Author: "Norifumi, Hino" / Topic: humans - Searchworks@Jio Institute Digital Library Search Results

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Author: Satoshi, Mori, Yongping, Cao, Takahisa, Yamadab, Kenichi, Sogawa, Kazuya, Kondo, Norifumi, Hino, Tatsuhiko, Miyazaki, Yoji, Kawaguchi, Shiro, Oka, Kojiro, Kawasaki, Tasuku, Mashiba, and Hiromichi, Norimatsu
Subjects: Osteosarcoma, Chondrosarcoma, Phosphoprotein Phosphatases, Humans, Sarcoma, Ewing, Phosphorylation, Telomerase
Abstract: We previously reported that PP1gamma1 is highly expressed in osteosarcoma and chondrosarcoma, and suggested that this protein plays a role in malignancy of osteogenic tumors. In this study, we investigated the correlation of the expression of PP1gamma1 with telomerase activity. PP2A protein was not positive in any of the 5 cases of Ewing's sarcoma, but PP1gamma1 protein was strongly positive in all cases. Furthermore, malignant cells had high telomerase activity. We investigated the correlation of the expression of PP1gamma1 with telomerase activity, and showed that telomerase activity is regulated by protein phosphorylation in Ewing's sarcoma cells.
Published: 2005

Author: Satoshi, Mori, Yongping, Cao, Kenichi, Sogawa, Kazuya, Kondo, Tohru, Sakai, Norifumi, Hino, Hisakazu, Yamashiro, Masanao, Okada, Kazuo, Miyamoto, Yoji, Kawaguchi, Tasuku, Mashiba, and Hiromichi, Norimatsu
Subjects: Histones, Alzheimer Disease, Case-Control Studies, Phosphotransferases, Phosphoprotein Phosphatases, Humans, Protein Phosphatase 2, Phosphorylation
Abstract: In this study, we analyzed high expression of protein phosphatase (PP) 2A in Alzheimer's disease brain compared to that of the control brain, which result from hyperphosphorylation of histone H1. PP1alpha and PP1gamma1 were slightly expressed in all cases, but there was no relation to the levels of the phosphate in histone H1.
Published: 2005

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