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We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt %), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery. [ABSTRACT FROM AUTHOR]

Nanotechnology Biodegradable hybrid materials that combine high porosity and drug payload without drug leakage are in high demand. In their Communication on page 14806 ff., N. M. Khashab and et al. report the first completely biodegradable mesoporous hybrid nanovectors in the presence of proteases. Oxamide‐phenylene‐based mesoporous organosilica nanoparticles were synthesized with oxamide functions to enable the biodegradability in the presence of trypsin. Exceptionally high payloads of drugs (up to 84 wt%) and a unique zero premature leakage without the pore capping were observed. [ABSTRACT FROM AUTHOR]