1. MRPS22 mutation causes fatal neonatal lactic acidosis with brain and heart abnormalities
- Author
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Berit Hadzik, Fabian Baertling, Holger Prokisch, Annette Seibt, Felix Distelmaier, Ertan Mayatepek, Richard J. Rodenburg, Tobias B. Haack, Gündüz Selcan, Jörg Schaper, Tim M. Strom, and Thomas Meitinger
- Subjects
Male ,Ribosomal Proteins ,Pathology ,medicine.medical_specialty ,Mitochondrial Diseases ,Heart malformation ,Mitochondrial disease ,Oxidative phosphorylation ,Biology ,medicine.disease_cause ,Mitochondrial Proteins ,Cellular and Molecular Neuroscience ,Fatal Outcome ,Genetics ,Mitochondrial ribosome ,medicine ,Humans ,Agenesis of the corpus callosum ,Frameshift Mutation ,Genetics (clinical) ,Mutation ,Myocardium ,Infant, Newborn ,Brain ,Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6] ,Fibroblasts ,medicine.disease ,Molecular medicine ,Lactic acidosis ,Acidosis, Lactic - Abstract
The mitochondrial ribosomes are required for the synthesis of mitochondrial DNA-encoded subunits of the oxidative phosphorylation (OXPHOS) system. Here, we present a neonate with fatal lactic acidosis and combined OXPHOS deficiency caused by a homozygous mutation in MRPS22, a gene encoding a mitochondrial ribosomal small subunit protein. Brain imaging revealed several structural abnormalities, including agenesis of the corpus callosum, multiple periventricular cysts, and suspected intracerebral calcifications. Moreover, echocardiography demonstrated atrial and ventricular septal defects as well as a coronary artery fistula. Our report expands the clinical spectrum of this rare mitochondrial disorder and confirms the severe clinical phenotype associated with this defect.
- Published
- 2015