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Multiple myeloma in Nigeria: a multi-centre epidemiological and biomedical study
- Source :
- The Pan African Medical Journal, Pan African Medical Journal; Vol 22, No 1 (2015), The Pan African Medical Journal, Vol 22, Iss 292 (2015)
- Publication Year :
- 2015
- Publisher :
- The African Field Epidemiology Network, 2015.
-
Abstract
- Introduction : Myelomatosis is a malignant proliferation of plasma cells in the bone marrow, with relatively high prevalence in African populations. Variation in genetic mutations has been observed in individual patients and may be responsible for differences in disease pattern and treatment outcomes. This study described the presentations and treatment outcomes of multiple myeloma in nigerian. Methods : The data was obtained retrospectively from the case notes of 135 patients diagnosed with multiple myeloma from eight tertiary health institutions across the six geopolitical zones of Nigeria from 2005 to 2014. Data analysis was carried out using SPSS 17.0. Results : The predominant presentations were bone pain in 97 (74%), nephropathy in 47 (35.9%) and pathological fractures in 58 (44.3%). Sixty-seven percent (67%) of the patients were less than 60 years, and 35% had Bence Jones proteinuria. The overall survival beyond 6 months was 91.3%, mean duration of survival rate was 7.4 months. Majority (66.2%) were on Melphalan alone or on melphalan-containing combinations. A higher packed cell volume (PCV) and total serum protein levels at presentation were associated with increased survival, p=0.033 and 0.036, respectively. Conclusion : This study portrayed the importance of detail investigation on the causes of bone pain and anaemia in person's aged 40 years and above. There is a high prevalence of nephropathy in this cohort of patients which needs to be further investigated. Majority of the patients, though < 65 years of age were placed on melphalan-containing combinations, which foreclosed chances of future autologous bone marrow transplantation. Key words : Multiple myeloma, Nigeria, presentation, treatment modalities
- Subjects :
- Melphalan
Male
medicine.medical_specialty
Nigeria
Pain
Fractures, Bone
Multiple myeloma
Internal medicine
Epidemiology
Prevalence
Medicine
Humans
Bone pain
Survival rate
Aged
Retrospective Studies
treatment modalities
lcsh:R5-920
business.industry
lcsh:Public aspects of medicine
Research
lcsh:RA1-1270
Anemia
General Medicine
Middle Aged
medicine.disease
Bence Jones protein
Surgery
Survival Rate
medicine.anatomical_structure
Treatment Outcome
Multiple myeloma, Nigeria, presentation, treatment modalities
Cohort
Female
Kidney Diseases
Bone marrow
medicine.symptom
lcsh:Medicine (General)
business
presentation
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 19378688
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- The Pan African Medical Journal
- Accession number :
- edsair.doi.dedup.....2ebdff80b80f3f0eeebc298b729d39ca