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Absorption of digoxin from the distal parts of the intestine in man
- Source :
- European Journal of Clinical Pharmacology. 9:95-97
- Publication Year :
- 1975
- Publisher :
- Springer Science and Business Media LLC, 1975.
-
Abstract
- In 12 patients undergoing coloscopy, 0.5 mg digoxin in aqueous alcoholic solution was injected into the transverse colon. The late maximum of the blood level curve at about 2 hours after the administration suggested delayed absorption of the glycoside. However, the 24 hour urinary excretion of 17 +/- 3.4% in 8 patients with normal colonic mucosa demonstrated extensive absorption in the distal part of the bowel. The results have been contrasted with the findings in 4 patients with ulcerative colitis who excreted only 1.66 +/- 0.6% of the given dose in 24 hours.
- Subjects :
- Adult
Male
Blood level
Digoxin
medicine.medical_specialty
Adolescent
Colon
Biological Availability
Absorption (skin)
Gastroenterology
Urinary excretion
Internal medicine
Humans
Medicine
Pharmacology (medical)
Pharmacology
business.industry
Transverse colon
General Medicine
Middle Aged
medicine.disease
Ulcerative colitis
Bioavailability
Kinetics
Colonic mucosa
Intestinal Absorption
Colitis, Ulcerative
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 14321041 and 00316970
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Pharmacology
- Accession number :
- edsair.doi.dedup.....0b2ffec0eafba164defcce519182e4f6