1. Multiple myeloma in Nigeria: a multi-centre epidemiological and biomedical study
- Author
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Okocha Onyichide Emmanuel, Akingbola Titilola Stella, Joseph Aondowase Orkuma, Asuquo Inyama Marcus, Ujah Innocent Otobo, Kalejaiye Olufunto Olufela, Nnodu Obigeli Eunice, Balogun Modupe Taiwo, Aneke John Chinawaeze, Madu Anazoeze, Odunukwe Nkiruka Nnonyelum, and Gwarzo Gwarzo Dalhat
- Subjects
Melphalan ,Male ,medicine.medical_specialty ,Nigeria ,Pain ,Fractures, Bone ,Multiple myeloma ,Internal medicine ,Epidemiology ,Prevalence ,Medicine ,Humans ,Bone pain ,Survival rate ,Aged ,Retrospective Studies ,treatment modalities ,lcsh:R5-920 ,business.industry ,lcsh:Public aspects of medicine ,Research ,lcsh:RA1-1270 ,Anemia ,General Medicine ,Middle Aged ,medicine.disease ,Bence Jones protein ,Surgery ,Survival Rate ,medicine.anatomical_structure ,Treatment Outcome ,Multiple myeloma, Nigeria, presentation, treatment modalities ,Cohort ,Female ,Kidney Diseases ,Bone marrow ,medicine.symptom ,lcsh:Medicine (General) ,business ,presentation ,medicine.drug - Abstract
Introduction : Myelomatosis is a malignant proliferation of plasma cells in the bone marrow, with relatively high prevalence in African populations. Variation in genetic mutations has been observed in individual patients and may be responsible for differences in disease pattern and treatment outcomes. This study described the presentations and treatment outcomes of multiple myeloma in nigerian. Methods : The data was obtained retrospectively from the case notes of 135 patients diagnosed with multiple myeloma from eight tertiary health institutions across the six geopolitical zones of Nigeria from 2005 to 2014. Data analysis was carried out using SPSS 17.0. Results : The predominant presentations were bone pain in 97 (74%), nephropathy in 47 (35.9%) and pathological fractures in 58 (44.3%). Sixty-seven percent (67%) of the patients were less than 60 years, and 35% had Bence Jones proteinuria. The overall survival beyond 6 months was 91.3%, mean duration of survival rate was 7.4 months. Majority (66.2%) were on Melphalan alone or on melphalan-containing combinations. A higher packed cell volume (PCV) and total serum protein levels at presentation were associated with increased survival, p=0.033 and 0.036, respectively. Conclusion : This study portrayed the importance of detail investigation on the causes of bone pain and anaemia in person's aged 40 years and above. There is a high prevalence of nephropathy in this cohort of patients which needs to be further investigated. Majority of the patients, though < 65 years of age were placed on melphalan-containing combinations, which foreclosed chances of future autologous bone marrow transplantation. Key words : Multiple myeloma, Nigeria, presentation, treatment modalities
- Published
- 2015