58 results on '"Tatsuya Ito"'
Search Results
2. Feasibility and impact of extra‐vascular ultrasound‐guided endovascular treatment for infrapopliteal artery occlusive disease
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Takahiro Tokuda, Yasuhiro Oba, Ai Kagase, Hiroaki Matsuda, Yoriyasu Suzuki, Akira Murata, Tatsuya Ito, and Keisuke Hirano
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Radiology, Nuclear Medicine and imaging ,General Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2023
3. Development of an ultralow-latency communication system using shared internet access: promoting the implementation of telemedicine
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Takahiro Korai, Kenji Okita, Koichi Okuya, Atsushi Hamabe, Masaaki Miyo, Emi Akizuki, Yu Sato, Masayuki Ishii, Ryo Miura, Tatsuya Ito, Takayuki Nobuoka, and Ichiro Takemasa
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Surgery ,General Medicine - Published
- 2023
4. Right hemicolectomy for ascending colon cancer using the hinotori surgical robot system: The first ever case report for colon cancer
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Masaaki Miyo, Kenji Okita, Koichi Okuya, Tatsuya Ito, Emi Akizuki, Tadashi Ogawa, Masayuki Ishii, Ryo Miura, Momoko Ichihara, Takahiro Korai, Akina Kimura, and Ichiro Takemasa
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General Medicine - Published
- 2023
5. Comparison of Dosage of Nivolumab in Efficacy and Safety for Recurrent Metastatic Squamous Cell Carcinoma
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TAKURO OKADA, CHIHIRO FUSHIMI, TAKASHI MATSUKI, ISAKU OKAMOTO, HIROKI SATO, TAKAHITO KONDO, KUNIHIKO TOKASHIKI, TAKUMA KISHIDA, TATSUYA ITO, GAI YAMASHITA, YUSUKE AIHARA, KENJI HANYU, YUKIOMI KUSHIHASHI, TATSUO MASUBUCHI, YUICHIRO TADA, KOUKI MIURA, YUKI HARADA, KAHO MOMIYAMA, TAKU YAMASHITA, GO OMURA, HIDEAKI TAKAHASHI, NOBUHIKO ORIDATE, and KIYOAKI TSUKAHARA
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Adult ,Aged, 80 and over ,Male ,Cancer Research ,Time Factors ,Squamous Cell Carcinoma of Head and Neck ,General Medicine ,Middle Aged ,Progression-Free Survival ,Young Adult ,Nivolumab ,Oncology ,Head and Neck Neoplasms ,Humans ,Female ,Neoplasm Recurrence, Local ,Tokyo ,Immune Checkpoint Inhibitors ,Aged ,Retrospective Studies - Abstract
There are no real-world comparative data of nivolumab doses of 3 mg/kg and 240 mg/body for recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). We investigated the efficacy and safety of nivolumab in treating recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) at different doses using real-world data.R/M SCCHN patients who received nivolumab were divided into the 3 mg/kg and 240 mg/body groups and retrospectively examined for efficacy and safety.A total of 199 patients (3 mg/kg and 240 mg/body, 88 and 111 patients, respectively) were included. The 3 mg/kg vs. 240 mg/body groups had similar overall response rates (15% vs. 25, p=0.15), disease control rates (46% vs. 57%, p=0.15), overall survival (9.5 months vs. 10.9 months), and progression-free survival (3.7 months vs. 3.8 months, p=0.95). The incidence of immune-related adverse events was also similar in both groups.In R/M SCCHN patients, nivolumab showed similar efficacy and safety at doses of 3 mg/kg and 240 mg/body.
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- 2022
6. Management system of home transfusion in Japan: A nationwide survey in 2019
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Asashi Tanaka, Hiroshi Fujita, Kota Ohashi, Akihito Tsujikawa, Kanami Uchiyama, Tatsuya Ito, Koichiro Kawashima, Reiko Kodama, Takashi Mine, Makoto Okuda, Teruo Endoh, Youko Fukuyoshi, Junichi Kitazawa, Eisaburo Sueoka, Kazuhiro Nagai, Akaru Ishida, Koji Matsuzaki, Yoko Kato, Kazuo Takanashi, and Koki Takahashi
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Hematology ,General Medicine - Abstract
In Japan, there are various opinions on the pros and cons of home transfusion because of safety concerns. We hence aimed to elucidate the safety and availability of home transfusion in Japan, which has not been clarified to date.Clinics throughout Japan that provide home care and have experience in performing blood transfusions were surveyed. The analysis period was February to December 2019. Basic information about the clinics, their collaboration system with core hospitals, storage method of red blood cells (RBCs) and the system for the management of patient information regarding transfusion reactions were investigated.Detailed information was obtained regarding the implementation of home transfusions by 51 clinics. The proportion of home care clinics performing home transfusions was 17.6%, and they were more frequently performed in urban regions. Approximately half of the clinics collaborated with a core hospital for emergency responses to transfusion reactions. At 84% of the clinics, RBC units were stored in refrigerators that were not exclusively allocated to blood storage. Nurses and family members were involved as patient attendants in 83% and 77% of the home transfusions, respectively. No serious transfusion reactions were reported among the 150 patients in 2019, nor the 623 patients up to 2018.From data on its availability and safety, home transfusions are considered to be in the developing phase in Japan. Increased cooperation between hospitals and clinics is crucial towards improving the home transfusion system in Japan in the future.
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- 2022
7. Nivolumab for Platinum-refractory and -sensitive Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma
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TAKURO OKADA, TAKASHI MATSUKI, CHIHIRO FUSHIMI, ISAKU OKAMOTO, HIROKI SATO, TAKAHITO KONDO, KUNIHIKO TOKASHIKI, TATSUYA ITO, TATSUO MASUBUCHI, YUICHIRO TADA, KOUKI MIURA, KENJI HANYU, GO OMURA, HIDEKI TAKAHASHI, TAKU YAMASHITA, NOBUHIKO ORIDATE, and KIYOAKI TSUKAHARA
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Cancer Research ,Nivolumab ,Oncology ,Head and Neck Neoplasms ,Squamous Cell Carcinoma of Head and Neck ,Carcinoma, Squamous Cell ,Humans ,Antineoplastic Agents ,General Medicine ,Neoplasm Recurrence, Local ,Platinum ,Retrospective Studies - Abstract
Nivolumab has antitumor efficacy in patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) who relapse within 6 months after platinum-based therapy; however, the efficacy of nivolumab for platinum-sensitive R/M HNSCC has not been shown. Therefore, this study compared the efficacy and safety of nivolumab for platinum-refractory and platinum-sensitive R/M HNSCC.This was a retrospective study of patients who received nivolumab for R/M HNSCC who had been previously treated with platinum-based anticancer drugs. Patients were divided into a platinum-sensitive and a platinum-refractory group, and progression-free survival (PFS), overall survival (OS), the overall response rate (ORR) [complete response (CR) + partial response (PR)], the disease control rate (DCR) (CR + PR + stable disease), and the incidence of immune-related adverse events (irAEs) were compared between the two groups.We included 88 patients with squamous cell carcinoma: 60 with platinum-refractory disease and 28 with platinum-sensitive disease. The median PFS in the platinum-refractory and platinum-sensitive groups were 2.7 months and 5.3 months, respectively (p=0.03), and the median OS were 8.8 months and 17.1 months, respectively (p=0.06). There were no significant differences in the ORR, DCR, or incidence of irAEs between the two groups (p0.99, p=0.11, and p0.99, respectively).Nivolumab is a safe and effective treatment for platinum-sensitive R/M HNSCC.
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- 2022
8. Neck dissection prolongs survival in patient with stage IVC hypopharyngeal carcinoma with mixed responses to nivolumab
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Hiroki Sato, Toshitaka Nagao, Hideaki Hirai, Kiyoaki Tsukahara, Keitaro Miyake, Takahiro Tsujikawa, Isaku Okamoto, and Tatsuya Ito
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Hypopharyngeal Carcinoma ,03 medical and health sciences ,0302 clinical medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Stage (cooking) ,030223 otorhinolaryngology ,Immune Checkpoint Inhibitors ,Lymph node ,Aged ,Hypopharyngeal Neoplasms ,business.industry ,Neck dissection ,General Medicine ,medicine.disease ,Combined Modality Therapy ,Dissection ,Regimen ,Nivolumab ,medicine.anatomical_structure ,Otorhinolaryngology ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Neck Dissection ,Surgery ,Radiology ,business ,Progressive disease - Abstract
Surgical intervention aids in maintaining quality of life in patients with recurrent metastatic head and neck carcinoma with mixed responses to nivolumab treatment. However, the mechanisms involved in these mixed responses remain unclear. Systemic chemotherapy using the EXTREME regimen was administered to the patient with hypopharyngeal carcinoma and liver metastases as well as cervical lymph node metastases. The patient was subsequently treated with nivolumab after developing signs of progressive disease. Although the hypopharyngeal tumors and liver metastases were well-controlled, cervical lymph node dissection was performed because of the enlargement of some of the lymph node metastases. Postoperative nivolumab administration was resumed, and this patient is presently alive and disease-free. Immediately after neck dissection, the LNs that responded and those that did not respond to nivolumab were separated and evaluated. The LNs that responded well to nivolumab presented with prominent interstitial fibrosis. Conversely, in LNs that enlarged after nivolumab, significant proliferation of the viable tumor cells and almost no degeneration or necrosis was observed. Additionally, we performed immunohistological assessments on pathologic samples of multiple lesions with differing responses to treatment. Targeted surgical intervention appears to be a valuable adjunct to treatment with nivolumab.
- Published
- 2021
9. A multicenter, phase II study of R-THP-COP therapy for elderly patients with newly diagnosed, advanced-stage, indolent B-cell lymphoma
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Takaaki Ono, Tomomitsu Hotta, Kazuma Ohyashiki, Kazuhito Yamamoto, Kaneyuki Ohbayashi, Tatsuya Ito, Koichi Miyamura, Yoshitoyo Kagami, Kazunori Ohnishi, Michinori Ogura, Mitsune Tanimoto, Kensuke Naito, Kiyoshi Ando, Ken Ohmachi, Kunihiro Tsukasaki, Tomohiro Kinoshita, and Takayo Suzuki
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Male ,medicine.medical_specialty ,Lymphoma, B-Cell ,Prednisolone ,Follicular lymphoma ,Phases of clinical research ,Neutropenia ,elderly patients ,Gastroenterology ,Indolent B-cell lymphoma ,Internal medicine ,R-THP-COP ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,B-cell lymphoma ,Cyclophosphamide ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Performance status ,business.industry ,Combination chemotherapy ,General Medicine ,medicine.disease ,Treatment Outcome ,Doxorubicin ,Vincristine ,Original Article ,Mantle cell lymphoma ,Rituximab ,Neoplasm Grading ,business ,medicine.drug - Abstract
The optimal combined chemotherapy regimen with rituximab has yet to be established for elderly patients with advanced-stage indolent B-cell lymphoma (B-NHL). A multicenter study was performed to evaluate the efficacy and toxicity of R-THP-COP therapy in elderly patients (aged 70–79 years) with newly diagnosed advanced-stage indolent B-NHL using the complete response rate (%CR) as the primary endpoint. Patients with newly diagnosed, clinical stage III/IV, indolent B-NHL, aged 70–79 years, with a performance status of 0–2 were eligible for this study. R-THP-COP consists of 375 mg/m2 of rituximab, 50 mg/m2 of pirarubicin, 750 mg/m2 of cyclophosphamide, 1.4 mg/m2 of vincristine, and 100 mg/day of oral prednisolone for 5 days. This study was discontinued due to poor accrual after the enrollment of 18 patients, although the planned sample size was 40 patients. The numbers of patients with follicular lymphoma, mucosa-associated lymphoid tissue lymphoma, and mantle cell lymphoma were 16, 1, and 1, respectively. The median age was 73 (range, 70 to 79) years. The %CR including unconfirmed CR was 45% (95% confidence interval: 25-66%) and the overall response rate was 72%. The estimated 5-year overall survival and progression-free survival rates were 55% and 28%, respectively. The major toxicity observed was grade 4 neutropenia (94%). Grade 4 non-hematological toxicities were not observed and no patients developed grade 3/4 cardiac toxicities. This phase II study provides useful information regarding the efficacy and toxicity of R-THP-COP therapy for patients aged 70 years or older with newly diagnosed, advanced-stage, indolent B-NHL, although the sample size was small.
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- 2021
10. Utility of the tibial nerve somatosensory evoked potentials in differentiating between neuromyelitis optica spectrum disorders and multiple sclerosis
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Takamichi Kanbayashi, Go Ogawa, Tatsuya Ito, Keiichi Hokkoku, Chizuko Oishi, Yuki Hatanaka, and Masahiro Sonoo
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Neurology ,Neurology (clinical) ,General Medicine - Abstract
Somatosensory evoked potentials (SEPs) are widely used for the diagnosis and evaluation of neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). However, whether the parameters of tibial nerve SEPs can help to distinguish NMOSD from MS remains unclear. Thus, the aim of this study was to investigate the utility of tibial nerve SEP parameters in differentiating patients with NMOSD and MS.The clinical data of patients with NMOSD or MS treated in our institution between 2005 and 2021 were retrospectively extracted from our electronic database. Additional inclusion criteria were presentation with sensory symptoms in the lower extremities with corresponding lesions in the magnetic resonance images as well as available data on anti-aquaporin-4 antibodies and tibial nerve SEPs. The Z-scores of the N21-P38 interval (central sensory conduction time), P38 latency, and P38 amplitude were compared between the patients with NMOSD and MS. The relationship of disease severity with the parameters of the tibial nerve SEPs was also evaluated.Twenty patients with NMOSD and 13 patients with MS were enrolled. The Z-scores of the N21-P38 interval and P38 latency were significantly higher in the MS group than in the NMOSD group (p0.05 and p0.01, respectively), whereas there was no difference in the Z-scores of the P38 amplitude between the two groups. In the MS group, only the N21-P38 interval and P38 latency were significantly correlated with disease severity (p0.05 and p0.01, respectively). In contrast, none of the tibial nerve SEP parameters were significantly correlated with disease severity in the NMOSD group.Evaluation of the N21-P38 interval and P38 latency in tibial nerve SEPs potentially helps in differentiating between NMOSD and MS.
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- 2023
11. PD-L1 Expression and Survival Rates Using TPS and CPS for Nivolumab-treated Head-and-Neck Cancer
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TATSUYA ITO, ISAKU OKAMOTO, KUNIHIKO TOKASHIKI, HIROKI SATO, TAKURO OKADA, GAI YAMASHITA, TOSHITAKA NAGAO, HIDEAKI HIRAI, NATSUKI SAIGUSA, and KIYOAKI TSUKAHARA
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Adult ,Aged, 80 and over ,Male ,Cancer Research ,Time Factors ,Squamous Cell Carcinoma of Head and Neck ,General Medicine ,Middle Aged ,B7-H1 Antigen ,Progression-Free Survival ,Nivolumab ,Oncology ,Head and Neck Neoplasms ,Humans ,Female ,Neoplasm Recurrence, Local ,Immune Checkpoint Inhibitors ,Aged ,Neoplasm Staging ,Retrospective Studies - Abstract
This study investigated the expression and survival rates of programmed cell death ligand 1 using the tumor proportion score (TPS)and combined positive score (CPS) for recurrent/metastatic head and neck cancer administered nivolumab.Forty-seven patients with recurrent/metastatic head and neck cancer with a history of platinum-based chemotherapy who received nivolumab between June 1st, 2017, and January 31st, 2019 were included in this study.TPS and CPS were strongly correlated (r=0.546). When the TPS was high (≥40%), overall and progression-free survival were significantly better. The median overall survival was 8.5 months, median progression-free survival was not reached, and the 1-year progression-free survival rate was 71.4%. However, there was no significant difference in overall and progression-free survival between the groups with high CPS (≥20).This is the first report to show a strong correlation between TPS and CPS. High TPS (40% or higher) may be used as a predictor of prognosis and efficacy. Further studies are warranted to determine the use of the CPS as a biomarker.
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- 2022
12. The Impact of Femoropopliteal Artery Calcium Score after Endovascular Treatment
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Tatsuya Ito, Ryoji Koshida, Yasuhiro Oba, Yoriyasu Suzuki, Akira Murata, and Takahiro Tokuda
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Male ,medicine.medical_specialty ,Time Factors ,Computed Tomography Angiography ,medicine.medical_treatment ,chemistry.chemical_element ,030204 cardiovascular system & hematology ,Calcium ,Severity of Illness Index ,Amputation, Surgical ,030218 nuclear medicine & medical imaging ,Lesion ,Peripheral Arterial Disease ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,medicine ,Humans ,Popliteal Artery ,Endovascular treatment ,Vascular Calcification ,Vascular Patency ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,General Medicine ,Limb Salvage ,medicine.disease ,Femoral Artery ,Treatment Outcome ,medicine.anatomical_structure ,Amputation ,chemistry ,Cardiology ,Female ,Stents ,Surgery ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Angioplasty, Balloon ,Calcium score ,Kidney disease ,Calcification ,Artery - Abstract
The coronary artery calcium score is a widely known independent predictor of cardiac events. Tibial artery calcification had been reported as an amputation risk, but the femoropopliteal artery calcium score is rarely known.A retrospective analysis was performed using the data collected from the patients who underwent endovascular treatment for the femoropopliteal artery between January 2010 and December 2017. The femoropopliteal artery calcium scores on preprocedural computed tomography were calculated according to the Agatston definition. The mean value of total of femoropopliteal artery calcium scores was used to divide the scores into two groups. The prognostic value of the calcium score was analyzed based on primary patency, clinically driven target lesion revascularization, major amputation, and all-cause death.In total, 132 consecutive limbs that underwent successful endovascular intervention were analyzed in this study; 44 and 88 limbs were assigned to the high and low calcium score groups, respectively. There were no significant differences between the two groups in terms of patient and lesion characteristics, except for chronic kidney disease (7% vs. 25%, P 0.01), hemodialysis (80% vs. 25%, P 0.01), and coronary artery disease (73% vs. 53%, P = 0.03). Compared with the low calcium score group, the high calcium score group had a significantly higher rate of loss of primary patency and clinically driven target lesion revascularization at one year, based on the Kaplan-Meier curve (55% vs. 81%, 44% vs. 8%, both P 0.01). There were no significant differences between the two groups in terms of major amputation and death. Multivariate analysis revealed that hemodialysis [hazard ratio (HR): 1.9; 95% confidence interval (CI): 1.01-5.28; P = 0.04] runoff grade 0 (HR: 2.9; 95% CI: 1.02-10.9; P = 0.04), lesion length 200 mm (HR: 3.9; 95% CI: 1.1-13.7; P = 0.03), and calcium score per 100 increase (HR: 1.05; 95% CI: 1.02-1.08; P 0.01) were predictors of clinically driven target lesion revascularization. As per receiver operating characteristic analysis, the best cutoff value of target lesion calcium score for target lesion revascularization was 206.A high femoropopliteal artery calcium score might increase loss of patency and the risk for clinically driven target lesion revascularization.
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- 2020
13. The evaluation of technical outcome and wire manipulation time within 30 min in patients with poor distal vessel quality on percutaneous coronary intervention for chronic total occlusion
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Yoriyasu Suzuki, Yusuke Ochiumi, Akira Murata, and Tatsuya Ito
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Coronary Angiography ,Lesion ,03 medical and health sciences ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Internal medicine ,Occlusion ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Registries ,030212 general & internal medicine ,Aged ,medicine.diagnostic_test ,business.industry ,Percutaneous coronary intervention ,Interventional radiology ,General Medicine ,Odds ratio ,Middle Aged ,Confidence interval ,Treatment Outcome ,Coronary Occlusion ,Chronic Disease ,Conventional PCI ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
The technical outcome of poor distal vessel quality (PDV) on chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is yet to be clearly elucidated. PDV has not been evaluated in scoring systems. We examined 193 consecutive CTO–PCIs performed in January 2013–December 2017. The endpoint, including the technical outcomes in these patients between with and without PDV, was analyzed. Moreover, we re-evaluated the predictors for CTO–PCI difficulty according to Japan-CTO score. Out of 193 CTO–PCIs, 181 (93.8%) achieved technical success [including 101 (55.8%) with and 80 (44.2%) without PDV]. In patients with and without PDV, the success rates of guidewire crossing using only the antegrade technique were 46.5% vs. 83.8%, respectively (p
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- 2020
14. Development of Dried Emulsion/Mannitol Composite Microparticles through a Unique Spray Nozzle for Efficient Delivery of Hydrophilic Anti-tuberculosis Drug against Alveolar Macrophages
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Tatsuaki Tagami, Tetsuya Ozeki, Takemasa Takii, Ryo Maeda, and Tatsuya Ito
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0301 basic medicine ,Drug ,Drug Compounding ,media_common.quotation_subject ,Antitubercular Agents ,Pharmaceutical Science ,Mice ,Surface-Active Agents ,03 medical and health sciences ,Drug Delivery Systems ,0302 clinical medicine ,In vivo ,Administration, Inhalation ,Macrophages, Alveolar ,medicine ,Animals ,Tuberculosis ,Mannitol ,Rats, Wistar ,Microparticle ,Lung ,media_common ,Pharmacology ,Chromatography ,Chemistry ,General Medicine ,Rats ,RAW 264.7 Cells ,030104 developmental biology ,Targeted drug delivery ,030220 oncology & carcinogenesis ,Spray drying ,Emulsion ,Alveolar macrophage ,Nanoparticles ,Emulsions ,Hydrophobic and Hydrophilic Interactions ,medicine.drug - Abstract
As alveolar macrophages are attractive targets for the treatment of tuberculosis, effective methods for delivery to alveolar macrophages are under development. We investigated a pulmonary formulation for the efficient delivery of high water-soluble drugs at high concentration targeting alveolar macrophages. In this study, a surfactant-coated high water-soluble drug complex (SDC, a hydrophobic dried emulsion), which can preferably target alveolar macrophages and be expected to deliver drug at a high concentration, was prepared in the first process. OCT313, a high water-soluble sugar derivative with anti-tuberculosis activity was used. Then, a unique two-solution, mixing-type nozzle was used to prepare the SDC nanoparticles in mannitol (MAN) microparticles (SDC/MAN microparticles) because it was difficult to disperse the SDC nanoparticles in aqueous solution. The single micron size of OCT313-SDC/MAN microparticles contained OCT313-SDC nanoparticles (mean particle size of OCT313-SDC nanoparticles, 277.9 nm; drug contents, 1.31 ± 0.041 wt%). We found that the treatment of SDC/MAN microparticles exhibited significantly higher drug accumulation in macrophage cells (Raw264.7 cells, 7.5-fold, at 4 h after treatment) in vitro and in alveolar macrophages in rats (9.1-fold, at 4 h after treatment) in vivo than that of drug alone. These results suggest that the SDC/MAN microparticle formulation prepared by spray drying through a two-solution mixing-type nozzle provides efficient delivery of a water-soluble drug targeting alveolar macrophages and may be useful for tuberculosis treatment.
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- 2019
15. An External Iliac Artery Pseudoaneurysm Resulting From Stent Graft Migration
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Takahiro Tokuda, Akira Murata, Tatsuya Ito, Yoriyasu Suzuki, Hiroaki Matsuda, Ryoji Koshida, Ai Kagase, and Yasuhiro Oba
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medicine.medical_specialty ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Lesion ,03 medical and health sciences ,Pseudoaneurysm ,0302 clinical medicine ,medicine.artery ,Intravascular ultrasound ,Occlusion ,medicine ,cardiovascular diseases ,medicine.diagnostic_test ,business.industry ,External iliac artery ,Stent ,General Medicine ,equipment and supplies ,medicine.disease ,surgical procedures, operative ,030220 oncology & carcinogenesis ,Angiography ,Surgery ,Radiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Claudication ,business - Abstract
The case of an 80-year-old male with claudication of his left foot who was referred to our hospital for evaluation and treatment. Computed tomography (CT) angiography revealed occlusion of left common and external iliac (EIA) arteries. Recanalization of the EIA lesion under intravascular ultrasound (IVUS) guidance and placement of 2 stent grafts was completed successfully. Nine months later, 27 × 29 mm pseudoaneurysm of the left EIA was identified that appeared to have developed secondary to migration of the original stent graft. A new stent graft was placed.
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- 2020
16. Integrated genetic and epigenetic analysis revealed heterogeneity of acute lymphoblastic leukemia in Down syndrome
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Tsutomu Toki, Yasuhide Hayashi, Jiro Kagawa, Masafumi Seki, Kenichi Yoshida, Yuichi Shiraishi, Tomoko Kawai, Kenichiro Hata, Nobutaka Kiyokawa, Kenichi Chiba, Satoru Miyano, Junko Takita, Hiroko Tanaka, Tadayuki Kumagai, Hiromichi Suzuki, Tatsuya Ito, Yasuo Kubota, Keisuke Kataoka, Kiminori Terui, Etsuro Ito, Akira Oka, Tomoya Isobe, Kentaro Ohki, Seishi Ogawa, Kumiko Uryu, and Atsushi Sato
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Male ,0301 basic medicine ,Cancer Research ,Down syndrome ,Lineage (genetic) ,Chromosomes, Human, Pair 21 ,Population ,acute lymphoblastic leukemia ,genetic analysis ,Biology ,Genetic analysis ,Epigenesis, Genetic ,03 medical and health sciences ,0302 clinical medicine ,children ,medicine ,Humans ,Genetic Predisposition to Disease ,Philadelphia Chromosome ,Epigenetics ,Child ,Promoter Regions, Genetic ,education ,Genetics, Genomics, and Proteomics ,Gene ,Genetics ,education.field_of_study ,Sequence Analysis, RNA ,Gene Expression Profiling ,High-Throughput Nucleotide Sequencing ,Cell Differentiation ,Sequence Analysis, DNA ,Original Articles ,General Medicine ,DNA Methylation ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,medicine.disease ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Core Binding Factor Alpha 2 Subunit ,DNA methylation ,Female ,Original Article ,Chromosome 21 ,epigenetic analysis - Abstract
Children with Down syndrome (DS) are at a 20‐fold increased risk for acute lymphoblastic leukemia (ALL). Compared to children with ALL and no DS (non‐DS‐ALL), those with DS and ALL (DS‐ALL) harbor uncommon genetic alterations, suggesting DS‐ALL could have distinct biological features. Recent studies have implicated several genes on chromosome 21 in DS‐ALL, but the precise mechanisms predisposing children with DS to ALL remain unknown. Our integrated genetic/epigenetic analysis revealed that DS‐ALL was highly heterogeneous with many subtypes. Although each subtype had genetic/epigenetic profiles similar to those found in non‐DS‐ALL, the subtype distribution differed significantly between groups. The Philadelphia chromosome‐like subtype, a high‐risk B‐cell lineage variant relatively rare among the entire pediatric ALL population, was the most common form in DS‐ALL. Hypermethylation of RUNX1 on chromosome 21 was also found in DS‐ALL, but not non‐DS‐ALL. RUNX1 is essential for differentiation of blood cells, especially B cells; thus, hypermethylation of the RUNX1 promoter in B‐cell precursors might be associated with increased incidence of B‐cell precursor ALL in DS patients.
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- 2019
17. Separation of Y(III) and Sr(II) from acid solutions by extraction chromatography using HDEHP-impregnated adsorbent and its medical application
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Tatsuya Ito and Seong Yun Kim
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Adsorption ,Chromatography ,Chemistry ,Extraction (chemistry) ,General Medicine - Published
- 2018
18. Comparison of ultrasound‐guided versus angiography‐guided endovascular treatment for femoropopliteal artery occlusive disease
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Takahiro Tokuda, Shinsuke Mori, Keisuke Hirano, Ryoji Koshida, Hiroaki Matsuda, Yasuhiro Oba, Akira Murata, Ai Kagase, Yoriyasu Suzuki, and Tatsuya Ito
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medicine.medical_specialty ,medicine.medical_treatment ,Occlusive disease ,030204 cardiovascular system & hematology ,Revascularization ,Lesion ,Peripheral Arterial Disease ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Popliteal Artery ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Endovascular treatment ,Ultrasonography, Interventional ,Vascular Patency ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Endovascular Procedures ,Angiography ,General Medicine ,Ultrasound guided ,Femoral Artery ,Radiation exposure ,Treatment Outcome ,medicine.anatomical_structure ,Radiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
PURPOSE This study aimed to compare the efficacy of ultrasound-guided and angiography-guided intraluminal approach for femoropopliteal (FP) artery occlusive disease. METHODS A retrospective analysis was performed using the data collected regarding patients that underwent endovascular treatment (EVT) for FP artery occlusive disease between January 2010 and April 2018 at two centers. A total of 221 consecutive de novo lesions were analyzed according to the method of recanalization. Propensity score-matched analysis was performed to compare the clinical outcomes of recanalization methods for FP occlusive lesions. The prognostic value was analyzed based on the number of guidewires, wire cross time, distal puncture rate, radiation exposure, the amount of contrast media, primary patency, and clinically driven-target lesion revascularization (CD-TLR) at 1 year. RESULTS A total of 44 matched pairs of patients were analyzed after propensity score-matched analysis. The number of guidewires, distal puncture rate, wire passage time, radiation exposure, and the amount of contrast media were significantly lower in the ultrasound-guide group, with 3.4 vs. 4.7, 9.1% vs. 54.5%, 47 min vs. 83 min, 207 mGy vs. 821 mGy, 66 ml vs. 109 ml, respectively (p
- Published
- 2020
19. Survival benefit of conversion surgery after intensive chemotherapy for unresectable metastatic gastric cancer: a propensity score-matching analysis
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Hiroyuki Ohnuma, Koji Miyanishi, Naoki Onoyama, Naotaka Hayasaka, Kazuyuki Murase, Ichiro Takemasa, Kota Hamaguchi, Yasushi Sato, Takayuki Nobuoka, Takeshi Murakami, Junji Kato, Kohichi Takada, Tatsuya Ito, and Masanori Sato
- Subjects
0301 basic medicine ,Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Multivariate analysis ,medicine.medical_treatment ,Subgroup analysis ,Adenocarcinoma ,Risk Assessment ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Gastrectomy ,Stomach Neoplasms ,Antineoplastic Combined Chemotherapy Protocols ,Medicine ,Humans ,Neoplasm Metastasis ,Propensity Score ,Aged ,Retrospective Studies ,Chemotherapy ,business.industry ,Confounding ,Cancer ,Combination chemotherapy ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Survival Analysis ,Surgery ,030104 developmental biology ,Treatment Outcome ,Oncology ,Chemotherapy, Adjuvant ,030220 oncology & carcinogenesis ,Propensity score matching ,Female ,business - Abstract
The clinical benefit of conversion surgery (CS) for unresectable gastric cancer (GC), whereby unresectable GC responds to chemotherapy and subsequently receives curative-intent surgery, remains unclear. Here, we aimed to clarify the clinical value of CS. In this retrospective cohort study, we analyzed 175 unresectable GC, who received triple combined chemotherapy between 2004 and 2019. We divided patients into two groups: those who underwent CS and those receiving chemotherapy only (CS and C groups, respectively). Propensity score matching was used to minimize confounding bias. Of 175 cases, 61 (34.9%) underwent CS. R0 resection was obtained in 85.2%. After matching, 44 pairs were selected; there were no significant differences in baseline covariants. Group CS had a significantly better median overall survival (OS) (18.8 vs. 46.0 months, p
- Published
- 2020
20. Double small bowel cancers leading to the diagnosis of Lynch syndrome with germline MSH6 mutation in an elderly patient
- Author
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Sae Ohwada, Kohei Nakachi, Kei Mitsuhashi, Hiroshi Nakase, Akiko Ichiyanagi, Kentaro Yamashita, Hiro-o Yamano, Tatsuya Ito, Takayuki Nobuoka, Tomoe Kazama, and Wataru Sasao
- Subjects
medicine.medical_specialty ,Amsterdam criteria ,digestive system ,Gastroenterology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Germline mutation ,Capsule endoscopy ,law ,Double-balloon enteroscopy ,Internal medicine ,medicine ,Humans ,Germ-Line Mutation ,Aged ,medicine.diagnostic_test ,business.industry ,digestive, oral, and skin physiology ,Cancer ,Sigmoid colon ,General Medicine ,medicine.disease ,Colorectal Neoplasms, Hereditary Nonpolyposis ,digestive system diseases ,Lynch syndrome ,DNA-Binding Proteins ,Ileal Neoplasms ,medicine.anatomical_structure ,Germ Cells ,030220 oncology & carcinogenesis ,Mutation ,Adenocarcinoma ,030211 gastroenterology & hepatology ,Female ,business - Abstract
A female patient in her 80s was referred to our hospital because of an ileal tumor identified by capsule endoscopy. FDG-PET suggested double intestinal tumors not only in the ileum but also in the jejunum. The patient has cancer past history including sigmoid colon, rectum, and endometrium, and also had cancer family history fulfilling the revised Amsterdam criteria. Double balloon enteroscopy disclosed two ulcerated tumors in the jejunum and the ileum. Biopsy was diagnosed as adenocarcinoma pathologically, and microsatellite instability-high (MSI-H) genetically. Surgical resection was performed, and the jejunal and the ileal tumors were tubular (T2N0M0) and mucinous adenocarcinoma (T4N0M0), respectively. Germline mutation analysis revealed a pathogenic splice-site mutation in MSH6.
- Published
- 2020
21. Management of Multiple Arteriovenous Malformations of the Small Bowel
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Kazuyuki Murase, Naotaka Hayasaka, Masahiro Hirakawa, Koji Miyanishi, Hiroyuki Ohnuma, Kohichi Takada, Masayoshi Kobune, Junji Kato, Takayuki Nobuoka, Rie Ishizuka, Ichiro Takemasa, Tatsuya Ito, and Masanori Sato
- Subjects
Enteroscopy ,medicine.medical_specialty ,Gastrointestinal bleeding ,Surgical margin ,business.industry ,lcsh:R ,Pulsatile flow ,lcsh:Medicine ,Arteriovenous malformation ,Case Report ,General Medicine ,030230 surgery ,medicine.disease ,Jejunum ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,medicine.anatomical_structure ,chemistry ,Ectasia ,medicine ,030211 gastroenterology & hepatology ,Radiology ,business ,Indocyanine green - Abstract
A 62-year-old Japanese female was referred to our hospital with gastrointestinal bleeding. Although small-bowel bleeding was suspected, no bleeding source was identified by enhanced computed tomography (CT), video capsule endoscopy (VCE), and double-balloon enteroscopy (DBE). Five years later, the patient had recurrent intermittent bloody stools with a significant decrease in hemoglobin levels. Although no active bleeding was observed on antegrade DBE, we detected a pulsatile submucosal uplift accompanied by a small red patch on the top of the uplift in the jejunum. Arteriovenous malformation (AVM) was suspected as the cause of small-bowel bleeding. Multiple-phase CT showed a number of small vascular ectasias during the arterial phase in the jejunum, and we confirmed the presence of multiple AVMs in the jejunum by selective angiography. To identify the location of the lesions and determine the minimal surgical margins, we performed intraoperative selective angiography with indocyanine green (ICG) injection. This technique allowed us to clearly observe the region and perform segmental small-bowel resection with minimal surgical margin. The patient reported that she has had no gastrointestinal bleeding at the two years follow-up visit.
- Published
- 2019
22. Neoadjuvant chemotherapy with docetaxel, nedaplatin, and fluorouracil for resectable esophageal cancer : A phase II study
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Tamotsu Sagawa, Masahiro Hirakawa, Koji Miyanishi, Motoh Ohi, Yasushi Sato, Teppei Matsuno, Chisa Fujita, Koshi Fujikawa, Tatsuya Ito, Masanori Sato, Masayoshi Kobune, Takayuki Nobuoka, Ichiro Takemasa, Yutaka Okagawa, Michiaki Hirayama, Hiroyuki Ohnuma, Takahiro Osuga, Yasushi Tsuji, Junji Kato, and Naotaka Hayasaka
- Subjects
Male ,Cancer Research ,Esophageal Neoplasms ,Organoplatinum Compounds ,medicine.medical_treatment ,Phases of clinical research ,Gastroenterology ,chemistry.chemical_compound ,0302 clinical medicine ,Japan ,Antineoplastic Combined Chemotherapy Protocols ,docetaxel ,030212 general & internal medicine ,esophageal cancer ,General Medicine ,Esophageal cancer ,Middle Aged ,nedaplatin ,Neoadjuvant Therapy ,esophageal squamous cell carcinoma ,Treatment Outcome ,Oncology ,Docetaxel ,Esophagectomy ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Original Article ,Female ,Taxoids ,Fluorouracil ,medicine.drug ,neoadjuvant chemotherapy ,medicine.medical_specialty ,Neutropenia ,Drug Administration Schedule ,03 medical and health sciences ,Clinical Research ,Internal medicine ,medicine ,Humans ,Nedaplatin ,Aged ,Chemotherapy ,business.industry ,Original Articles ,medicine.disease ,Survival Analysis ,chemistry ,Feasibility Studies ,business ,Febrile neutropenia - Abstract
Cisplatin plus 5‐fluorouracil is regarded as standard neoadjuvant chemotherapy for esophageal squamous cell carcinoma (ESCC) in Japan, but the prognosis remains poor. We have previously described how definitive chemoradiotherapy with docetaxel, nedaplatin, and 5‐fluorouracil (DNF) led to a very high response rate and promising survival times. We therefore undertook a phase II trial to evaluate the feasibility and efficacy of neoadjuvant DNF. The study included patients with clinical stage Ib‐III ESCC. Chemotherapy consisted of i.v. docetaxel (30 mg/m2) and nedaplatin (50 mg/m2) on days 1 and 8, and a continuous infusion of 5‐fluorouracil (400 mg/m2/day) on days 1‐5 and 8‐12, every 3 weeks. After three courses of chemotherapy, esophagectomy was carried out. The primary end‐point was the completion rate of the protocol treatment. Twenty‐eight patients were enrolled (cStage Ib/II/III, 2/3/23) and all received at least two cycles of chemotherapy. Twenty‐five patients underwent surgery, all of whom achieved an R0 resection, leading to a completion rate of 89.3%. The overall response rate was 87.0%. A pathological complete response was confirmed in eight (32.0%) cases. Grade 3/4 adverse events included leukopenia (32.1%), neutropenia (39.3%), febrile neutropenia (10.7%), thrombocytopenia (10.7%), and diarrhea (14.3%), but were manageable. Treatment‐related deaths and major surgical complications did not occur. Estimated 2‐year progression‐free and overall survival rates were 70.4% and 77.2%, respectively. Thus, DNF therapy was well tolerated and deemed feasible, with a strong tumor response in a neoadjuvant setting for ESCC. This trial is registered with the University Hospital Medical Information Network (UMIN ID: 000014305).
- Published
- 2018
23. Short- and long-term clinical impact of tissue protrusion after newer-generation drug-eluting stent implantation for acute coronary syndrome
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Akira Murata, Yusuke Ochiumi, Yoriyasu Suzuki, Tatsuya Ito, and Suguru Murase
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Male ,medicine.medical_specialty ,Acute coronary syndrome ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Culprit ,03 medical and health sciences ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Recurrence ,Internal medicine ,Intravascular ultrasound ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Acute Coronary Syndrome ,Ultrasonography, Interventional ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Coronary Thrombosis ,Incidence (epidemiology) ,Percutaneous coronary intervention ,Drug-Eluting Stents ,Interventional radiology ,General Medicine ,Middle Aged ,medicine.disease ,Plaque, Atherosclerotic ,Drug-eluting stent ,Conventional PCI ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Although stent implantation may be associated with tissue protrusion (TP), especially in patients with acute coronary syndrome (ACS), its long-term clinical outcomes remain unknown. The aim of the current study was to evaluate the long-term clinical outcomes of ACS patients with TP after the implantation of newer-generation drug-eluting stents (DESs). We retrospectively evaluated 366 consecutive ACS patients who underwent primary percutaneous coronary intervention (PCI) with newer-generation DESs. All culprit lesions underwent pre- and post-PCI intravascular ultrasound (IVUS) examinations and were classified according to the presence or absence of post-stent TP. After primary PCI, 198 lesions (54.1%) displayed TP on IVUS examination. At the 12-month follow-up, the incidence of target lesion revascularization did not differ between patients with (n = 198) and without (n = 168) TP (3.5 vs. 4.2%, p = 0.790). The incidence of recurrent ACS (r-ACS) was higher in patients with versus those without TP (7.1 vs. 2.4%; log-rank test p = 0.043). Cox proportional hazard analysis showed that triple-vessel disease (HR = 9.258, p = 0.001), TP (HR = 3.149, p = 0.008), and low-density lipoprotein cholesterol reduction rate ≥ 50% (HR = 0.184, p = 0.008) were the independent predictors of r-ACS. TP detected using IVUS after DES implantation may be associated with the occurrence of r-ACS after the 12-month follow-up, although short-term clinical outcomes were not worse during the 12-month follow-up.
- Published
- 2018
24. Disseminated Cutaneous Infection of Mycobacterium colombiense in a Patient with Myelodysplastic Syndrome
- Author
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Tatsuya Ito, Yoshitaka Ono, Yuichiro Inagaki, Tomonori Kato, and Masashi Sawa
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0301 basic medicine ,030106 microbiology ,Microbiology ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,Clarithromycin ,Internal Medicine ,medicine ,030212 general & internal medicine ,Ethambutol ,Polymerase chain reaction ,biology ,business.industry ,Mycobacterium colombiense ,General Medicine ,bacterial infections and mycoses ,biology.organism_classification ,Virology ,Rash ,Nontuberculous mycobacteria ,medicine.symptom ,business ,Rifampicin ,medicine.drug ,Mycobacterium - Abstract
Mycobacterium colombiense (M. colombiense) is a member of the Mycobacterium avium complex (MAC). To our knowledge, this is the third case report of an M. colombiense infection. An 80-year-old man, immunocompromised by myelodysplastic syndrome (MDS), developed a skin rash with exfoliation and eruption on his face and scalp. Mycobacteria were detected in pus samples. Broad-range polymerase chain reaction (PCR) revealed the mycobacteria to be M. colombiense. The lesions resolved after daily administration of rifampicin, ethambutol, and clarithromycin. In conclusion, broad-range PCR identified this rare mycobacterium, allowing for the administration of appropriate combination antibiotic therapy.
- Published
- 2018
25. Glomerular expression of myxovirus resistance protein 1 in human mesangial cells: Possible activation of innate immunity in the pathogenesis of lupus nephritis
- Author
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Hiroshi Tanaka, Hidemi Yoshida, Tadaatsu Imaizumi, Kazushi Tsuruga, Kensuke Joh, Tatsuya Ito, Etsuro Ito, Tomoh Matsumiya, Tomomi Aizawa, and Shojiro Watanabe
- Subjects
Innate immune system ,Mesangial cell ,Lupus nephritis ,RNA ,General Medicine ,Biology ,medicine.disease ,Proinflammatory cytokine ,Nephrology ,RNA interference ,Interferon ,Immunology ,medicine ,Nephritis ,medicine.drug - Abstract
Since viral infections activate type I interferon (IFN) pathways and cause subsequent release of IFN-dependent proinflammatory chemokines and cytokines, the innate immune system plays an important role in the pathogenesis of lupus nephritis (LN). It has been reported that human myxovirus resistance protein 1 (Mx1), a type I IFN-dependent transcript, acts against a wide range of RNA viruses. Although the expression of Mx1 in biopsy specimens obtained from patients with dermatomyositis and cutaneous lupus has been described, the expression of Mx1 in human mesangial cells (MCs) has remained largely unknown. We treated normal human MCs in culture with polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA, and analyzed the expression of Mx1 by reverse transcription-polymerase chain reaction and western blotting. To elucidate the poly IC-signalling pathway, we subjected the cells to RNA interference against IFN-β. We also conducted an immunofluorescence study to examine mesangial Mx1 expression in biopsy specimens from patients with LN. Poly IC-induced Mx1 expression in MCs are shown both time- and dose-dependently, and RNA interference against IFN-β inhibited poly IC-induced Mx1 expression. Intense glomerular Mx1 expression was observed in biopsy specimens from patients with LN, whereas negative staining occurred in specimens from patients with IgA nephropathy or purpura nephritis. These preliminary observations support, at least in part, the theory of innate immune system activation in the pathogenesis of LN.
- Published
- 2013
26. The relationship between re-endothelialization and endothelial function after DES implantation: Comparison between paclitaxcel eluting stent and zotarolims eluting stent
- Author
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Yoriyasu Suzuki, Akira Murata, Osamu Matsuda, Tatsuya Ito, Suguru Murase, and Toshikazu Yamaguchi
- Subjects
Male ,Time Factors ,medicine.medical_treatment ,Coronary Artery Disease ,Coronary Angiography ,Coronary artery disease ,Re-Epithelialization ,endothelial function ,Vasoconstrictor Agents ,Drug-Eluting Stents ,General Medicine ,Middle Aged ,TAXUS ,Coronary Vessels ,Treatment Outcome ,surgical procedures, operative ,medicine.anatomical_structure ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Tomography, Optical Coherence ,medicine.drug ,Neointima ,medicine.medical_specialty ,Paclitaxel ,Prosthesis Design ,Percutaneous Coronary Intervention ,Internal medicine ,medicine ,Humans ,Infusions, Intra-Arterial ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,endeavor ,Aged ,Retrospective Studies ,Sirolimus ,business.industry ,Endothelial Cells ,Percutaneous coronary intervention ,Stent ,Cardiovascular Agents ,re-endothelialization ,equipment and supplies ,medicine.disease ,Acetylcholine ,Coronary arteries ,Vasoconstriction ,Cardiovascular agent ,business - Abstract
Background Several studies have reported re-endothelialization and endothelial function after drug-eluting stent (DES) implantation; however, the relationship between re-endothelialization and endothelial function after DES implantation has not been investigated yet. Methods A total of 14 patients underwent evaluation of re-endothelialization by optical coherence tomography (OCT) and endothelial function by incremental Ach infusion at 9 months after DES implantation (ZES: N = 7, PES: N = 7). The neointimal thickness (NIT) inside each strut, strut coverage, and malapposition at every 1 mm cross-section were evaluated by OCT and the endothelial function was estimated by measuring the coronary vaso-reactivity in response to acetylcholine (Ach) infusion into coronary arteries. Results Zotarolims eluting stent (ZES), compared with paclitaxcel eluting stent (PES), showed more homogeneous neointimal coverage of stent struts and low rate of malapposition. Vasoconstriction in response to Ach in the peri-stent region was also less pronounced in ZES than PES. In particular, vasoconstriction was more often observed in cases with inhomogeneous neointimal coverage of stent struts in the PES group. Conclusions Our findings suggest that endothelial function seems to be better preserved with ZES than PES, and homogeneous neointimal coverage of stent struts seem to be associated with the preserved endothelial function. © 2013 Wiley Periodicals, Inc.
- Published
- 2013
27. Protein kinase Cα inhibitor protects against downregulation of claudin-1 during epithelial–mesenchymal transition of pancreatic cancer
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Hiroshi Yamaguchi, Yasutoshi Kimura, Masafumi Imamura, Tatsuya Ito, Masaki Murata, Takashi Kojima, Daisuke Kyuno, Akira Takasawa, Norimasa Sawada, Koichi Hirata, and Satoshi Tanaka
- Subjects
MAPK/ERK pathway ,Cancer Research ,Epithelial-Mesenchymal Transition ,Protein Kinase C-alpha ,endocrine system diseases ,Carbazoles ,Down-Regulation ,Occludin ,Transforming Growth Factor beta1 ,Downregulation and upregulation ,Cell Line, Tumor ,Pancreatic cancer ,Claudin-1 ,Nitriles ,Butadienes ,medicine ,Humans ,Epithelial–mesenchymal transition ,Claudin-4 ,Enzyme Inhibitors ,RNA, Small Interfering ,Extracellular Signal-Regulated MAP Kinases ,Protein kinase A ,Chemistry ,Kinase ,Pancreatic Ducts ,Epithelial Cells ,General Medicine ,medicine.disease ,Cell Hypoxia ,digestive system diseases ,Up-Regulation ,Pancreatic Neoplasms ,Protein Biosynthesis ,Claudins ,Cancer research ,RNA Interference ,Snail Family Transcription Factors ,Signal transduction ,Signal Transduction ,Transcription Factors - Abstract
Protein kinase Cα (PKCα) is highly expressed in pancreatic cancer. However, the effects of PKCα on Snail and claudin-1, which play crucial roles in epithelial cell polarity during epithelial-mesenchymal transition (EMT), remain unclear. In this study, we investigated the mechanisms of regulation of Snail and claudin-1 via a PKCα signal pathway during EMT in pancreatic cancer cells and in normal human pancreatic duct epithelial cells (HPDEs). By immunostaining, overexpression of PKCα and downregulation of claudin-1 were observed in poorly differentiated human pancreatic cancer tissues and the pancreatic cancer cell line PANC-1. Treatment with the PKCα inhibitor Gö6976 transcriptionally decreased Snail and increased claudin-1 in PANC-1 cells. The PKCα inhibitor prevented upregulation of Snail and downregulation of claudin-1 during EMT induced by transforming growth factor-β1 (TGF-β1) treatment and under hypoxia in PANC-1 cells. The effects of the PKCα inhibitor were in part regulated via an extracellular signal-regulated kinase (ERK) signaling pathway. The PKCα inhibitor also prevented downregulation of the barrier function and fence function during EMT in well-differentiated pancreatic cancer cell line HPAC. In normal HPDEs, the PKCα inhibitor transcriptionally induced not only claudin-1 but also claudin-4, -7 and occludin without a change of Snail. Treatment with the PKCα inhibitor in normal HPDEs prevented downregulation of claudin-1 and occludin by TGF-β1 treatment and enhanced upregulation of claudin-1, -4, -7 and occludin under hypoxia. These findings suggest that PKCα regulates claudin-1 via Snail- and mitogen-activated protein kinase/ERK-dependent pathways during EMT in pancreatic cancer. Thus, PKCα inhibitors may be potential therapeutic agents against the malignancy of human pancreatic cancer cells.
- Published
- 2013
28. Successful Treatment of Class IV+V Lupus Nephritis with Combination Therapy of High-dose Corticosteroids, Tacrolimus and Intravenous Cyclophosphamide
- Author
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Hirofumi Takei, Ayumi Okuyama, Eiko Nishi, Hiroe Ogawa, K. Chino, Tsuneo Kondo, A. Shibata, Hayato Nagasawa, Hitoshi Kato, Tatsuya Ito, Takahiko Kurasawa, Koji Nishimura, Koichi Amano, and Ryota Sakai
- Subjects
medicine.medical_specialty ,Hypertension, Renal ,Nephrotic Syndrome ,Adolescent ,Cyclophosphamide ,Combination therapy ,Prednisolone ,medicine.medical_treatment ,Lupus nephritis ,Tetrazoles ,Azathioprine ,Pharmacology ,Severity of Illness Index ,Gastroenterology ,Tacrolimus ,Recurrence ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Lupus Erythematosus, Systemic ,Infusions, Intravenous ,Antihypertensive Agents ,Mizoribine ,business.industry ,Biphenyl Compounds ,Immunosuppression ,Irbesartan ,General Medicine ,medicine.disease ,Lupus Nephritis ,Transplantation ,Pulse Therapy, Drug ,Cyclosporine ,Drug Therapy, Combination ,Female ,Ribonucleosides ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
A substantial number of patients with lupus nephritis (LN) are refractory to conventional glucocorticoid (GC) treatment. Although many of these patients respond to immunosuppressive drugs such as intravenous cyclophosphamide (IVCY), azathioprine (AZA), mizoribine, tacrolimus, cyclosporine A (CSA) and mycofenolate mofetil (MMF), some remain refractory to such therapies. Recent studies of multi-target therapies have reported effective outcomes for immunosuppression following renal transplantation and refractory LN when therapy consists of two or more immunosuppressive drugs with different mechanisms of action. We herein report a case of LN unresponsive to IVCY that was successfully treated with the addition of tacrolimus and discuss the usefulness of multi-target therapy for LN.
- Published
- 2013
29. Adsorption and separation behavior of yttrium and strontium in nitric acid solution by extraction chromatography using a macroporous silica-based adsorbent
- Author
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Yuanlai Xu, Yoshihito Funaki, Keizo Ishii, T. Tada, Keitaro Hitomi, Seong Yun Kim, Tatsuya Ito, and Kasane Nakazawa
- Subjects
Langmuir ,Chromatography ,Elution ,Organic Chemistry ,Inorganic chemistry ,Extraction (chemistry) ,chemistry.chemical_element ,General Medicine ,Yttrium ,Nitric Oxide ,Silicon Dioxide ,Biochemistry ,Analytical Chemistry ,Solutions ,chemistry.chemical_compound ,Adsorption ,chemistry ,Distilled water ,Strontium ,Nitric acid ,Diethylenetriamine ,Microscopy, Electron, Scanning - Abstract
To separate (90)Y from the fission product (90)Sr-(90)Y group, a silica-based TODGA/SiO(2)-P adsorbent was prepared by impregnating N,N,N',N'-tetraoctyl-3-oxapentane-1,5-diamide (TODGA) extractant into the macroporous SiO(2)-P support with a mean diameter of 60 μm. The adsorption behavior of Sr(II) and Y(III) onto TODGA/SiO(2)-P adsorbent from HNO(3) solution and their mutual separation were investigated. Under the experimental conditions, this adsorbent showed high adsorption affinity to Y(III) and weak adsorption to Sr(II). It was found that the adsorption process of Y(III) could be expressed by both of Langmuir monomolecular layer adsorption mode and the pseudo-second order model. From the results of stability experiments, it became clear that TODGA/SiO(2)-P adsorbent is stable in 3M HNO(3) solution for 1 month contact time at 298 K. Using a column packed with TODGA/SiO(2)-P adsorbent, Sr(II) and Y(III) were eluted by distilled water and diethylenetriamine pentaacetic acid (DTPA) solution, respectively. The separation of Y(III) from Sr(II)-Y(III) group was achieved successfully.
- Published
- 2012
30. Successful treatment of adult-onset Still’s disease with tocilizumab monotherapy: two case reports and literature review
- Author
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Tatsuya Ito, Tsuneo Kondo, Ayumi Okuyama, Yuichiro Shirai, Takahiko Kurasawa, Eiko Nishi, Hayato Nagasawa, Ryota Sakai, Tsutomu Takeuchi, Koji Nishimura, Koichi Amano, Hirofumi Takei, and Hideto Kameda
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adult-onset Still's disease ,Adolescent ,Disease ,Antibodies, Monoclonal, Humanized ,chemistry.chemical_compound ,Tocilizumab ,Rheumatology ,Refractory ,Internal medicine ,medicine ,Humans ,Interleukin-6 ,business.industry ,General Medicine ,Surgery ,Treatment Outcome ,chemistry ,Antirheumatic Agents ,Concomitant ,Monoclonal ,Etiology ,Female ,business ,Still's Disease, Adult-Onset - Abstract
Adult-onset Still's disease (AOSD) is a systemic inflammatory disease of unknown etiology. Recently, it has been reported that quite a few cases of refractory AOSD were successfully treated with tocilizumab (TCZ) and corticosteroids were withdrawn in some of these patients. We report two AOSD patients who were treated successfully with TCZ monotherapy; thus, avoiding corticosteroid treatment. Because both of the patients refused to take corticosteroids, we planned to treat them with 8 mg/kg of TCZ monotherapy at weeks 0, 2, 6 and subsequently every 4 weeks. The efficacy of TCZ was assessed by patients' clinical symptoms such as fever, arthralgia, skin eruptions, and laboratory markers such as serum levels of CRP, ferritin, and IL-6. We also reviewed 14 previous case reports including 30 cases who had been treated with TCZ for AOSD. Our patients responded rapidly and have been maintained in clinical remission without corticosteroid treatment. In the literature review, concomitant corticosteroid treatment described in 13 cases was successfully tapered in 7 and discontinued in 6 cases. TCZ monotherapy can be a candidate for the first-line therapy for some AOSD patients.
- Published
- 2012
31. Multiple forms of α-glucosidase in rice seeds (Oryza sativa L., var Nipponbare)
- Author
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Masatoshi Hayashi, Atsuo Kimura, Seiya Chiba, Wongchawalit Jintanart, Kazuki Matsubara, Haruhide Mori, Tatsuya Ito, Takeshi Yamamoto, Masayuki Okuyama, Hiroyuki Nakai, Young-Min Kim, Koutarou Kamiya, and Yoshio Sano
- Subjects
Proteolysis ,Molecular Sequence Data ,Biology ,Plant Proteins, Dietary ,Polymerase Chain Reaction ,Biochemistry ,Substrate Specificity ,Post-translational proteolysis ,Sequence Homology, Nucleic Acid ,Complementary DNA ,medicine ,Starch granules degradation ,Amino Acid Sequence ,RNA, Messenger ,Gene ,chemistry.chemical_classification ,Oryza sativa ,Base Sequence ,Sequence Homology, Amino Acid ,medicine.diagnostic_test ,Alternative splicing ,food and beverages ,Oryza ,alpha-Glucosidases ,Ripening ,General Medicine ,Blotting, Northern ,Molecular biology ,Amino acid ,Isoenzymes ,Blotting, Southern ,Enzyme ,chemistry ,Multigene Family ,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ,Seeds ,α-Glucosidase isoforms and isozymes ,Electrophoresis, Polyacrylamide Gel ,α-Glucosidase multigene family ,Protein Processing, Post-Translational - Abstract
Two isoforms of alpha-glucosidases (ONG2-I and ONG2-II) were purified from dry rice seeds (Oryza sativa L., var Nipponbare). Both ONG2-I and ONG2-II were the gene products of ONG2 mRNA expressed in ripening seeds. Each enzyme consisted of two components of 6kDa-peptide and 88kDa-peptide encoded by this order in ONG2 cDNA (ong2), and generated by post-translational proteolysis. The 88kDa-peptide of ONG2-II had 10 additional N-terminal amino acids compared with the 88kDa-peptide of ONG2-I. The peptides between 6kDa and 88kDa components (26 amino acids for ONG2-I and 16 for ONG2-II) were removed by post-translational proteolysis. Proteolysis induced changes in adsorption and degradation of insoluble starch granules. We also obtained three alpha-glucosidase cDNAs (ong1, ong3, and ong4) from ripening seeds. The ONG1, ONG2, and ONG4 genes were situated in distinct locus of rice genome. The transcripts encoding ONG2 and ONG3 were generated by alternative splicing. Members of alpha-glucosidase multigene family are differentially expressed during ripening and germinating stages in rice.
- Published
- 2007
32. Diagnostic Accuracy of 64-Slice Computed Tomography for Detecting Angiographically Significant Coronary Artery Stenosis in an Unselected Consecutive Patient Population Comparison With Conventional Invasive Angiography
- Author
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Tetsuo Matsubara, Yoshihiro Takeda, Etsuo Tsuchikane, Tomomichi Suzuki, Jean-Francois Surmely, Yoshihisa Kinoshita, Akira Murata, Masato Kawai, Yasuyuki Suzuki, Kenya Nasu, Mitsuyasu Terashima, Nobuyoshi Tanaka, Osamu Katoh, Takahiko Suzuki, Koyo Sato, Mariko Ehara, and Tatsuya Ito
- Subjects
Tachycardia ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,Coronary artery disease ,Stenosis ,Text mining ,Predictive value of tests ,Angiography ,Heart rate ,medicine ,cardiovascular diseases ,Radiology ,Tomography ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Multislice computed tomography (MSCT) is a promising noninvasive method of detecting coronary artery disease (CAD). However, most data have been obtained in selected series of patients. The purpose of the present study was to investigate the accuracy of 64-slice MSCT (64 MSCT) in daily practice, without any patient selection. Methods and Results Using 64-slice MSCT coronary angiography (CTA), 69 consecutive patients, 39 (57%) of whom had previously undergone stent implantation, were evaluated. The mean heart rate during scan was 72 beats/min, scan time 13.6 s and the amount of contrast media 72 mL. The mean time span between invasive coronary angiography (ICAG) and CTA was 6 days. Significant stenosis was defined as a diameter reduction of >50%. Of 966 segments, 884 (92%) were assessable. Compared with ICAG, the sensitivity of CTA to diagnose significant stenosis was 90%, specificity 94%, positive predictive value (PPV) 89% and negative predictive value (NPV) 95%. With regard to 58 stented lesions, the sensitivity, specificity, PPV and NPV were 93%, 96%, 87% and 98%, respectively. On the patient-based analysis, the sensitivity, specificity, PPV and NPV of CTA to detect CAD were 98%, 86%, 98% and 86%, respectively. Eighty-two (8%) segments were not assessable because of irregular rhythm, calcification or tachycardia. Conclusion Sixty-four-MSCT has a high accuracy for the detection of significant CAD in an unselected patient population and therefore can be considered as a valuable noninvasive technique. (Circ J 2006; 70: 564 - 571)
- Published
- 2006
33. Impact of minimum contrast media volumes during elective percutaneous coronary intervention for prevention of contrast-induced nephropathy in patients with stable coronary artery disease
- Author
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Takahiko Suzuki, Mitsuyasu Terashima, Tatsuya Ito, Soichiro Ebisawa, Masashi Kimura, Kenya Nasu, Yoshihisa Kinoshita, Tairo Kurita, Etsuo Tsuchikane, and Nobuyoshi Tanaka
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Contrast-induced nephropathy ,Contrast Media ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Gastroenterology ,Nephropathy ,Coronary artery disease ,Diabetes Complications ,03 medical and health sciences ,0302 clinical medicine ,Percutaneous Coronary Intervention ,Risk Factors ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,030212 general & internal medicine ,Aged ,Retrospective Studies ,Dose-Response Relationship, Drug ,business.industry ,Incidence (epidemiology) ,Incidence ,Age Factors ,virus diseases ,Percutaneous coronary intervention ,General Medicine ,medicine.disease ,female genital diseases and pregnancy complications ,Surgery ,surgical procedures, operative ,Sodium Bicarbonate ,Creatinine ,Conventional PCI ,Multivariate Analysis ,Population study ,Female ,Kidney Diseases ,Isotonic Solutions ,Cardiology and Cardiovascular Medicine ,Complication ,business - Abstract
Contrast-induced nephropathy (CIN) is an important complication following percutaneous coronary intervention (PCI). The clinical importance of a minimum contrast media volume (CMV) for PCI to prevent CIN has not been well evaluated. The purpose of this study was to evaluate the impact of minimum CMV to prevent CIN after PCI. In this study, 2052 consecutive patients who underwent elective PCI in our institute were analyzed. We divided patients into two groups according to CMV: a minimum CMV PCI group [CMV ≤50 ml (n = 94)] and a non-minimum CMV PCI group [CMV >50 ml (n = 1958)]. CIN occurred in 160 (7.8 %) patients. The incidence of CIN was significantly lower in the minimum CMV PCI group than in the non-minimum CMV PCI group (2.1 vs. 8.1 %; P = 0.03). According to multivariate analysis, elderly patients and diabetes mellitus patients were at high risk of developing CIN in this study population. When analyzing only high-risk patients, the incidence of CIN was also significantly lower in the minimum CMV group than in the non-minimum CMV group (2.6 vs. 10.3 %; P = 0.03). Minimum CMV PCI could reduce the incidence of CIN, particularly in high-risk patients; as such, defining the minimum CMV clinical cut-off values may be useful for the prevention of CIN.
- Published
- 2014
34. [Untitled]
- Author
-
Kouzou Hiramatsu, Kiyonobu Kasama, Tatsuya Ito, Guangqi Chen, and Kouki Zen
- Subjects
Engineering ,Suction ,business.industry ,Suction force ,Foundation (engineering) ,Sea bottom ,Submarine ,Caisson ,Submarine pipeline ,Geotechnical engineering ,General Medicine ,Bearing capacity ,business - Abstract
Suction foundation is a new type of foundation for offshore structures. It forms like a tea caddy. It is built by installing hollow cylindrical caisson upside-down, into sea bottom, and carrying out forcible drainage of the internal water using a pump after the inner side of foundation is sealed by the submarine side. The difference of water pressure (suction) between inner and outer side of caisson and it will use this suction force as pushing power into the ground. Using suction foundation is useful for working term and constructing cost.This study pays attention to the characteristics of bearing capacity of the suction foundation over drawing-out, and bearing capacity formula.
- Published
- 2005
35. First clinical experience of a novel penetration catheter for patients with severe coronary artery stenosis
- Author
-
Manabu Shimogami, Etsuo Tsuchikane, Takahiko Suzuki, Tatsuya Ito, Hidetoshi Sato, Mariko Ehara, Osamu Katoh, and Tetsuo Matsubara
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,macromolecular substances ,Coronary Angiography ,Balloon ,Catheterization ,Coronary artery disease ,Angioplasty ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Angioplasty, Balloon, Coronary ,Aged ,business.industry ,Coronary Stenosis ,Balloon catheter ,Calcinosis ,Percutaneous coronary intervention ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Catheter ,medicine.anatomical_structure ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Complication ,Artery - Abstract
The study aimed to evaluate the efficacy of a novel penetration catheter for severe coronary artery disease. Severe coronary artery diseases such as chronic total occlusions or severe calcified stenoses sometimes obstruct the subsequent crossing of balloon catheter after successful wire crossing. A novel penetration over-the-wire catheter has been developed for severe coronary artery disease. The main shaft is a coreless stainless coil that consists of eight stranded stainless wires to cross through a severe stenosis by manual rotation. This device was applied during percutaneous coronary intervention for patients with severe coronary artery disease obstructing the subsequent crossing of balloon or microcatheters after successful wire crossing. Initial results were examined. Fourteen eligible patients were enrolled consecutively. Among those, 10 patients had chronic total occlusion and 7 patients showed severe angiographical calcification. The device was successfully crossed through the lesion and enabled subsequent dilatation in all patients without any complication. This new device enables the crossing of severe coronary artery stenoses and therefore favors further dilatation in this lesion subset.
- Published
- 2005
36. A Case of Ileus due to Ileal Stenosis caused by Oral Intake of Calcium Polystyrene Sulfonate
- Author
-
Tadashi Hasegawa, Sosuke Kato, Tomofumi Takagi, Yuji Ono, Jiro Ogino, Junichi Yoshida, Masahiro Hirakawa, Katsuya Nakanishi, and Tatsuya Ito
- Subjects
Ileal stenosis ,medicine.medical_specialty ,Ileus ,business.industry ,medicine ,General Medicine ,medicine.disease ,Calcium polystyrene sulfonate ,business ,Surgery - Published
- 2013
37. Facile synthesis of 7–10 membered rings by intramolecular condensation using dialkylcarbonate as solvent
- Author
-
Kiminori Tomimatsu, Atsuko Nishiguchi, Tatsuya Ito, and Tomomi Ikemoto
- Subjects
Solvent ,chemistry.chemical_compound ,chemistry ,Product (mathematics) ,Intramolecular force ,Organic Chemistry ,Drug Discovery ,Condensation ,Compound 17 ,Carbonate ,Organic chemistry ,General Medicine ,Biochemistry - Abstract
A convenient large-scalable synthesis of 1-benzazepines 19 as an important intermediate of CCR5 antagonist, oral HIV-1 therapy, was established. The anilination of o -halogenobenzaldehyde 9 with alkylamino-acid 16 gave o -formylaniline-acid 17 . Compound 17 was esterified followed by the improved reaction using the combination of alcoholate and dialkyl carbonate in one-pot, to easily produce 19 . Namely, these new processes afforded the desired product 19 in only two steps from the starting materials, as compared with the previous 10 steps. Moreover, these convenient methodologies were applied to other heterocycles to give 8–10 membered rings, such as 1-benzazocine, 1-benzazonine, and 1-benzazecine.
- Published
- 2004
38. Induction of p16INK4a Transcription and of Cellular Senescence by Aclacinomycin-Derivatives and Cardiac Glycosides
- Author
-
Kiyoshi Egawa, Masahiko Matsumoto, Kiyoshi Nose, Yosuke Kurihara, and Tatsuya Ito
- Subjects
Transcription, Genetic ,Pharmaceutical Science ,Cardiac Glycosides ,Tumor Cells, Cultured ,medicine ,Humans ,Luciferase ,Aclarubicin ,Cells, Cultured ,Cellular Senescence ,Cardiac glycoside ,Pharmacology ,Regulation of gene expression ,Reporter gene ,biology ,Cell growth ,Genes, p16 ,Biological activity ,General Medicine ,biology.organism_classification ,Gene Expression Regulation, Neoplastic ,Gene Expression Regulation ,Biochemistry ,Actinomycetales ,Cell aging ,medicine.drug - Abstract
Stable transformants of Saos-2 cells that contain the luciferase reporter gene under the control of the human p16INK4a transcriptional regulatory region were established, and were used to identify growth-inhibiting substances from culture broths of actinomycetes and extracts of plants. Among the active substances so far identified were an aclacinomycin-derivative, cenerubin B, and a cardiac glycoside, periplocin. These substances inhibited growth of normal human fibroblasts, and induced senescent phenotypes including a flattened morphology and increased acidic beta-galactosidase activity, although the activities of their derivatives to induce p16CDKN2 and beta-galactosidase did not coincided with each other. These results suggest that the reporter system using the p16CDKN2 transcriptional regulatory region is a useful means for screening growth inhibiting substances that are potential anti-tumor agents.
- Published
- 2002
39. ChemInform Abstract: Synthesis of a Stable Triformylmethane Synthon and Its Scalable Application to 7-Acylamino-3-formylquinoline Syntheses
- Author
-
Tatsuya Ito, Yasuhiro Sawai, Mitsuhisa Yamano, and Masahiro Mizuno
- Subjects
chemistry.chemical_classification ,chemistry.chemical_compound ,chemistry ,Synthon ,Aminal ,Salt (chemistry) ,Organic chemistry ,Amine gas treating ,General Medicine ,Triformylmethane - Abstract
Novel 2-iminiomethylvinamidinium trihalides were isolated as stable crystals and found to be useful triformylmethane synthons with non-deliquescent nature in air. They were easier to manufacture, handle, and store than the known 2-iminiomethylvinamidinium dichloride. By virtue of in situ aminal protection, a combination of the vinamidinium salt with a secondary amine achieved an efficient and scalable synthesis of 7-acylamino-3-formylquinoline, a versatile synthetic intermediate for potent anti-obesity drugs 7-acylamino-3-aminomethyl-8-methylquinolines.
- Published
- 2014
40. ChemInform Abstract: Enantioselective Synthesis of Angularly Substituted 1-Azabicyclic Rings: Coupled Dynamic Kinetic Epimerization and Chirality Transfer
- Author
-
Zachary D. Aron, Jocelyn Wang, Tatsuya Ito, Larry E. Overman, and Tircia L. May
- Subjects
Chemistry ,Stereochemistry ,Enantioselective synthesis ,Epimer ,General Medicine ,Enantiomer ,Kinetic energy ,Chirality (chemistry) ,Stereocenter - Abstract
This method starts from substrates with high enantiomeric excesses and proceeds with excellent chirality transfers (usually ≥ 96%) yielding products with up to three stereocenters.
- Published
- 2014
41. Clinical feasibility of laparoscopic lateral pelvic lymph node dissection following total mesorectal excision for advanced rectal cancer
- Author
-
Makoto Meguro, Tatsuya Ito, Kazuharu Kukita, Hiroshi Yamaguchi, Tadashi Ogawa, Toshihiko Nishidate, Kenji Okita, Tomohisa Furuhata, Emi Akizuki, Koichi Hirata, Tomomi Ueki, Yasutoshi Kimura, and Toru Mizuguchi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Colorectal cancer ,Endoscopy, Gastrointestinal ,Pelvis ,Low rectal cancer ,Surgical oncology ,Medicine ,Humans ,In patient ,Laparoscopy ,Lymph node ,Aged ,Neoplasm Staging ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Rectal Neoplasms ,Rectum ,General Medicine ,Middle Aged ,medicine.disease ,Total mesorectal excision ,Surgery ,Dissection ,medicine.anatomical_structure ,Treatment Outcome ,Feasibility Studies ,Lymph Node Excision ,Female ,business - Abstract
To evaluate the technical feasibility, safety and oncological outcomes of laparoscopic lateral pelvic lymph node dissection in patients with advanced low rectal cancer.Laparoscopic lateral pelvic lymph node dissection was performed in 18 patients from November 2009 to September 2012. The data regarding the patient demographics, surgical outcomes and short-term oncological outcomes were analyzed.In all 18 patients, the procedures were completed without conversion to open surgery. The mean length of the operation was 603.7 min (473-746 min). The mean number of harvested lateral pelvic lymph nodes was 16.9 (7-27), and five patients (27.8 %) had lymph node metastases. The postoperative mortality and morbidity rates were 0 and 16.7 %, respectively. Three patients developed Grade 2 urinary retention. No local recurrence had developed after a mean follow-up period of 23.6 months.Laparoscopic lateral pelvic lymph node dissection is technically feasible, safe and oncologically acceptable within the limitations of the short-term follow-up period.
- Published
- 2013
42. Distribution of Hearing Level in Aged Hearing Aid Users
- Author
-
Shouji Saruya, Kazuoki Kodera, Tatsuya Ito, and Naoko Maekawa
- Subjects
Hearing aid ,medicine.medical_specialty ,Hearing level ,business.industry ,medicine.medical_treatment ,medicine ,General Medicine ,Audiology ,business - Abstract
補聴器を購入した65歳より89歳までの2,031名について年齢群別に聴力レベルの分布を検討した。 3分法平均聴力レベルによる良聴耳において, 125Hzから2000Hzの周波数での聴力レベルが70dB以内に分布したものは, 年齢群にかかわらず対象者の約90%であった。 年齢群間の聴力レベルの差は少なかった。
- Published
- 2000
43. Stent Strut Fracture-Induced Restenosis in a Bifurcation Lesion Treated With the Crush Stenting Technique
- Author
-
Nobuyoshi Tanaka, Yoshihiro Takeda, Debabrata Dash, Mitsuyasu Terashima, Kenya Nasu, Jean-Francois Surmely, Osamu Katoh, Takahiko Suzuki, Mariko Ehara, Tetsuo Matsubara, Yoshihisa Kinoshita, and Tatsuya Ito
- Subjects
Male ,medicine.medical_specialty ,Percutaneous ,medicine.medical_treatment ,Constriction, Pathologic ,Coronary Angiography ,Coronary Restenosis ,Lesion ,Restenosis ,Side branch ,Humans ,Medicine ,Complication rate ,cardiovascular diseases ,Angioplasty, Balloon, Coronary ,Bifurcation lesion ,Aged ,business.industry ,Percutaneous coronary intervention ,Stent ,General Medicine ,equipment and supplies ,medicine.disease ,Coronary Vessels ,Surgery ,surgical procedures, operative ,Stents ,Radiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Percutaneous treatment of a bifurcation lesion still shows a significant complication rate, mainly because of restenosis at the ostial site of the side branch vessel. Different techniques, such as V-stenting, culottes-stenting or crush stenting, allow full ostial coverage and may therefore achieve uniform drug distribution within the lesion. The crush technique results in a strong mechanical constraint on the side branch stent. A case of stent strut fracture-induced restenosis in a bifurcation lesion treated with the crush stenting technique is described. (Circ J 2006; 70: 936 - 938)
- Published
- 2006
44. Chromatographic separation of platinum group metals from simulated high level liquid waste using macroporous silica-based adsorbents
- Author
-
Keizo Ishii, Yuanlai Xu, Keitaro Hitomi, Haruki Tokuda, Tatsuya Ito, and Seong Yun Kim
- Subjects
Packed bed ,Chromatography ,Elution ,Chemistry ,Silicon dioxide ,Organic Chemistry ,chemistry.chemical_element ,Alcohol ,General Medicine ,Platinum group ,Wastewater ,Nuclear Energy ,Silicon Dioxide ,Biochemistry ,Chromatography, Affinity ,Analytical Chemistry ,chemistry.chemical_compound ,Chromatographic separation ,Adsorption ,Platinum - Abstract
To separate platinum group metals (PGMs) from high level liquid waste, three novel macroporous silica-based adsorbents, namely, (Crea+Dodec)/SiO2-P, (Crea+TOA)/SiO2-P and (MOTDGA+TOA)/SiO2-P, were synthesized by introducing extractants Crea (N',N'-di-n-hexyl-thiodiglycolamide), TOA (Tri-n-octylamine), MOTDGA (N,N'-dimethyl-N,N'-di-n-octyl-thiodiglycolamide) along with theirs modifier, Dodec (n-dodecyl alcohol), into 50μm diameter SiO2-P particles by impregnation. Chromatographic separation of PGMs from simulated high level liquid waste was investigated by column method. It was found that 100% of Pd(II) and Re(VII) could be eluted out from simulate HLLW in 3.0M HNO3 solution using three adsorbents. For Ru(III) and Rh(III), high temperature has distinct effect on the adsorption rate and a further study for Ru(III) and Rh(III) is necessary to separate them from HLLW completely. In all six column experiments, a relatively satisfactory chromatographic separation operating for PGMs from simulated HLLW was obtained using (Crea+TOA)/SiO2-P adsorbent packed column at 323K.
- Published
- 2013
45. A case of multiple giant coronary aneurysms and abdominal aortic aneurysm coexisting with IgG4-related disease
- Author
-
Tatsuya Ito, Hiroe Ogawa, Hayato Nagasawa, Ayumi Okuyama, Koichi Amano, Koji Nishimura, Tsuneo Kondo, Hirofumi Takei, Eiko Nishi, Ryota Sakai, Yuichiro Shirai, and Takahiko Kurasawa
- Subjects
Male ,medicine.medical_specialty ,Disease ,Plasma cell ,Autoimmune Diseases ,Aortic aneurysm ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Aged ,Salivary gland ,Bile duct ,business.industry ,Coronary Aneurysm ,General Medicine ,medicine.disease ,Abdominal aortic aneurysm ,medicine.anatomical_structure ,Immunoglobulin G ,cardiovascular system ,Cardiology ,IgG4-related disease ,business ,Artery ,Aortic Aneurysm, Abdominal - Abstract
IgG4-related disease (IgG4RD) is a unique systemic lymphoproliferative disorder characterized by elevated serum IgG4 levels and IgG4-producing plasma cell expansion in the affected tissues, which are accompanied by fibrotic or sclerotic changes. Vascular lesions may also be a part of IgG4RD as a number of case reports have discussed inflammatory abdominal aortic aneurysms associated with IgG4RD, but coronary artery lesions seem to be rare complications of IgG4RD. A 71-year-old man suffered from multiple giant coronary aneurysms and an abdominal aortic aneurysm with concurrent pancreatic, gall bladder, bile duct, and salivary gland lesions resulting from IgG4RD. The present observations suggest that coronary aneurysms may also develop as a consequence of this disease.
- Published
- 2012
46. The impact of epicardial fat volume on coronary plaque vulnerability: insight from optical coherence tomography analysis
- Author
-
Yoshihisa Kinoshita, Mitsuyasu Terashima, Mariko Ehara, Masashi Kimura, Maoto Habara, Takahiko Suzuki, Nobuyoshi Tanaka, Etsuo Tsuchikane, Tsuyoshi Ito, Kenya Nasu, and Tatsuya Ito
- Subjects
Male ,medicine.medical_specialty ,Acute coronary syndrome ,medicine.medical_treatment ,Statistics as Topic ,Coronary Artery Disease ,Coronary Angiography ,Risk Assessment ,Coronary artery disease ,Optical coherence tomography ,Predictive Value of Tests ,Internal medicine ,Angioplasty ,Multidetector Computed Tomography ,Confidence Intervals ,Odds Ratio ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Angioplasty, Balloon, Coronary ,Coronary Artery Bypass ,Adiposity ,Aged ,Analysis of Variance ,medicine.diagnostic_test ,business.industry ,Fibrous cap ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Coronary Vessels ,Confidence interval ,medicine.anatomical_structure ,Cross-Sectional Studies ,Predictive value of tests ,Multivariate Analysis ,Cardiology ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Pericardium ,Tomography, Optical Coherence - Abstract
Epicardial fat volume (EFV) has been implicated in coronary artery disease. Relationship between EFV and coronary plaque vulnerability has not been elucidated. The aim of this study was to investigate the association of EFV with coronary plaque vulnerability by using optical coherence tomography (OCT).We enrolled 117 patients who underwent multislice computed tomography (MSCT) and OCT. EFV was quantified on MSCT. Patients were categorized according to tertiles of EFV: low tertile, EFV104.1 cm(3); mid-tertile, 104.1 cm(3)≤ EFV ≤ 130.7 cm(3); high tertile, EFV130.7 cm(3). A total of 180 vessels and 221 plaques were assessed with OCT to detect a thin-capped fibroatheroma (TCFA). TCFA was defined as a plaque with necrotic lipid pools ≥ 2 quadrants and minimum fibrous cap thickness measuring65 μm. Patients with low computed tomographic attenuation and positive remodelling were frequently observed and patients with OCT-derived TCFA were more common in the high tertile EFV. EFV was associated with a maximal lipid arc (103.4 ± 28.2 cm(3) in 0 quadrant, 120.2 ± 35.2 cm(3) in 1-2 quadrants, and 131.5 ± 41.1 cm(3) in2 quadrants; P= 0.01) and inversely correlated with a minimum fibrous cap thickness of the patients (r = -0.400, P0.01). In multivariate analysis, the high tertile of EFV remained an independent predictor for patients with OCT-derived TCFA [odds ratio (OR) 2.92; 95% confidence interval (CI) 1.13-7.55; P= 0.027] and acute coronary syndrome (ACS) patients (OR 2.89; 95% CI 1.14-7.29; P= 0.025).EFV was associated with coronary plaque vulnerability and high EFV was an independent predictor of ACS in patients with coronary artery disease.
- Published
- 2012
47. Integrin VLA-5 Negative Primary Plasma Cell Leukemia
- Author
-
Koichi Amano, Isao Ito, Ken-ichi Ohtake, Jun Koide, Tsutomu Takeuchi, Yasuhide Takano, Osamu Hosono, Tohru Abe, Hiroshi Suzuki, Tatsuya Ito, Kazutoshi Aoki, and Keiko Saito
- Subjects
Pathology ,medicine.medical_specialty ,Prednisolone ,Osteolysis ,CD38 ,Leukemia, Plasma Cell ,Fatal Outcome ,Receptors, Fibronectin ,Antigen ,Antigens, CD ,Antigens, Neoplasm ,Bone Marrow ,Antineoplastic Combined Chemotherapy Protocols ,Internal Medicine ,Humans ,Medicine ,ADP-ribosyl Cyclase ,Cyclophosphamide ,Multiple myeloma ,Aged ,Plasma cell leukemia ,Membrane Glycoproteins ,Proteinuria ,business.industry ,VLA-4 ,Combination chemotherapy ,General Medicine ,medicine.disease ,ADP-ribosyl Cyclase 1 ,Antigens, Differentiation ,Bence Jones protein ,Neoplasm Proteins ,Doxorubicin ,Vincristine ,Neoplastic Stem Cells ,Female ,medicine.symptom ,business ,Bence Jones Protein - Abstract
We present a case of primary plasma cell leukemia with Bence Jones proteinuria. After combination chemotherapy, leukemic cells and the urinary levels Bence Jones protein were decreased. Small lytic bone lesions were detected only in the skull. Typical plasma cells were rarely seen in peripheral blood on the hyperleukocytic phase, however they were increased in the advanced stages. The most important diagnostic sign was persistent expression of CD38 antigen on leukemic cells throughout the entire course of the illness and these leukemic cells expressed very late antigen-4 (VLA-4) but not VLA-5.(Internal Medicine 32: 565-568, 1993)
- Published
- 1993
48. ChemInform Abstract: The First Example of the (4+2) Cycloaddition Reaction of Silylketenes with 1,3-Dienes: A Convenient Preparation of 2-Pyranones and Isochromenes
- Author
-
Toyohiko Aoyama, Tatsuya Ito, and Takayuki Shioiri
- Subjects
Chemistry ,Organic chemistry ,General Medicine ,Cycloaddition - Abstract
Silylketenes easily undergo the [4+2] cycloaddition reaction with electron-rich 1,3-dienes and o-quinodimethanes to give the corresponding 2-pyranones and isochromenes, respectively.
- Published
- 2010
49. ChemInform Abstract: Enantioselective Synthesis of Angularly Substituted 1-Azabicyclic Ring Systems: Dynamic Kinetic Resolution Using Aza-Cope Rearrangements
- Author
-
Tatsuya Ito, Jocelyn Wang, and Larry E. Overman
- Subjects
chemistry.chemical_compound ,Bicyclic molecule ,Chemistry ,Stereochemistry ,Pyridine ,Diastereomer ,Enantioselective synthesis ,Iminium ,General Medicine ,Sigmatropic reaction ,Cis–trans isomerism ,Kinetic resolution - Abstract
A useful enantioselective synthesis of angularly substituted 1-azabicyclic molecules that delivers the bicyclic amine products in good yield and 99% ee is reported. Angularly substituted cis-octahydrocyclopenta[b]pyrroles, cis-octahydroindoles, cis-decahydrocyclohepta[b]pyrroles, and cis-octahydrocyclopenta[b]pyridine are formed in good yields and 99% ee exclusively as the cis stereoisomers. Decahydroquinolines are generated as mixtures of cis and trans stereoisomers in similarly high ee. The starting materials for this cascade transformation are assembled in five steps from cycloalkanones and enantiomerically pure (R)-2-phenyl-3-butenamine. This enantioselective synthesis introduces a new strategy for dynamic kinetic resolution in which a rapid tautomeric equilibration of diastereomeric iminium cations is combined with a diastereoselective sigmatropic rearrangement.
- Published
- 2010
50. Function-unknown glycoside hydrolase family 31 proteins, mRNAs of which were expressed in rice ripening and germinating stages, are alpha-glucosidase and alpha-xylosidase
- Author
-
Young-Min Kim, Makoto Sakai, Takeshi Yamamoto, Koutarou Kamiya, Seiya Chiba, Hiroyuki Sato, Tatsuya Ito, Shigeki Tanizawa, Yoshio Sano, Hiroyuki Nakai, Haruhide Mori, Atsuo Kimura, Tokio Imbe, Masayuki Okuyama, and Kazuki Matsubara
- Subjects
Signal peptide ,Kojibiose ,Starch ,Nigerose ,Germination ,Biochemistry ,Pichia ,Pichia pastoris ,Substrate Specificity ,chemistry.chemical_compound ,Glycoside hydrolase family 31 ,Hydrolase ,RNA, Messenger ,Cloning, Molecular ,Molecular Biology ,biology ,food and beverages ,Oryza ,alpha-Glucosidases ,General Medicine ,biology.organism_classification ,Xyloglucan ,Xylosidases ,chemistry ,Seeds - Abstract
In rice (Oryza sativa L., var Nipponbare) seeds, there were three mRNAs encoding for function-unknown hydrolase family 31 homologous proteins (ONGX-H1, ONGX-H3 and ONGX-H4): ONGX-H1 mRNA was expressed in ripening stage and mRNAs of ONGX-H3 and ONGX-H4 were found in both the ripening and germinating stages [Nakai et al., (2007) Biochimie 89, 49-62]. This article describes that the recombinant proteins of ONGX-H1 (rONGXG-H1), ONGX-H3 (rONGXG-H3) and ONG-H4 (rONGXG-H4) were overproduced in Pichia pastoris as fusion protein with the alpha-factor signal peptide of Saccharomyces cerevisiae. Purified rONGXG-H1 and rONGXG-H3 efficiently hydrolysed malto-oligosaccharides, kojibiose, nigerose and soluble starch, indicating that ONGX-H1 and ONGX-H3 are alpha-glucosidases. Their substrate specificities were similar to that of ONG2, a main alpha-glucosidase in the dry and germinating seeds. The rONGXG-H1 and rONGX-H3 demonstrated the lower ability to adsorb to and degradation of starch granules than ONG2 did, suggesting that three alpha-glucosidases, different in action to starch granules, were expressed in ripening stage. Additionally, purified rONGXG-H4 showed the high activity towards alpha-xylosides, in particular, xyloglucan oligosaccharides. The enzyme hardly hydrolysed alpha-glucosidic linkage, so that ONGX-H4 was an alpha-xylosidase. Alpha-xylosidase encoded in rice genome was found for the first time.
- Published
- 2007
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