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Your search keyword '"Morgan, Jerry"' showing total 4 results
Start Over Author "Morgan, Jerry" Topic estrogen
4 results on '"Morgan, Jerry"'

1. Estrogen receptor ligands. Part 14: Application of novel antagonist side chains to existing platforms

Author

Blizzard, Timothy A., Morgan, Jerry D., Chan, Wanda, Birzin, Elizabeth T., Pai, Lee-Yuh, Hayes, Edward C., DaSilva, Carolyn A., Mosley, Ralph T., Yang, Yi Tien, Rohrer, Susan P., DiNinno, Frank, and Hammond, Milton L.

Subjects
*ESTROGEN, *SEX hormones, *STEROID hormones, *ESTROGEN antagonists
Abstract

Abstract: Two novel side chains which had previously been found to enhance antagonist activity in the dihydrobenzoxathiin SERM series were applied to three existing platforms. The novel side chains did not improve the antagonist activity of the existing platforms. [Copyright &y& Elsevier]

Published
2005
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2. Androstene-3,5-dienes as ER-β selective SERMs

Author

Blizzard, Timothy A., Gude, Candido, Morgan, Jerry D., Chan, Wanda, Birzin, Elizabeth T., Mojena, Marina, Tudela, Consuelo, Chen, Fang, Knecht, Kristin, Su, Qin, Kraker, Bryan, Mosley, Ralph T., Holmes, Mark A., Rohrer, Susan P., and Hammond, Milton L.

Subjects
*SEX hormones, *STEROID hormones, *HORMONES, *STEROIDS
Abstract

Abstract: A series of androstene-3,5-diene derivatives were prepared. Despite lacking the C-3 hydroxyl previously believed necessary for ER activity, some of the analogs retained surprising affinity for ER-β. For example, diene 4 retained excellent selectivity and potency as an ER-β agonist and was more selective for ER-β over the androgen receptor (AR). [Copyright &y& Elsevier]

Published
2007
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3. Androstenediol analogs as ER-β-selective SERMs

Author

Blizzard, Timothy A., Gude, Candido, Morgan, Jerry D., Chan, Wanda, Birzin, Elizabeth T., Mojena, Marina, Tudela, Consuelo, Chen, Fang, Knecht, Kristin, Su, Qin, Kraker, Bryan, Mosley, Ralph T., Holmes, Mark A., Sharma, Nandini, Fitzgerald, Paula M.D., Rohrer, Susan P., and Hammond, Milton L.

Subjects
*ESTROGEN, *ANDROSTENEDIOL, *LIGANDS (Biochemistry), *PERFORMANCE-enhancing drugs
Abstract

Abstract: A series of 19-substituted androstenediol derivatives was prepared. Some of the novel analogs were surprisingly potent and selective ligands for ER-β. [Copyright &y& Elsevier]

Published
2006
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4. Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers

Author

Blizzard, Timothy A., DiNinno, Frank, Morgan, Jerry D., Chen, Helen Y., Wu, Jane Y., Kim, Seongkon, Chan, Wanda, Birzin, Elizabeth T., Yang, Yi Tien, Pai, Lee-Yuh, Fitzgerald, Paula M.D., Sharma, Nandini, Li, Ying, Zhang, Zhoupeng, Hayes, Edward C., DaSilva, Carolyn A., Tang, Wei, Rohrer, Susan P., Schaeffer, James M., and Hammond, Milton L.

Published
2005
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