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4 results on '"clade 2.3.4"'

1. Emergence of novel clade 2.3.4 influenza A (H5N1) virus subgroups in Yunnan Province, China.

Author

Hu T, Song J, Zhang W, Zhao H, Duan B, Liu Q, Zeng W, Qiu W, Chen G, Zhang Y, Fan Q, and Zhang F

Subjects
China epidemiology, Hemagglutinin Glycoproteins, Influenza Virus genetics, Humans, Mutation, Neuraminidase genetics, Phylogeny, Viral Proteins genetics, Communicable Diseases, Emerging, Genotype, Influenza A Virus, H5N1 Subtype classification, Influenza A Virus, H5N1 Subtype genetics, Influenza, Human epidemiology, Influenza, Human virology
Abstract

From December 2013 to March 2014, a major wave of highly pathogenic avian influenza outbreak occurred in poultry in Yunnan Province, China. We isolated and characterized eight highly pathogenic avian influenza A (H5N1) viruses from poultry. Full genome influenza sequences and analyses have been performed. Sequence analyses revealed that they belonged to clade 2.3.4 but did not fit within the three defined subclades. The isolated viruses were provisional subclade 2.3.4.4e. The provisional subclade 2.3.4.4e viruses with six internal genes from avian influenza A (H5N2) viruses in 2013 were the novel reassortant influenza A (H5N1) viruses which were associated with the outbreak of H5N1 occurred in egg chicken farms in Yunnan Province. The HA genes were similar to subtype H5 viruses isolated from January to March of 2014 in Asia including H5N6 and H5N8. The NA genes were most closely related to A/chicken/Vietnam/NCVD-KA423/2013 (H5N1) from the subclade 2.3.2. The HI assay demonstrated a lack of antigenic relatedness between clades 2.3.4.4e and 2.3.4.1 (RE-5 vaccine strain) or 2.3.2.2 (RE-6 vaccine strain)., (Copyright © 2015 Elsevier B.V. All rights reserved.)

Published
2015
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2. Novel variants of clade 2.3.4 highly pathogenic avian influenza A(H5N1) viruses, China.

Author

Gu M, Zhao G, Zhao K, Zhong L, Huang J, Wan H, Wang X, Liu W, Liu H, Peng D, and Liu X

Subjects
Animals, Chickens, China epidemiology, Hemagglutinin Glycoproteins, Influenza Virus genetics, Phylogeny, Poultry virology, Poultry Diseases epidemiology, Poultry Diseases virology, Genotype, Influenza A Virus, H5N1 Subtype classification, Influenza A Virus, H5N1 Subtype genetics, Influenza in Birds epidemiology, Influenza in Birds virology
Abstract

We characterized 7 highly pathogenic avian influenza A(H5N1) viruses isolated from poultry in China during 2009-2012 and found that they belong to clade 2.3.4 but do not fit within the 3 defined subclades. Antigenic drift in subtype H5N1 variants may reduce the efficacy of vaccines designed to control these viruses in poultry.

Published
2013
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3. Novel Variants of Clade 2.3.4 Highly Pathogenic Avian Influenza A(H5N1) Viruses, China

Author

Hongquan Wan, Lei Zhong, Min Gu, Xiufan Liu, Wang Xiaoquan, Daxin Peng, Huimou Liu, Guo Zhao, Junqing Huang, Kunkun Zhao, and Wenbo Liu

Subjects
Microbiology (medical), clade 2.3.4, China, Genotype, Epidemiology, Highly pathogenic, highly pathogenic, lcsh:Medicine, Hemagglutinin Glycoproteins, Influenza Virus, HPAI, avian influenza virus, Biology, medicine.disease_cause, phylogeny, H5N1 genetic structure, Antigenic drift, Poultry, influenza virus, lcsh:Infectious and parasitic diseases, Phylogenetics, medicine, Influenza A virus, Animals, viruses, lcsh:RC109-216, Clade, Poultry Diseases, AIV, flu, Influenza A Virus, H5N1 Subtype, clade, avian, lcsh:R, Dispatch, virus diseases, H5N1, Virology, Influenza A virus subtype H5N1, Infectious Diseases, H5, birds, Influenza in Birds, chickens, influenza
Abstract

We characterized 7 highly pathogenic avian influenza A(H5N1) viruses isolated from poultry in China during 2009–2012 and found that they belong to clade 2.3.4 but do not fit within the 3 defined subclades. Antigenic drift in subtype H5N1 variants may reduce the efficacy of vaccines designed to control these viruses in poultry.

Published
2013

4. Rapid Emergence of Highly Pathogenic Avian Influenza Subtypes from a Subtype H5N1 Hemagglutinin Variant

Author

de Vries, Erik, Guo, Hongbo, Dai, Meiling, Rottier, Peter J M, van Kuppeveld, Frank J M, de Haan, Cornelis A M, LS Virologie, dI&I I&I-1, LS Virologie, and dI&I I&I-1

Subjects
Epidemiology, highly pathogenic, lcsh:Medicine, HPAI, rapid emergence, medicine.disease_cause, Poultry, Disease Outbreaks, Monophyly, reassortment events, Influenza A virus, Clade, Phylogeny, Dispatch, virus diseases, H5N1, virulent, Infectious Diseases, Hemagglutinins, reassortant, influenza, Reassortant Viruses, monophyletic group, Microbiology (medical), clade 2.3.4, Genotype, Hemagglutinin (influenza), Biology, H5N1 genetic structure, lcsh:Infectious and parasitic diseases, subtype, Rapid Emergence of Highly Pathogenic Avian Influenza Subtypes from a Subtype H5N1 Hemagglutinin Variant, Phylogenetics, Influenza, Human, evolution, medicine, Animals, Humans, viruses, lcsh:RC109-216, hemagglutinin, Influenza A Virus, H5N1 Subtype, lcsh:R, Genetic Variation, Virology, Influenza A virus subtype H5N1, variant, Influenza in Birds, biology.protein, avian influenza
Abstract

In 2014, novel highly pathogenic avian influenza A H5N2, H5N5, H5N6, and H5N8 viruses caused outbreaks in Asia, Europe, and North America. The H5 genes of these viruses form a monophyletic group that evolved from a clade 2.3.4 H5N1 variant. This rapid emergence of new H5Nx combinations is unprecedented in the H5N1 evolutionary history.

Published
2015

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