Back to Search
Start Over
N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride nanoparticle as a novel delivery system for Parathyroid Hormone-Related Protein 1–34
- Source :
- International Journal of Pharmaceutics. 393:269-273
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Chitosan (CS) and epoxy propyl trimethyl ammonium chloride (EPTAC) were used to prepare the water-soluble N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (HTCC). HTCC and sodium tripolyphosphate (TPP) were mixed to form HTCC nanoparticles based on ionic gelation. Parathyroid Hormone-Related Protein 1–34 (PTHrP1–34) was incorporated into the HTCC nanoparticles. The particle size and morphology of nanoparticles were determined by transmission electron microscopy (TEM). HTCC/PTHrP1–34 nanoparticles were 100–180 nm in size and their encapsulation efficiency and loading capacity were related to HTCC concentration, TPP concentration and initial concentration of PTHrP1–34. Relatively optimum encapsulation efficiency (78.4%) and loading capacity (13.7%) of PTHrP1–34 is achieved, and the in vitro release profile of PTHrP1–34 from nanoparticles has an initial burst, which is followed up by a slow release phase. These studies showed that HTCC/PTHrP1–34 nanoparticles are suitable for the treatment of osteoporosis, because of their slow-continuous-release properties, and the relevant in vivo experiments and clinical trials should be further studied.
- Subjects :
- Magnetic Resonance Spectroscopy
Surface Properties
Chemistry, Pharmaceutical
Drug Compounding
Sodium
Pharmaceutical Science
Nanoparticle
chemistry.chemical_element
Chitin
Chloride
Chitosan
chemistry.chemical_compound
Microscopy, Electron, Transmission
Spectroscopy, Fourier Transform Infrared
medicine
Humans
Technology, Pharmaceutical
Ammonium
Particle Size
Microparticle
Drug Carriers
Bone Density Conservation Agents
Parathyroid Hormone-Related Protein
Water
Peptide Fragments
Quaternary Ammonium Compounds
Kinetics
Solubility
chemistry
Biochemistry
Delayed-Action Preparations
Nanoparticles
Osteoporosis
Ammonium chloride
Particle size
Nuclear chemistry
medicine.drug
Subjects
Details
- ISSN :
- 03785173
- Volume :
- 393
- Database :
- OpenAIRE
- Journal :
- International Journal of Pharmaceutics
- Accession number :
- edsair.doi.dedup.....e74e7f275afef97c5c630ab159011b41