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Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer
- Source :
- British Journal of Cancer
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- Background: Amino-acid transporters are necessary for the tumour cell growth and survival, and have a crucial role in the development and invasiveness of cancer cells. But, it remains unclear about the prognostic significance of L-type amino-acid transporter 1 (LAT1), system ASC amino-acid transporter-2 (ASCT2), and xCT expression in patients with tongue cancer. We conducted the clinicopathological study to investigate the protein expression of these amino-acid transporters in tongue cancer. Methods: Eighty-five patients with surgically resected tongue cancer were evaluated. Tumour sections were stained by immunohistochemistry for LAT1, ASCT2, xCT, 4F2hc/CD98hc (4F2hc), Ki-67, and microvessel density (MVD) determined by CD34, and p53. Results: L-type amino-acid transporter 1 and 4F2hc were highly expressed in 61% (52 out of 85) and 45% (38 out of 47), respectively. ASC amino-acid transporter-2 and xCT were positively expressed in 59% (50 out of 85) and 21% (18 out of 85), respectively. The expression of both LAT1 and ASCT2 was significantly associated with disease staging, lymph-node metastasis, lymphatic permeation, 4F2hc expression and cell proliferation (Ki-67). xCT expression indicated a significant association with advanced stage and tumour factor. By univariate analysis, disease staging, lymphatic permeation, vascular invasion, LAT1, ASCT2, 4F2hc, and Ki-67 had a significant relationship with overall survival. Multivariate analysis confirmed that LAT1 was an independent prognostic factor for predicting poor prognosis. Conclusions: L-type amino-acid transporter 1 and ASCT2 can serve as a significant prognostic factor for predicting worse outcome after surgical treatment and may have an important role in the development and aggressiveness of tongue cancer.
- Subjects :
- Male
Cancer Research
Pathology
Docetaxel
Kaplan-Meier Estimate
Metastasis
Antineoplastic Combined Chemotherapy Protocols
prognostic factor
Aged, 80 and over
tongue cancer
Middle Aged
Prognosis
Combined Modality Therapy
ASCT2
Neoplasm Proteins
Tongue Neoplasms
Drug Combinations
Treatment Outcome
Lymphatic system
medicine.anatomical_structure
Oncology
Chemotherapy, Adjuvant
Lymphatic Metastasis
Carcinoma, Squamous Cell
Immunohistochemistry
Female
Taxoids
Adult
Amino Acid Transport System ASC
medicine.medical_specialty
Amino Acid Transport System y+
Fusion Regulatory Protein 1, Heavy Chain
Biology
Disease-Free Survival
Large Neutral Amino Acid-Transporter 1
Minor Histocompatibility Antigens
Tongue
Biomarkers, Tumor
Carcinoma
medicine
Humans
Tongue Neoplasm
Molecular Diagnostics
Aged
Neoplasm Staging
Tegafur
xCT
Cancer
medicine.disease
LAT1
Oxonic Acid
Ki-67 Antigen
Cancer cell
Tumor Suppressor Protein p53
Subjects
Details
- ISSN :
- 15321827 and 00070920
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....e3e1def0fa2338c5e42bb4440312f93f