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Involvement of TNF-alpha secreting macrophages in lethal forms of human graft-versus-host disease.
- Source :
-
Bone marrow transplantation [Bone Marrow Transplant] 1997 Sep; Vol. 20 (6), pp. 511-5. - Publication Year :
- 1997
-
Abstract
- We report three patients with lethal forms of acute GVHD in whom all biopsy specimens showed a striking preponderance of macrophages in the inflammatory infiltrate with production of TNF-alpha. The role of the macrophage/TNF-alpha axis in human acute GVHD is examined and the existence of primary macrophagic forms of GVHD is discussed.
- Subjects :
- Adult
Bone Marrow Transplantation
Child
Fatal Outcome
Female
Graft vs Host Disease immunology
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive immunology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive pathology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive therapy
Leukemia, Myeloid, Acute immunology
Leukemia, Myeloid, Acute pathology
Leukemia, Myeloid, Acute therapy
Macrophages physiology
Middle Aged
Tumor Necrosis Factor-alpha physiology
Graft vs Host Disease pathology
Macrophages metabolism
Tumor Necrosis Factor-alpha metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0268-3369
- Volume :
- 20
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bone marrow transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 9313887
- Full Text :
- https://doi.org/10.1038/sj.bmt.1700912