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Your search keyword '"O'BRIEN, STEPHEN J."' showing total 3 results
Start Over Author "O'BRIEN, STEPHEN J." Topic hiv infection genetics
3 results on '"O'BRIEN, STEPHEN J."'

1. POLYGENIC AND MULTIFACTORIAL DISEASE GENE ASSOCIATION IN MAN: Lessons from AIDS.

Author

O'Brien, Stephen J., Nelson, George W., Winkler, Cheryl A., and Smith, Michael W.

Subjects
*HIV infection genetics, *HUMAN genetic variation
Abstract

Reports on the identification of human genetic variants that influence the outcome of exposure to HIV-1. Identified genes that affect HIV-1 infection, progression to AIDS and AIDS outcome; Survival analysis for dynamic disease phenotypes; Disease category analysis to detect genetic epidemiologic signals; Functional interpretation for AIDS restriction alleles.

Published
2000
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2. HLA and HIV-1: Heterozygote Advantage and B*35-Cw*04 Disadvantage.

Author

Carrington, Mary, Nelson, George W., Martin, Maureen P., Kissner, Teri, Vlahov, David, Goedert, James J., Kaslow, Richard, Buchbinder, Susan, Hoots, Keith, and O'Brien, Stephen J.

Subjects
*HETEROZYGOSITY, *HIV infection genetics, *AIDS, *HLA histocompatibility antigens, *ANALYTICAL chemistry, *GENETICS
Abstract

Examines the effects of increased heterozygosity on the development of AIDS in patients infected with HIV-1. Delay of the onset of AIDS in those with maximum human leukocyte antigen (HLA) heterozygosity of class I loci; Homozygosity of loci and the development of AIDS; HLA class I alleles B*35 and Cw*04 associated with the development of AIDS in Caucasians; Heterozygosity and survival rate.

Published
1999
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3. Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5.

Author

Martin, Maureen P., Dean, Michael, Smith, Michael W., Winkler, Cheryl, Gerrard, Bernard, Michael, Nelson L., Lee, Benhur, Doms, Robert W., Margolick, Joseph, Buchbinder, Susan, Goedert, James J., O'Brien, Thomas R., Hilgartner, Margaret W., Vlahov, David, O'Brien, Stephen J., and Carrington, Mary

Subjects
*HIV infection genetics, *PROMOTERS (Genetics), *MACROPHAGES, *EXONS (Genetics)
Abstract

Presents research which studied the progression of HIV-1 in patients with various kinds of CCR5 promoter genotypes. CCR5 gene encoding in macrophage-tropic (R5) strains of HIV-1; Results of genetic association analysis; Results of composite genetic epidemiologic analyses; Reasons for variations in progression; Multigenic nature of host factors limiting AIDS disease progression.

Published
1998
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