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Start Over Author "Walter MP" Topic graft vs host disease
3 results on '"Walter MP"'

1. Involvement of TNF-alpha secreting macrophages in lethal forms of human graft-versus-host disease.

Author

Facon T, Jouet JP, Noel-Walter MP, Bloget F, Bauters F, and Janin A

Subjects
Adult, Bone Marrow Transplantation, Child, Fatal Outcome, Female, Graft vs Host Disease immunology, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive immunology, Leukemia, Myelogenous, Chronic, BCR-ABL Positive pathology, Leukemia, Myelogenous, Chronic, BCR-ABL Positive therapy, Leukemia, Myeloid, Acute immunology, Leukemia, Myeloid, Acute pathology, Leukemia, Myeloid, Acute therapy, Macrophages physiology, Middle Aged, Tumor Necrosis Factor-alpha physiology, Graft vs Host Disease pathology, Macrophages metabolism, Tumor Necrosis Factor-alpha metabolism
Abstract

We report three patients with lethal forms of acute GVHD in whom all biopsy specimens showed a striking preponderance of macrophages in the inflammatory infiltrate with production of TNF-alpha. The role of the macrophage/TNF-alpha axis in human acute GVHD is examined and the existence of primary macrophagic forms of GVHD is discussed.

Published
1997
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2. Cytomegalovirus expression in minor salivary glands and chronic graft-versus-host disease.

Author

Quiquandon I, Janin A, Noel-Walter MP, Facon T, Morel P, Copin MC, Bauters F, and Jouet JP

Subjects
Chronic Disease, Cytomegalovirus immunology, Cytomegalovirus Infections diagnosis, Cytomegalovirus Infections etiology, Graft vs Host Disease pathology, Graft vs Host Disease virology, Humans, Immediate-Early Proteins isolation & purification, Lip virology, Neoplasms therapy, Risk Factors, Salivary Glands, Minor pathology, Bone Marrow Transplantation adverse effects, Cytomegalovirus isolation & purification, Graft vs Host Disease diagnosis, Membrane Glycoproteins, Salivary Glands, Minor virology, Trans-Activators, Viral Envelope Proteins, Viral Proteins
Abstract

A systematic survey of human cytomegalovirus (CMV) was performed in 29 allogeneic bone marrow transplant (BMT) recipients. At day 100 a lip biopsy was performed and histological grading according to Sale's score was compared with the immunohistochemical detection of the immediate early protein IE2 of HCMV. In 10 patients without chronic graft-versus-host disease (GVHD), 3 had lip biopsy grade 1, 7 had grade 0 Sale's score and in 19 patients with chronic GVHD, 11 had grade 2, 1 had grade 1 and 7 had grade 0. On the same lip biopsies, we found IE2 protein in 8 of the 19 patients with chronic GVHD. None of the lip biopsies from patients without chronic GVHD expressed the protein, suggesting that HCMV expression is strongly associated with chronic GVHD and Sale's grade 2. To conclude, in our group of patients with a risk for HCMV infection, detection of the protein IE2 was a good predictive criterion of chronic GVHD with a sensitivity of 61% and a specificity of 100%.

Published
1994

3. Involvement of TNF-alpha secreting macrophages in lethal forms of human graft-versus-host disease

Author

F Bloget, Anne Janin, J P Jouet, Francis Bauters, Thierry Facon, and Noel-Walter Mp

Subjects
Adult, Pathology, medicine.medical_specialty, medicine.medical_treatment, Graft vs Host Disease, chemical and pharmacologic phenomena, Pathogenesis, Fatal Outcome, immune system diseases, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Biopsy, Macrophage, Medicine, Humans, Child, Bone Marrow Transplantation, Transplantation, medicine.diagnostic_test, business.industry, Tumor Necrosis Factor-alpha, Macrophages, Hematology, Middle Aged, medicine.disease, Leukemia, Leukemia, Myeloid, Acute, surgical procedures, operative, medicine.anatomical_structure, Cytokine, Graft-versus-host disease, Immunology, Tumor necrosis factor alpha, Female, Bone marrow, business
Abstract

We report three patients with lethal forms of acute GVHD in whom all biopsy specimens showed a striking preponderance of macrophages in the inflammatory infiltrate with production of TNF-alpha. The role of the macrophage/TNF-alpha axis in human acute GVHD is examined and the existence of primary macrophagic forms of GVHD is discussed.

Published
1997

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