1. Liver transplant complications in hepatitis C infected recipients: recurrence versus rejection
- Author
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Daniel G. Maluf, Jihee L. Suh, Valeria R. Mas, and Ricardo C. Gehrau
- Subjects
Genetic Markers ,Graft Rejection ,medicine.medical_specialty ,medicine.medical_treatment ,Disease ,Liver transplantation ,Diagnosis, Differential ,Predictive Value of Tests ,Recurrence ,Transplant complications ,medicine ,Humans ,Disease biomarker ,Biomarker discovery ,Intensive care medicine ,Hepatology ,business.industry ,Gastroenterology ,Hcv recurrence ,Hepatitis C ,medicine.disease ,Liver Transplantation ,Treatment Outcome ,Molecular Diagnostic Techniques ,Acute Disease ,Immunology ,Differential diagnosis ,business ,Biomarkers - Abstract
Despite improvement on outcomes post liver transplantation (LT), complications such as HCV recurrence (HCV-rec) and acute cellular rejection (ACR) continue to be a challenge for transplant physicians. Accurate diagnostic tools to better dissect between those complications post-LT are crucial for prompt and correct diagnosis and treatment. It is well known that the overlapping features of clinical and histo-pathological characteristics between these conditions turn difficult the appropriate differential diagnosis. Recently, new technological advances had supported the field of biomarker discovery in many diseases. Disease biomarkers capable to differentiate ACR versus HCV-rec post-LT is a long waited task in the transplant community. This editorial describes and discusses potential biomarkers of disease differentiation including recent reports in the field of genomics, proteomics, immunohistochemistry among other technologies.
- Published
- 2014