1. Preparation of MPEG–PLA nanoparticle for honokiol delivery in vitro
- Author
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ShaoZhi Fu, Yuquan Wei, Zhiyong Qian, Feng Luo, Xia Zhao, Lijuan Chen, XiuLing Zheng, Maling Gou, Yinglan Zhao, Bing Kan, Juan Zhang, and Ke Men
- Subjects
Honokiol ,Magnetic Resonance Spectroscopy ,Cell Survival ,Surface Properties ,Chemistry, Pharmaceutical ,Polyesters ,Pharmaceutical Science ,Nanoparticle ,Hemolysis ,Lignans ,Polyethylene Glycols ,Gel permeation chromatography ,chemistry.chemical_compound ,Cell Line, Tumor ,Humans ,Nanotechnology ,Technology, Pharmaceutical ,Particle Size ,Microparticle ,Cell Proliferation ,Ovarian Neoplasms ,chemistry.chemical_classification ,Drug Carriers ,Chromatography ,Dose-Response Relationship, Drug ,Molecular Structure ,Chemistry ,Biphenyl Compounds ,Polymer ,Antineoplastic Agents, Phytogenic ,Molecular Weight ,Solvent ,Kinetics ,Solubility ,Polymerization ,Chromatography, Gel ,Solvents ,Nanoparticles ,Female ,Ethylene glycol - Abstract
Honokiol (HK) shows potential application in cancer treatment, but its poor water solubility restricts clinical application greatly. In this paper, monomethoxy poly(ethylene glycol)–poly(lactic acid) (MPEG–PLA) was synthesized by ring-opening polymerization and processed into nanoparticle for honokiol delivery. Chemical structure of the synthesized polymer was confirmed by 1 H NMR, and its molecular weight was determined by gel permeation chromatography (GPC). Honokiol loaded MPEG–PLA nanoparticles were prepared by solvent extract method. And particle size distribution, morphology, drug loading, drug release profile and anticancer activity in vitro were studied in detail. The described honokiol loaded MPEG–PLA nanoparticles in this paper might be a novel formulation for honokiol delivery.
- Published
- 2010