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Stanniocalcin 1 Enhances Carbon Flux from Glucose to Lipids in White Retroperitoneal Adipose Tissue in the Fed Rat.
- Source :
-
Lipids [Lipids] 2016 Nov; Vol. 51 (11), pp. 1303-1307. Date of Electronic Publication: 2016 Oct 11. - Publication Year :
- 2016
-
Abstract
- The present work assesses in vitro the role of human Stanniocalcin 1 (hSTC-1) in glucose metabolism in white retroperitoneal adipose tissue (WRAT) from fed rat. In the fed state, hSTC1 increases the incorporation of <superscript>14</superscript> C from glucose into lipids in the rat WRAT. The increase in lipogenesis capacity supports the hypothesis that the activity of the glycerol-3-phosphate-generating pathway (glycolysis) from glucose is regulated by hSTC-1. The effect of hSTC-1 on de novo fatty acid synthesis and on glucose oxidation in WRAT is supported by an 85 % increase in <superscript>14</superscript> CO <subscript>2</subscript> production from <superscript>14</superscript> C-glucose. The incubation of WRAT in the presence of hSTC-1 maintained the ADP/ATP ratio close to the control group. The presence of hSTC-1 in the incubation medium did not inhibit the lipolytic effect of epinephrine. In conclusion, hSTC-1 is one of the hormonal factors that control glucose metabolism in WRAT in the fed state.
Details
- Language :
- English
- ISSN :
- 1558-9307
- Volume :
- 51
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Lipids
- Publication Type :
- Academic Journal
- Accession number :
- 27730346
- Full Text :
- https://doi.org/10.1007/s11745-016-4202-5