10 results on '"Endale Tadesse"'
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2. Typhoid fever: clinical presentation and associated factors in febrile patients visiting Shashemene Referral Hospital, southern Ethiopia
- Author
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Limenih Habte, Endale Tadesse, Getachew Ferede, and Anteneh Amsalu
- Subjects
Blood culture ,Typhoid fever ,Prevalence ,Ethiopia ,Medicine ,Biology (General) ,QH301-705.5 ,Science (General) ,Q1-390 - Abstract
Abstract Objective Although typhoid fever is a major public health problem in Ethiopia, data is not available in the study area. Therefore, this study aimed to determine the prevalence, clinical presentation at the time of diagnosis and associated factors of typhoid fever among febrile patients visiting Shashemene Referral Hospital, southern Ethiopia. A cross-sectional study was conducted from January 1, 2016, to October 30, 2016. Socio-demographic and clinical data were collected using a structured questionnaire. A blood sample was collected and inoculated into Tryptic soy broth. Results A total of 421 adult febrile patients suspected of typhoid fever were included in the study. Of these, the overall prevalence of culture-confirmed typhoid fever was 5.0% (21/421). The prevalence of typhoid fever was significantly associated with rural residence (8.4%). As compared to the urban resident, the rural resident was 3.6 times more likely found to have culture-confirmed typhoid fever. The prevalence of typhoid fever was significantly associated with those patients whose water source was spring 7 (12.3%) and river 7 (13.2%). All of those study participants who used treated water were culture negative. Fever for ≥ 5 days, abdominal pain, and skin rash independently predicted blood culture-confirmed typhoid fever.
- Published
- 2018
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3. Typhoid fever: clinical presentation and associated factors in febrile patients visiting Shashemene Referral Hospital, southern Ethiopia
- Author
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Getachew Ferede, Limenih Habte, Endale Tadesse, Anteneh Amsalu, Habte, Limenih, Tadesse, Endale, Ferede, Getachew, and Amsalu, Anteneh
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Adult ,Male ,medicine.medical_specialty ,Abdominal pain ,Adolescent ,Referral ,prevalence ,030231 tropical medicine ,lcsh:Medicine ,blood culture ,Blood culture ,General Biochemistry, Genetics and Molecular Biology ,Typhoid fever ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Prevalence ,Humans ,030212 general & internal medicine ,lcsh:Science (General) ,Referral and Consultation ,lcsh:QH301-705.5 ,Treated water ,medicine.diagnostic_test ,business.industry ,Public health ,lcsh:R ,General Medicine ,Middle Aged ,Salmonella typhi ,bacterial infections and mycoses ,medicine.disease ,Rash ,Research Note ,Cross-Sectional Studies ,lcsh:Biology (General) ,Female ,Ethiopia ,Presentation (obstetrics) ,medicine.symptom ,business ,typhoid fever ,lcsh:Q1-390 - Abstract
Refereed/Peer-reviewed Objective: Although typhoid fever is a major public health problem in Ethiopia, data is not available in the study area. Therefore, this study aimed to determine the prevalence, clinical presentation at the time of diagnosis and associated factors of typhoid fever among febrile patients visiting Shashemene Referral Hospital, southern Ethiopia. A cross-sectional study was conducted from January 1, 2016, to October 30, 2016. Socio-demographic and clinical data were collected using a structured questionnaire. A blood sample was collected and inoculated into Tryptic soy broth. Results: A total of 421 adult febrile patients suspected of typhoid fever were included in the study. Of these, the overall prevalence of culture-confirmed typhoid fever was 5.0% (21/421). The prevalence of typhoid fever was significantly associated with rural residence (8.4%). As compared to the urban resident, the rural resident was 3.6 times more likely found to have culture-confirmed typhoid fever. The prevalence of typhoid fever was significantly associated with those patients whose water source was spring 7 (12.3%) and river 7 (13.2%). All of those study participants who used treated water were culture negative. Fever for ≥ 5 days, abdominal pain, and skin rash independently predicted blood culture-confirmed typhoid fever.
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- 2018
4. Genital Chlamydia trachomatis Infection among Women of Reproductive Age Attending the Gynecology Clinic of Hawassa University Referral Hospital, Southern Ethiopia
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Techalew Shimelis, Million Teshome, Endale Tadesse, Anteneh Amsalu, Tadesse, Endale, Teshome, Million, Amsalu, Anteneh, and Shimelis, Techalew
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sexually transmitted infections (STIs) ,Cross-sectional study ,Gynecologic Infections ,lcsh:Medicine ,Chlamydia trachomatis ,medicine.disease_cause ,Pathology and Laboratory Medicine ,Chlamydia Infection ,Hospitals, University ,Geographical Locations ,Gonorrhea ,0302 clinical medicine ,Risk Factors ,Epidemiology ,Female Infertility ,Prevalence ,Medicine and Health Sciences ,Mass Screening ,030212 general & internal medicine ,Chlamydia ,lcsh:Science ,Referral and Consultation ,education.field_of_study ,Multidisciplinary ,Obstetrics ,Reproduction ,Obstetrics and Gynecology ,Middle Aged ,Bacterial Pathogens ,Infectious Diseases ,Medical Microbiology ,Female ,Pathogens ,Neisseria ,Research Article ,Adult ,medicine.medical_specialty ,Referral ,Adolescent ,Urology ,030231 tropical medicine ,Population ,Sexually Transmitted Diseases ,Microbiology ,03 medical and health sciences ,Young Adult ,medicine ,Humans ,Sex organ ,education ,Microbial Pathogens ,Mass screening ,Gynecology ,Chlamydia trachomatis(CT) ,Bacteria ,business.industry ,lcsh:R ,Organisms ,Biology and Life Sciences ,Chlamydia Infections ,Neisseria gonorrhoeae ,Cross-Sectional Studies ,Infertility ,People and Places ,Africa ,Women's Health ,lcsh:Q ,Ethiopia ,business - Abstract
Background: Urogenital infection with Chlamydia trachomatis(CT) is one of the most common bacterial sexually transmitted infections (STIs) world-wide, especially in developing nations where routine laboratory diagnosis is unavailable. Little is known about the epidemiology of this infection in Ethiopia where other STIs are prevalent. This study was conducted to determine the prevalence and associated factors of CT infection among women of reproductive age. Methods: A cross-sectional study was conducted among 322 consecutive women aged between 15–49 years at Hawassa University Referral Hospital from November 2014 to April 2015. Data on socio-demography and potential risk factors for genital infection were collected using structured questionnaires. Moreover, endocervical swabs were collected from all participants, screened for CT antigen using rapid immunochromatography assay, and cultured following the standard bacteriological method to isolate Neisseria gonorrhoeae. Result: In this study, the overall prevalence of CT antigen and N. gonorrhoeae infection was 61(18.9%) and 1(0.31%), respectively. Women aged 15–24 years had the highest prevalence of CT infection (24.2%), followed by those aged 25–34 years (16.8%) and those aged 35–49 years (9.6%). CTinfection was associated with women who had unprotected sex within the last six months (aOR = 3.459; 95% CI = 1.459–8.222) and were sexually active for 6–10 years (aOR = 3.076; 95% CI = 1.152–8.209). None of the clinical symptoms and diagnoses was significantly associated with CT antigen positivity. Conclusions: The high prevalence of genital CT infection in this study highlights the need for further large-scale studies on the general population. Thus, screening of women regardless of their symptoms should be in place. Refereed/Peer-reviewed
- Published
- 2016
5. Syphilis among people with HIV infection in southern Ethiopia: sero-prevalence and risk factors
- Author
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Techalew Shimelis, Kinfe Lemma, Henock Ambachew, and Endale Tadesse
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Adult ,Male ,medicine.medical_specialty ,Population ,Context (language use) ,HIV Infections ,Syphilis Serodiagnosis ,Sex Factors ,Risk Factors ,Seroepidemiologic Studies ,Environmental health ,Epidemiology ,medicine ,Prevalence ,Humans ,Mass Screening ,Syphilis ,Risk factor ,education ,Mass screening ,education.field_of_study ,Transmission (medicine) ,business.industry ,Age Factors ,virus diseases ,HIV ,Middle Aged ,medicine.disease ,Infectious Diseases ,Cross-Sectional Studies ,Immunology ,Female ,Ethiopia ,business ,Research Article - Abstract
Background Syphilis facilitates both HIV (human immunodeficiency virus) transmission and acquisition, reflecting the complex interplay between the two infections. Scarce information exists regarding syphilis epidemiology in Ethiopian context. Thus, this study determined the sero-prevalence of syphilis and associated risk factors in people with HIV infection. Methods A cross-sectional study was conducted at Hawassa Referral Hospital, southern Ethiopia from January to May, 2014. A consecutive 993 HIV–infected participants were studied; but individuals under 15 years of age or treated for syphilis or those with a CD4+ T–cell count below 50 cells/μl were excluded. Structured questionnaires were used to collect data on socio-demography and potential risk factors for syphilis. Moreover, blood samples were collected from all participants and screened for syphilis using rapid plasma reagin (RPR) test, and those found sero-positive were confirmed using treponema pallidum haemagglutination assay (TPHA). Results The sero-prevalence of syphilis was found to be 7.3% (95% CI 5.7– 9%). The rate of infection was significantly higher among participants who were ART (antiretroviral therapy) naive (odds ratio (OR) = 2.2; 95% CI 1.22 – 4.1), men (OR = 2.2; 95% CI 1.22 – 3.87), older than 50 years of age (OR = 3.9; 95% CI 1.45 – 6.94), had only primary school level education (OR = 7.8; 95% CI 2.63 – 23.2) and had a history of blood transfusion (OR = 3.9; 95% CI 1.5 – 10.4). Conclusion The high prevalence of syphilis among HIV-infected population warrants integrating syphilis screening with HIV care to limit the clinical consequences of untreated syphilis as well as its adverse impact on HIV transmission.
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- 2015
6. The diagnostic performance evaluation of the SD BIOLINE HIV/syphilis Duo rapid test in southern Ethiopia: a cross-sectional study
- Author
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Techalew Shimelis and Endale Tadesse
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,HIV Infections ,Antibodies, Viral ,Sensitivity and Specificity ,Syphilis Serodiagnosis ,Young Adult ,Acquired immunodeficiency syndrome (AIDS) ,Predictive Value of Tests ,Internal medicine ,medicine ,False positive paradox ,Humans ,Mass Screening ,Syphilis ,Treponema pallidum ,Diagnostics ,Mass screening ,Aged ,Antigens, Bacterial ,Treponema ,biology ,business.industry ,Research ,virus diseases ,AIDS Serodiagnosis ,HIV ,General Medicine ,Hemagglutination Tests ,Middle Aged ,medicine.disease ,biology.organism_classification ,Cross-Sectional Studies ,Predictive value of tests ,Immunology ,Female ,Ethiopia ,Reagent Kits, Diagnostic ,business ,Serostatus ,Biomarkers - Abstract
Objective To determine the diagnostic performance of the SD BIOLINE HIV/syphilis Duo rapid test. Design A hospital-based cross-sectional study. Setting This evaluation was conducted at one of the largest hospitals in southern Ethiopia. Participants Serum samples obtained from clients attending the antiretroviral therapy and voluntary counselling and testing centres were used. Sera were originally collected for the purpose of investigating syphilis epidemiology. The performance of the test to detect HIV was evaluated using 400 sera (200 HIV positives and 200 HIV negatives). Also, its performance to detect syphilis was evaluated using 85 syphilis positive and 100 syphilis negative serum samples. Individuals
- Published
- 2015
7. Seroprevalence of Helicobacter pylori infection and its related risk factors in symptomatic patients in southern Ethiopia
- Author
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Demo Yemane, Techalew Shimelis, Deresse Daka, and Endale Tadesse
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Peptic ,Chronic gastritis ,Seroprevalence ,General Biochemistry, Genetics and Molecular Biology ,ABO Blood-Group System ,Helicobacter Infections ,Young Adult ,Age Distribution ,Risk Factors ,Seroepidemiologic Studies ,Internal medicine ,ABO blood group system ,medicine ,Humans ,Aged ,Medicine(all) ,Blood type ,Aged, 80 and over ,Rh-Hr Blood-Group System ,biology ,Helicobacter pylori ,Biochemistry, Genetics and Molecular Biology(all) ,business.industry ,General Medicine ,ABO blood groups ,Middle Aged ,biology.organism_classification ,medicine.disease ,Immunology ,Etiology ,Female ,Ethiopia ,business ,Rh blood group system ,Research Article - Abstract
Background Helicobacter pylori is the main etiology of peptic ulcers and chronic gastritis. Various studies showed that blood type ‘O’ is more common among patients with peptic ulcer. The aim of this study was to determine the seroprevalence of H. pylori antibodies and its relationship with ABO/Rhesus blood groups, age, sex and residence of symptomatic patients in southern Ethiopia. Methods A cross-sectional study was conducted in a total of 408 consecutive patients with upper abdominal complaints at Hawassa University Hospital from October 2012 to January 2013. Data on demographic factors was collected from all participants using questionnaires. Blood samples were also collected and tested for ABO and Rh blood group phenotype using hemagglutination test and for anti-H. pylori antibody (IgG) using two different ELISAs.. Results The overall seroprevalence of H. pylori infection was 83.3% (340/408), and it was significantly higher in rural (71.2%) compared to urban residents (28.8%) (p = 0.008). Participants with blood group AB, A, O, B, and Rh positive had H. pylori prevalence of 88.9, 84.2, 83.7, 80.9, and 83.5%, respectively. H. pylori infection was not significantly influenced by age, sex, occupation, educational status and ABO/ Rh status (p >0.05). Conclusion The high seroprevalence of H. pylori infection especially among rural residents calls for immediate intervention measures so that its clinical consequences could be minimized. ABO/Rh blood group was not found to be associated with H. pylori infection.
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- 2014
8. Burden of metabolic syndrome among HIV-infected patients in Southern Ethiopia
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Girmay Medhin, Yoseph Cherinet Megerssa, Endale Tadesse, Agete Tadewos, Techalew Shimelis, Samuel Kinde, and Demo Yemane Tesfaye
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Adult ,Male ,medicine.medical_specialty ,Anti-HIV Agents ,Endocrinology, Diabetes and Metabolism ,Population ,HIV Infections ,Insulin resistance ,Sex Factors ,Diabetes mellitus ,Internal medicine ,Antiretroviral Therapy, Highly Active ,Internal Medicine ,medicine ,Prevalence ,Humans ,education ,National Cholesterol Education Program ,Dyslipidemias ,Metabolic Syndrome ,education.field_of_study ,medicine.diagnostic_test ,Anthropometry ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Cholesterol ,Cross-Sectional Studies ,Logistic Models ,Immunology ,Multivariate Analysis ,Female ,Ethiopia ,Lipodystrophy ,Metabolic syndrome ,business ,Lipid profile ,Dyslipidemia - Abstract
Background HIV infection and highly active antiretroviral therapy (HAART) can induce metabolic disturbances including lipodystrophy, dyslipidemia, and insulin resistance, which are reminiscences of metabolic syndrome (MS). However, little is known regarding the magnitude of MS in Ethiopian HIV population. This study, aimed to estimate the prevalence of MS among HIV positive patients with and without HAART. Methods A cross-sectional study was conducted at Hawassa University Referral Hospital, southern Ethiopia between February 2012 and April 2013. Data on demographic and anthropometric characteristics were collected from a total of 374 HIV positive participants (188 on ART and 186 on Pre-ART) using WHO stepwise approach. Fasting blood glucose, total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol was measured. The International Diabetes Federation (IDF) and the National Cholesterol Education Program: Adult Treatment Panel III (ATP) Criteria were used to define MS. Result Of the 374 study participants 68% were females, and 50.3% were receiving ART. Using the IDF criteria, metabolic syndrome was diagnosed in 25% of patients receiving ART compared to 22.5% of the ART naive group (OR: 1.14 CI: 0.71–1.84). Using the ATP criteria, the prevalence of MS was 18.1% in the ART groups compared to 15.6% in ART naive group (OR: 1.20, CI: 0.69–2.06). Patients receiving ART had significantly elevated Cholesterol, triglyceride, glucose and LDL-c levels but lower CD4+ cell counts than the Pre-ART groups. Being a female, having BMI of at least 25, older age (i.e. age ≥ 45 years) and having total cholesterol of at least 200 mg/dl were significantly associated with the presence of MS. Using the ATP criteria to define MS, taking d4T-3TC-EFV regimen was significantly associated with higher odds of MS. Conclusion Almost a quarter of HIV patients on ART developed metabolic syndrome. Furthermore patients on ART had elevated lipid profile and glucose metabolism disturbance than the ART naive.
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- 2014
9. Asymptomatic urinary tract infection among pregnant women attending the antenatal clinic of Hawassa Referral Hospital, Southern Ethiopia
- Author
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Belayhun Kibret, Techalew Shimelis, Million Teshome, Yared Merid, and Endale Tadesse
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Adult ,medicine.medical_specialty ,Pediatrics ,Staphylococcus aureus ,Adolescent ,Bacteriuria ,Cross-sectional study ,Antibiotic sensitivity ,Staphylococcus ,Population ,Prenatal care ,Microbial Sensitivity Tests ,Asymptomatic ,General Biochemistry, Genetics and Molecular Biology ,Young Adult ,Pregnancy ,Ampicillin ,medicine ,Escherichia coli ,Prevalence ,Humans ,Pregnancy Complications, Infectious ,education ,Hospitals, Teaching ,Asymptomatic Infections ,Referral and Consultation ,Medicine(all) ,education.field_of_study ,Urinary tract infection ,Biochemistry, Genetics and Molecular Biology(all) ,Obstetrics ,business.industry ,Pregnant women ,Prenatal Care ,General Medicine ,Middle Aged ,medicine.disease ,Anti-Bacterial Agents ,Cross-Sectional Studies ,Urinary Tract Infections ,Female ,Ethiopia ,medicine.symptom ,business ,Asymptomatic bacteriuria ,medicine.drug ,Research Article - Abstract
Background Untreated asymptomatic bacteriuria (ASB) during pregnancy may cause serious complications including pyelonephritis and delivery of premature or low-birth-weight infants. However, little is known about asymptomatic bacteriuria in pregnancy in Ethiopia. This study aimed to assess the prevalence of asymptomatic bacteriuria, bacterial agents, and their antibiotic susceptibility pattern in pregnant women attending antenatal clinic of the Hawassa Teaching and Referral Hospital. Methods A cross-sectional study was conducted in a total of 244 pregnant women with no sign and symptom of urinary tract infection from March 2012 to September 2012. Clean catch mid-stream urine samples were collected from all study participants using sterile containers. Urine samples were cultured using standard bacteriological methods. Identification of suspected colonies and antibiotic sensitivity testing were done. Result Out of 244 pregnant women, 46(18.8%) were positive for asymptomatic bacteriuria (Colony Forming Unit ≥ 105/mL). There was no difference in prevalence of asymptomatic bacteriuria with respect to age (p = 0.07) and trimester (p = 0.27).The most frequently isolated bacteria were coagulase negative Staphylococcus (32.6%), followed by Escherichia coli (26.1%), and Staphylococcus auerus (13%). The susceptibility rate of bacterial isolate was highest for norfloxacin (64.7%) and lowest for ampicillin (17.6%). Conclusion The high prevalence of ASB in pregnant women warrant the need to screen all pregnant women and treat those infected with appropriate antimicrobial regimens in order to reduce its complications.
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- 2014
10. Preservice laboratory education strengthening enhances sustainable laboratory workforce in Ethiopia
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Habtamu Mitiku, Aster Tsegaye, Meseret Alem, Wendy Arneson, Waqtola Cheneke, Samuel Kinde, Endale Tadesse, Thomas A. Kenyon, Kedir Yimer, Yenew Kebede, Peter N. Fonjungo, and Derese Tefera
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Public Administration ,030231 tropical medicine ,Medical laboratory ,Laboratory Technologist ,Health administration ,Preservice education ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,Medical Laboratory Personnel ,Medicine ,Training ,Humans ,030212 general & internal medicine ,Remedial education ,Curriculum ,Academic year ,business.industry ,4. Education ,Research ,Teaching ,Public Health, Environmental and Occupational Health ,PEPFAR ,Standardization ,3. Good health ,Laboratory workforce strengthening ,Sustainability ,Workforce ,Workforce planning ,Feasibility Studies ,Ethiopia ,business ,Education, Medical, Undergraduate ,Program Evaluation - Abstract
Background There is a severe healthcare workforce shortage in sub Saharan Africa, which threatens achieving the Millennium Development Goals and attaining an AIDS-free generation. The strength of a healthcare system depends on the skills, competencies, values and availability of its workforce. A well-trained and competent laboratory technologist ensures accurate and reliable results for use in prevention, diagnosis, care and treatment of diseases. Methods An assessment of existing preservice education of five medical laboratory schools, followed by remedial intervention and monitoring was conducted. The remedial interventions included 1) standardizing curriculum and implementation; 2) training faculty staff on pedagogical methods and quality management systems; 3) providing teaching materials; and 4) procuring equipment for teaching laboratories to provide practical skills to complement didactic education. Results A total of 2,230 undergraduate students from the five universities benefitted from the standardized curriculum. University of Gondar accounted for 252 of 2,230 (11.3%) of the students, Addis Ababa University for 663 (29.7%), Jimma University for 649 (29.1%), Haramaya University for 429 (19.2%) and Hawassa University for 237 (10.6%) of the students. Together the universities graduated 388 and 312 laboratory technologists in 2010/2011 and 2011/2012 academic year, respectively. Practical hands-on training and experience with well-equipped laboratories enhanced and ensured skilled, confident and competent laboratory technologists upon graduation. Conclusions Strengthening preservice laboratory education is feasible in resource-limited settings, and emphasizing its merits (ample local capacity, country ownership and sustainability) provides a valuable source of competent laboratory technologists to relieve an overstretched healthcare system.
- Published
- 2013
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