1. Human lung fibroblasts release chemokinetic activity for monocytes constitutively
- Author
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Koyama, Sekiya, Sato, Etsuro, Masubuchi, Tsuyoshi, Takamizawa, Akemi, Nomura, Hiroshi, Kubo, Keishi, Nagai, Sonoko, and Izumi, Takateru
- Subjects
Fibroblasts -- Physiological aspects ,Lungs -- Physiological aspects ,Monocytes -- Physiological aspects ,Transforming growth factors -- Physiological aspects ,Granulocyte-macrophage colony stimulating factor -- Physiological aspects ,Immune response -- Regulation ,Biological sciences - Abstract
Experiments were performed to investigate the capacity of the human lung fibroblast (HLF) to induce monocyte chemokinetic activity (MCA) through the release of the transforming growth factor-beta, leukotriene B4 (LTB4) and the granulocyte-macrophage colony-stimulating factor. The attenuation of the MCA and its lowest molecular weight peak was attributed to an LTB4-receptor antagonist. These findings emphasize the role of HLFs as modulators of monocyte recruitment in the lungs.
- Published
- 1998