1. Increased factor VIII coagulant activity levels in male carriers of the factor V R2 polymorphism
- Author
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Barbara Lunghi, Paolo Ferraresi, Francesco Bernardi, Franco Manzato, Roberto Corrocher, Oliviero Olivieri, Nicola Martinelli, and Domenico Girelli
- Subjects
Male ,Heterozygote ,medicine.medical_specialty ,Genotype ,Polymorphism (computer science) ,Internal medicine ,medicine ,Humans ,Thrombophilia ,Blood Coagulation ,Aged ,Molecular Epidemiology ,Factor VIII ,Polymorphism, Genetic ,biology ,Data Collection ,Haplotype ,Factor V ,Biological activity ,Hematology ,General Medicine ,Odds ratio ,Middle Aged ,Confidence interval ,Endocrinology ,Haplotypes ,biology.protein ,Population study ,Female ,Factor V gene polymorphism ,FV ,R2 ,haplotype - Abstract
A common factor V gene haplotype, the FVR2 haplotype (FVHR2), has been associated with a reduced cofactor activity in activated protein C-mediated activated factor VIII inactivation. Our aim was to investigate the role of FVHR2 as a possible determinant of factor VIII levels in a population study. A total of 516 individuals (401 men, 115 women; mean age 58.4 +/- 10.8 years) were enrolled within the frame of a regional cardiovascular survey, characterized for factor VIII coagulant activity (FVIII:c) and factor V coagulant activity (FV:c) levels, and genotyped for factor V polymorphisms. In men without signs of overt inflammation, FVHR2 carriers had higher levels of FVIII:c than noncarriers (154 IU/dl, 95% confidence interval = 143-166 versus 142 IU/dl, 95% confidence interval = 138-147; P = 0.045) and were more represented in individuals with high (> or = 150 IU/dl) FVIII:c levels (21.2 versus 10.8%; odds ratio = 2.27, 95% confidence interval = 1.17-4.39 after adjustment for age, blood group and high-sensitivity C-reactive protein levels). In conclusion, this clinical report suggests the common FVHR2 as a possible independent determinant of FVIII:c levels. The report concomitantly addresses the relationship between factor V and factor VIII levels and supports the hypothesis of a mild prothrombotic role of FVHR2 by means of increased factor VIII levels.
- Published
- 2007