1. Imaging the effect of ketamine on synaptic density (SV2A) in the living brain
- Author
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Sophie E. Holmes, Sjoerd J. Finnema, Mika Naganawa, Nicole DellaGioia, Daniel Holden, Krista Fowles, Margaret Davis, Jim Ropchan, Paul Emory, Yunpeng Ye, Nabeel Nabulsi, David Matuskey, Gustavo A. Angarita, Robert H. Pietrzak, Ronald S. Duman, Gerard Sanacora, John H. Krystal, Richard E. Carson, and Irina Esterlis
- Subjects
Depressive Disorder, Major ,Cellular and Molecular Neuroscience ,Psychiatry and Mental health ,Membrane Glycoproteins ,Positron-Emission Tomography ,Animals ,Brain ,Humans ,Ketamine ,Nerve Tissue Proteins ,Macaca mulatta ,Molecular Biology ,Antidepressive Agents - Abstract
The discovery of ketamine as a rapid and robust antidepressant marks the beginning of a new era in the treatment of psychiatric disorders. Ketamine is thought to produce rapid and sustained antidepressant effects through restoration of lost synaptic connections. We investigated this hypothesis in humans for the first time using positron emission tomography (PET) and [
- Published
- 2022