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We have synthesized a novel bronsted acidic surfactant, 3-methyl-1-sulfonic acid imidazolium dioctyl sulfosuccinate [MSIM]+ [DOSS]−. We explored catalytic activity of [MSIM]+ [DOSS]− for regioselective synthesis of novel class of thiazolotriazolones from the reaction of aldehydes/ketones, thiosemicarbazide and ethylbromo acetate in aqueous medium at room temperature. The regio-selectivity was confirmed by DFT and IR frequency calculations. The present methodology offers a feasible approach for swift access to collection of extremely pure products with wide substrate scope having several advantages such as excellent yields, short reaction time, easy work-up procedure for isolation of product and use of surfactant as eco-friendly catalyst, use of water as an universal solvent and novelty in synthesis of surfactant [MSIM]+ [DOSS]− as well as investigation of regioselective synthesis of novel class of thiazolotriazolones. [ABSTRACT FROM AUTHOR]

Our present study deals with the synthesis of a heterogeneous catalyst (CuL@Al2O3). Initially [CuL], having the formula [Cu(L)(H2O)](NO3) (HL = 2-[(3,5-dichloro-2-hydroxy-benzylidene)-amino]-2-hydroxymethyl-propane-1,3-diol, obtained from condensation between 3,5-dichloro-2-hydroxybenzaldehyde and 2-amino-2-(hydroxymethyl)propane-1,3-diol), has been synthesized, followed by immobilization of [CuL] on alumina to generate the catalyst. The catalyst has been characterized by SXRD, UV-vis, FT-IR and SEM. Ground-state structure of the homogeneous catalyst [CuL] was optimized by Density Functional Theory (DFT) and Time-Dependent DFT (TD-DFT) calculations. This catalyst exhibits appreciable catalytic activity towards oxidation of alcohols by using hydrogen peroxide as oxidant. Through ESI-MS study, it becomes possible to isolate intermediate species of the catalytic oxidation. Finally, a plausible mechanistic pathway has been proposed to elucidate the role of each substituent of the catalytic system. Prepared (CuL@Al2O3) offers a number of advantages such as easy work-up and separation of the catalyst from the reaction mixture by centrifugation, recyclability for six times with minimal loss of activity along with the high yield of product. [ABSTRACT FROM AUTHOR]