1. Impacts of sarcopenia with or without obesity on patients with gastric cancer.
- Author
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Wu, Hao-Fan, Zhang, Xian-Zhong, Zhang, Feng-Min, and Zhuang, Cheng-Le
- Subjects
OBESITY complications ,GASTRECTOMY ,PEARSON correlation (Statistics) ,STOMACH tumors ,RESEARCH funding ,BODY mass index ,ACADEMIC medical centers ,BODY composition ,MULTIPLE regression analysis ,FISHER exact test ,TREATMENT effectiveness ,CANCER patients ,MULTIVARIATE analysis ,DESCRIPTIVE statistics ,CHI-squared test ,MANN Whitney U Test ,LONGITUDINAL method ,SURGICAL complications ,ODDS ratio ,STATISTICS ,CONFIDENCE intervals ,DATA analysis software ,SARCOPENIA ,OVERALL survival ,PROPORTIONAL hazards models ,EVALUATION - Abstract
Background: Obesity and sarcopenia are both viewed as pathological body composition issues and indicators of compromised nutritional status. The aim of this study was to evaluate the effects of sarcopenic obesity on short- and long-term clinical outcomes. Methods: The clinical data of patients who underwent radical gastrectomy between 2013 and 2019 were prospectively collected. Sarcopenia is defined by European Working Group on Sarcopenia in Older People (EWGSOP2) and obesity is defined by the body mass index (BMI). To identify the independent predictors of postoperative complications and overall survival, we performed univariate and multivariate logistic and Cox regression analyses. Results: In a total of 508 cases, 372 (73.2%) cases were diagnosed with non-sarcopenia, 112 (22.0%) with non-obese sarcopenia, and 24 (4.7%) with sarcopenic obesity. In the multivariate logistic regression, both of non-obese sarcopenia (OR = 2.305, 95% CI = 1.444–3.679, P < 0.001) and sarcopenic obesity (OR = 2.589, 95% CI = 1.088–6.156, P = 0.031) were independent risk factors for postoperative complications. In the multivariate Cox analysis, only non-obese sarcopenia (HR = 2.614, 95% CI = 1.882–3.631, P < 0.001) was independent risk factor for overall survival. Conclusions: Sarcopenic obesity serves as an independent risk factor for postoperative complications, but not for overall survival. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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