1. Herbicidal aryldiones incorporating a 5-methoxy-[1,2,5]triazepane ring.
- Author
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Smejkal, Tomas, Hachisu, Shuji, Scutt, James N., Willetts, Nigel J., Sayer, Danielle, Wildsmith, Laura, Oliver, Sophie, Thompson, Caroline, and Muehlebach, Michel
- Subjects
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HETEROCYCLIC chemistry , *CARBOXYLASES , *ENZYME inhibitors , *CHEMICAL inhibitors , *FUNCTIONAL groups - Abstract
Novel 2-aryl-cyclic-1,3-diones containing a 5-methoxy-[1,2,5]triazepane unit were explored towards an effective and wheat safe control of grass weeds. Their preparation builds on the ease of synthetic access to 7-membered heterocyclic [1,2,5]triazepane building blocks. Substitution and pattern hopping in the phenyl moiety revealed structure–activity relationships in good agreement with previously disclosed observations amongst the pinoxaden family of acetyl-CoA carboxylase inhibitors. In light of basic physicochemical, enzyme inhibitory and binding site properties, the N- methoxy functionality effectively acts as a bioisostere of the ether group in the seven-membered hydrazine ring. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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