1. Carbon-ion Radiotherapy for Inoperable Head and Neck Bone and Soft-tissue Sarcoma: Prospective Observational Study
- Author
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Atsushi, Musha, Nobuteru, Kubo, Hidemasa, Kawamura, Naoko, Okano, Hiro, Sato, Kohei, Okada, Naoto, Osu, Hikaru, Yumisaki, Akiko, Adachi, Yukihiro, Takayasu, Masato, Shino, Osamu, Nikkuni, Shota, Ida, Katsuyuki, Shirai, Jun-Ichi, Saitoh, Satoshi, Yokoo, Kazuaki, Chikamatsu, and Tatsuya, Ohno
- Subjects
Adult ,Male ,Osteosarcoma ,Cancer Research ,Time Factors ,Heavy Ion Radiotherapy ,Sarcoma ,General Medicine ,Middle Aged ,Radiation Dosage ,Progression-Free Survival ,Young Adult ,Oncology ,Head and Neck Neoplasms ,Humans ,Female ,Prospective Studies ,Aged - Abstract
Bone and soft-tissue sarcomas of the head and neck have very poor prognoses. This prospective study aimed to investigate the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for bone and soft-tissue sarcoma of the head and neck.The present study was a prospective clinical study that included 10 consecutive patients diagnosed with bone and soft-tissue sarcoma of the head and neck who were treated with C-ion RT between 2012 and 2018 at our institution. C-Ion RT consisted of 70.4 Gy (relative biological effectiveness) in 16 fractions.The 3-year local control, overall survival, and progression-free survival rates for patients overall were 72.9%, 77.8%, and 36%, respectively.The present study demonstrated the efficacy of C-ion RT for bone and soft-tissue sarcoma of the head and neck; adverse events were within the expected range.
- Published
- 2022