathway. In GIST, PD‐1/PD‐L1 not only function as predictive biomarkers but also improve current therapies as treatment targets.
- Published
- 2019
29. Proteomic Maps of Human Gastrointestinal Stromal Tumor Subgroups
- Author
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Heng Xu, Xiao-Ting Wu, Yuqin Yao, Yanqiu Gong, Shuangqing Li, Zhiqiang Xu, Yu Liu, Zhaofen Xu, Lunzhi Dai, Yong Peng, Zhigui Li, Yong Zhou, Xuyang Xia, and Xiuxiu Jin
- Subjects
Adult ,Male ,Proteomics ,Proteome ,Gastrointestinal Stromal Tumors ,Quantitative proteomics ,Biology ,Biochemistry ,Analytical Chemistry ,Metastasis ,Transcriptome ,03 medical and health sciences ,medicine ,Humans ,Stromal tumor ,Molecular Biology ,neoplasms ,030304 developmental biology ,Aged ,0303 health sciences ,Gastrointestinal tract ,GiST ,Tumor Suppressor Proteins ,Research ,030302 biochemistry & molecular biology ,Middle Aged ,medicine.disease ,digestive system diseases ,Neoplasm Proteins ,Cancer research ,Immunohistochemistry ,Female ,Sarcoma - Abstract
Gastrointestinal stromal tumor (GIST) is a common sarcoma of gastrointestinal tract (GIT) with high metastatic and recurrence rates, but the proteomic features are still less understood. Here we performed systematic quantitative proteome profiling of GIST from 13 patients classified into very low/low, intermediate and high risk subgroups. An extended cohort of GIST (n = 131) was used for immunohistochemical validation of proteins of interest. In total, 9177 proteins were quantified, covering 55.9% of the GIT transcriptome from The Human Protein Altas. Out of the 9177 quantified proteins, 4930 proteins were observed in all 13 cases with 517 upregulated and 187 downregulated proteins in tumorous tissues independent of risk stage. Pathway analysis showed that the downregulated proteins were mostly enriched in metabolic pathway, whereas the upregulated proteins mainly belonged to spliceosome pathway. In addition, 131 proteins showed differentially expressed patterns among GIST subgroups with statistical significance. The 13 GIST cases were classified into 3 subgroups perfectly based on the expression of these proteins. The intensive comparison of molecular phenotypes and possible functions of quantified oncoproteins, tumor suppressors, phosphatases and kinases between GIST subgroups was carried out. Immunohistochemical analysis of the phosphatase PTPN1 (n = 117) revealed that the GIST patients with high PTPN1 expression had low chances of developing metastasis. Collectively, this work provides valuable information for understanding the inherent biology and evolution of GIST.
- Published
- 2019
30. Effects of the resistant starch on glucose, insulin, insulin resistance, and lipid parameters in overweight or obese adults: a systematic review and meta-analysis
- Author
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Yi Chen, Lin Xia, Yaping Cui, Zhiyong Rao, Wen Zhuang, Xiao-Ting Wu, Yong Zhou, Jing Chen, Yong Wang, Rui Zhao, and Yinghan Song
- Subjects
0301 basic medicine ,Blood Glucose ,medicine.medical_specialty ,food.ingredient ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Review Article ,Overweight ,Gastroenterology ,Fasting insulin ,03 medical and health sciences ,0302 clinical medicine ,food ,Insulin resistance ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Insulin ,Obesity ,Resistant starch ,lcsh:RC620-627 ,Nutrition ,030109 nutrition & dietetics ,business.industry ,Starch ,medicine.disease ,Lipids ,lcsh:Nutritional diseases. Deficiency diseases ,Treatment Outcome ,Meta-analysis ,Dietary Supplements ,medicine.symptom ,Insulin Resistance ,business ,Body mass index - Abstract
Background The role of resistant starch (RS) in glucose, insulin, insulin resistance or sensitivity, and lipid parameters have been reported in several studies and remained controversial. A pooled analysis which assessed these parameters has not been performed. Thus, we conducted a meta-analysis to sum up existing evidence about the issue. Methods We searched in MEDLINE and PUBMED for studies that were published before November 2018. Meta-analysis of diabetics and nondiabetics trials were performed by use of a random-effects model. Results A total of 13 case–control studies that included 428 subjects with body mass index ≥25 were identified. RS supplementation reduced fasting insulin in overall and stratified (diabetics and nondiabetics trials) analysis (SMD = –0.72; 95% CI: –1.13 to –0.31; SMD = –1.26; 95% CI: –1.66 to –0.86 and SMD = –0.64; 95% CI: –1.10 to –0.18, respectively), and reduced fasting glucose in overall and stratified analysis for diabetic trials (SMD = –0.26; 95% CI: –0.5 to –0.02 and SMD = –0.28; 95% CI: –0.54 to –0.01, respectively). RS supplementation increased HOMA-S% (SMD = 1.19; 95% CI: 0.59–1.78) and reduced HOMA-B (SMD =–1.2; 95% CI: –1.64 to –0.77), LDL-c concentration (SMD =–0.35; 95% CI: –0.61 to −0.09), and HbA1c (SMD = –0.43; 95% CI: –0.74 to –0.13) in overall analysis. Conclusions This meta-analysis has provided evidence that RS supplementation can improve fasting glucose, fasting insulin, insulin resistance and sensitivity, especially for diabetic with overweight or obesity. However, owing to potential sophistication, individual difference and composition of intestinal microbiota, this result should be carefully taken into account.
- Published
- 2018
31. Can a nickel–titanium memory-shape device serve as a substitute for the stapler in gastrointestinal anastomosis? A systematic review and meta-analysis
- Author
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Xiao-Ting Wu, Ning-Ning Li, and Wen-Tao Zhao
- Subjects
medicine.medical_specialty ,Anastomosis ,law.invention ,Eating ,03 medical and health sciences ,Postoperative Complications ,Surgical Staplers ,0302 clinical medicine ,Randomized controlled trial ,Nickel ,law ,medicine ,Flatulence ,Humans ,CLIPS ,Digestive System Surgical Procedures ,computer.programming_language ,Titanium ,business.industry ,Anastomosis, Surgical ,Length of Stay ,Confidence interval ,Surgery ,Gastrointestinal Tract ,Clinical trial ,Treatment Outcome ,030220 oncology & carcinogenesis ,Meta-analysis ,030211 gastroenterology & hepatology ,Gastrointestinal anastomosis ,medicine.symptom ,business ,computer - Abstract
Background Recently, a nickel–titanium (NiTi) memory-shape device has been successfully used in gastrointestinal anastomosis. The aim of this study was to investigate the feasibility and safety of the device. Methods Four databases, reference lists, and the World Health Organization International Clinical Trials Registry Platform were systematically searched for randomized controlled trials assessing the clinical efficacy of a NiTi memory-shape device compared with that of a stapler in gastrointestinal or colorectal anastomosis. Results Seven randomized controlled trials regarding the use of compression anastomosis clips (CACs) were enrolled for meta-analysis. The use of CACs was associated with a significant reduction in hospital duration (mean = −0.88 d; 95% confidence interval [CI], −1.38 to −0.38), the time to flatus (mean = −0.36 d; 95% CI, −0.08 to −0.04), and the start of oral intake (mean = −0.45 d; 95% CI, −0.83 to −0.06), as well as a nonsignificant change in postoperative complications and mortality. These clinical outcomes did not significantly change with the use of compression anastomosis rings. Conclusions Colonic anastomosis with a CAC is likely to reduce hospital duration, time to flatus, and the start of oral intake without influencing mortality or postoperative complications and may be a safe and preferable choice in colonic anastomosis. Further well-designed trials should be performed to determine the safety and efficacy of the newly developed compression anastomosis ring in both ileocolic and colorectal anastomosis.
- Published
- 2016
32. Dose-response meta-analysis of coffee consumption and risk of colorectal adenoma
- Author
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Yaping Cui, Yong Zhou, Zhiyong Rao, Xiao-Ting Wu, Jing Chen, Rui Zhao, Yong Wang, and Lin Xia
- Subjects
0301 basic medicine ,Adenoma ,Risk ,medicine.medical_specialty ,Colon Adenoma ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Subgroup analysis ,Colorectal adenoma ,Coffee ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,030109 nutrition & dietetics ,Nutrition and Dietetics ,business.industry ,Odds ratio ,medicine.disease ,Meta-analysis ,Relative risk ,Case-Control Studies ,Cohort ,business ,Colorectal Neoplasms ,Cohort study - Abstract
The association between coffee and colorectal adenoma risk remains controversial. We conducted a meta-analysis of cohort and case–control studies to sum up the existing proof about this matter. We searched Pubmed, Medline, and Embase for studies published before 1 September 2018 on coffee consumption and colorectal adenoma in any language. The different ORs were calculated for cohort and case–control studies in this study, and we use a random-effects model to aggregate the relative risks of individual studies and conduct dose response, heterogeneity, and publication bias. A total of 8 studies (6 case–control studies, 2 cohort studies) were identified, including 7090 subjects. In a summary analysis of all studies, high coffee intake (compared the highest with the lowest categories) was associated with a reduced risk of colorectal adenoma (odds ratio [OR] = 0.70, 95% confidence interval [CI] = 0.55–0.90). The results of subgroup analysis of adenoma location were similar with the pooled analysis, except for rectal adenoma. In the dose–response meta-analysis study, the estimated total odds ratio for increasing coffee consumption by 150 ml per day (about one cup) was 0.91 (95% CI = 0.87–0.95). The meta-analysis demonstrates possible evidence that increased coffee intake is related to a reduced risk of colon adenoma. However, because of latent confusion and different exposure classification, this finding should be carefully considered.
- Published
- 2018
33. The dynamic change of neutrophil to lymphocyte ratio can predict clinical outcome in stage I-III colon cancer
- Author
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Rui Zhao, Yaping Cui, Zhigui Li, Yong Zhou, and Xiao-Ting Wu
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Prognostic factor ,Multivariate analysis ,Neutrophils ,Colorectal cancer ,lcsh:Medicine ,Gastroenterology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Internal medicine ,parasitic diseases ,Humans ,Medicine ,Lymphocyte Count ,Lymphocytes ,Neutrophil to lymphocyte ratio ,Stage (cooking) ,lcsh:Science ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Multidisciplinary ,business.industry ,lcsh:R ,fungi ,Univariate ,Middle Aged ,medicine.disease ,Survival Analysis ,Predictive value ,030104 developmental biology ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,lcsh:Q ,Female ,business - Abstract
Whether the dynamic change of neutrophil to lymphocyte ratio (delta-NLR) can predict the outcome in various malignancies remained controversial. The delta-NLR has not been evaluated in colon cancer. Thus, we conducted the study to evaluate the predictive value of the delta-NLR in patients with colon cancer who underwent curative resection. Three-hundred and fifty-four patients with stage I-III colon cancer were retrospectively analysed. Clinicopathological features, preoperative NLR and postoperative NLR were collected. Prognostic factors were evaluated by univariate and multivariate analysis. The one, three and five-year overall survival rate in the delta-NLR P = 0.002). Univariate and multivariate analysis showed that there was a strong relationship between delta-NLR and overall survival. In conclusion, the delta-NLR was an independent prognostic factor for overall survival in early stage colon cancer. Patients with increased delta-NLR had an favourable clinical outcome.
- Published
- 2018
34. The predictive value and the correlation of peripheral absolute monocyte count, tumor-associated macrophage and microvessel density in patients with colon cancer
- Author
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Yaping Cui, Yuqian Huang, Zhigui Li, Xiao-Ting Wu, Rui Zhao, Zhaofen Xu, and Yong Zhou
- Subjects
0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Colorectal cancer ,Observational Study ,colorectal cancer ,Tumor-associated macrophage ,Gastroenterology ,Monocytes ,03 medical and health sciences ,tumor-associated macrophage ,Leukocyte Count ,Young Adult ,0302 clinical medicine ,microvessel density ,Predictive Value of Tests ,Internal medicine ,medicine ,Blood test ,Humans ,Survival rate ,Aged ,Aged, 80 and over ,Tissue microarray ,medicine.diagnostic_test ,business.industry ,Macrophages ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Immunohistochemistry ,Peripheral ,Survival Rate ,030104 developmental biology ,colon cancer ,Tissue Array Analysis ,030220 oncology & carcinogenesis ,Predictive value of tests ,monocyte ,Colonic Neoplasms ,Microvessels ,Female ,business ,Research Article - Abstract
The tumor microenvironment plays a pivotal role in cancer progression. The purpose of the present study was designed to evaluate the predictive value of peripheral absolute monocyte count, tumor-associated macrophage, microvessel density, and to clarify the correlation between them in patients with colon cancer. A series of 216 patients with colon cancer were enrolled in this study. The peripheral absolute monocyte count was obtained from preoperative routine blood test. Tumor-associated macrophage and microvessel density were assessed on tissue microarray by immunohistochemistry. The one, three, five-year overall survival rate for the low absolute monocyte count group was 98.4%, 91.1%, 87.1%, respectively; and for the high absolute monocyte count group was 94.6%, 83.7%, 77.2%, respectively (P = .046). The one, three, five-year progression-free survival rate for the low absolute monocyte count group was 94.4%, 87.1%, 85.5%, respectively; and for the high absolute monocyte count group was 90.2%, 75.0%, 73.9%, respectively (P = .024). Univariate and multivariate analysis showed that there was a strong association between peripheral monocyte count and clinical outcome. The correlation between peripheral absolute monocyte count, tumor-associated macrophage, and microvessel density were not observed. The peripheral absolute monocyte count was an independent prognostic factor for overall survival and progression-free survival in colon cancer. The high absolute monocyte count was significantly associated with poor outcome.
- Published
- 2018
35. Clinicopathological and prognostic significance of cyclin D1 amplification in patients with breast cancer: a meta-analysis
- Author
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Qi, He, Jingxun, Wu, Xin-Li, Liu, Yi-Han, Ma, Xiao-Ting, Wu, Wen-Yi, Wang, and Han-Xiang, An
- Subjects
Carcinogenesis ,Biomarkers, Tumor ,Humans ,Breast Neoplasms ,Cyclin D1 ,Female ,Prognosis ,Survival Analysis - Abstract
Cyclin D1 plays a critical role in tumorigenesis and the regulation of the G1/S transition in the cell cycle. The relationship between cyclin D1 amplification and clinicopathological parameters in patients with breast cancer remains controversial and its impact on survival outcome is not completely clear. We conducted a meta-analysis to investigate the associations between cyclin D1 gene amplification and certain clinicopathological characteristics and the prognosis in breast cancer.Literature search of PubMed (up to August 3, 2016) was performed. We used Stata 12.0 (Stata Corporation, Texas, US) to analyze the correlations between cyclin D1 amplification and clinicopathological features and the prognostic indicator relapse free survival (RFS) and overall survival (OS) in patients with breast cancer. Publication bias analysis and sensitivity analysis were performed.A total of 9,238 breast cancer patients from 21 studies were included. The pooled odds ratios (ORs) indicated that cyclin D1 amplification was significantly associated with estrogen receptor (ER), progesterone receptor (PR), histological grade and lymph node status, but not associated with human epidermal growth factor receptor-2 (HER2) and tumor size. The combined hazard ratios (HRs) for RFS and OS showed that patients with cyclin D1 amplification displayed a 1.31-fold higher risk of recurrence (HR =1.31, 95% confidence interval (95% CI):1.02-1.60, p0.01), and a risk of mortality 1.22-fold higher times greater than those without cyclin D1 amplification (HR=1.22, 95% CI:0.99- 1.44, p0.01), respectively.Our meta-analysis indicated that cyclin D1 amplification is significantly associated with established clinicopathological variables and can be used as a poor prognostic indicator for patients with breast cancer.
- Published
- 2017
36. Effects of fiber and probiotics on diarrhea associated with enteral nutrition in gastric cancer patients: A prospective randomized and controlled trial
- Author
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Lin Xia, Yaping Cui, Xiao-Ting Wu, Rui Zhao, Yuqian Huang, Yong Zhou, Zhiyong Rao, and Yong Wang
- Subjects
0301 basic medicine ,Diarrhea ,Dietary Fiber ,Male ,medicine.medical_specialty ,Treatment outcome ,Gastroenterology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Enteral Nutrition ,Randomized controlled trial ,law ,Stomach Neoplasms ,Internal medicine ,medicine ,Humans ,Postoperative Period ,Prospective Studies ,Prospective cohort study ,Aged ,030109 nutrition & dietetics ,business.industry ,Probiotics ,gastric cancer ,Cancer ,General Medicine ,Clinical Trial/Experimental Study ,Middle Aged ,medicine.disease ,Surgery ,Parenteral nutrition ,Treatment Outcome ,030211 gastroenterology & hepatology ,Female ,medicine.symptom ,Complication ,business ,Hospital stay ,Research Article ,fiber - Abstract
Background and objectives: Diarrhea is a common complication of enteral nutrition (EN), which affects recovery and prolongs the length of hospital stay (LOHS). To investigate the effect of fiber and probiotics in reducing diarrhea associated with EN in postoperative patients with gastric cancer (GC), the authors designed this prospective randomized-controlled trial. Methods and study design: This study included 120 patients with GC, and the patients were classified into 3 groups via random picking of envelopes: fiber-free nutrition formula (FF group, n = 40), fiber-enriched nutrition formula (FE group, n = 40), and fiber- and probiotic-enriched nutrition formula (FEP group, n = 40). All patients were given EN formulas for 7 consecutive days after surgery. Results: The number of diarrhea cases was higher in the FF group than in the FE group (P = .007). The FEP group had a lower number of diarrhea cases compared with the FE group (P = .003). Patients in the FE group had a significantly shorter first flatus time than the FF group (P = .002). However, no significant difference was observed between the FE group and FEP group (P = .30). Intestinal disorders were similar between the FE group and FF group (P = .38). The FEP group had a lower number of intestinal disorder cases than the FF group (P = .03). LOHS in the FE and FEP groups was shorter than that in the FF group (P = .004; P
- Published
- 2017
37. Multiple ectopic hepatocellular carcinomas in the pancreas: A case report
- Author
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Wen Peng, Zhigui Li, Chuan Li, Xiao-Ting Wu, and Tianfu Wen
- Subjects
Oncology ,Adult ,medicine.medical_specialty ,Pathology ,Carcinoma, Hepatocellular ,ectopic hepatocellular carcinomas ,Choristoma ,Metastasis ,Diagnosis, Differential ,Neoplasms, Multiple Primary ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Rare case ,medicine ,Carcinoma ,Humans ,Clinical Case Report ,pancreas ,ectopic liver ,business.industry ,Histopathological analysis ,General Medicine ,medicine.disease ,Ectopic liver ,Multiple masses ,digestive system diseases ,Pancreatic Neoplasms ,medicine.anatomical_structure ,Liver ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Female ,Good prognosis ,Pancreas ,business ,Research Article - Abstract
RATIONALE: Ectopic liver tissue can develop at various sites near the liver. Ectopic hepatocellular carcinomas (HCCs) arising from ectopic liver tissue have a rare clinical incidence. A very rare case has been observed to have metastasis after operation. PATIENT CONCERNS: We report an extremely rare case with multiple masses which were identified in the head and body of the pancreas. DIAGNOSES: Ectopic hepatocellular carcinomas. INTERVENTIONS: The masses were removed by surgical resection. Histopathological analysis showed that both masses were ectopic HCC. OUTCOMES: The patient was still alive and did not have metastasis and relapse. LESSONS: The literature review for this rare case is also presented to highlight the risk of ectopic HCC and good prognosis of operation for ectopic HCC.
- Published
- 2017
38. XRCC3 Thr241Met polymorphism and gastric cancer susceptibility: A meta-analysis
- Author
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Yi Chen, Xian-Peng Qin, Xiao-Ting Wu, Ning-Ning Li, and Yong Zhou
- Subjects
education.field_of_study ,Polymorphism, Genetic ,Genotype ,Hepatology ,business.industry ,Racial Groups ,Population ,Gastroenterology ,Exons ,Odds ratio ,Bioinformatics ,DNA-Binding Proteins ,Study heterogeneity ,XRCC3 ,Stomach Neoplasms ,Meta-analysis ,Genetic model ,Humans ,Medicine ,Genetic Predisposition to Disease ,Gene polymorphism ,business ,education - Abstract
Summary Background and objective X-ray repair cross-complementing group 3 (XRCC3) is responsible for maintaining the integrity of the genome, playing a critical role in protecting it against mutations which lead to cancer. Polymorphisms at exons 7 of the XRCC3 gene may alter the XRCC3 repair efficiency. The aim of this study is to derive a precise estimation of the relationship between XRCC3 Thr241Met polymorphism and gastric cancer (GC) risk. Methods Two investigators independently searched the databases of Pubmed, EMBASE and China National Knowledge Infrastructure (CNKI) up to May 15, 2013. Odds ratio (OR) and 95% confidence intervals (CI) for XRCC3 Thr241Met polymorphism and GC were calculated in a fixed- or random- effects model depending on statistical heterogeneity. Results This meta-analysis included 9 case-control studies, which included 2209 cases and 3269 controls. Overall, the combined results based on all studies indicated that there was no association between XRCC3 Thr241Met polymorphism and GC susceptibility for all genetic models. When stratifying for race, we found the 241Met/Met genotype carriers might be at high risk of GC among Asians, but not among Caucasians. When stratifying by the location of gastric cancer, the combined results showed that Met/Met genotype carriers might have an increased risk of GC in non-cardiac gastric cancer, but not in cardiac cancer. Conclusion This meta-analysis confirmed that the XRCC3 Thr241Met gene polymorphism might be a risk factor for GC among Asians, and that differences in genotype distribution may be related to the location of gastric cancer. More well-designed studies based on larger population are needed to confirm our results.
- Published
- 2014
39. Soy and Isoflavone Consumption and Multiple Health Outcomes: Umbrella Review of Systematic Reviews and Meta‐Analyses of Observational Studies and Randomized Trials in Humans
- Author
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Mengshi Yi, Yi Chen, Rui Zhao, Wen Zhuang, Liang Du, Ni Li, Qianyi Wan, Lin Xia, Xiao-Ting Wu, and Yong Zhou
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Disease ,Health outcomes ,law.invention ,03 medical and health sciences ,Randomized controlled trial ,law ,Neoplasms ,Internal medicine ,Humans ,Medicine ,Randomized Controlled Trials as Topic ,Consumption (economics) ,030109 nutrition & dietetics ,business.industry ,Healthy diet ,Isoflavones ,Observational Studies as Topic ,030104 developmental biology ,Systematic review ,Cardiovascular Diseases ,Meta-analysis ,Female ,Observational study ,Soybeans ,business ,Food Science ,Biotechnology - Abstract
Scope To assess the existing evidence of associations between consumption of soy and isoflavone and multiple health outcomes. Methods and results This is an umbrella review of meta-analyses and systematic reviews of randomized trials and observational studies in humans. 114 Meta-analyses and systematic reviews are identified with 43 unique outcomes. Soy and isoflavone consumption seems more beneficial than harmful for a series of health outcomes. Beneficial associations are identified for cancers, cardiovascular disease, gynecological, metabolic, musculoskeletal, endocrine, neurological, and renal outcomes, particularly in perimenopausal women. Harmful association is only found for gastric cancer (RR: 1.17, 95% CI: 1.02-1.36) for high intake of miso soup (1-5 cups per day) in male. Conclusion Generally, soy and isoflavone consumption is more beneficial than harmful. The results herein support promoting soy intake as part of a healthy diet. Randomized controlled trials are necessary to confirm this finding.
- Published
- 2019
40. CDH1 −160C>A gene polymorphism is an ethnicity-dependent risk factor for gastric cancer
- Author
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Bo Chen, Xiao-Ting Wu, Liu Liu, Yong Zhou, Xian-Peng Qin, and Ping Yang
- Subjects
medicine.medical_specialty ,Immunology ,Bioinformatics ,Polymorphism, Single Nucleotide ,Biochemistry ,Gastroenterology ,CDH1 ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,Genetic model ,Ethnicity ,Odds Ratio ,medicine ,Humans ,Immunology and Allergy ,Genetic Predisposition to Disease ,Allele ,Molecular Biology ,Alleles ,biology ,Hematology ,Odds ratio ,Publication bias ,Cadherins ,Confidence interval ,Case-Control Studies ,Meta-analysis ,biology.protein ,Gene polymorphism - Abstract
The associations between E-cadherin ( CDH1 ) gene polymorphisms and gastric cancer (GC) susceptibility are still controversial. Given this uncertainty, we carried out a meta-analysis of published case–control studies to derive more precise estimations of these relationships. Relevant studies were identified from PubMed and EMBASE up to March 2011. Seventeen studies with 3511 GC cases and 4826 controls were selected. Crude odds ratios (OR) and 95% confidence intervals (CI) were used to investigate the strength of the associations. No associations between CDH1 (+54T>C, −160C>A, −347G>GA, −616G>C, −2076C>T and −3159T>C) gene polymorphisms and GC risk for all genetic models were found. As for CDH1 −160C>A polymorphism, subgroup analyses by country, gender, study design, smoking status, Helicobacter pylori infection, and the Lauren classification of GC did not change the results. When stratified by ethnicity, we found the A allele carriers had a significantly increased risk of GC among Caucasians (AA vs . CA + CC: OR = 1.50, 95% CI = 1.03–2.19, P = 0.03), but not among Asians (AA vs . CA + CC: OR = 0.87, 95% CI = 0.56–1.37, P = 0.56). No publication bias was found in the present study. This meta-analysis suggests that CDH1 −160C>A gene polymorphism may contribute to increased risk of GC among Caucasians.
- Published
- 2011
41. Polymorphisms of XRCC1 and gastric cancer susceptibility: a meta-analysis
- Author
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Xiao-Ting Wu, Yong Zhou, Bo Chen, and Ping Yang
- Subjects
Oncology ,medicine.medical_specialty ,Helicobacter pylori infection ,Biology ,Bioinformatics ,White People ,XRCC1 ,Asian People ,Stomach Neoplasms ,Internal medicine ,Genotype ,Genetic model ,Odds Ratio ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,Molecular Biology ,Significant difference ,Cancer susceptibility ,General Medicine ,DNA-Binding Proteins ,X-ray Repair Cross Complementing Protein 1 ,Meta-analysis ,Regression Analysis ,Cohort study - Abstract
Studies investigating the association between X-ray repair cross-complementing gene 1 (XRCC1) polymorphisms and gastric cancer (GC) risk have reported conflicting results. We performed a meta-analysis of published case-control and cohort studies to better compare results between studies. Published literature from PubMed, EMBASE, and China National Knowledge Infrastructure were retrieved. 18 studies with 3,915 GC cases and 6,759 controls were selected. For XRCC1 Arg194Trp polymorphism, we only found the Trp/Trp genotype carriers might be at high risk of GC (TT vs. CC+CT: OR = 1.31, 95%CI = 1.04-1.65). When stratifying for ethnicity, the results showed there was a significant difference in genotype distribution between GC cases and controls among Asians (especially, in Chinese population), but not among Caucasians. When stratifying for control sources, significant association between Arg194Trp polymorphism and GC risk was only observed in the hospital-based controls' subgroup (TT vs. CC+CT: OR = 1.45, 95%CI = 1.13-1.87). Additionally, no significant association was detected in the gastric cardia cancer's subgroup. The results of the overall meta-analysis did not suggest any association between Arg280His/Arg399Gln polymorphisms and GC susceptibility for all genetic models. There was no evidence for the association between these two gene polymorphisms and GC risk in subgroup analyses based on study design, ethnicity, country, tumor location, Helicobacter pylori infection and the Lauren's classification of GC. In conclusion, XRCC1 Arg194Trp homozygous mutant genotype (Trp/Trp) was found to be associated with increased risk of GC.
- Published
- 2011
42. p53 Codon 72 Polymorphism and Gastric Cancer Risk in a Chinese Han Population
- Author
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Yong Zhou, Wen Zhuang, Ni Li, and Xiao-Ting Wu
- Subjects
Male ,China ,medicine.medical_specialty ,Biology ,Bioinformatics ,Gastroenterology ,Asian People ,Risk Factors ,Stomach Neoplasms ,Polymorphism (computer science) ,Internal medicine ,Genotype ,medicine ,Carcinoma ,Humans ,Codon ,Stomach cancer ,Genetics (clinical) ,Aged ,Polymorphism, Genetic ,Stomach ,Haplotype ,Cancer ,General Medicine ,Odds ratio ,Middle Aged ,Genes, p53 ,medicine.disease ,medicine.anatomical_structure ,Amino Acid Substitution ,Female - Abstract
studies investigating the association between p53 codon 72 polymorphism and gastric cancer risk report conflicting results. Our recent meta-analysis suggests that the p53 codon 72 polymorphism may be associated with gastric cancer among Asians.the objective of this study was to investigate the association between p53 codon 72 polymorphism and gastric cancer risk in Chinese Han patients.we extracted the peripheral blood samples from 150 patients with gastric cancer and 150 control subjects. Polymerase chain reaction-restriction fragment length polymorphism analysis was performed to detect p53 codon 72 polymorphism in these patients.patients with gastric cancer had a significantly lower frequency of Arg/Arg (odds ratio [OR] = 0.48, 95% confidence interval [95% CI] = 0.28, 0.80; p = 0.005) than control subjects. Patients with cardia gastric cancer had a significantly higher frequency of Pro/Pro (OR = 2.26, 95% CI = 1.12, 4.55; p = 0.02) than those with noncardia gastric cancer. Patients with advanced gastric cancer had a significantly higher frequency of Arg/Arg (OR = 2.66, 95% CI = 1.06, 6.65; p = 0.03) than those with early gastric cancer. When stratified by the Lauren's classification, histological differentiation of gastric cancer, no statistically significant result was observed.this study suggests that the p53 codon 72 polymorphism may be associated with gastric cancer in Chinese Han patients, and that difference in genotype distribution may be associated with the location and stage of gastric cancer.
- Published
- 2010
43. ERCC2 Lys751Gln and Asp312Asn polymorphisms and gastric cancer risk: a meta-analysis
- Author
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Xiao-Ting Wu, Bo Chen, Yong Zhou, and Ping Yang
- Subjects
Risk ,Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,Polymorphism, Genetic ,Genotype ,Cancer ,General Medicine ,Biology ,medicine.disease ,Asian People ,Stomach Neoplasms ,Internal medicine ,Meta-analysis ,Epidemiology ,medicine ,Humans ,ERCC2 ,Cancer risk ,Stomach cancer ,Xeroderma Pigmentosum Group D Protein ,Nucleotide excision repair - Abstract
Studies investigating the association between excision repair cross-complimentary group 2 (ERCC2) polymorphisms and gastric cancer (GC) risk have reported conflicting results. We performed a meta-analysis of published epidemiological studies to derive a more precise estimation of the relationship.Published literature from PubMed, EMBASE, and China National Knowledge Infrastructure was retrieved. Ten studies with 2,141 GC cases and 5,343 controls were selected.No association between ERCC2 Lys751Gln polymorphism and GC susceptibility for all genetic models was found. When stratified by race, we found the Gln/Gln genotype carriers might be at high risk of GC among Asians, but not among Caucasians. Also, the pooled results showed there was a significant difference in genotype distribution between non-gastric cardia cancer cases and controls. For ERCC2 Asp312Asn polymorphism, significantly elevated GC risk was associated with Asn/Asn genotype (AA vs. GG + GA: OR = 1.36, 95%CI = 1.04-1.77, P = 0.02). We also found this genotype was associated with GC susceptibility among Asians and subjects without Helicobacter pylori infection. No publication bias was found in the present study.This meta-analysis concluded that both ERCC2 Lys751Gln and Asp312Asn polymorphisms might contribute to increased risk of GC among Asians.
- Published
- 2010
44. Interleukin-10 −1082 promoter polymorphism and gastric cancer risk in a Chinese Han population
- Author
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Wen Zhuang, Xiao-Ting Wu, Wen Hu, and Yong Zhou
- Subjects
Male ,China ,medicine.medical_specialty ,Pathology ,Clinical Biochemistry ,Gastroenterology ,Asian People ,Gene Frequency ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,Genotype ,Ethnicity ,medicine ,Humans ,Genetic Predisposition to Disease ,Stage (cooking) ,Promoter Regions, Genetic ,Molecular Biology ,Allele frequency ,Polymorphism, Genetic ,business.industry ,digestive, oral, and skin physiology ,Case-control study ,Cancer ,Cell Biology ,General Medicine ,Middle Aged ,medicine.disease ,digestive system diseases ,Interleukin-10 ,Early Gastric Cancer ,Interleukin 10 ,Genetics, Population ,Case-Control Studies ,Female ,Gene polymorphism ,business - Abstract
Studies investigating the association between interleukin-10 (IL-10) -1082 promoter polymorphism and gastric cancer risk report conflicting results. Our recent meta-analysis suggests that the IL-10 -1082 promoter polymorphism may be associated with gastric cancer among Asians. The objective of this study was to investigate the association between IL-10 -1082 promoter polymorphism and gastric cancer risk in Chinese Han patients. We extracted the peripheral blood samples in 150 patients with gastric cancer and 150 controls. PCR-RFLP analysis was performed to detect IL-10 -1082 promoter polymorphism in these patients. Patients with gastric cancer had a significantly lower frequency of AA (OR = 0.45, 95% CI = 0.27, 0.76; P = 0.003) than controls. Patients with cardia gastric cancer had a significantly higher frequency of GG (OR = 2.17, 95% CI = 1.08, 4.38; P = 0.03) than those with noncardia gastric cancer. Patients with advanced gastric cancer had a significantly higher frequency of AA (OR = 5.21, 95% CI = 1.71, 15.87; P = 0.004) than those with early gastric cancer. When stratified by the Lauren's classification, histological differentiation of gastric cancer, no statistically significant results were observed. This study suggests that the IL-10 -1082 promoter polymorphism may be associated with gastric cancer in Chinese Han patients, and that difference in genotype distribution may be associated with the location and stage of gastric cancer.
- Published
- 2010
45. Glutathione S-transferase M1 Gene Polymorphism and Gastric Cancer Risk: An Updated Analysis
- Author
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Bo Chen, Xiao-Ting Wu, Ping Yang, and Yong Zhou
- Subjects
Oncology ,China ,PubMed ,medicine.medical_specialty ,Genotype ,Biology ,Bioinformatics ,Helicobacter Infections ,Asian People ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,Genetic variation ,medicine ,Humans ,Genetic Predisposition to Disease ,Allele ,Stomach cancer ,Glutathione Transferase ,Polymorphism, Genetic ,Smoking ,General Medicine ,medicine.disease ,Study heterogeneity ,Meta-analysis ,Gene polymorphism ,Cohort study - Abstract
Background and Aims Studies investigating the association between glutathione S-transferase M1 ( GSTM1 ) gene polymorphism and gastric cancer (GC) risk have reported conflicting results. In order to clarify the effect of GSTM1 genotype on the GC risk, we performed an updated meta-analysis of published case-control and cohort studies to better compare results between studies. Methods Published literature from PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) were retrieved, and the literature search was updated on June 15, 2010. 49 studies with 7746 cases of GC and 13,230 controls were selected. A fixed- or random- effects model was used to calculate pooled effect estimates depending on statistical heterogeneity. Results The combined analyses showed that there was a significant difference in genotype distribution between GC cases and controls among Asians, but not among Caucasians. Stratified analyses according to control sources also showed the positive association between GSTM1 null genotype and increased risk of GC. However, smoking and Helicobacter pylori infection did not modify the association between this polymorphism and GC susceptibility ( p = 0.56 and 0.31, respectively). When stratifying by the location, Lauren's classification, and histological differentiation of GC, we observed no statistically significant differences in genotype distribution. A strong correlation between increased GC risk and the combined GSTM1 and GSTT1 null genotype was observed. Conclusions This meta-analysis demonstrated that the GSTM1 gene polymorphism might be a risk factor for GC among Asians (especially, in some Eastern countries). Smoking, Helicobacter pylori infection status did not modify the association between GSTM1 null genotype and GC risk.
- Published
- 2010
46. Resection combined with imatinib therapy for liver metastases of gastrointestinal stromal tumors
- Author
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Xiao-Ting Wu, Lin Ji, Lin Xia, Xin Li, and Ming-Ming Zhang
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Gastrointestinal Stromal Tumors ,medicine.drug_class ,medicine.medical_treatment ,Administration, Oral ,Antineoplastic Agents ,Gastroenterology ,Piperazines ,Tyrosine-kinase inhibitor ,Surgical oncology ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Adjuvant therapy ,Hepatectomy ,Humans ,neoplasms ,Neoadjuvant therapy ,Aged ,Retrospective Studies ,Chemotherapy ,Dose-Response Relationship, Drug ,GiST ,business.industry ,Liver Neoplasms ,Imatinib ,General Medicine ,Middle Aged ,Protein-Tyrosine Kinases ,Pyrimidines ,Treatment Outcome ,Imatinib mesylate ,Chemotherapy, Adjuvant ,Benzamides ,Imatinib Mesylate ,Female ,Surgery ,business ,Follow-Up Studies ,medicine.drug - Abstract
To evaluate the effectiveness of resecting liver metastases of gastrointestinal stromal tumors (GISTs), when performed in conjunction with imatinib treatment. Forty-one patients with pathologically diagnosed GIST and liver metastases were randomly assigned to an operation group (neoadjuvant therapy + resection + adjuvant therapy with imatinib) or a nonoperation group (imatinib alone). Patients were monitored for up to 36 months, and survival was analyzed. We monitored 39 patients throughout the 36-month follow-up period, recording 1- and 3-year survival rates of 100% and 89.5% in the operation group and 85% and 60% in the nonoperation group, respectively. There was a significant difference in overall survival between the operation and nonoperation groups (P = 0.03). Furthermore, resection improved the survival of patients who responded poorly to 6 months of preoperative imatinib treatment, compared with that of their counterparts in the nonoperation group (P = 0.04). These findings suggest that surgical intervention in combination with imatinib treatment is more effective than imatinib alone against GIST liver metastases, with minimal complications and side effects.
- Published
- 2010
47. Vascular Endothelial Growth Factor (Vegf) +936 C/T Gene Polymorphisms and Gastric Cancer Risk: A Meta-Analysis Involving 4,138 Subjects
- Author
-
Yong Zhou, Wen Hu, Mao-Ling Wei, Xiao-Ting Wu, Xun Yao, Liang Du, Tai-Xiang Wu, Guan-Jian Liu, and Wen Zhuang
- Subjects
Vascular Endothelial Growth Factor A ,0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Clinical Biochemistry ,Subgroup analysis ,Bioinformatics ,Polymorphism, Single Nucleotide ,Gastroenterology ,White People ,Pathology and Forensic Medicine ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Asian People ,Risk Factors ,Stomach Neoplasms ,Internal medicine ,Humans ,Medicine ,Genetic Predisposition to Disease ,Stage (cooking) ,Genetic Association Studies ,business.industry ,Cancer ,Odds ratio ,medicine.disease ,Confidence interval ,Vascular endothelial growth factor ,Vascular endothelial growth factor A ,030104 developmental biology ,Oncology ,chemistry ,030220 oncology & carcinogenesis ,Meta-analysis ,business - Abstract
The association between vascular endothelial growth factor (VEGF) +936 C/T gene polymorphisms and gastric cancer risk is still controversial and ambiguous. The objective of our study was to investigate this association. The Medline and Embase databases were searched by two investigators. Crude odds ratios (OR) and 95% confidence intervals (CI) were used to test the association between VEGF +936 C/T polymorphisms and gastric cancer risk. Our meta-analysis comprised seven case-control studies, which included 1,893 gastric cancer cases and 2,245 controls. The combined results showed that there was no relationship between VEGF +936 C/T gene polymorphisms and gastric cancer risk (cc: OR 0.97, 95% CI 0.85, 1.11; CT: OR 1.01, 95% CI 0.88, 1.16; TT: OR 1.10, 95% CI 0.79, 1.55). Subgroup analysis by ethnicity and stage, location, and Lauren classification of gastric cancer did not change the results. This meta-analysis suggests that there is no association between VEGF +936 C/T polymorphisms and gastric cancer risk. Further studies should pay attention to other potentially functional SNPs.
- Published
- 2010
48. N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride nanoparticle as a novel delivery system for Parathyroid Hormone-Related Protein 1–34
- Author
-
Yu-min Du, Xiao-ting Wu, Ling Yu, Weichun Guo, Jin Tang, and Sheng-hao Zhao
- Subjects
Magnetic Resonance Spectroscopy ,Surface Properties ,Chemistry, Pharmaceutical ,Drug Compounding ,Sodium ,Pharmaceutical Science ,Nanoparticle ,chemistry.chemical_element ,Chitin ,Chloride ,Chitosan ,chemistry.chemical_compound ,Microscopy, Electron, Transmission ,Spectroscopy, Fourier Transform Infrared ,medicine ,Humans ,Technology, Pharmaceutical ,Ammonium ,Particle Size ,Microparticle ,Drug Carriers ,Bone Density Conservation Agents ,Parathyroid Hormone-Related Protein ,Water ,Peptide Fragments ,Quaternary Ammonium Compounds ,Kinetics ,Solubility ,chemistry ,Biochemistry ,Delayed-Action Preparations ,Nanoparticles ,Osteoporosis ,Ammonium chloride ,Particle size ,Nuclear chemistry ,medicine.drug - Abstract
Chitosan (CS) and epoxy propyl trimethyl ammonium chloride (EPTAC) were used to prepare the water-soluble N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (HTCC). HTCC and sodium tripolyphosphate (TPP) were mixed to form HTCC nanoparticles based on ionic gelation. Parathyroid Hormone-Related Protein 1–34 (PTHrP1–34) was incorporated into the HTCC nanoparticles. The particle size and morphology of nanoparticles were determined by transmission electron microscopy (TEM). HTCC/PTHrP1–34 nanoparticles were 100–180 nm in size and their encapsulation efficiency and loading capacity were related to HTCC concentration, TPP concentration and initial concentration of PTHrP1–34. Relatively optimum encapsulation efficiency (78.4%) and loading capacity (13.7%) of PTHrP1–34 is achieved, and the in vitro release profile of PTHrP1–34 from nanoparticles has an initial burst, which is followed up by a slow release phase. These studies showed that HTCC/PTHrP1–34 nanoparticles are suitable for the treatment of osteoporosis, because of their slow-continuous-release properties, and the relevant in vivo experiments and clinical trials should be further studied.
- Published
- 2010
49. Genetic polymorphism of glutathione S-transferase T1 and the risk of colorectal cancer: A meta-analysis
- Author
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Xiao-Ting Wu, Bo Chen, Gui-Qing Jia, Ping Yang, Hong-Wei Wan, and Yong Zhou
- Subjects
Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,Epidemiology ,Colorectal cancer ,Rectum ,Glutathione-S-Transferase T1 ,Risk Factors ,Internal medicine ,Genotype ,medicine ,Humans ,Aged ,Glutathione Transferase ,Polymorphism, Genetic ,business.industry ,Odds ratio ,Middle Aged ,medicine.disease ,Confidence interval ,medicine.anatomical_structure ,Meta-analysis ,Observational study ,Colorectal Neoplasms ,business - Abstract
Background : Studies investigating the association between genetic polymorphism of glutathione S-transferase T1 (GSTT1) and risk of colorectal cancer have reported conflicting results. In order to clarify the effect of GSTT1 polymorphism on the risk of developing colorectal cancer, we carried out a meta-analysis using published data to obtain more precise estimates of risk. Methods : Electronic searches of PubMed and EMBASE were conducted to select studies for this meta-analysis. Papers were included if they were observational studies investigating the association between GSTT1 polymorphism and colorectal cancer risk. The principal outcome measure was the odds ratio (OR) with 95% confidence interval (CI) for the risk of colorectal cancer associated with GSTT1 null genotype. Results : We identified 30 eligible studies, which included 7635 cases and 12,911 controls. The combined results based on all studies showed that there was a statistically significant link between GSTT1 null genotype and colorectal cancer risk (OR=1.20, 95% CI=1.03–1.40). In the analysis of ethnic groups, we observed distinct differences associated with GSTT1 null genotype, the pooled odds ratios for the GSTT1 polymorphism were 1.32 in Caucasians (95% CI=1.09–1.58) and 1.03 in Asians (95% CI=0.81–1.32). As far as concerned the interaction between GSTT1 genotype and colorectal cancer risk in relation to smoking history, there was no increase in risk for smokers or nonsmokers with the GSTT1 null genotype (smokers: OR=1.13, 95% CI=0.80–1.60, nonsmokers: OR=0.99, 95% CI=0.71–1.38). When stratifying by the location of colorectal cancer, we found that there was a statistically significant link in rectal cancer (OR=1.50, 95% CI=1.09–2.07), but not in colon cancer (OR=1.33, 95% CI=0.94–1.88). No associations could be detected between null GSTT1 polymorphism and age, sex, tumor stage and differentiation. Conclusion : Our current study demonstrates that GSTT1 null genotype is associated with an increased risk of colorectal cancer, specifically, among Caucasians.
- Published
- 2010
50. Glutathione S-Transferase T1 (GSTT1) Gene Polymorphism and Gastric Cancer Susceptibility: A Meta-Analysis of Epidemiologic Studies
- Author
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Hong-Wei Wan, Yong Zhou, Gui-Qing Jia, Xiao-Ting Wu, Lei Cao, Liu Liu, Ping Yang, and Bo Chen
- Subjects
Male ,Asia ,Physiology ,Bioinformatics ,Risk Assessment ,White People ,chemistry.chemical_compound ,Asian People ,GSTT1 Gene ,Stomach Neoplasms ,Genotype ,Humans ,Medicine ,Genetic Predisposition to Disease ,Stomach cancer ,Glutathione Transferase ,Genetics ,Polymorphism, Genetic ,business.industry ,Incidence ,Gastroenterology ,Case-control study ,Cancer ,Glutathione ,Prognosis ,medicine.disease ,Survival Analysis ,United States ,Europe ,Gene Expression Regulation, Neoplastic ,chemistry ,Case-Control Studies ,Meta-analysis ,Female ,Gene polymorphism ,business - Abstract
Studies investigating the association between genetic polymorphism of glutathione S-transferase T1 (GSTT1) and gastric cancer risk have reported conflicting results. Therefore, we conducted this meta-analysis to provide more precise evidence.We searched the databases Medline, PubMed, Embase, and China National Knowledge Infrastructure up to July 30, 2009. Thirty-six studies with 4,357 gastric cancer cases and 9,796 controls were selected. Odds ratio (OR) and 95% confidence intervals (CI) were calculated based on fixed- and random-effects models.The combined results based on all studies showed there was a significant link between GSTT1 null genotype and gastric cancer risk (OR = 1.14, 95%CI = 1.01-1.28). In subgroup analysis stratified on the basis of ethnic group, we also observed positive association between GSTT1 polymorphism and gastric cancer risk among Caucasians (non-Europeans + non-Americans), but not among East Asians. When stratifying by control source, the overall ORs for population- and hospital-based studies were 1.09 (95%CI = 0.94-1.28) and 1.17 (95%CI = 1.03-1.34), respectively. Subjects with both GSTM1 and GSTT1 negative genotypes had increased gastric cancer risk compared with those who had nonnull genotypes of both GST genes. Subgroup analyses for Helicobacter pylori infection and smoking habit did not reveal any significant association between GSTT1 polymorphism and gastric cancer development.This meta-analysis suggests that GSTT1 gene polymorphism may be not associated with increased gastric cancer risk among Europeans, Americans, and East Asians. More large-scale studies based on the same racial group are needed.
- Published
- 2009
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