Back to Search
Start Over
Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging
- Source :
- Annals of Neurology
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Objective Parkinson disease is characterized by motor and nonmotor symptoms, reduced striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now known that the pathological process in Parkinson disease may begin decades before the clinical diagnosis and include a variety of neuronal alterations in addition to the dopamine system. Methods This study examined the density of all synapses with synaptic vesicle glycoprotein 2A (SV2A) in Parkinson disease subjects with mild bilateral disease (n = 12) and matched normal controls (n = 12) using in vivo high‐resolution positron emission tomographic imaging as well as postmortem autoradiography in an independent sample with Parkinson disease (n = 15) and normal controls (n = 13) in the substantia nigra and putamen. Results A group‐by‐brain region interaction effect (F 10, 22 = 3.52, p = 0.007) was observed in the primary brain areas with in vivo SV2A binding. Post hoc analyses revealed that the Parkinson disease group exhibited lower SV2A in the substantia nigra (−45%; p
- Subjects :
- Male
0301 basic medicine
Pathology
medicine.medical_specialty
Pyrrolidines
Pyridines
Red nucleus
Nerve Tissue Proteins
Substantia nigra
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Dopamine
Humans
Medicine
Research Articles
Red Nucleus
SV2A
Membrane Glycoproteins
business.industry
Functional Neuroimaging
Putamen
Parkinson Disease
Middle Aged
3. Good health
Substantia Nigra
Early Diagnosis
030104 developmental biology
nervous system
Neurology
Case-Control Studies
Positron-Emission Tomography
Synapses
Autoradiography
Locus coeruleus
Female
Locus Coeruleus
Neurology (clinical)
Brainstem
business
030217 neurology & neurosurgery
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 15318249 and 03645134
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Annals of Neurology
- Accession number :
- edsair.doi.dedup.....1de6aaf38d4fec52872144d7772cc873