1. Biologische Verfügbarkeit von Digoxin bei Patienten mit und ohne Magenresektion nach Billroth II
- Author
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Savic B, Kodrat G, Baur Mp, Bodem G, and Ochs H
- Subjects
Billroth II ,medicine.medical_specialty ,Digoxin ,business.industry ,medicine.medical_treatment ,digestive, oral, and skin physiology ,General Medicine ,Urine ,medicine.disease ,Gastroenterology ,Surgery ,carbohydrates (lipids) ,Excretion ,Urinary excretion ,Maintenance therapy ,Internal medicine ,Heart failure ,polycyclic compounds ,medicine ,cardiovascular diseases ,business ,medicine.drug ,Biological availability - Abstract
Biological availability of digoxin tablets was measured during maintenance therapy in ten hospitalized patients who had had a Billroth II gastric resection at least two years previously. Twelve patients on digoxin maintenance for heart failure but without gastro-intestinal disease served as controls. The mean value of daily digoxin urinary excretion over ten days in the resection group was 38.09 +/- 0.70% of the administered dose. The serum-digitalis level 12 and 24 hours after the last dose of glycoside (0.5 mg) was 1.30 +/- 0.04 ng/ml and did not significantly differ from that of the control group, nor did digoxin elimination in urine and the digoxin/creatinin excretion ratio. It is concluded that two-third gastric resection with exclusion of antigrade duodenal passage does not influence biological availability of digoxin given in tablets.
- Published
- 1975