1. Search for "in vitro" antiviral activity of a new isoflavonic glycoside from Ulex europaeus.
- Author
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De Rodriguez DJ, Chulia J, Simões CM, Amoros M, Mariotte AM, and Girre L
- Subjects
- Animals, Cells, Cultured, Glucosides isolation & purification, Glycosides isolation & purification, Humans, Isoflavones isolation & purification, Molecular Structure, Poliovirus drug effects, Simplexvirus drug effects, Antiviral Agents isolation & purification, Flavonoids pharmacology, Glucosides pharmacology, Glycosides pharmacology, Isoflavones pharmacology, Plants analysis
- Abstract
Extracts from Ulex europaeus L. (Fabaceae) were tested for antiviral activity against HSV-1 and poliovirus. It was found that the n-butanolic extract significantly inhibited the replication of these viruses, as shown by inhibition of cytophathic effects and reduction of plaques; the extract has neither a prophylactic nor a virucidal activity. From this extract has been isolated and identified by chromatographic, chemical, and spectroscopic methods, the 5-O-methylgenistein 7-O-beta D-glucopyranoside. This isoflavonic glycoside has not been previously described and it is responsible at least partially for the antiviral activity.
- Published
- 1990
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