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Fatal Non-accidental Alpha-lipoic Acid Intoxication in an Adolescent Girl
- Source :
- Klinische Pädiatrie. 226:292-294
- Publication Year :
- 2014
- Publisher :
- Georg Thieme Verlag KG, 2014.
-
Abstract
- The aim of our report is to increase awareness that the antioxidant alpha-lipoic acid, which is marketed primarily as weight loss and energy supplement, has potentially lethal effects. A 14-year-old girl ingested in suicidal intention a large amount of alpha-lipoic acid, which led to multiorgan failure and subsequent death within 24 h. Multiorgan failure consisted of decreased myocardial contractility, seizures, anuria, thrombocytopenia, and coagulopathy. Therapy consisted of ventilation, anticonvulsive treatment and circulatory support with high-dose catecholamines. CONCLUSION: According to alpha-lipoic acid serum levels following ingestion the girl must have ingested a minimum of 10 alpha-lipoic acid tablets of 600 mg each. This is the first report on a fatal case of alpha-lipoic acid ingestion, which is intended to inform physicians, pharmacists and patients about critical side effects of this allegedly innocuous drug. Key words alpha-lipoic acid - ingestion - multiorgan failure - suicide Schlusselworter Alphaliponsaure - Ingestion - Multiorganversagen - Selbstmord Language: de
- Subjects :
- medicine.medical_specialty
Adolescent
Critical Care
Multiple Organ Failure
Alpha-Lipoic Acid
Poison control
Suicide, Attempted
Antioxidants
Contractility
Fatal Outcome
Weight loss
medicine
Coagulopathy
Humans
Ingestion
Octopamine
Acetaminophen
Thioctic Acid
business.industry
medicine.disease
Surgery
Anesthesia
Accidental
Pediatrics, Perinatology and Child Health
Female
lipids (amino acids, peptides, and proteins)
Anuria
Anti-Obesity Agents
Drug Overdose
medicine.symptom
business
Subjects
Details
- ISSN :
- 14393824 and 03008630
- Volume :
- 226
- Database :
- OpenAIRE
- Journal :
- Klinische Pädiatrie
- Accession number :
- edsair.doi.dedup.....8a0fd8220031091ee1cc1349c8af7a90