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HLA and HIV-1: Heterozygote Advantage and B*35-Cw*04 Disadvantage.

Authors :
Carrington, Mary
Nelson, George W.
Martin, Maureen P.
Kissner, Teri
Vlahov, David
Goedert, James J.
Kaslow, Richard
Buchbinder, Susan
Hoots, Keith
O'Brien, Stephen J.
Source :
Science. 3/12/1999, Vol. 283 Issue 5408, p1748-1752. 5p. 3 Charts, 6 Graphs.
Publication Year :
1999

Abstract

Examines the effects of increased heterozygosity on the development of AIDS in patients infected with HIV-1. Delay of the onset of AIDS in those with maximum human leukocyte antigen (HLA) heterozygosity of class I loci; Homozygosity of loci and the development of AIDS; HLA class I alleles B*35 and Cw*04 associated with the development of AIDS in Caucasians; Heterozygosity and survival rate.

Subjects

Subjects :
*HETEROZYGOSITY
*HIV infection genetics
*AIDS
*HLA histocompatibility antigens
*ANALYTICAL chemistry
*GENETICS

Details

Language :
English
ISSN :
00368075
Volume :
283
Issue :
5408
Database :
Academic Search Index
Journal :
Science
Publication Type :
Academic Journal
Accession number :
1665155
Full Text :
https://doi.org/10.1126/science.283.5408.1748
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