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Herbicidal aryldiones incorporating a 5-methoxy-[1,2,5]triazepane ring.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Feb2018, Vol. 28 Issue 3, p339-343. 5p. - Publication Year :
- 2018
-
Abstract
- Novel 2-aryl-cyclic-1,3-diones containing a 5-methoxy-[1,2,5]triazepane unit were explored towards an effective and wheat safe control of grass weeds. Their preparation builds on the ease of synthetic access to 7-membered heterocyclic [1,2,5]triazepane building blocks. Substitution and pattern hopping in the phenyl moiety revealed structure–activity relationships in good agreement with previously disclosed observations amongst the pinoxaden family of acetyl-CoA carboxylase inhibitors. In light of basic physicochemical, enzyme inhibitory and binding site properties, the N- methoxy functionality effectively acts as a bioisostere of the ether group in the seven-membered hydrazine ring. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 28
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 127640975
- Full Text :
- https://doi.org/10.1016/j.bmcl.2017.12.042