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Start Over Author "Guo QM" Topic granulocyte-macrophage colony-stimulating factor
2 results on '"Guo QM"'

1. In vivo expression of Toll-like receptor 2, Toll-like receptor 4, CSF2 and LY64 in Chinese chronic periodontitis patients.

Author

Sun Y, Guo QM, Liu DL, Zhang MZ, and Shu R

Subjects
Adult, Aged, Antigens, CD genetics, Case-Control Studies, China, Chronic Periodontitis ethnology, Female, Gingiva metabolism, Gingival Crevicular Fluid metabolism, Granulocyte-Macrophage Colony-Stimulating Factor genetics, Humans, Immunohistochemistry, Male, Middle Aged, Periodontal Index, RNA, Messenger analysis, Reference Values, Toll-Like Receptor 2 genetics, Toll-Like Receptor 4 genetics, Antigens, CD metabolism, Chronic Periodontitis metabolism, Granulocyte-Macrophage Colony-Stimulating Factor metabolism, Toll-Like Receptor 2 metabolism, Toll-Like Receptor 4 metabolism
Abstract

Objective: Toll-like receptors (TLRs) are the essential components in the innate and adaptive immune systems. Colony stimulating factor 2 (CSF2) is a cytokine that may prevent endotoxin tolerance, and LY64 has the ability to interfere with the recognition of bacteria via TLR4. The aim of this study was to explore the in vivo expressions of TLR2, TLR4, CSF2 and LY64 in Chinese chronic periodontitis patients., Methods: Gingival biopsies were collected from 24 chronic periodontitis patients and 19 healthy controls. The gene expression profiles of TLR2, TLR4, CSF2 and LY64 were investigated by real-time polymerase chain reaction, and the protein expressions of TLR2 and TLR4 were detected by immunohistochemistry. In addition, the levels of CSF2 in gingival crevicular fluid (GCF) were determined by ELISA., Results: The higher mRNA expressions of TLR2, TLR4 and CSF2, and the lower mRNA expression of LY64 were detected in chronic periodontitis patients. And the increased protein expressions of TLR2 and TLR4 were confirmed by immunohistochemistry. In addition, the increase of total amount of CSF2 in GCF was observed in chronic periodontitis patients., Conclusions: Our results suggest that TLR2 and TLR4 may play a role in periodontal pathogenesis. In addition, CSF2 and LY64 may contribute to the regulation of inflammatory response and maintaining periodontal homeostasis.

Published
2010
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2. In vivoexpression of Toll-like receptor 2, Toll-like receptor 4, CSF2 and LY64 in Chinese chronic periodontitis patients

Author

Ming-zhu Zhang, Rong Shu, Guo Qm, Dengtang Liu, and Yang Sun

Subjects
Adult, Male, China, medicine.medical_treatment, Gingiva, Biology, Pathogenesis, Immune system, Antigens, CD, Reference Values, medicine, Humans, RNA, Messenger, Receptor, General Dentistry, Aged, Toll-like receptor, Granulocyte-Macrophage Colony-Stimulating Factor, Gingival Crevicular Fluid, Middle Aged, medicine.disease, Immunohistochemistry, Chronic periodontitis, Toll-Like Receptor 2, Toll-Like Receptor 4, TLR2, Cytokine, Otorhinolaryngology, Case-Control Studies, Chronic Periodontitis, Immunology, TLR4, Female, Periodontal Index
Abstract

Oral Diseases (2010) 16, 343–350 Objective: Toll-like receptors (TLRs) are the essential components in the innate and adaptive immune systems. Colony stimulating factor 2 (CSF2) is a cytokine that may prevent endotoxin tolerance, and LY64 has the ability to interfere with the recognition of bacteria via TLR4. The aim of this study was to explore the in vivo expressions of TLR2, TLR4, CSF2 and LY64 in Chinese chronic periodontitis patients. Methods: Gingival biopsies were collected from 24 chronic periodontitis patients and 19 healthy controls. The gene expression profiles of TLR2, TLR4, CSF2 and LY64 were investigated by real-time polymerase chain reaction, and the protein expressions of TLR2 and TLR4 were detected by immunohistochemistry. In addition, the levels of CSF2 in gingival crevicular fluid (GCF) were determined by ELISA. Results: The higher mRNA expressions of TLR2, TLR4 and CSF2, and the lower mRNA expression of LY64 were detected in chronic periodontitis patients. And the increased protein expressions of TLR2 and TLR4 were confirmed by immunohistochemistry. In addition, the increase of total amount of CSF2 in GCF was observed in chronic periodontitis patients. Conclusions: Our results suggest that TLR2 and TLR4 may play a role in periodontal pathogenesis. In addition, CSF2 and LY64 may contribute to the regulation of inflammatory response and maintaining periodontal homeostasis.

Published
2010

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