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Increased factor VIII coagulant activity levels in male carriers of the factor V R2 polymorphism
- Source :
- Blood Coagulation & Fibrinolysis. 18:125-129
- Publication Year :
- 2007
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2007.
-
Abstract
- A common factor V gene haplotype, the FVR2 haplotype (FVHR2), has been associated with a reduced cofactor activity in activated protein C-mediated activated factor VIII inactivation. Our aim was to investigate the role of FVHR2 as a possible determinant of factor VIII levels in a population study. A total of 516 individuals (401 men, 115 women; mean age 58.4 +/- 10.8 years) were enrolled within the frame of a regional cardiovascular survey, characterized for factor VIII coagulant activity (FVIII:c) and factor V coagulant activity (FV:c) levels, and genotyped for factor V polymorphisms. In men without signs of overt inflammation, FVHR2 carriers had higher levels of FVIII:c than noncarriers (154 IU/dl, 95% confidence interval = 143-166 versus 142 IU/dl, 95% confidence interval = 138-147; P = 0.045) and were more represented in individuals with high (> or = 150 IU/dl) FVIII:c levels (21.2 versus 10.8%; odds ratio = 2.27, 95% confidence interval = 1.17-4.39 after adjustment for age, blood group and high-sensitivity C-reactive protein levels). In conclusion, this clinical report suggests the common FVHR2 as a possible independent determinant of FVIII:c levels. The report concomitantly addresses the relationship between factor V and factor VIII levels and supports the hypothesis of a mild prothrombotic role of FVHR2 by means of increased factor VIII levels.
- Subjects :
- Male
Heterozygote
medicine.medical_specialty
Genotype
Polymorphism (computer science)
Internal medicine
medicine
Humans
Thrombophilia
Blood Coagulation
Aged
Molecular Epidemiology
Factor VIII
Polymorphism, Genetic
biology
Data Collection
Haplotype
Factor V
Biological activity
Hematology
General Medicine
Odds ratio
Middle Aged
Confidence interval
Endocrinology
Haplotypes
biology.protein
Population study
Female
Factor V gene polymorphism
FV
R2
haplotype
Subjects
Details
- ISSN :
- 09575235
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Blood Coagulation & Fibrinolysis
- Accession number :
- edsair.doi.dedup.....fdb65ef05f84ec472dd61fa1e3751628