1. Stanniocalcin 1 Enhances Carbon Flux from Glucose to Lipids in White Retroperitoneal Adipose Tissue in the Fed Rat.
- Author
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Cozer AG, Trapp M, Vieira Marques C, Martins TL, Model JF, Schein V, Kucharski LC, and Da Silva RS
- Subjects
- Adenosine Triphosphate metabolism, Animals, Carbon Dioxide metabolism, Fatty Acids metabolism, Humans, Lipogenesis, Male, Oxidation-Reduction, Rats, Rats, Wistar, Adipose Tissue, White metabolism, Glucose metabolism, Glycoproteins metabolism, Lipid Metabolism
- Abstract
The present work assesses in vitro the role of human Stanniocalcin 1 (hSTC-1) in glucose metabolism in white retroperitoneal adipose tissue (WRAT) from fed rat. In the fed state, hSTC1 increases the incorporation of
14 C from glucose into lipids in the rat WRAT. The increase in lipogenesis capacity supports the hypothesis that the activity of the glycerol-3-phosphate-generating pathway (glycolysis) from glucose is regulated by hSTC-1. The effect of hSTC-1 on de novo fatty acid synthesis and on glucose oxidation in WRAT is supported by an 85 % increase in14 CO2 production from14 C-glucose. The incubation of WRAT in the presence of hSTC-1 maintained the ADP/ATP ratio close to the control group. The presence of hSTC-1 in the incubation medium did not inhibit the lipolytic effect of epinephrine. In conclusion, hSTC-1 is one of the hormonal factors that control glucose metabolism in WRAT in the fed state.- Published
- 2016
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